LOCUS       NM_019285               3441 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus adenylate cyclase 4 (Adcy4), mRNA.
ACCESSION   NM_019285
VERSION     NM_019285.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3441)
  AUTHORS   Bagavandoss,P. and Grimshaw,S.
  TITLE     Distribution of adenylyl cyclases in the rat ovary by
            immunofluorescence microscopy
  JOURNAL   Anat Rec (Hoboken) 295 (10), 1717-1726 (2012)
   PUBMED   22899545
REFERENCE   2  (bases 1 to 3441)
  AUTHORS   Sadana,R. and Dessauer,C.W.
  TITLE     Physiological roles for G protein-regulated adenylyl cyclase
            isoforms: insights from knockout and overexpression studies
  JOURNAL   Neurosignals 17 (1), 5-22 (2009)
   PUBMED   18948702
  REMARK    Review article
REFERENCE   3  (bases 1 to 3441)
  AUTHORS   Rhim,J.H., Jang,I.S., Yeo,E.J., Song,K.Y. and Park,S.C.
  TITLE     Role of protein kinase C-dependent A-kinase anchoring proteins in
            lysophosphatidic acid-induced cAMP signaling in human diploid
            fibroblasts
  JOURNAL   Aging Cell 5 (6), 451-461 (2006)
   PUBMED   17081159
REFERENCE   4  (bases 1 to 3441)
  AUTHORS   Wang,H.Y. and Burns,L.H.
  TITLE     Gbetagamma that interacts with adenylyl cyclase in opioid tolerance
            originates from a Gs protein
  JOURNAL   J Neurobiol 66 (12), 1302-1310 (2006)
   PUBMED   16967511
REFERENCE   5  (bases 1 to 3441)
  AUTHORS   Ostrom,R.S., Naugle,J.E., Hase,M., Gregorian,C., Swaney,J.S.,
            Insel,P.A., Brunton,L.L. and Meszaros,J.G.
  TITLE     Angiotensin II enhances adenylyl cyclase signaling via
            Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in
            cardiac fibroblasts
  JOURNAL   J Biol Chem 278 (27), 24461-24468 (2003)
   PUBMED   12711600
REFERENCE   6  (bases 1 to 3441)
  AUTHORS   Serazin-Leroy,V., Morot,M., de Mazancourt,P. and Giudicelli,Y.
  TITLE     Differences in type II, IV, V and VI adenylyl cyclase isoform
            expression between rat preadipocytes and adipocytes
  JOURNAL   Biochim Biophys Acta 1550 (1), 37-51 (2001)
   PUBMED   11738086
REFERENCE   7  (bases 1 to 3441)
  AUTHORS   Cote,M., Guillon,G., Payet,M.D. and Gallo-Payet,N.
  TITLE     Expression and regulation of adenylyl cyclase isoforms in the human
            adrenal gland
  JOURNAL   J Clin Endocrinol Metab 86 (9), 4495-4503 (2001)
   PUBMED   11549699
REFERENCE   8  (bases 1 to 3441)
  AUTHORS   Baker,L.P., Nielsen,M.D., Impey,S., Hacker,B.M., Poser,S.W.,
            Chan,M.Y. and Storm,D.R.
  TITLE     Regulation and immunohistochemical localization of
            betagamma-stimulated adenylyl cyclases in mouse hippocampus
  JOURNAL   J Neurosci 19 (1), 180-192 (1999)
   PUBMED   9870949
REFERENCE   9  (bases 1 to 3441)
  AUTHORS   Zimmermann,G. and Taussig,R.
  TITLE     Protein kinase C alters the responsiveness of adenylyl cyclases to
            G protein alpha and betagamma subunits
  JOURNAL   J Biol Chem 271 (43), 27161-27166 (1996)
   PUBMED   8900209
REFERENCE   10 (bases 1 to 3441)
  AUTHORS   Gao,B.N. and Gilman,A.G.
  TITLE     Cloning and expression of a widely distributed (type IV) adenylyl
            cyclase
  JOURNAL   Proc Natl Acad Sci U S A 88 (22), 10178-10182 (1991)
   PUBMED   1946437
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC081813.1.
            
            On Mar 8, 2007 this sequence version replaced NM_019285.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081813.1, M80633.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132291,
                                           SAMEA5756307 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3441              BC081813.1         1-3441
FEATURES             Location/Qualifiers
     source          1..3441
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..3441
                     /gene="Adcy4"
                     /note="adenylate cyclase 4"
                     /db_xref="GeneID:54223"
                     /db_xref="RGD:2034"
     exon            1..111
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            112..302
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..3362
                     /gene="Adcy4"
                     /EC_number="4.6.1.1"
                     /note="ATP pyrophosphate-lyase 4; adenylate cyclase type
                     IV; adenylyl cyclase 4"
                     /codon_start=1
                     /product="adenylate cyclase type 4"
                     /protein_id="NP_062158.2"
                     /db_xref="GeneID:54223"
                     /db_xref="RGD:2034"
                     /translation="MARLFSPRPPPSEDLFYETYYSLSQQYPLLILLLVIVLCAIVAL
                     PAVAWASGRELTSDPSFLTTVLCALGGFSLLLGLASREQQLQRWTRPLSGLIWAALLA
                     LGYGFLFTGGVVSAWDQVSFFLFIIFTVYAMLPLGMRDAAAAGVISSLSHLLVLGLYL
                     GWRPESQRDLLPQLAANAVLFLCGNVVGAYHKALMERALRATFREALSSLHSRRRLDT
                     EKKHQEHLLLSILPAYLAREMKAEIMARLQAGQSSRPENTNNFHSLYVKRHQGVSVLY
                     ADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSL
                     PDHAINCVRMGLDMCRAIRKLRVATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHD
                     VTLANHMEAGGVPGRVHITGATLALLAGAYAVERADMEHRDPYLRELGEPTYLVIDPW
                     AEEEDEKGTERGLLSSLEGHTMRPSLLMTRYLESWGAAKPFAHLSHVDSPASTSTPLP
                     EKAFSPQWSLDRSRTPRGLHDELDTGDAKFFQVIEQLNSQKQWKQSKDFNLLTLYFRE
                     KEMEKQYRLSALPAFKYYAACTFLVFLSNFTIQMLVTTRPPALATTYSITFLLFLLLL
                     FVCFSEHLTKCVQKGPKMLHWLPALSVLVATRPGLRVALGTATILLVFTMAVVSLLFL
                     PVSSDCPFLAPNVSSVAFNTSWELPASLPLISIPYSMHCCVLGFLSCSLFLHMSFELK
                     LLLLLLWLVASCSLFLHSHAWLSDCLIARLYQGSLGSRPGVLKEPKLMGAIYFFIFFF
                     TLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNR
                     RNEDLYHQSYECVCVLFASIPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPK
                     FSGVEKIKTIGSTYMAATGLNATPGQDTQQDAERSCSHLGTMVEFAVALGSKLGVINK
                     HSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETA
                     RALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGSPSAS"
     exon            303..500
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            501..662
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            663..812
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            813..961
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1073
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1201
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1360
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1493
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1667
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1702
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1789
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1859
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1957
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2042
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2180
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2291
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2476
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2561
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2720
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2867
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..2975
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            2976..3090
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            3091..3215
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3418
                     /gene="Adcy4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggccctga gccactagca aagcagcgag ggtgagtggc agccagccta cccaggttcc
       61 ctcctggagc ctagctttgc tacgagaact tcaggagctt aacacaaagc aggcaggggc
      121 tccgggctgg ggcgggggat atcatggccc gcctcttcag tccccggcct cctcccagcg
      181 aagatctctt ctacgagact tactacagcc tgagccaaca gtatccactg ctaattctgc
      241 ttctggtcat tgtgctctgc gcgatcgtgg cactgcccgc cgtcgcctgg gccagcggca
      301 gggagctgac ctcagaccca agcttcctga caactgtgct gtgtgctttg ggtggcttct
      361 ccctgctttt ggggctcgct tcccgggagc agcaactgca gcgatggaca cgacctcttt
      421 ctggcctcat atgggctgca ttgctggctc tgggctatgg gtttctattc actgggggtg
      481 tggtgagcgc ctgggatcag gtgtcctttt tcctcttcat cattttcacc gtgtacgcca
      541 tgctgccctt gggcatgcgg gatgctgctg ccgcgggggt catctcatcc ctctcacacc
      601 tgctggtcct tggactgtac cttgggtggc ggcctgagtc gcagagggat ctgctaccac
      661 agttggcagc gaatgcggtg ttgttcctgt gtgggaacgt ggtgggagca taccacaagg
      721 ccctgatgga gcgagcattg cgcgccacgt tccgggaggc tcttagctcc ctgcattcac
      781 gccggaggtt ggacactgag aaaaagcacc aggagcacct cctcttgtct atccttcctg
      841 cctacctggc ccgagagatg aaggcagaga tcatggctcg gctgcaggct ggacagagct
      901 cacggccaga gaacacaaac aactttcaca gcctgtatgt caagaggcac caaggagtga
      961 gtgtgctgta tgctgacatc gtgggcttca cacggctggc cagtgagtgt tcccctaagg
     1021 agctggtgct aatgctcaat gaactcttcg gcaaattcga ccaaattgca aaggagcacg
     1081 aatgcatgcg gatcaagatc ctgggagact gttactactg tgtatccggg ctgcccctct
     1141 ctctgcctga ccacgccatc aattgcgtgc gcatgggact ggacatgtgc cgggccatca
     1201 ggaaacttcg ggtagccacc ggtgtggata tcaacatgcg tgtcggtgtg cactcaggca
     1261 gcgtcctctg tggagtcatc gggctacaga agtggcagta tgatgtctgg tcccatgatg
     1321 tcacattggc caaccatatg gaagcaggcg gcgttccagg acgagtgcac atcacagggg
     1381 ccacgctggc cctgctggca ggagcttatg ctgtggagag agcagacatg gagcatcgag
     1441 acccatacct tcgggagcta ggggaaccca catacctggt cattgatcct tgggctgagg
     1501 aggaagacga gaagggcacc gagagaggat tgctgtcttc tctagagggg cacacgatgc
     1561 gtccgtcact actgatgact cgttatctgg agtcttgggg tgcagccaag cctttcgccc
     1621 acctaagcca cgtcgacagt cctgcatcca catccactcc actcccggag aaagccttca
     1681 gcccccagtg gagcctggac cggagtcgca ccccccgcgg gctacacgat gaactggaca
     1741 ctggagatgc caagttcttc caggtcatcg aacaactcaa ctctcaaaaa cagtggaaac
     1801 agtcgaagga cttcaacctc ctgacgctct acttcagaga gaaggagatg gagaaacagt
     1861 atcggctgtc tgcgctcccc gccttcaaat actacgcagc ctgcaccttc ctggtttttc
     1921 tgtccaactt cacaatccaa atgctggtga caaccaggcc cccagctctg gccaccacct
     1981 acagcatcac cttccttctc ttccttctcc tcctcttcgt ctgcttctca gagcacctga
     2041 cgaagtgcgt ccagaaaggc cccaagatgt tgcactggct gcctgcgctg tctgtcctgg
     2101 tggccacacg gccgggattg cgagtagccc tgggcacagc caccatcctc ctggtgttca
     2161 ctatggccgt cgtcagcctg ctcttcttac cagtgtcgtc agactgccct ttcctggctc
     2221 ccaatgtgtc gtcagtggct tttaatactt cctgggagct gccagcatcc ctgcctctca
     2281 tcagcatccc atactccatg cattgttgcg tgctgggttt cctttcctgc tccctttttc
     2341 tgcacatgag cttcgaactg aagctgcttc tgcttctgct gtggctggtg gcatcttgtt
     2401 ccctatttct gcactcccac gcctggctgt ccgactgcct cattgcccgc ctttatcaag
     2461 gctcattggg ctccaggccg ggggtactga aggaaccgaa actgatggga gctatctact
     2521 tcttcatctt cttcttcaca ctcctcgtcc tggctcggca gaatgagtat tactgtcgcc
     2581 tggacttcct atggaaaaag aaactgaggc aggagcgaga ggaaactgag acaatggaga
     2641 acctgacccg gctcctcctg gagaatgtac tccctgcaca cgtggcgccc cagttcatcg
     2701 gccagaaccg gcgcaatgag gacctctacc atcagtcgta cgaatgtgtt tgtgtcctct
     2761 ttgcatccat cccagacttt aaggaattct actcggaatc caacatcaac catgaggggc
     2821 tagagtgtct gcggctgctc aatgagatca ttgccgactt tgatgagctg ctctccaagc
     2881 caaagttcag tggagtagag aagatcaaaa ctatcggcag cacctacatg gcggccacag
     2941 gcctaaatgc cacccctggg caggacacac aacaggacgc tgagagaagc tgcagccatc
     3001 tgggcaccat ggtggaattt gcagtggccc tggggtctaa gctgggtgtc atcaataagc
     3061 actcgttcaa caacttccgc ctgcgtgtgg ggttaaacca tggaccagtc gtagcagggg
     3121 tgattggggc gcagaagcca caatatgaca tctgggggaa tacagtgaac gtggccagcc
     3181 gcatggagag cacaggagtt ctcggcaaga tccaagtgac cgaggagaca gctagggctc
     3241 tgcaatccct gggttacaca tgctacagcc gaggtgtcat caaggtcaag ggcaaagggc
     3301 aactctgtac ctacttcctg aacacagacc tgacacgaac cggatctccc tcagcatcct
     3361 agacacctga gctccccttc tccaagatcc tcaataaaat gtctccaggc atctgaaaaa
     3421 aaaaaaaaaa aaaaaaaaaa a
//
