LOCUS       NM_012821               5913 bp    mRNA    linear   ROD 11-AUG-2024
DEFINITION  Rattus norvegicus adenylate cyclase 6 (Adcy6), transcript variant
            2, mRNA.
ACCESSION   NM_012821
VERSION     NM_012821.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5913)
  AUTHORS   Sanguesa,G., Shaligram,S., Akther,F., Roglans,N., Laguna,J.C.,
            Rahimian,R. and Alegret,M.
  TITLE     Type of supplemented simple sugar, not merely calorie intake,
            determines adverse effects on metabolism and aortic function in
            female rats
  JOURNAL   Am J Physiol Heart Circ Physiol 312 (2), H289-H304 (2017)
   PUBMED   27923787
REFERENCE   2  (bases 1 to 5913)
  AUTHORS   Emery,A.C., Liu,X.H., Xu,W., Eiden,M.V. and Eiden,L.E.
  TITLE     Cyclic Adenosine 3',5'-Monophosphate Elevation and Biological
            Signaling through a Secretin Family Gs-Coupled G Protein-Coupled
            Receptor Are Restricted to a Single Adenylate Cyclase Isoform
  JOURNAL   Mol Pharmacol 87 (6), 928-935 (2015)
   PUBMED   25769305
  REMARK    GeneRIF: AC isoform, and not the others expressed in PC12 cells,
            may reside in a plasma membrane compartment that is uniquely
            accessible to the family B Gs-coupled GPCR PAC1.
REFERENCE   3  (bases 1 to 5913)
  AUTHORS   Ehrlich,A.T., Furuyashiki,T., Kitaoka,S., Kakizuka,A. and
            Narumiya,S.
  TITLE     Prostaglandin E receptor EP1 forms a complex with dopamine D1
            receptor and directs D1-induced cAMP production to adenylyl cyclase
            7 through mobilizing G(betagamma) subunits in human embryonic
            kidney 293T cells
  JOURNAL   Mol Pharmacol 84 (3), 476-486 (2013)
   PUBMED   23842570
REFERENCE   4  (bases 1 to 5913)
  AUTHORS   Shpakov,A.O., Derkach,K.V., Chistyakova,O.V., Moyseyuk,I.V. and
            Bondareva,V.M.
  TITLE     Alteration of hormonal sensitivity of adenylyl cyclase in the brain
            of rats with prolonged streptozotocin diabetes
  JOURNAL   Dokl Biochem Biophys 446, 217-219 (2012)
   PUBMED   23132712
  REMARK    GeneRIF: Alteration of hormonal sensitivity of adenylyl cyclase in
            the brain of rats with prolonged streptozotocin diabetes.
REFERENCE   5  (bases 1 to 5913)
  AUTHORS   Jourdan,K.B., Mason,N.A., Long,L., Philips,P.G., Wilkins,M.R. and
            Morrell,N.W.
  TITLE     Characterization of adenylyl cyclase isoforms in rat peripheral
            pulmonary arteries
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 280 (6), L1359-L1369 (2001)
   PUBMED   11350817
REFERENCE   6  (bases 1 to 5913)
  AUTHORS   Helies-Toussaint,C., Aarab,L., Gasc,J.M., Verbavatz,J.M. and
            Chabardes,D.
  TITLE     Cellular localization of type 5 and type 6 ACs in collecting duct
            and regulation of cAMP synthesis
  JOURNAL   Am J Physiol Renal Physiol 279 (1), F185-F194 (2000)
   PUBMED   10894801
REFERENCE   7  (bases 1 to 5913)
  AUTHORS   Rossler,P., Kroner,C., Krieger,J., Lobel,D., Breer,H. and
            Boekhoff,I.
  TITLE     Cyclic adenosine monophosphate signaling in the rat vomeronasal
            organ: role of an adenylyl cyclase type VI
  JOURNAL   Chem Senses 25 (3), 313-322 (2000)
   PUBMED   10866989
REFERENCE   8  (bases 1 to 5913)
  AUTHORS   Krupinski,J., Lehman,T.C., Frankenfield,C.D., Zwaagstra,J.C. and
            Watson,P.A.
  TITLE     Molecular diversity in the adenylylcyclase family. Evidence for
            eight forms of the enzyme and cloning of type VI
  JOURNAL   J Biol Chem 267 (34), 24858-24862 (1992)
   PUBMED   1332969
REFERENCE   9  (bases 1 to 5913)
  AUTHORS   Premont,R.T., Chen,J., Ma,H.W., Ponnapalli,M. and Iyengar,R.
  TITLE     Two members of a widely expressed subfamily of hormone-stimulated
            adenylyl cyclases
  JOURNAL   Proc Natl Acad Sci U S A 89 (20), 9809-9813 (1992)
   PUBMED   1409703
REFERENCE   10 (bases 1 to 5913)
  AUTHORS   Yoshimura,M. and Cooper,D.M.
  TITLE     Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase
            from NCB-20 cells
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6716-6720 (1992)
   PUBMED   1379717
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012821.4.
            
            Transcript Variant: This variant (2) uses an alternate first exon
            in place of that of exon 1. The resulting isoform (2) is shorter at
            the N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L01115.1, SRR21887622.2832322.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000007.1  131641879-131641967 c
            90-948              JAXUCZ010000007.1  131635870-131636728 c
            949-1098            JAXUCZ010000007.1  131633002-131633151 c
            1099-1220           JAXUCZ010000007.1  131632535-131632656 c
            1221-1332           JAXUCZ010000007.1  131632328-131632439 c
            1333-1460           JAXUCZ010000007.1  131632070-131632197 c
            1461-1619           JAXUCZ010000007.1  131631040-131631198 c
            1620-1761           JAXUCZ010000007.1  131630804-131630945 c
            1762-1890           JAXUCZ010000007.1  131630548-131630676 c
            1891-1916           JAXUCZ010000007.1  131630274-131630299 c
            1917-2064           JAXUCZ010000007.1  131629928-131630075 c
            2065-2162           JAXUCZ010000007.1  131629587-131629684 c
            2163-2250           JAXUCZ010000007.1  131629209-131629296 c
            2251-2367           JAXUCZ010000007.1  131628947-131629063 c
            2368-2526           JAXUCZ010000007.1  131628517-131628675 c
            2527-2705           JAXUCZ010000007.1  131628059-131628237 c
            2706-2741           JAXUCZ010000007.1  131627056-131627091 c
            2742-2871           JAXUCZ010000007.1  131626843-131626972 c
            2872-3135           JAXUCZ010000007.1  131626275-131626538 c
            3136-3340           JAXUCZ010000007.1  131625318-131625522 c
            3341-3465           JAXUCZ010000007.1  131624502-131624626 c
            3466-5913           JAXUCZ010000007.1  131621860-131624307 c
FEATURES             Location/Qualifiers
     source          1..5913
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..5913
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /note="adenylate cyclase 6"
                     /db_xref="GeneID:25289"
                     /db_xref="RGD:2035"
     exon            1..89
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            90..948
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..3591
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /EC_number="4.6.1.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     adenylate cyclase type 6; ATP pyrophosphate-lyase 6;
                     adenylate cyclase type VI; ca(2+)-inhibitable adenylyl
                     cyclase; adenylyl cyclase 6"
                     /codon_start=1
                     /product="adenylate cyclase type 6 isoform 2"
                     /protein_id="NP_036953.5"
                     /db_xref="GeneID:25289"
                     /db_xref="RGD:2035"
                     /translation="MSWFSGLLVPKVDERKTAWGERNGQKRPRQATRARGFCAPRYMS
                     CLKNVEPPSPTPAARTRCPWQDEAFIRRAGPGRGVELGLRSVALGFDDTEVTTPMGTA
                     EVAPDTSPRSGPSCWHRLAQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLL
                     MAVLLTFHAAPALPQPAYVALLTCASVLFVVLMVVCNRHSFRQDSMWVVSYVVLGILA
                     AVQVGGALAANPRSPSAGLWCPVFFVYITYTLLPIRMRAAVLSGLGLSTLHLILAWHL
                     NNGDPFLWKQLGANVVLFLCTNAIGVCTHYPAEVSQRQAFQETRGYIQARLHLQHENR
                     QQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQ
                     CTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGV
                     DMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGR
                     AGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQCIETFLILGASQKRKEEKAMLVK
                     LQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKENRGAQDALNPEDEVDE
                     FLGRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFIC
                     FIQFLVFPHSALILGIYAGIFLLLLVTVLICAVCSCGSFFPNALQRLSRSIVRSRVHS
                     TAVGVFSVLLVFISAIANMFTCSHTPLRTCAARMLNLTPSDVTACHLRQLNYSLGLEA
                     PLCEGTAPTCSFPEYFVGSVLLSLLASSVFLHISSIGKLVMTFVLGFIYLLLLLLGPP
                     ATIFDNYDLLLSVHGLASSNETFDGLDCPAVGRVALKYMTPVILLVFALALYLHAQQV
                     ESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQS
                     CECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKT
                     IGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMG
                     PVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGV
                     VKVKGKGEMTTYFLNGGPSS"
     exon            949..1098
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1220
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1332
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1460
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1619
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1761
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1890
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..1916
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2064
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2162
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2250
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2367
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2526
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2705
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2741
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2871
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..3135
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3340
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            3341..3465
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
     exon            3466..5913
                     /gene="Adcy6"
                     /gene_synonym="AC6; ACVI; ADCYB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcaggacg gcgggacggc cggccctccg ggccggagcc cgcgagcgcg gtggggcggc
       61 ggccccgggc aggcgccgac ccttggcagc atgtcatggt ttagcggcct cctggttccc
      121 aaagtggatg aacggaaaac agcctggggc gaacgcaatg gacagaagcg cccacgccag
      181 gcgacccgag cccgtggctt ctgcgcgccc cgctacatga gctgcctcaa gaatgtggag
      241 ccacccagcc ccactcctgc agctcgcact cggtgcccct ggcaggatga agccttcatc
      301 aggagggctg gcccgggaag gggtgtggag ctggggctgc ggtcagtggc cttgggtttt
      361 gatgacactg aggtgaccac accgatgggg acagctgaag tggcacccga cacatcgcct
      421 cgaagcggtc cgtcctgctg gcaccggcta gcgcaggtgt tccagtctaa gcagttccgc
      481 tccgccaagc tggagcgtct gtaccagcgg tacttcttcc agatgaacca gagcagcctc
      541 acgctgctca tggcggtgct tgtgctcctc atggctgtac tgttgacctt ccacgccgcg
      601 cctgccctgc ctcagcctgc ttatgtggcc ctgctgacct gtgcctccgt cctttttgtg
      661 gtactcatgg tagtgtgtaa ccgacatagc ttccgccagg actccatgtg ggtagtgagc
      721 tatgtggttc tgggcatcct agcagccgtg caagtcgggg gtgccctggc agccaaccca
      781 cgcagcccct cagcaggcct ttggtgcccc gtgttcttcg tctacatcac ctacacactt
      841 cttcccattc gtatgcgagc ggccgtgctc agtggcctgg gtctttccac cctgcatttg
      901 attttggcct ggcatctcaa caatggtgac cccttccttt ggaagcagct cggtgctaac
      961 gtggtgctct tcctgtgcac caatgccatc ggtgtctgca cgcactaccc cgctgaagtg
     1021 tctcagcgcc aagcctttca ggagacccgt ggttacatcc aggcccggct gcacttgcag
     1081 catgagaatc gacagcagga acggctgctg ctgtcggtgt tgccccagca tgttgccatg
     1141 gaaatgaaag aggatatcaa cacaaaaaag gaagacatga tgttccacaa gatttacatc
     1201 cagaagcatg acaatgtcag catcctgttt gccgacatcg agggcttcac cagcctggcc
     1261 tcccagtgca ctgcccagga actggtcatg accttgaatg agctctttgc ccggttcgac
     1321 aagctggctg cggagaatca ctgtctgagg atcaagatct taggagactg ttactactgt
     1381 gtgtcggggc tgccggaggc ccgggcagac catgcccact gctgtgtgga gatgggggta
     1441 gacatgatcg aggccatctc gctggtgcgt gaggtaacgg gtgtaaatgt gaacatgcgc
     1501 gtgggcatcc acagcgggcg tgtacactgc ggtgtccttg gtctgcggaa atggcagttt
     1561 gatgtctggt ccaacgatgt gaccctggcc aaccacatgg aggcgggggg ccgggccggc
     1621 cgcatccaca tcactcgggc cacactgcag tacctgaacg gggactatga ggtggagcca
     1681 ggccgtggcg gtgagcgcaa cgcgtacctc aaggagcagt gcattgagac cttcctcata
     1741 ctaggagcca gccagaaacg gaaagaggag aaggccatgc tggtcaagct gcagcggacg
     1801 cgggccaact ccatggaagg actgatgccc cgctgggttc ctgaccgtgc cttctcccgg
     1861 accaaggact ctaaggcatt ccgacagatg ggcatcgatg actctagcaa agagaaccgg
     1921 ggtgcccaag atgctctgaa ccctgaggat gaggtggacg agtttctggg ccgagccatc
     1981 gatgcccgaa gcatcgacca gctgcgtaag gaccatgtgc gccggttcct gctcaccttc
     2041 cagagggagg atctcgagaa gaagtattca cggaaagtag accctcgttt cggagcctac
     2101 gtcgcctgtg ccctcctggt tttctgcttc atctgtttca tccagttcct cgtattccca
     2161 cactccgccc tgatactcgg gatttatgcc gggatcttcc ttttgctgct ggtcaccgtg
     2221 ctcatctgtg ctgtgtgctc ctgtgggtct ttcttcccca acgccctgca gcgcctgtcc
     2281 cgcagtatcg tccgctcacg ggtgcacagc acggctgttg gagtcttctc ggttctgctt
     2341 gtgttcatct ctgccattgc caacatgttc acctgcagtc acaccccact gaggacctgt
     2401 gcggcccgga tgctgaactt aacaccgtcc gatgtcaccg cctgccacct acgacagctc
     2461 aattactctc tgggactgga agctcccctg tgtgagggca ccgcacccac ctgcagcttc
     2521 cctgagtact ttgtcgggag tgtgctgctg agtctcttgg ccagctccgt cttcctccac
     2581 atcagcagca ttggcaagct agttatgacc tttgtcttgg ggttcatcta cttgcttctg
     2641 cttttgctgg gtcccccagc caccatcttt gacaactatg atctactgct tagcgtccat
     2701 ggcttggctt cctccaatga gaccttcgat gggctggact gcccagccgt agggagggta
     2761 gcgctcaaat acatgacccc tgtgattctc ctcgtgttcg ccctggcact gtatctacac
     2821 gcacaacagg tggaatctac cgcccgcctg gacttcctgt ggaaactgca ggccacaggg
     2881 gagaaggagg agatggagga gttgcaggcc tacaaccggc ggctgctgca taacatcctt
     2941 cccaaggacg tggctgccca cttcctggcc cgggagcgcc gcaacgacga gctgtactac
     3001 caatcctgcg agtgcgtggc tgtcatgttt gcctccatcg ccaacttctc tgagttctat
     3061 gtggaactgg aggcgaacaa tgagggcgtg gagtgcctgc gactgctcaa tgagatcatc
     3121 gcggactttg atgagatcat cagtgaggag aggttccggc agctggagaa gatcaagacc
     3181 atcggtagca cttacatggc cgcctccggg ctaaatgcca gcacctatga ccaggtcggc
     3241 cgctcgcaca tcaccgccct ggcagactac gccatgcggc ttatggagca aatgaaacac
     3301 atcaacgaac actctttcaa caacttccag atgaagatcg ggttgaacat gggtccggtt
     3361 gtagcaggtg tcattggggc ccggaagcca cagtatgaca tctggggaaa cacggtgaat
     3421 gtttccagcc gtatggacag cacaggagtt cctgaccgaa tacaggtgac cacggatctg
     3481 taccaggttc tagctgccaa gggctaccaa ctggagtgtc gaggggtggt caaggtgaag
     3541 ggaaaggggg agatgaccac ctacttcctc aatgggggcc ccagcagtta gcagagcgca
     3601 gcagtggaaa ttcaaccaaa gggaccaagg tgggcactga gtggactttt ctgctcactg
     3661 gatggagctg tggcaggggg ctctgagcct ccaggtcttg ctgacagcaa aagggaacac
     3721 cccagcaggc tgtgcttgga ccatatccgt ctgccttcag agcagcaaag gaagggacgc
     3781 cgagaggatt attatccaag tgactttctt aatcagagta aggctgtttg cttttttttt
     3841 tccccccctt tggacgcagc tgagagcaga gcctcctgtt tgagagtaaa atggcaactt
     3901 actctgccta ctgtttccct gtctgggcga caggctcagg gctgggacct ttctttccct
     3961 atttttcctg ggactatttt tgtacaaaga ctggggcagg catgaggaat gcttgccttc
     4021 actggcctgt gtcagcagca tttgtcttgg gcactcccag taccagccaa gtctccttcc
     4081 tagcacaaca aggcagagga aggaggtgct gtgggaccta gctctgacca gatttcaggg
     4141 gaatgtttcc atttgccaaa tcctagtccc gtgatctgtc cccaaagggg aacaaaggga
     4201 cctctgacag tgaaaattta gcctcaattc ctgcatgctc cagggaaagg ggcatctggc
     4261 ctcactggta ctgtgaaagt gaccagccag ggtgcaagcc tgggtgtgag gtcatcagaa
     4321 gaacaggaac tggatgttca cctgcaggtg ccgaagagtg cacgcagcca gggaggagga
     4381 ggaggaggag gagggggagg aggccacatt gacctgaggc cccagtgtgc ccagggtcag
     4441 ctctcttggc ccatgtgctc acttgctgtc tgctggcagg gggcatgggc catctctacc
     4501 ccttgtattg ccaaatagcg aagggtcagg gttccaagaa agataatcct gaccctaaac
     4561 ttggcctcct aagtctggca ctagggaggc cctgtgtgtg tgtgtgtctg tctttctgtc
     4621 tgtctgtctg tctgtctgtc tgtctgaggt ctccatgtgt ccttatgctc cagctcctca
     4681 gctctccact ggggactgcc tctcccccat gggcctctgt cttctggtgt taaggcgggg
     4741 tttcctatgc caagggatgg agagtaattt ccaggttgca caggagtggg atggggtttg
     4801 gtagcaaaat gagagtggtc tggggagagg agtccttttt gtgccaaatc cctaagtgcc
     4861 atttgagggg ggggccacat atgcagtatg actgtccccc tgcctagggt ggggacccaa
     4921 gcacctgctt aatctctagt gttcctcgga cttgaactgt tggaggtttg tgggtagagg
     4981 ctcaggcatt tgctgaattc ctcagcttgt gtctcggggg tgtggtaata ctttctgact
     5041 ggggtggtgt gggtcccctc tcagaggacc cagattttgg tactaagggg acggagccta
     5101 ggaacttgga acttggttgt cccaagcctt tctgcctgaa tctagcatga ctagactcta
     5161 gtcctggctc ccaatcctcg tgaggcccgc aagggttgta ctctgtcctg tcttaccctt
     5221 gtagcctcct tgactctggt ctgaattagc ctggtgcctt gatttctctg cacctattta
     5281 agccagaggc gtttcgcctc gattttgacc agcgattgct ttgtcttaga tgctgacagg
     5341 aaaggcagag gagtttcagg atgtatggga ggaccaggcc agtacttttg cctttcctta
     5401 agcctttgcc accagttctc tgcagaggcc tggtttcggg cttgggacta ctttcctggg
     5461 actctccatg tgccactcga tggaccactg ggcgcttaat tagccaaggc agaagagagg
     5521 aggattatct ggtccaggca gaagatcacc tccccgtctc cccccagcca tattctatcc
     5581 ctggttagga agggactact cgatgccgat ggggtgggcg tgaggtgtat aaaccaaagc
     5641 agggagacct cggctttggg aactttgtct gcttcttacc aggtgggagg ggcttgtcta
     5701 caccctggct ccctgcacca cagtgccagc ctgtcgtgtc ctctgagtta ccgttgcccc
     5761 tctcctcacc agttgatgga ggagtcaggg tacgggaggc catgggctct ggttttataa
     5821 tgtaaccact gtgggagtgg gggagggcga cgtaccatgt atttcagtga aatatttaat
     5881 atatttaaat atcaataaaa tcaaactctt tgt
//
