LOCUS       NM_022600               4850 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus adenylate cyclase 5 (Adcy5), mRNA.
ACCESSION   NM_022600
VERSION     NM_022600.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4850)
  AUTHORS   Nair,A.G., Gutierrez-Arenas,O., Eriksson,O., Vincent,P. and
            Hellgren Kotaleski,J.
  TITLE     Sensing Positive versus Negative Reward Signals through Adenylyl
            Cyclase-Coupled GPCRs in Direct and Indirect Pathway Striatal
            Medium Spiny Neurons
  JOURNAL   J Neurosci 35 (41), 14017-14030 (2015)
   PUBMED   26468202
REFERENCE   2  (bases 1 to 4850)
  AUTHORS   Hodson,D.J., Mitchell,R.K., Marselli,L., Pullen,T.J., Gimeno
            Brias,S., Semplici,F., Everett,K.L., Cooper,D.M., Bugliani,M.,
            Marchetti,P., Lavallard,V., Bosco,D., Piemonti,L., Johnson,P.R.,
            Hughes,S.J., Li,D., Li,W.H., Shapiro,A.M. and Rutter,G.A.
  TITLE     ADCY5 couples glucose to insulin secretion in human islets
  JOURNAL   Diabetes 63 (9), 3009-3021 (2014)
   PUBMED   24740569
REFERENCE   3  (bases 1 to 4850)
  AUTHORS   Chen,Y.Z., Friedman,J.R., Chen,D.H., Chan,G.C., Bloss,C.S.,
            Hisama,F.M., Topol,S.E., Carson,A.R., Pham,P.H., Bonkowski,E.S.,
            Scott,E.R., Lee,J.K., Zhang,G., Oliveira,G., Xu,J., Scott-Van
            Zeeland,A.A., Chen,Q., Levy,S., Topol,E.J., Storm,D., Swanson,P.D.,
            Bird,T.D., Schork,N.J., Raskind,W.H. and Torkamani,A.
  TITLE     Gain-of-function ADCY5 mutations in familial dyskinesia with facial
            myokymia
  JOURNAL   Ann Neurol 75 (4), 542-549 (2014)
   PUBMED   24700542
REFERENCE   4  (bases 1 to 4850)
  AUTHORS   Wu,C.S., Lin,J.T., Chien,C.L., Chang,W.C., Lai,H.L., Chang,C.P. and
            Chern,Y.
  TITLE     Type VI adenylyl cyclase regulates neurite extension by binding to
            Snapin and Snap25
  JOURNAL   Mol Cell Biol 31 (24), 4874-4886 (2011)
   PUBMED   21986494
REFERENCE   5  (bases 1 to 4850)
  AUTHORS   Choi,Y.H., Suzuki,A., Hajarnis,S., Ma,Z., Chapin,H.C., Caplan,M.J.,
            Pontoglio,M., Somlo,S. and Igarashi,P.
  TITLE     Polycystin-2 and phosphodiesterase 4C are components of a ciliary
            A-kinase anchoring protein complex that is disrupted in cystic
            kidney diseases
  JOURNAL   Proc Natl Acad Sci U S A 108 (26), 10679-10684 (2011)
   PUBMED   21670265
REFERENCE   6  (bases 1 to 4850)
  AUTHORS   Serazin-Leroy,V., Morot,M., de Mazancourt,P. and Giudicelli,Y.
  TITLE     Differences in type II, IV, V and VI adenylyl cyclase isoform
            expression between rat preadipocytes and adipocytes
  JOURNAL   Biochim Biophys Acta 1550 (1), 37-51 (2001)
   PUBMED   11738086
REFERENCE   7  (bases 1 to 4850)
  AUTHORS   Jourdan,K.B., Mason,N.A., Long,L., Philips,P.G., Wilkins,M.R. and
            Morrell,N.W.
  TITLE     Characterization of adenylyl cyclase isoforms in rat peripheral
            pulmonary arteries
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 280 (6), L1359-L1369 (2001)
   PUBMED   11350817
REFERENCE   8  (bases 1 to 4850)
  AUTHORS   Helies-Toussaint,C., Aarab,L., Gasc,J.M., Verbavatz,J.M. and
            Chabardes,D.
  TITLE     Cellular localization of type 5 and type 6 ACs in collecting duct
            and regulation of cAMP synthesis
  JOURNAL   Am J Physiol Renal Physiol 279 (1), F185-F194 (2000)
   PUBMED   10894801
REFERENCE   9  (bases 1 to 4850)
  AUTHORS   Matsuoka,I., Suzuki,Y., Defer,N., Nakanishi,H. and Hanoune,J.
  TITLE     Differential expression of type I, II, and V adenylyl cyclase gene
            in the postnatal developing rat brain
  JOURNAL   J Neurochem 68 (2), 498-506 (1997)
   PUBMED   9003034
REFERENCE   10 (bases 1 to 4850)
  AUTHORS   Premont,R.T., Chen,J., Ma,H.W., Ponnapalli,M. and Iyengar,R.
  TITLE     Two members of a widely expressed subfamily of hormone-stimulated
            adenylyl cyclases
  JOURNAL   Proc Natl Acad Sci U S A 89 (20), 9809-9813 (1992)
   PUBMED   1409703
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022600.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M96159.1, SRR26360186.2224068.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1570              JAXUCZ010000011.1  79121774-79123343   c
            1571-1720           JAXUCZ010000011.1  79031145-79031294   c
            1721-1842           JAXUCZ010000011.1  79026906-79027027   c
            1843-1954           JAXUCZ010000011.1  79011040-79011151   c
            1955-2082           JAXUCZ010000011.1  79009461-79009588   c
            2083-2241           JAXUCZ010000011.1  79007428-79007586   c
            2242-2383           JAXUCZ010000011.1  79006195-79006336   c
            2384-2524           JAXUCZ010000011.1  79003928-79004068   c
            2525-2547           JAXUCZ010000011.1  78999753-78999775   c
            2548-2692           JAXUCZ010000011.1  78998925-78999069   c
            2693-2790           JAXUCZ010000011.1  78997770-78997867   c
            2791-2878           JAXUCZ010000011.1  78994796-78994883   c
            2879-2995           JAXUCZ010000011.1  78990975-78991091   c
            2996-3160           JAXUCZ010000011.1  78990412-78990576   c
            3161-3336           JAXUCZ010000011.1  78988962-78989137   c
            3337-3366           JAXUCZ010000011.1  78987603-78987632   c
            3367-3499           JAXUCZ010000011.1  78986595-78986727   c
            3500-3763           JAXUCZ010000011.1  78982457-78982720   c
            3764-3968           JAXUCZ010000011.1  78981449-78981653   c
            3969-4093           JAXUCZ010000011.1  78978650-78978774   c
            4094-4850           JAXUCZ010000011.1  78976861-78977617   c
FEATURES             Location/Qualifiers
     source          1..4850
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4850
                     /gene="Adcy5"
                     /note="adenylate cyclase 5"
                     /db_xref="GeneID:64532"
                     /db_xref="RGD:71014"
     exon            1..1570
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     CDS             434..4222
                     /gene="Adcy5"
                     /EC_number="4.6.1.1"
                     /note="adenylyl cyclase 5; adenylate cyclase type V; ATP
                     pyrophosphate-lyase 5; adenylyl cyclase type V"
                     /codon_start=1
                     /product="adenylate cyclase type 5"
                     /protein_id="NP_072122.2"
                     /db_xref="GeneID:64532"
                     /db_xref="RGD:71014"
                     /translation="MSGSKSVSPPGYAAQTAASPAPGGGPEHRAAWGEADSRANGYPH
                     APGGSTRGSTKRSGGAVTPQQQQRLASRWRGGDDDEDPPLSGDDPLVGGFGFSFRSKS
                     AWQERGGDDGGRGSRRQRRGAAGGGSTRAPPAGGSGSSAAAAAAAGGTEVRPRSVEVG
                     LEERRGKGRAAEELEPGTGTVEDGDGSEDGGSSVASGSGTGTVLSLGACCLALLQIFR
                     SKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQVVYLAVLA
                     AAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTV
                     FFIYTIYTLLPVRMRAAVLSGVLLSALHLAISLHTNAQDQFLLKQLVSNVLIFSCTNI
                     VGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADIN
                     AKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAE
                     NHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGI
                     HSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPG
                     CGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFY
                     NHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRK
                     FLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSLFMLSFYLSCF
                     LLLALVVFISVIYACVKLFPTPLQTLSRKIVRSKKNSTLVGVFTITLVFLSAFVNMFM
                     CNSKNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQSNCNFPEYFTYS
                     VLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFSN
                     NGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEM
                     EELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVEL
                     EANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKAGK
                     THIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTV
                     NVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
                     "
     exon            1571..1720
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1842
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1954
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2082
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2241
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2383
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2524
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2547
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2692
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2790
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2878
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..2995
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3160
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3336
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3366
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..3499
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            3500..3763
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            3764..3968
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            3969..4093
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
     exon            4094..4850
                     /gene="Adcy5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgcgtcc gggaactgcc agcttcggag aggcgccgcc cgcaaggaca cctctccgtc
       61 ccgcctggtc ctcaactccc ggcccgagct cgacgcgagc caggagtccg gacgtctctg
      121 cgcgcggcgc agcagccaga gctgtcccca ctgcccccgc tcggagccaa ctccgtctcg
      181 gacctgggac tctggactct gattcgtagc tacttctcac ctcggggctg cgctgtctcc
      241 ccgctagcct tcccgttgtc ctccaccgct caggacgggg gtgccacgat gtcccgctgc
      301 tgcgcagggc cctgggcctc cctcgacgtg tgaccctagc ctggtccccc tgcttggccg
      361 tccgccctct ccttggagac ccccggcccg gcccccgggg gaagaggaag aagacgacga
      421 agccgagggg gggatgtccg gctccaaaag cgtgagcccc ccgggctacg ctgcacagac
      481 agcagcgtcg cccgcgcccg ggggaggccc ggagcatcgc gccgcgtggg gagaagccga
      541 ttcccgcgcc aatggctacc cccacgcccc cgggggatcg acccgcggct ccaccaagcg
      601 atctggggga gcggtgaccc cacaacagca gcagcgcctg gctagccgtt ggcgcggtgg
      661 cgacgacgat gaagaccctc cactaagcgg tgacgaccct ctggtcggag gcttcggctt
      721 cagcttccgt tctaagtcgg cctggcagga gcgcggcggc gacgacggcg gtcgcggcag
      781 caggcggcag cggcggggcg cggctggagg gggcagcacc cgggcgcccc ctgcgggcgg
      841 cagtggcagt tcggcggcgg ccgcagcagc cgcaggtggc acggaggtgc gcccccgctc
      901 ggtggaggtg ggcctggagg agcgtcgagg aaaaggccga gcggccgagg agctggagcc
      961 cggaactggc accgtcgagg atggagacgg gtccgaggat ggaggcagtt ccgtggcgtc
     1021 aggctctggg accggcacgg tgctgtcgtt gggcgcctgc tgcctggcct tgctgcagat
     1081 attccgctct aagaagttcc cgtcggacaa actggagcgt ctgtaccagc gctatttctt
     1141 ccgcctgaac cagagcagcc tcaccatgct catggccgtg ctggtgctcg tgtgcctggt
     1201 catgctcgct ttccacgcgg cacggccccc gctccaggta gtctacctgg ccgtgttggc
     1261 agctgctgtg ggcgtgatcc ttatcatggc tgtgctctgc aaccgtgcag ccttccacca
     1321 ggaccacatg ggcctggcct gctatgcgct cattgcagtg gtgctggccg tccaggtagt
     1381 gggcctgttg ctgccacagc cacgcagcgc ctccgagggc atctggtgga ccgtgttctt
     1441 catctatacc atctacaccc tgctgcctgt gcgcatgagg gctgcggtgc tcagcggggt
     1501 gcttctgtcg gctctccact tggccatctc tctgcacacc aacgcccagg accagtttct
     1561 gctgaaacag cttgtctcca acgtcctcat cttctcttgc accaacatcg tgggtgtgtg
     1621 cactcactac ccagccgagg tctcccagag acaggccttc caggagaccc gggagtgcat
     1681 ccaagctcgg ctccactcac agcgggagaa ccagcaacag gagcgtctcc tgctgtctgt
     1741 ccttccccgt catgttgcca tggagatgaa agcagacatc aacgccaaac aggaggatat
     1801 gatgttccac aagatttaca tccagaaaca tgacaatgtg agcatcctgt ttgctgacat
     1861 cgaaggcttc actagcctgg catcccagtg tactgcccaa gaactggtca tgaccctcaa
     1921 cgagctcttc gcccgctttg acaagttggc tgcggagaat cactgcttac ggattaagat
     1981 cctcggggat tgttactact gtgtctcggg gctgcctgaa gccagagctg accacgccca
     2041 ctgctgcgta gagatgggaa tggacatgat cgaggccatc tcgttggtcc gggaggtgac
     2101 aggggtgaac gtgaacatgc gtgtgggaat tcacagcggg agagtacact gcggtgtcct
     2161 tggcctcaga aagtggcaat tcgacgtgtg gtctaacgat gtcacactgg ccaaccacat
     2221 ggaagctggc ggcaaggcag gccgcatcca catcaccaag gccacactca actacctgaa
     2281 cggggactat gaggtggagc caggctgtgg tggtgagcgc aatgcctacc tcaaggagca
     2341 cagcatcgag accttcctca tcctgcgctg tacccagaag cggaaagaag agaaggccat
     2401 gatcgccaag atgaaccgcc agagaaccaa ctccattgga cacaatccgc ctcactgggg
     2461 agctgagcgc cccttctaca accacttggg tggcaaccag gtgtccaagg agatgaagag
     2521 gatgggcttt gaggacccca aggacaagaa tgcccaggaa agtgccaacc ctgaggatga
     2581 agtggacgag tttctgggtc gagccatcga tgccaggagt attgacagac tgcgatccga
     2641 acacgtccga aagttcctct tgacctttag ggagcccgac ttagagaaga agtactccaa
     2701 gcaggtggat gaccgatttg gtgcctatgt ggcctgtgcc tcgcttgttt tcctcttcat
     2761 ctgctttgtc cagatcacca ttgtgcccca ctccctgttc atgctgagct tctacctgtc
     2821 gtgtttcctg ctactggcct tggtggtgtt tatatctgtg atctacgcct gtgtgaagct
     2881 cttccctact cccctgcaga cactctccag gaagatagtg cgatccaaga agaacagcac
     2941 cctggtcggg gtgttcacca tcaccctggt gttcctctcg gcttttgtca acatgttcat
     3001 gtgcaactct aagaacctgg tgggttgcct ggcagaggag cacaacatca cggtgaacca
     3061 ggtgaacgca tgtcatgtga tggagtcggc cttcaactac agcctgggcg acgagcaggg
     3121 cttctgtggc agcccccagt ccaactgcaa cttcccagag tacttcacct acagcgtgct
     3181 gctcagcctg ctggcctgct ccgtgttcct gcagatcagc tgcatcggga agctggtgct
     3241 catgctggcc atcgagctca tctacgtgct catcgtagag gtgcccggtg tcacactctt
     3301 tgacaacgct gaccttctgg tcaccgccaa tgccatagac ttcagcaaca acgggacctc
     3361 ccagtgccct gagcatgcga ccaaggtggc gctgaaggtg gtgacgccca tcatcatctc
     3421 tgtcttcgtg ctggctctgt atctgcatgc tcagcaggtg gaatccactg ctcgccttga
     3481 cttcctctgg aaactgcagg ccacagaaga gaaggaggag atggaggagc tgcaggccta
     3541 caaccggcgc ttgctgcaca acattctgcc caaggacgtg gctgcccact tcctggcccg
     3601 ggagcggcgc aatgatgaac tgtactacca atcctgcgag tgcgtggctg tcatgtttgc
     3661 ctccatcgcc aacttctccg aattctacgt ggagctagag gccaacaatg agggcgttga
     3721 atgcctacgg ctgctcaatg agatcatcgc agactttgat gagatcatca gtgaggatcg
     3781 gttcaggcag ctggaaaaga tcaagaccat aggtagcacc tacatggctg cctctggcct
     3841 caacgactcc acctatgaca aggcaggcaa gacccacatc aaggctcttg cagacttcgc
     3901 catgaagctg atggaccaaa tgaagtacat caatgagcac tccttcaaca acttccagat
     3961 gaagatcggg cttaacattg gacctgtagt ggctggggtc attggggctc gcaagcctca
     4021 gtatgacatc tggggcaata cagtaaatgt ggccagccgt atggacagca ctggggtgcc
     4081 tgaccgcatc caggttacta cagatatgta ccaggtgctg gccgccaaca cataccagct
     4141 ggagtgccgg ggtgtggtca aggtcaaggg caagggtgag atgatgacct acttcctcaa
     4201 tggagggcct cccctcagtt agcagatacc agcagcatcc tggcctccag aggattgaac
     4261 agcttctctg tgcaccatgg gcagataggg cctgtgcccc aggctcacag ctgtgctggt
     4321 aaaatttcta cttggactca gaagcaactt ctgcctttgc tggtgggcat ggcttttggc
     4381 ctaggcccag ggtgccagcg tcctgcgagc accgagctga ccaaagatgt tgcccttggc
     4441 agaagactgt agactcgagc tgacccttga ggttctgaca agtgctgcta ctgcacggtg
     4501 gatgtgctac cggagcacag cctggcacag agtggctggc ctgaggggag gccttggtca
     4561 tgaaggggag gtaggcaagc ttgaagctgg cctgggggat gtccatggac ctcatgggtc
     4621 tgcttttcca ctgtggagag gctatgcccc ctcacaacat tttgggggca ggaactggga
     4681 gagatgcggc ctgtgccatt ctctcctcac acctccatgc acacagacaa tgccctgtac
     4741 gggaaacagg actgttgata agggggaggc aagaggacac caggcaagga gcagtggctc
     4801 tgagcaaaag aaaatattta ttaaataaaa caaaagtttt ctctgccctt
//
