LOCUS       NM_001107239            3219 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus adenylate cyclase 1 (Adcy1), mRNA.
ACCESSION   NM_001107239 XM_001053224 XM_223616
VERSION     NM_001107239.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3219)
  AUTHORS   Zhang X, Pizzoni A, Hong K, Naim N, Qi C, Korkhov V and Altschuler
            DL.
  TITLE     CAP1 binds and activates adenylyl cyclase in mammalian cells
  JOURNAL   Proc Natl Acad Sci U S A 118 (24) (2021)
   PUBMED   34099549
  REMARK    GeneRIF: CAP1 binds and activates adenylyl cyclase in mammalian
            cells.
REFERENCE   2  (bases 1 to 3219)
  AUTHORS   Santos-Cortez RL, Lee K, Giese AP, Ansar M, Amin-Ud-Din M, Rehn K,
            Wang X, Aziz A, Chiu I, Hussain Ali R, Smith JD, Shendure J,
            Bamshad M, Nickerson DA, Ahmed ZM, Ahmad W, Riazuddin S and Leal
            SM.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     Adenylate cyclase 1 (ADCY1) mutations cause recessive hearing
            impairment in humans and defects in hair cell function and hearing
            in zebrafish
  JOURNAL   Hum Mol Genet 23 (12), 3289-3298 (2014)
   PUBMED   24482543
REFERENCE   3  (bases 1 to 3219)
  AUTHORS   Hwang CK, Chaurasia SS, Jackson CR, Chan GC, Storm DR and Iuvone
            PM.
  TITLE     Circadian rhythm of contrast sensitivity is regulated by a
            dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling
            pathway in retinal ganglion cells
  JOURNAL   J Neurosci 33 (38), 14989-14997 (2013)
   PUBMED   24048828
REFERENCE   4  (bases 1 to 3219)
  AUTHORS   Ehling P, Kanyshkova T, Baumann A, Landgraf P, Meuth SG, Pape HC
            and Budde T.
  TITLE     Adenylyl cyclases: expression in the developing rat thalamus and
            their role in absence epilepsy
  JOURNAL   J Mol Neurosci 48 (1), 45-52 (2012)
   PUBMED   22531884
  REMARK    GeneRIF: Despite previous hints pointing to a major contribution of
            ACs, the presented data show that there is no apparent causality
            between AC activity and the occurrence of the epileptic phenotype.
REFERENCE   5  (bases 1 to 3219)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 3219)
  AUTHORS   Jensen JB, Mikkelsen JD and Mork A.
  TITLE     Increased adenylyl cyclase type 1 mRNA, but not adenylyl cyclase
            type 2 in the rat hippocampus following antidepressant treatment
  JOURNAL   Eur Neuropsychopharmacol 10 (2), 105-111 (2000)
   PUBMED   10706991
REFERENCE   7  (bases 1 to 3219)
  AUTHORS   Wong ST, Athos J, Figueroa XA, Pineda VV, Schaefer ML, Chavkin CC,
            Muglia LJ and Storm DR.
  TITLE     Calcium-stimulated adenylyl cyclase activity is critical for
            hippocampus-dependent long-term memory and late phase LTP
  JOURNAL   Neuron 23 (4), 787-798 (1999)
   PUBMED   10482244
REFERENCE   8  (bases 1 to 3219)
  AUTHORS   Villacres EC, Wong ST, Chavkin C and Storm DR.
  TITLE     Type I adenylyl cyclase mutant mice have impaired mossy fiber
            long-term potentiation
  JOURNAL   J Neurosci 18 (9), 3186-3194 (1998)
   PUBMED   9547227
REFERENCE   9  (bases 1 to 3219)
  AUTHORS   Matsuoka I, Suzuki Y, Defer N, Nakanishi H and Hanoune J.
  TITLE     Differential expression of type I, II, and V adenylyl cyclase gene
            in the postnatal developing rat brain
  JOURNAL   J Neurochem 68 (2), 498-506 (1997)
   PUBMED   9003034
REFERENCE   10 (bases 1 to 3219)
  AUTHORS   Tzavara ET, Pouille Y, Defer N and Hanoune J.
  TITLE     Diurnal variation of the adenylyl cyclase type 1 in the rat pineal
            gland
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 11208-11212 (1996)
   PUBMED   8855334
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474055.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_223616.4, XM_001053224.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3219
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3219
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /note="adenylate cyclase 1"
                     /db_xref="GeneID:305509"
                     /db_xref="RGD:1309318"
     exon            1..495
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..3219
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /EC_number="4.6.1.1"
                     /note="adenylate cyclase 1 (brain)"
                     /codon_start=1
                     /product="adenylate cyclase type 1"
                     /protein_id="NP_001100709.1"
                     /db_xref="GeneID:305509"
                     /db_xref="RGD:1309318"
                     /translation="MGSAVAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLL
                     VTAALVPAKRPRLWRTLGANALLFFGVNMYGVFVRILTERSQRKAFLQARNCIEDRLR
                     LEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFT
                     GLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCC
                     VEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVM
                     EAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNTFLRTHNIETFFIVPSHRRKIFPG
                     LILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEK
                     LRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQ
                     LQDEYFTSAVVLALILATLFGLIYLLVIPQSVAVLLLLVFSICFLVACTLYLHITRVQ
                     CFPGCLTIQIRTALCVFIVVLIYSVAQGCVVSCLPWAWSSHSNSSLVVLAAGGRRTVL
                     PALPCESAHHGLLCCLVGTLPLAIFLRVSSLPKMILLSGLTTSYILVLELSGYTKVGG
                     GALSGRSYEPIMAILLFSCTLALHARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKR
                     ILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVEC
                     LRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAPTAGTRAKKSISSHLSTL
                     ADFAIDMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRM
                     DSTGVQGRIQVTEEVHRLLNRCSYQFVCRGKVSVKGKGEMLTYFLEGRTDGSSSHSRS
                     LRLERRMFPYGRGGGGQARRPPLCPAAGPPIKPGLSPAPTSQYLSSTAAGKEA"
     exon            496..645
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..764
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..876
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1004
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1163
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1305
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1461
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1656
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1754
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1839
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1929
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2183
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2310
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2427
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2574
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2673
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2788
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2913
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3219
                     /gene="Adcy1"
                     /gene_synonym="Ac1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccgcggct acacgttgcg gctggagcag gcggccacgc tgaaagcgct ggcggtgctt
       61 agcctgctgg cgggagccct ggcgctggcc gagctgctgg gcgcaccggg gccagcgcct
      121 ggcctcgcca aggggtcgca cccagtgcac tgcatccttt tcctggcgct gttcgtggtc
      181 accaatgtcc gatccctgca ggtgtcccag ctgcagcagg tcggtcagct ggcgctgttc
      241 ttcagcctca ccttcgcgct actctgctgc cccttcgcgc tgggcggccc cgcgaggagc
      301 tctgcgggag gcgcaatggg ctcggcggtt gccgaacagg gggtttggca actccttttg
      361 gtcaccttcg tgtcctatgc cttgctgccc gtgcgcagcc tactggccat cggcttcggg
      421 ctcgtggtgg ctgcctcgca cttactggtc acagccgcct tggtccctgc caagcgccca
      481 cgtctctgga ggacgcttgg tgccaatgcc ctgctcttct ttggtgtgaa catgtatggc
      541 gtcttcgtgc ggatcttgac tgagcgctcc cagaggaagg ccttcctgca ggctcgaaac
      601 tgcattgagg accggctgcg gctggaagat gagaatgaga aacaggagcg gttgctcatg
      661 agcctcttgc cccggaatgt cgccatggag atgaaggaag acttcctgaa gccccctgag
      721 aggatatttc acaagattta catccagagg cacgacaatg tgagcatcct gtttgcagac
      781 atcgtgggtt tcacaggtct ggcgtcccag tgcacggccc aggagctggt gaaactgctc
      841 aatgaactct ttggcaagtt cgatgagtta gccacggaaa accactgtcg ccgaatcaag
      901 atccttggag actgctacta ctgtgtgtct ggcctcaccc agcccaagac ggatcacgcc
      961 cactgctgtg tggagatggg acttgacatg atcgatacca tcacatccgt ggctgaggct
     1021 actgaagtag acctgaacat gcgtgtgggc ctacacactg gcagggtcct ctgtggtgtc
     1081 ctgggcctac gcaagtggca gtacgacgta tggtccaacg acgtcaccct ggccaatgtc
     1141 atggaggctg ctggcttacc agggaaggtc cacatcacga agacaaccct tgcgtgcttg
     1201 aacggggact acgaggtgga gccgggccac ggccatgaga ggaacacctt tctgagaact
     1261 cacaacatcg agaccttctt tattgtgcca tcccatcgga ggaagatatt tccaggtttg
     1321 attctctcgg atatcaaacc agccaagagg atgaagttca agaccgtctg ctacctgctg
     1381 gtgcagctca tgcattgccg gaaaatgttc aaggctgaga tccccttctc caacgtaatg
     1441 acctgtgagg atgatgacaa gcgaagggca ttgagaacgg cctcggagaa gctcagaaac
     1501 cgttcgtcat tctctaccaa cgtggtctac accactccgg gtacgcgtgt caacaggtac
     1561 atcagccgcc ttcttgaagc ccgccagaca gagctggaga tggccgacct gaacttcttt
     1621 accctcaagt acaagcatgt tgaacgggaa caaaaatacc accagcttca agatgagtac
     1681 ttcaccagcg ccgttgtcct cgccctcatc ctggctacct tatttgggct tatctacctt
     1741 ctggtaatcc cacagagcgt ggctgtcctg ctgctgctgg tgttttctat ctgcttcttg
     1801 gtggcctgta ccctgtacct gcacatcacg agggtccagt gttttccagg gtgcctgacc
     1861 atccagatcc gcaccgctct gtgtgtgttc atcgtggtct taatctactc agtagctcaa
     1921 ggatgtgtgg tgagctgtct gccttgggcc tggagctctc actccaacag ctccctagtg
     1981 gtcctcgcag ctggtggccg gcgcactgtg ctgcctgccc tgccctgtga gtctgcacac
     2041 catggcctgc tctgctgcct ggtgggcacc ctcccactag ccatattcct gcgggtgtcc
     2101 tccttgccaa agatgatcct gctgtctggg ctgacgactt cctacatcct tgtcctggag
     2161 ctcagtggat acaccaaggt tgggggcggt gccctctctg ggcgcagcta tgagcccatc
     2221 atggctatcc tgctgttctc atgcacgctg gccctgcacg ccaggcaggt ggacgtcagg
     2281 ctacggctgg actacctctg ggcagcacag gcggaggagg aacgggacga catggagagg
     2341 gtaaagctgg acaacaagag gatcctcttc aacctcctgc cagcgcacgt cgcacagcac
     2401 ttcctcatgt ccaatccccg gaacatggat ctctattacc agtcctactc ccaggtgggc
     2461 gtcatgttcg cctccatccc caacttcaac gacttctaca tagaactgga tggcaacaac
     2521 atgggcgttg agtgtctgcg gctcctcaat gagatcattg ctgactttga tgagctcatg
     2581 gacaaggact tctacaagga cctggagaag atcaagacca ttgggagtac ctatatggct
     2641 gccgtggggc tggcgcccac agcaggaacc agggctaaga agtccatctc ttcccatctg
     2701 agcacgctgg cagactttgc catcgacatg tttgatgtcc tggatgagat caactaccag
     2761 tcctacaacg acttcgttct ccgagtcggc atcaacgttg gccccgtggt cgctggagtg
     2821 atcggtgctc gcaggcccca gtacgacatc tggggaaaca cagtcaatgt ggccagtcgg
     2881 atggatagca ctggggtcca gggaagaatt caggtgactg aggaagtcca ccgactgctg
     2941 aacaggtgct cataccagtt tgtgtgcaga ggcaaagtca gcgtcaaggg caagggagag
     3001 atgctaacgt actttctaga aggcaggact gatgggagca gttcccacag caggtccctt
     3061 cgcttggagc gaaggatgtt tccttatggg agaggcggcg gaggccaggc caggcggccc
     3121 ccattgtgtc ctgcagctgg acccccaatc aaaccggggc tctctccagc ccccactagc
     3181 cagtacctgt catccacagc agcagggaag gaagcctag
//
