LOCUS       NM_031007               4251 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus adenylate cyclase 2 (Adcy2), mRNA.
ACCESSION   NM_031007
VERSION     NM_031007.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4251)
  AUTHORS   Shen,J.X., Wachten,S., Halls,M.L., Everett,K.L. and Cooper,D.M.
  TITLE     Muscarinic receptors stimulate AC2 by novel phosphorylation sites,
            whereas Gbetagamma subunits exert opposing effects depending on the
            G-protein source
  JOURNAL   Biochem J 447 (3), 393-405 (2012)
   PUBMED   22906005
  REMARK    GeneRIF: AC2 is poised to yield both stimulatory and inhibitory
            outcomes of receptor activation.
REFERENCE   2  (bases 1 to 4251)
  AUTHORS   Halls,M.L. and Cooper,D.M.
  TITLE     Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79,
            AC2, beta-arrestin 2, PDE4D3 complex
  JOURNAL   EMBO J 29 (16), 2772-2787 (2010)
   PUBMED   20664520
  REMARK    GeneRIF: AC2 interacts with RXFP1 through AKAP79, whereas the
            association with PDE4D3 and PKA depends upon beta-arrestin 2
            binding to Ser704.
REFERENCE   3  (bases 1 to 4251)
  AUTHORS   Townsend,P.D., Holliday,P.M., Fenyk,S., Hess,K.C., Gray,M.A.,
            Hodgson,D.R. and Cann,M.J.
  TITLE     Stimulation of mammalian G-protein-responsive adenylyl cyclases by
            carbon dioxide
  JOURNAL   J Biol Chem 284 (2), 784-791 (2009)
   PUBMED   19008230
  REMARK    GeneRIF: soluble adenylyl cyclase is responsive to both CO(2) and
            bicarbonate ion
REFERENCE   4  (bases 1 to 4251)
  AUTHORS   Sadana,R. and Dessauer,C.W.
  TITLE     Physiological roles for G protein-regulated adenylyl cyclase
            isoforms: insights from knockout and overexpression studies
  JOURNAL   Neurosignals 17 (1), 5-22 (2009)
   PUBMED   18948702
  REMARK    Review article
REFERENCE   5  (bases 1 to 4251)
  AUTHORS   Piggott,L.A., Bauman,A.L., Scott,J.D. and Dessauer,C.W.
  TITLE     The A-kinase anchoring protein Yotiao binds and regulates adenylyl
            cyclase in brain
  JOURNAL   Proc Natl Acad Sci U S A 105 (37), 13835-13840 (2008)
   PUBMED   18772391
REFERENCE   6  (bases 1 to 4251)
  AUTHORS   Baker,L.P., Nielsen,M.D., Impey,S., Hacker,B.M., Poser,S.W.,
            Chan,M.Y. and Storm,D.R.
  TITLE     Regulation and immunohistochemical localization of
            betagamma-stimulated adenylyl cyclases in mouse hippocampus
  JOURNAL   J Neurosci 19 (1), 180-192 (1999)
   PUBMED   9870949
REFERENCE   7  (bases 1 to 4251)
  AUTHORS   Tesmer,J.J., Sunahara,R.K., Gilman,A.G. and Sprang,S.R.
  TITLE     Crystal structure of the catalytic domains of adenylyl cyclase in a
            complex with Gsalpha.GTPgammaS
  JOURNAL   Science 278 (5345), 1907-1916 (1997)
   PUBMED   9417641
REFERENCE   8  (bases 1 to 4251)
  AUTHORS   Zhang,G., Liu,Y., Ruoho,A.E. and Hurley,J.H.
  TITLE     Structure of the adenylyl cyclase catalytic core
  JOURNAL   Nature 386 (6622), 247-253 (1997)
   PUBMED   9069282
  REMARK    Erratum:[Nature 1997 Jul 10;388(6638):204]
REFERENCE   9  (bases 1 to 4251)
  AUTHORS   Chen,J., DeVivo,M., Dingus,J., Harry,A., Li,J., Sui,J., Carty,D.J.,
            Blank,J.L., Exton,J.H., Stoffel,R.H. et al.
  TITLE     A region of adenylyl cyclase 2 critical for regulation by G protein
            beta gamma subunits
  JOURNAL   Science 268 (5214), 1166-1169 (1995)
   PUBMED   7761832
REFERENCE   10 (bases 1 to 4251)
  AUTHORS   Feinstein,P.G., Schrader,K.A., Bakalyar,H.A., Tang,W.J.,
            Krupinski,J., Gilman,A.G. and Reed,R.R.
  TITLE     Molecular cloning and characterization of a
            Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain
  JOURNAL   Proc Natl Acad Sci U S A 88 (22), 10173-10177 (1991)
   PUBMED   1719547
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 26, 2021 this sequence version replaced NM_031007.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M80550.1, SRR26643295.472.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-511               JAXUCZ010000001.1  36204054-36204564
            512-709             JAXUCZ010000001.1  36220493-36220690
            710-871             JAXUCZ010000001.1  36326350-36326511
            872-1021            JAXUCZ010000001.1  36431896-36432045
            1022-1170           JAXUCZ010000001.1  36512033-36512181
            1171-1282           JAXUCZ010000001.1  36517040-36517151
            1283-1410           JAXUCZ010000001.1  36519796-36519923
            1411-1569           JAXUCZ010000001.1  36521339-36521497
            1570-1702           JAXUCZ010000001.1  36522449-36522581
            1703-1879           JAXUCZ010000001.1  36524174-36524350
            1880-1923           JAXUCZ010000001.1  36527224-36527267
            1924-2004           JAXUCZ010000001.1  36530745-36530825
            2005-2074           JAXUCZ010000001.1  36537483-36537552
            2075-2172           JAXUCZ010000001.1  36540275-36540372
            2173-2257           JAXUCZ010000001.1  36560929-36561013
            2258-2395           JAXUCZ010000001.1  36578555-36578692
            2396-2515           JAXUCZ010000001.1  36584808-36584927
            2516-2685           JAXUCZ010000001.1  36588043-36588212
            2686-2770           JAXUCZ010000001.1  36598999-36599083
            2771-2929           JAXUCZ010000001.1  36604620-36604778
            2930-3076           JAXUCZ010000001.1  36611361-36611507
            3077-3184           JAXUCZ010000001.1  36613209-36613316
            3185-3299           JAXUCZ010000001.1  36639875-36639989
            3300-3424           JAXUCZ010000001.1  36645868-36645992
            3425-4251           JAXUCZ010000001.1  36649819-36650645
FEATURES             Location/Qualifiers
     source          1..4251
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..4251
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /note="adenylate cyclase 2"
                     /db_xref="GeneID:81636"
                     /db_xref="RGD:619965"
     exon            1..511
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..3577
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /EC_number="4.6.1.1"
                     /note="ATP pyrophosphate-lyase 2; adenylate cyclase type
                     II; adenylyl cyclase 2; adenylate cyclase 2 (brain)"
                     /codon_start=1
                     /product="adenylate cyclase type 2"
                     /protein_id="NP_112269.2"
                     /db_xref="GeneID:81636"
                     /db_xref="RGD:619965"
                     /translation="MWQEAMRRRRYLRDRAEAAAAAAAGGGEGLQRSRDWLYESYYCM
                     SQQHPLIVFLLLIVMGACLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCI
                     ESVFKKLLRVFSLVIWICLVAMGYLFMCFGGTVSAWDQVSFFLFIIFVVYTMLPFNMR
                     DAIIASILTSSSHTIVLSVYLSATPGAKEHLFWQILANVIIFICGNLAGAYHKHLMEL
                     ALQQTYRDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQM
                     ENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENE
                     CMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHS
                     GNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDG
                     EIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAA
                     KPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAID
                     GINAQKQWLKSEDIQRISLLFYNKNIEKEYRATALPAFKYYVTCACLIFLCIFIVQIL
                     VLPKTSILGFSFGAAFLSLIFILFVCFAGQLLQCSKKASTSLMWLLKSSGIIANRPWP
                     RISLTIVTTAIILTMAVFNMFFLSNSEETTLPTANTSNANVSVPDNQASILHARNLFF
                     LPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLDAYSQVLFQ
                     RPGIWKDLKTMGSVSLSIFFITLLVLGRQSEYYCRLDFLWKNKFKKEREEIETMENLN
                     RVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGL
                     ECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAIPSQEHAQEPERQYM
                     HIGTMVEFAYALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVN
                     VASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSL
                     SQSNLAS"
     exon            512..709
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            710..871
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1021
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1170
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1282
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1410
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1569
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1702
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1879
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1923
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2004
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2074
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2172
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2257
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2395
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2515
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2685
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2770
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2929
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3076
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3184
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3299
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3424
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3425..4251
                     /gene="Adcy2"
                     /gene_synonym="AC2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcgcgggg tggggcgagg cgggccgagg ggcccggtgg ctcccgccct cgagagtggt
       61 ggcggcagcg gcgcccggga gctgccctga ggccgccccc ggcccccgcc cgcgcgtcag
      121 cgcgcccagc ccggggctcc gagctccgcc cgcgcccgag gcccctgcgt acagctccgg
      181 gcgggccacc ggcgggtcgc ggcggcgcgg gggcggcagg cggtaggcga ccgcagagcg
      241 gcgctgcccg ggcagggcgc gcacggcggg cgccccgcga gccgccccga tgtggcagga
      301 ggcgatgcgg cggcgccgct acctgcggga ccgcgccgag gcggcggcgg cagcggcggc
      361 gggaggcgga gaggggctgc agcggtcccg ggactggctc tacgagtcct actactgcat
      421 gagccagcag cacccgctca tcgtcttcct gctgctcatc gtcatgggcg cctgcctcgc
      481 cctgctagcc gtcttcttcg cgctcgggct ggaggtggaa gaccatgtgg catttttaat
      541 aacggttccc actgccctgg ccattttctt tgccatattc attcttgtct gcatagagtc
      601 tgtgttcaag aagctactcc gtgtgttttc gctggtgatt tggatatgtc tggttgccat
      661 gggatacctg ttcatgtgct tcggagggac tgtgtctgcc tgggaccagg tgtcattctt
      721 cctcttcatc atctttgtgg tatataccat gcttcccttc aacatgcgag atgccatcat
      781 tgccagcatc ctcacatctt catctcatac gatagtgctg agcgtctacc tgtctgcaac
      841 accaggggcc aaggagcacc tgttctggca gatactggcc aatgtgatca ttttcatttg
      901 tgggaacttg gcgggagcct accacaagca cctcatggag cttgccttgc agcaaaccta
      961 tcgggacacg tgtaattgca tcaagtcccg gatcaagctg gaatttgaaa aacggcagca
     1021 ggaacggctc ctgctctcct tgctgccagc tcacatcgcc atggagatga aagctgaaat
     1081 cattcagagg ctgcagggcc ccaaagcagg acagatggaa aacacaaaca acttccacaa
     1141 tctgtatgtc aaacgacaca ccaacgtgag catattatac gctgacattg ttggcttcac
     1201 ccgccttgca agcgattgct cccctggcga actggtccac atgctgaatg aactctttgg
     1261 gaagtttgat caaatagcaa aggagaatga atgcatgaga attaaaattt taggagactg
     1321 ctattactgt gtttccgggc tccctatatc actccctaac catgccaaga actgtgtgaa
     1381 aatgggattg gatatgtgcg aagccataaa gaaagtgagg gatgctaccg gagttgatat
     1441 caacatgcgt gtaggagtgc attctgggaa cgttctctgt ggtgtgattg gtctccagaa
     1501 gtggcagtat gatgtgtggt ctcatgatgt tactctggca aaccacatgg aagctggagg
     1561 agtccctggg cgtgttcaca tttcttcagt cactctggag cacttgaatg gggcttataa
     1621 agtggaggaa ggagatggtg agataagaga cccatattta aagcagcact tggtgaaaac
     1681 ctactttgta atcaatccca agggagagcg acggagtcct cagcatctct tcagacctcg
     1741 acacactctg gacggagcca agatgagagc atctgtccgc atgacccggt acttggagtc
     1801 ctggggagca gccaagccat tcgcacatct gcaccacaga gatagcatga ccacagagaa
     1861 tgggaagatt agtaccacgg atgtgccaat gggtcaacat aattttcaaa atcgcacctt
     1921 aagaactaag tcacagaaga agagatttga agaagaactg aatgaaagga tgatccaagc
     1981 aattgatggg atcaatgcac agaagcaatg gctcaagtca gaagacattc aaagaatctc
     2041 cctgcttttc tataacaaga atatagagaa agaataccga gctactgcac tgccagcatt
     2101 caagtactac gtgacctgtg cctgcctcat ctttctctgc atcttcattg tacagatact
     2161 tgtattgcca aaaacgtcca tccttggctt ctcctttgga gctgcatttc tctccctcat
     2221 cttcatcctc tttgtctgct tcgctggaca gcttttgcaa tgcagcaaaa aggcctccac
     2281 ctctctcatg tggcttttga aatcatcagg catcatcgcc aaccgcccat ggccacggat
     2341 ctccctcaca atcgtcacca cggctatcat actaaccatg gctgtgttca acatgttttt
     2401 cctgagcaac tctgaggaga caacccttcc cactgccaat acatcaaatg caaacgtttc
     2461 tgtcccggat aaccaggcgt cgattcttca tgctcgaaac ttgtttttcc tcccgtactt
     2521 catatacagc tgcatcctgg gcttgatctc ctgctccgtt ttcctgaggg tgaactatga
     2581 gttaaaaatg ttaatcatga tggtggcact cgtgggctac aacaccattc tactccacac
     2641 ccatgcccat gttctggatg cgtacagcca ggtcctgttt cagagaccag gcatttggaa
     2701 agacctgaag accatgggct ccgtgtcact ctccatattc ttcatcacgc tgctggttct
     2761 gggcagacag agtgaatatt actgtaggtt agacttcttg tggaagaaca agttcaaaaa
     2821 agagcgggag gagatagaaa ccatggagaa cctaaatcga gtgctgctgg agaacgtgct
     2881 tcctgcacac gtggctgaac acttcctggc caggagcctg aaaaatgagg agctgtacca
     2941 ccagtcctac gactgtgtct gtgtcatgtt tgcctccatt ccggacttca aggagttcta
     3001 cacagagtca gatgtgaaca aggaaggctt ggaatgcctg cggctcctga atgagatcat
     3061 tgctgacttt gatgatctgc tttctaagcc aaagttcagt ggtgttgaaa agatcaagac
     3121 cattgggagc acatacatgg cagccacggg actgagtgcc atacccagcc aggagcacgc
     3181 ccaggaacct gagcgtcagt acatgcacat aggcaccatg gtggagtttg catatgccct
     3241 ggtgggaaaa ctggatgcca tcaataagca ctccttcaac gacttcaaac tgcgagtggg
     3301 tatcaaccat gggcctgtaa tagctggcgt cataggggct caaaagccac agtatgacat
     3361 ctggggcaac actgtcaacg tggccagcag aatggacagc accggggtcc tggacaaaat
     3421 acaggtgact gaggagacaa gcctcatctt gcagacgctt ggctacacgt gtacatgtcg
     3481 aggtatcatc aatgtgaagg ggaaagggga cctgaagaca tattttgtaa acacagagat
     3541 gtcaaggtcc ctttctcaga gcaacttggc atcctgagaa gctgtctctt cctgacaaga
     3601 agaatgtact tgcaggaagg taccacgcac tttctgactg caacccttcc ccttcgtcct
     3661 gatgtacgtg ctgtgcccca tcctctggag cccctgcaga ctagttcctg tgacccagtg
     3721 acatactgtt tggtgtctgc gcgtgcccag gttgtcctgc cacttgcact gtgcttgctc
     3781 ctaagcagga ggggaaggaa ccatgtcctg gaaggagagc attggaagaa gtgatgaaga
     3841 ggtgaagtga acacacattc ttaaggcaat aaaaccgggg ggtgtatatt atcttctggt
     3901 gcatgttctt ctctggaaaa tacggtagct cgtaactgca tccctagtct gatattcaaa
     3961 cacacagtat ttgtgaataa gctgatcccg tcacccaaca tggagtctgt gttcacctac
     4021 ccatgtgtct cattgccagt ggtcgtcctt gggggctcag ctgagactct cagcttctgt
     4081 caccttgctg tcctgtcttg tggcagcagc acgttgccat ccatcaccag aattagtcct
     4141 cacagcctag gaccagtttt gtaccaaact catctgatgt tttgatgcca tttgtctttt
     4201 gtaaggttaa ttcattaaaa gttttatgta ctttggttta tagtgcccga a
//
