LOCUS       NM_130779               4611 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus adenylate cyclase 3 (Adcy3), mRNA.
ACCESSION   NM_130779
VERSION     NM_130779.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4611)
  AUTHORS   Okamoto,Y., Aung,N.Y., Tanaka,M., Takeda,Y., Takagi,D.,
            Igarashi,W., Ishii,K., Yamakawa,M. and Ono,K.
  TITLE     Preferential Expression of Ca2+-Stimulable Adenylyl Cyclase III in
            the Supraventricular Area, including Arrhythmogenic Pulmonary Vein
            of the Rat Heart
  JOURNAL   Biomolecules 12 (5), 724 (2022)
   PUBMED   35625651
  REMARK    GeneRIF: Preferential Expression of Ca(2+)-Stimulable Adenylyl
            Cyclase III in the Supraventricular Area, including Arrhythmogenic
            Pulmonary Vein of the Rat Heart.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4611)
  AUTHORS   Makeyeva,Y., Nicol,C., Ledger,W.L. and Ryugo,D.K.
  TITLE     Immunocytochemical Localization of Olfactory-signaling Molecules in
            Human and Rat Spermatozoa
  JOURNAL   J Histochem Cytochem 68 (7), 491-513 (2020)
   PUBMED   32603211
REFERENCE   3  (bases 1 to 4611)
  AUTHORS   Hu,M.L., Zhang,W.W., Cao,H. and Zhang,Y.Q.
  TITLE     Expression pattern of type 3 adenylyl cyclase in rodent dorsal root
            ganglion and its primary afferent terminals
  JOURNAL   Neurosci Lett 692, 16-22 (2019)
   PUBMED   30366013
  REMARK    GeneRIF: Data suggest that type 3 adenylyl cyclase is primarily
            expressed in the small to medium sized cell bodies and central
            terminals of CGRP-positive dorsal root ganglion neurons.
REFERENCE   4  (bases 1 to 4611)
  AUTHORS   Tong,T., Yu,R. and Park,T.
  TITLE     alpha-Cedrene protects rodents from high-fat diet-induced adiposity
            via adenylyl cyclase 3
  JOURNAL   Int J Obes (Lond) 43 (1), 202-216 (2019)
   PUBMED   30568259
REFERENCE   5  (bases 1 to 4611)
  AUTHORS   Keele,G.R., Prokop,J.W., He,H., Holl,K., Littrell,J., Deal,A.,
            Francic,S., Cui,L., Gatti,D.M., Broman,K.W., Tschannen,M.,
            Tsaih,S.W., Zagloul,M., Kim,Y., Baur,B., Fox,J., Robinson,M.,
            Levy,S., Flister,M.J., Mott,R., Valdar,W. and Solberg Woods,L.C.
  TITLE     Genetic Fine-Mapping and Identification of Candidate Genes and
            Variants for Adiposity Traits in Outbred Rats
  JOURNAL   Obesity (Silver Spring) 26 (1), 213-222 (2018)
   PUBMED   29193816
REFERENCE   6  (bases 1 to 4611)
  AUTHORS   Parkinson,N.A. and Bolsover,S.R.
  TITLE     A nuclear location for Ca2+-activated adenylyl cyclases I and III
            in neurones
  JOURNAL   Brain Res Mol Brain Res 91 (1-2), 43-49 (2001)
   PUBMED   11457491
REFERENCE   7  (bases 1 to 4611)
  AUTHORS   Jourdan,K.B., Mason,N.A., Long,L., Philips,P.G., Wilkins,M.R. and
            Morrell,N.W.
  TITLE     Characterization of adenylyl cyclase isoforms in rat peripheral
            pulmonary arteries
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 280 (6), L1359-L1369 (2001)
   PUBMED   11350817
REFERENCE   8  (bases 1 to 4611)
  AUTHORS   Wong,S.T., Trinh,K., Hacker,B., Chan,G.C., Lowe,G., Gaggar,A.,
            Xia,Z., Gold,G.H. and Storm,D.R.
  TITLE     Disruption of the type III adenylyl cyclase gene leads to
            peripheral and behavioral anosmia in transgenic mice
  JOURNAL   Neuron 27 (3), 487-497 (2000)
   PUBMED   11055432
REFERENCE   9  (bases 1 to 4611)
  AUTHORS   Menco,B.P., Tekula,F.D., Farbman,A.I. and Danho,W.
  TITLE     Developmental expression of G-proteins and adenylyl cyclase in
            peripheral olfactory systems. Light microscopic and
            freeze-substitution electron microscopic immunocytochemistry
  JOURNAL   J Neurocytol 23 (11), 708-727 (1994)
   PUBMED   7861185
REFERENCE   10 (bases 1 to 4611)
  AUTHORS   Bakalyar,H.A. and Reed,R.R.
  TITLE     Identification of a specialized adenylyl cyclase that may mediate
            odorant detection
  JOURNAL   Science 250 (4986), 1403-1406 (1990)
   PUBMED   2255909
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CB720821.1,
            M55075.1 and AW525494.1.
            
            On Mar 6, 2008 this sequence version replaced NM_130779.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M55075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               CB720821.1         1-344
            345-444             M55075.1           270-369
            445-522             CB720821.1         445-522
            523-4283            M55075.1           448-4208
            4284-4611           AW525494.1         19-346              c
FEATURES             Location/Qualifiers
     source          1..4611
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..4611
                     /gene="Adcy3"
                     /note="adenylate cyclase 3"
                     /db_xref="GeneID:64508"
                     /db_xref="RGD:71009"
     exon            1..262
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            263..1116
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     CDS             442..3876
                     /gene="Adcy3"
                     /EC_number="4.6.1.1"
                     /note="AC3; AC-III; adenylyl cyclase 3; ATP
                     pyrophosphate-lyase 3; adenylate cyclase type III;
                     adenylate cyclase, olfactive type; type III adenylyl
                     cyclase"
                     /codon_start=1
                     /product="adenylate cyclase type 3"
                     /protein_id="NP_570135.2"
                     /db_xref="GeneID:64508"
                     /db_xref="RGD:71009"
                     /translation="MPRNQGFSDPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSG
                     SCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSS
                     DKLAPLMVAGVGLVLDIILFVLCKKGLLPDRVSRKVVPYLLWLLITAQIFSYLGLNFS
                     RAHAASDTVGWQAFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQDELE
                     GMQLLREILANVFLYLCAIIVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQE
                     NLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSA
                     CSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGL
                     AMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGI
                     PGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLDEKGIETYLIIASKPEVKKTAQNGLN
                     GSALPNGAPASKPSSPALIETKEPNGSAHASGSTSEEAEEQEAQADNPSFPNPRRRLR
                     LQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLTMRFMDPEMETRYSV
                     EKEKQSGAAFSCSCVVLFCTAMVEILIDPWLMTNYVTFVVGEVLLLILTICSMAAIFP
                     RAFPKKLVAFSSWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYMGPYNVTTGIE
                     LDGGCMENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGAVTAINLYAWCPVFD
                     EYDHKRFQEKDSPMVALEKMQVLSTPGLNGTDSRLPLVPSKYSMTVMMFVMMLSFYYF
                     SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEEL
                     YSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVIT
                     KIKTIGSTYMAASGVTPDVNTNGFTSSSKEEKSDKERWQHLADLADFALAMKDTLTNI
                     NNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEE
                     TQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDRPAAFPNGSSVTLPHQVVDNP"
     exon            1117..1266
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1397
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1509
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1637
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1796
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1971
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2097
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2240
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2402
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2490
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2607
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2867
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..2933
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3018
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3019..3177
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3324
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..3444
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3568
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3569..3693
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
     exon            3694..4611
                     /gene="Adcy3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctggcag gctgccccgg cctgggcccg ccatccgcag cgtgagccac cgccgtcctc
       61 tgcgaccacg gatgctgaac cacagccccg cgcctctacc ggcccgaccc ggggcctgac
      121 cgcaagggga cccgcgcaca ggctccgggc ggaggagctg gcgcggcggc actgcgggaa
      181 gcagcctgcg gctcgctgaa gcccgcttgg cccggctccg cagccctggt ccggagcgcg
      241 cggctcccga gttcccgcac agttgcagat gatcggtgcc acctgtgtcc tgggaaccca
      301 ctaaacattc cagctccagt tggacgccct tcacccacaa ccaaggggag cctccccgcc
      361 ttcccaggtc ttaacgaagc cctggtgaag tggcttgacc tggacttctc cctccctcat
      421 tagaagcagc caccagtcaa catgccgagg aaccagggct tctcggatcc cgagtactcg
      481 gcagagtact cagccgagta ctcagtcagc ttgccctctg accccgaccg cggggtcggc
      541 cggacccatg aaatttctgt gcggaactct gggtcctgcc tgtgcctgcc tcgctttatg
      601 cggctgacct tcgtgcctga gtccttggag aacctctacc agacctactt taaaaggcag
      661 cgccatgaga cactgctggt gctggtggtc tttgcggccc tctttgactg ctacgtggta
      721 gtgatgtgcg cggtggtctt ttccagcgac aagctggcgc ccctcatggt ggcaggcgtc
      781 ggtctggtgt tggacatcat ccttttcgtg ctctgcaaaa aggggctgct cccggatcga
      841 gtgagccgca aagtggtacc ctacctgctg tggctgctca tcacagccca gatcttctcc
      901 tacctgggcc tgaacttttc gcgtgcccac gcagccagtg acactgtggg ttggcaggcc
      961 ttctttgtct tctccttctt cataacgctg ccactcagcc tcagccccat cgtgatcatc
     1021 tccgtggtct cctgtgttgt gcatacgctt gtcttggggg tcacggtggc ccagcagcag
     1081 caagacgagc tagaagggat gcagctgctg agggagatcc tggctaacgt cttcctctac
     1141 ctgtgcgcca tcatcgtggg catcatgtcc tactacatgg cagaccgtaa gcaccgaaag
     1201 gccttcctgg aggcccgcca gtcgctggag gtgaagatga atctggagga gcagagccag
     1261 cagcaggaaa accttatgct ttccatcctg ccaaagcatg tggctgacga gatgttgaag
     1321 gacatgaaga aagatgagag tcagaaggac cagcagcagt tcaacaccat gtacatgtac
     1381 cgccatgaga atgtcagcat cctgtttgca gatattgtgg gctttaccca gctgtcctct
     1441 gcttgcagtg cccaggagct cgtgaagcta ctcaacgagc tctttgcccg ctttgacaag
     1501 ctggcggcca aataccacca gctgaggatc aagatcctag gcgactgtta ctactgcatc
     1561 tgcggcctgc ctgactaccg ggaggaccac gccgtgtgct ccatcctgat ggggcttgcc
     1621 atggtagagg ccatctcgta cgtgcgggag aagaccaaga ccggagtgga catgcgtgtg
     1681 ggggtgcaca caggcactgt gctaggtggc gtcctgggcc agaagcgctg gcagtatgat
     1741 gtatggtcta ccgatgtcac tgtggcaaac aagatggagg ctggcggcat cccagggcgc
     1801 gtgcacattt cccagagcac catggactgc ctgaaagggg agttcgatgt cgaacctggt
     1861 gatggtggca gtcgctgcga ctacctagat gagaagggca tcgaaaccta cctcatcatt
     1921 gcctccaagc cagaggtgaa gaagacagct caaaatggcc tcaacggctc ggccctgcca
     1981 aacggagcac cggcatccaa gcccagctcc cctgccctta ttgagaccaa ggagcccaat
     2041 gggagtgccc atgccagcgg ctccacatca gaggaggctg aagaacagga ggcccaggct
     2101 gacaacccct cgttccccaa cccccgccgc aggctgcgcc tccaggacct ggcagaccgt
     2161 gtggtggacg cctctgagga tgagcacgaa ctgaaccagc ttcttaacga ggccctgctg
     2221 gagcgggagt ccgcccaggt ggtaaagaag agaaacacat tcctcctaac gatgaggttc
     2281 atggacccag agatggaaac acgctactcg gtggagaagg agaagcagag tggggctgcc
     2341 ttcagctgtt cctgtgtggt ccttttctgc acggccatgg tggagatact tatcgacccc
     2401 tggttgatga caaactacgt gaccttcgtg gttggagagg ttctgctctt gatcctgacc
     2461 atctgttcga tggctgccat cttccccagg gcatttccta agaagctcgt ggccttctca
     2521 tcttggattg accggacccg ctgggccaga aatacctggg ccatgttagc catcttcatt
     2581 ctggttatgg ccaatgttgt ggacatgctg agctgtctcc agtactacat gggaccttac
     2641 aacgtgacaa ccgggataga gctggacggt ggctgtatgg agaaccccaa gtactacaac
     2701 tatgttgctg tgctgtccct catcgccacc atcatgctgg tgcaggtcag ccacatggtg
     2761 aagctgacac tcatgctgct cgtcacaggc gccgtgactg ccatcaacct gtatgcctgg
     2821 tgtcctgtct ttgatgaata cgaccacaaa cgctttcagg aaaaggactc tcctatggtg
     2881 gccttagaga agatgcaggt actttccacc cctgggctca atggcactga cagcaggctg
     2941 cccctggtgc cttccaagta ctcgatgact gtgatgatgt tcgttatgat gctgagcttt
     3001 tactacttct cacgccacgt ggagaaactg gcccggacac tgttcttgtg gaagattgag
     3061 gtccatgacc agaaagaacg tgtgtacgag atgcgccggt ggaacgaggc cttggtcacc
     3121 aacatgttgc cagagcatgt tgcacgccat ttcctgggct ccaagaagag agatgaggag
     3181 ctgtacagcc agtcttatga cgagattgga gtcatgtttg cctccttgcc caactttgcc
     3241 gacttctaca ctgaggagag catcaataat ggtggcatcg agtgtctacg cttcctcaat
     3301 gagatcatct ctgattttga ctctctcctg gacaatccca aattccgggt catcaccaag
     3361 atcaaaacca tcggcagcac ctatatggca gcttctggag tcacaccaga tgtcaacacc
     3421 aatggcttta caagctccag caaggaggaa aagtcagaca aggagcgctg gcagcacctg
     3481 gctgacctgg cagactttgc actagccatg aaggacacgc ttacaaacat caacaaccag
     3541 tcattcaaca acttcatgct gcgcataggc atgaacaaag gaggagttct ggctggagtc
     3601 attggagccc ggaagccaca ctatgacatc tgggggaaca cggtcaatgt ggccagcagg
     3661 atggaatcca caggggtcat gggcaatatc caggtggtag aagagacaca ggtcatcctt
     3721 cgagagtatg gcttccgctt tgtgaggcga ggacccatct ttgtgaaggg caaaggggag
     3781 cttctgacct ttttcttaaa ggggcgggac aggccagctg ccttccccaa tggctcctct
     3841 gttacactgc cccaccaagt ggtggacaac ccctgaacag ccctggctcc acagcggtcc
     3901 acactggaag ggagacattt tggaagcaga gaaaagcttt gggaaagggc aaacgaccga
     3961 gtcccggggt tcccaactgt tgaagtgcac attcccatag actttaggtt tcagatttcc
     4021 tccagcctcc ctgtgtggct gtgagctctg agcgtggcta ttcctactcc tcagtgtgcc
     4081 tgtagcttcc ccaaagcagg ggtctaggca tagtactgga gcagcctttc cagagccttt
     4141 gttccagctc agcccttcac ccctagagag gccacagcca ctgtgagcag gatgccagca
     4201 gatgtgggat gaagctgcct gtgctgcagg gtgggggcac aggctgggct cagggccgag
     4261 aaggctcggc gcctggctgc gccctcctgt ctagttaagt caatggccct taccccgatg
     4321 ttcctgataa tcttgaaagg ttcttctgga acccccgtgt caccttagtc acgagagcag
     4381 aaagtgcaat atttcctttc acctggttgg gaaggggggt tatttctgaa agaaaaaaat
     4441 atataaacag atcttctaca tttatatttt taacctgttc aaaaaacaac tttccaatat
     4501 tgccttgtct tctgagctct tgctacagtc gcctttgcta ctgctttaac agagaatctg
     4561 caggtgttga taaagaacag gactgtttta ttaaaagctt tactcaactt g
//
