LOCUS       NM_001111055            6382 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus adenosine deaminase, RNA-specific, B1 (Adarb1),
            transcript variant 2, mRNA.
ACCESSION   NM_001111055
VERSION     NM_001111055.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6382)
  AUTHORS   Gurung,S., Evans,A.J., Wilkinson,K.A. and Henley,J.M.
  TITLE     ADAR2-mediated Q/R editing of GluK2 regulates kainate receptor
            upscaling in response to suppression of synaptic activity
  JOURNAL   J Cell Sci 131 (24) (2018)
   PUBMED   30559217
  REMARK    GeneRIF: that activity-dependent regulation of ADAR2 proteostasis
            and GluK2 Q/R editing are key determinants of kainate receptors
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6382)
  AUTHORS   Behm,M., Wahlstedt,H., Widmark,A., Eriksson,M. and Ohman,M.
  TITLE     Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA
            editing during neuronal development
  JOURNAL   J Cell Sci 130 (4), 745-753 (2017)
   PUBMED   28082424
  REMARK    GeneRIF: lower levels of ADAR2 in the nucleus of immature neurons
            than in mature neurons.
REFERENCE   3  (bases 1 to 6382)
  AUTHORS   Tariq,A., Garncarz,W., Handl,C., Balik,A., Pusch,O. and
            Jantsch,M.F.
  TITLE     RNA-interacting proteins act as site-specific repressors of
            ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation
  JOURNAL   Nucleic Acids Res 41 (4), 2581-2593 (2013)
   PUBMED   23275536
REFERENCE   4  (bases 1 to 6382)
  AUTHORS   Yang,L., Huang,P., Li,F., Zhao,L., Zhang,Y., Li,S., Gan,Z., Lin,A.,
            Li,W. and Liu,Y.
  TITLE     c-Jun amino-terminal kinase-1 mediates glucose-responsive
            upregulation of the RNA editing enzyme ADAR2 in pancreatic
            beta-cells
  JOURNAL   PLoS One 7 (11), e48611 (2012)
   PUBMED   23139803
  REMARK    GeneRIF: The JNK1 pathway may be functionally linked to the
            nutrient-sensing actions of ADAR2-mediated RNA editing in
            professional secretory cells.
REFERENCE   5  (bases 1 to 6382)
  AUTHORS   Rueter,S.M., Dawson,T.R. and Emeson,R.B.
  TITLE     Regulation of alternative splicing by RNA editing
  JOURNAL   Nature 399 (6731), 75-80 (1999)
   PUBMED   10331393
REFERENCE   6  (bases 1 to 6382)
  AUTHORS   Belcher,S.M. and Howe,J.R.
  TITLE     Characterization of RNA editing of the glutamate-receptor subunits
            GluR5 and GluR6 in granule cells during cerebellar development
  JOURNAL   Brain Res Mol Brain Res 52 (1), 130-138 (1997)
   PUBMED   9450685
REFERENCE   7  (bases 1 to 6382)
  AUTHORS   Gerber,A., O'Connell,M.A. and Keller,W.
  TITLE     Two forms of human double-stranded RNA-specific editase 1 (hRED1)
            generated by the insertion of an Alu cassette
  JOURNAL   RNA 3 (5), 453-463 (1997)
   PUBMED   9149227
REFERENCE   8  (bases 1 to 6382)
  AUTHORS   Lai,F., Chen,C.X., Carter,K.C. and Nishikura,K.
  TITLE     Editing of glutamate receptor B subunit ion channel RNAs by four
            alternatively spliced DRADA2 double-stranded RNA adenosine
            deaminases
  JOURNAL   Mol Cell Biol 17 (5), 2413-2424 (1997)
   PUBMED   9111310
REFERENCE   9  (bases 1 to 6382)
  AUTHORS   O'Connell,M.A., Gerber,A. and Keller,W.
  TITLE     Purification of human double-stranded RNA-specific editase 1
            (hRED1) involved in editing of brain glutamate receptor B pre-mRNA
  JOURNAL   J Biol Chem 272 (1), 473-478 (1997)
   PUBMED   8995285
REFERENCE   10 (bases 1 to 6382)
  AUTHORS   Melcher,T., Maas,S., Herb,A., Sprengel,R., Seeburg,P.H. and
            Higuchi,M.
  TITLE     A mammalian RNA editing enzyme
  JOURNAL   Nature 379 (6564), 460-464 (1996)
   PUBMED   8559253
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB576423.1, U43534.1,
            CB720085.1, CB556744.1, CB801553.1, BF388249.1, JAXUCZ010000020.1
            and CK840559.1.
            
            Summary: This gene encodes a double-stranded-RNA-specific adenosine
            deaminase that is involved in editing pre-mRNAs by site-specific
            conversion of adenosine (A) to inosine (I). Substrates for this
            enzyme include ionotropic glutamate receptors (GluR2-6) and
            serotonin receptor (5HT2C). Studies in rodents have shown that this
            protein can modify its own pre-mRNA by A->I editing to create a
            novel acceptor splice site, alternative splicing to which results
            in down regulation of its protein expression. Additional splicing
            events result in transcript variants encoding different isoforms.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2, also referred to as 2a) uses
            an alternate, in-frame donor splice site at one of the internal
            coding exons, compared to transcript variant 1. This results in a
            shorter isoform (2), missing a 10 aa segment found in isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.59584.1,
                                           SRR26643287.36924.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            undergoes RNA editing  :: PMID: 10331393
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               CB576423.1         1-253
            254-412             U43534.1           1-159
            413-534             CB720085.1         404-525
            535-1666            U43534.1           282-1413
            1667-1806           CB556744.1         541-680
            1807-2875           U43534.1           1584-2652
            2876-3063           CB801553.1         7-194
            3064-3168           BF388249.1         144-248
            3169-3281           CB801553.1         300-412
            3282-5738           JAXUCZ010000020.1  11347333-11349789
            5739-6382           CK840559.1         1-644               c
FEATURES             Location/Qualifiers
     source          1..6382
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..6382
                     /gene="Adarb1"
                     /gene_synonym="Adar2; Red1"
                     /note="adenosine deaminase, RNA-specific, B1"
                     /db_xref="GeneID:25367"
                     /db_xref="RGD:2033"
     exon            1..152
                     /gene="Adarb1"
                     /gene_synonym="Adar2; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            153..325
                     /gene="Adarb1"
                     /gene_synonym="Adar2; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            326..400
                     /gene="Adarb1"
                     /gene_synonym="Adar2; Red1"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..2478
                     /gene="Adarb1"
                     /gene_synonym="Adar2; Red1"
                     /EC_number="3.5.4.37"
                     /note="isoform 2 is encoded by transcript variant 2;
                     RNA-editing enzyme 1; double-stranded RNA-specific editase
                     1; dsRNA adenosine deaminase; RNA-editing deaminase 1; RNA
                     editing deaminase of glutamate receptors; double stranded
                     RNA specific deaminase RED1"
                     /codon_start=1
                     /product="double-stranded RNA-specific editase 1 isoform
                     2"
                     /protein_id="NP_001104525.1"
                     /db_xref="GeneID:25367"
                     /db_xref="RGD:2033"
                     /translation="MDIEDEENMSSSSTDVKENRNLDNMPPKDSSTPGPGEGIPLSNG
                     GGGSTSRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYMLLSQTG
                     PVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLS
                     VNTDFTSDQADFPDTLFNGFETPDKSEPPFYVGSNGDDSFSSSGDVSLSASPVPASLT
                     QPPLPIPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEG
                     SGRNKKLAKARAAQSALATVFNLHLDQTPSRQPVLSEGLQLHLPQVLADAVSRLVLGK
                     FSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALND
                     CHAEIISRRSLLRFLYAQLELYLNNKEDQKKSIFQKSERGGFRLKDTVQFHLYISTSP
                     CGDARIFSPHEPVLEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQG
                     ERLLTMSCSDKIARWNVVGIQGALLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISN
                     IEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDTAIEVINATTGKDELGRP
                     SRLCKHALYCRWMRVHGKVPPHLLRTKITKPTTYHESKLAAKEYQAAKARLFTAFIKA
                     GLGAWVEKPTEQDQFSFTP"
     exon            401..1335
                     /gene="Adarb1"
                     /gene_synonym="Adar2; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1450
                     /gene="Adarb1"
                     /gene_synonym="Adar2; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1619
                     /gene="Adarb1"
                     /gene_synonym="Adar2; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1768
                     /gene="Adarb1"
                     /gene_synonym="Adar2; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1937
                     /gene="Adarb1"
                     /gene_synonym="Adar2; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2119
                     /gene="Adarb1"
                     /gene_synonym="Adar2; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2298
                     /gene="Adarb1"
                     /gene_synonym="Adar2; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..6365
                     /gene="Adarb1"
                     /gene_synonym="Adar2; Red1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagaggcag aggctgagac agcggctgag gctgaggtgg ctgaggctga ggcggcggcg
       61 aggggctcct agccggggcc gcggggccag ccgaggccgc cgcagcgccg ggagccagac
      121 gccggcatcc cgcgggcgca gtgtgagctg agagtgaagt gtgtcaggct ggacatggag
      181 agctcaaggt gtggctaaag gaaacacgcc agcgccgtgc atcacgcctg ctgtttccgt
      241 actgctgagc aatgagctca ctttgctcgc cctgaaagag tttgcctcag atttgagcca
      301 aaataaaaac taaacaaatt tcaagacaaa agaggtctcc gccagtcaag aagccctcaa
      361 aagcatttta ccatggatat agaagacgaa gagaatatga gttccagcag cactgatgtt
      421 aaagaaaacc gcaatctgga caacatgccc cccaaggaca gcagcacacc cgggcctggc
      481 gagggtattc cgctctccaa cgggggtggt gggagcacca gcaggaagcg gcccctggag
      541 gagggcagca atggccactc caagtaccgc ctgaagaagc gaaggaaaac gccagggccc
      601 gttctaccca agaacgccct gatgcagctg aacgagatca aaccgggctt acagtacatg
      661 ctgctgtccc agacaggacc cgtgcacgca cctctgtttg tcatgtctgt ggaggtaaac
      721 gggcaggtct ttgaaggctc cggccctaca aagaagaagg caaagctgca tgctgctgag
      781 aaggccctgc ggtcttttgt ccagtttccc aacgcctctg aggcccacct ggccatggga
      841 aggaccctct ccgtgaacac agacttcacg tccgaccagg cggacttccc cgacacgctc
      901 ttcaatggct ttgagactcc agacaagtcg gagccaccct tctacgtagg ctccaatggg
      961 gatgactcct tcagctcaag cggagacgtt agcctgtcag cctccccagt gcctgccagc
     1021 cttacccagc ctcctctgcc catcccacca ccattcccac ccccaagtgg gaagaacccc
     1081 gtgatgatct tgaatgagct gcgcccaggg ctgaagtatg acttcctctc cgagagtggg
     1141 gagagccacg ccaagagctt tgtcatgtcc gtggtggtag atggccagtt ctttgagggc
     1201 tcagggagaa acaagaagct tgccaaggcc cgggctgcac agtctgcctt ggctactgtc
     1261 ttcaatttgc acttggacca aacgccatct cgccagcctg tcctcagtga gggtctccag
     1321 ttgcatttgc cacaggtatt ggcagatgct gtctcacgcc tggtcctggg taagttcagt
     1381 gacctgacag acaacttttc ctcccctcac gcacgaagaa aagtgctctc tggagtagtg
     1441 atgaccacag gtacagatgt caaagatgcc aaggtgataa gtgtttcgac agggacgaag
     1501 tgcatcaacg gcgaatacat gagtgaccgt ggcctggctc tcaatgactg ccacgcagag
     1561 ataatctccc gaaggtccct gctcaggttt ctatacgcac agctcgagct ttacttaaat
     1621 aacaaagaag accagaaaaa gtccatattt cagaagtcag agcggggtgg gttccggctg
     1681 aaggataccg tgcagttcca cctgtacatc agcacctcac cctgcggaga cgccagaata
     1741 ttctctcccc atgagcccgt gctagaggaa ccggctgata gacatccgaa tcgcaaagca
     1801 aggggacagc tgcggactaa aatagaatct ggcgagggga caatccctgt gcgctcaaat
     1861 gccagcatcc agacctggga tggggtgctg cagggggaac ggctgctcac catgtcctgc
     1921 agtgacaaga tagcacgctg gaacgtggtg ggcatccagg gggccctgct cagcattttc
     1981 gtggagccca tctacttctc cagcatcatc ctgggcagcc tgtaccacgg ggaccacctc
     2041 tccagggcca tgtaccagcg gatctccaac atagaggacc tgccaccgct ctacaccctc
     2101 aacaagcccc tgctcagcgg tatcagcaat gcagaggcac ggcagccagg gaaggcaccc
     2161 aacttcagtg tcaactggac ggtgggcgac acggccattg aggtcatcaa tgccacaaca
     2221 gggaaggatg agctaggccg cccctcccgc ctgtgtaagc acgcgctgta ctgtcgctgg
     2281 atgcgggtac acggaaaggt gcccccccac ctgctgcgca ccaagatcac caagcccacc
     2341 acctaccacg agtccaagct ggcagcgaag gagtaccagg ctgccaaggc acgtctgttc
     2401 actgccttca tcaaggcggg gctgggcgcc tgggtggaga agcccacaga gcaggaccag
     2461 ttctccttca ctccctgagc caggcggagt cgagagcaca gagtgcgagg ctgtggtgcc
     2521 gaactgtccc ccagagcctt gcgtctgacc tgggacaggt gtgcacctcg gggacggcac
     2581 ggggagtctg ggggaaccac tggacttcaa gcatcatccc cggcgcctct caccacccag
     2641 cagggcagtg tggggatgtg tagggtgctg ggcacctcac atctgagtag ggatcaggtg
     2701 cacagtgggg gtgcatgggg gcacaggggc ccatcaccac cccttgccac acatttcccc
     2761 tcttgagcta cccagtgacc gctttatatc tcagtttaca ttagacattg agttctactg
     2821 agtagggctt cctcaagtat aggaaaatag aaatttactt tgtgtgagat tcttgaataa
     2881 ataatttatt cagagctagg aatgagattt ataaaataag aagtaattat gtcaggtcac
     2941 ttttatgcca cattatttta attgcaaaag aaaaaaaaag cgtttctatg tgaaagaaca
     3001 caggaatcta gaggtaggaa gtagaagaga gctaccgcgc acacctctgt gcgtggctcc
     3061 tctccgtggg gccttcacac ttaggttctc acagtaggtt ttaacagctc tcctggggtg
     3121 accccagcat gatatggtgt gaccttggca cacactggcc ctgcagctgg gatgctgtgt
     3181 cctacagagc cgtgacctag gctctgctgc ctctagaatc gtccatgctc ccggttaggc
     3241 tcaaatcatg gaaaactcta tttgctacca ggtaactgaa gacccaatct gtccgtagcc
     3301 tgtcctggct ggccatcata cgggggtcct aaccatcgag gttttgtgac ctagaggcac
     3361 gcagtaggac tgctccacag tcagagcaca gtcttccttc tgctcccccc ttgggatctg
     3421 gtgggtagga accactgacc gctcagagag cctcacggga tggaaagagt tgtgagcagg
     3481 taccgtgctt ggagcgcgcc acctaaggcg gattatccgg taccccttcc agcttcagac
     3541 atgtttgaca agttaaacat tcaggttgaa gctggtggga cagtgtgaac cttggaacgc
     3601 tgcagaccag acattggtgt ctcgacaggc aggcctgggt gctcctggta tcttggggct
     3661 gaaccccaaa atgctgctga gcacccgtga ggcacagggt ggcacccagg gccctggagc
     3721 ggacacctgg acctcctgtg ctcagactcg ccccaggtgc cttgttgctt ccactcagga
     3781 ttagggagga gtagaggggg ggaggagggg ctgtggctgt cagctcagtg tgctagcctg
     3841 gtccagcagg ttgctctgaa gagcctcagg gcctcgagca gagaaggtgc aggctcatcc
     3901 cacagcacac atccaccacg gctgcatcca gagctctgac agctatggcc ctgagctgtt
     3961 cacccaggtg tgtgtgtgtg tccttgacac acttgagaaa gagacagaat aagaacatag
     4021 ccactgtggg ttccacctga ttcccagcag acctcaagag gctgtgtgtc attgcttaag
     4081 tgagacccac ttgtgtctcc gtgtcaggag ccctgtcgtg tccttgtagg tgtctccgtg
     4141 gttctcgtcc tgcggggctt gatcttcgag gcatgaaggt cctagcagaa ctccctagtg
     4201 acacatgcca tcttggatct cctcagatca ccacctgccc ccctgaaagg gagccctccc
     4261 aggctgcatt gcaggcccac cttcgggtga aacgcattgg ggctccttag agaaacggtc
     4321 tcattttacc ccagtaccac accttcccca cagctcctgc actttctaga aagaaaaaca
     4381 cacatgttgg tgtgctctta ctcttgtttt taagtcgaat ttttcctaat ggagatgggg
     4441 agatgattta gtttgttttt aagtacattt tggttataaa gtatagcaaa agtatatccc
     4501 atatacacca aaaaccatgc attacatcta gctttccatg tcagataaca ggctgcccaa
     4561 ccaggaagtg aaggttacat gtatagatca tctgaaacta caggggctgg tcctgcttag
     4621 acctgaccta ggcccagaaa ggagggggag cctggaggca ccctgtggtg aggagccggc
     4681 atgggacatg tgccaccttc ccctgcactc aagacatggc agctcgaaca gcccaaatgt
     4741 gaccagacaa aaaggaaaca aatattgatt taagacataa gccctttgag cctcttccca
     4801 aaggtcccca caatggtagt tcatgtccag gacctaaatg tcacagactc agcagaaagc
     4861 ttgacacacc aagagcctga tggaaatgtc ttggctacct cagcaggtga agaacatgag
     4921 tgtctgtgtt cagagcatgc agctaaacct gaagttttaa gtccataccg cagtatccct
     4981 caggattact cagaccgccg tcacagggct gcagctacac agcaggaaga cattgtggcc
     5041 gggagccttg gctgggctat cttgtttctg cagagccgag actctccact tagatgtagg
     5101 cagcgtgagt gtggcgtcca cgccgttagc cactcatgat gtcaggaggt agcacgtctc
     5161 ctagcgagag acaccaaaga acaactttaa agctgaatct gagtctctca ccattctgtt
     5221 tcgaagcttt tcctttagta attaaaacct gtctaagagc gcaggccccc atcttgtaag
     5281 gcattgctct ctgtttattt tatcacccag ctcctcttgc ctccagactg tacgtgctgc
     5341 ttggttttta aactttagtt tcagacaggt gcaccagggg cgggcagcca ccagagggtc
     5401 aggaacgtgg ggtgagctgc acgtcaccct gccccaagag taaatacaca cagtgcagga
     5461 gcagcttgtc acttccaaaa gactccagaa atgtcagctc ctccactcgg aactttgctc
     5521 cagagagaga agtaaaatga gctgaaattc aaacctgtca cgtcctcgaa atcagggaac
     5581 ctctcagaag atcccttcat gctccctcat tccccagact gcaccgggag aagggcagag
     5641 tgtatgcgtt cagtgtgcac agcttgtatg tgtccttgtc tctcggcaca tctgtcgtgt
     5701 gacagtctcc ccaaggctga gggggtggcc acccactctg cagctgtgaa ctgctccaca
     5761 ctggggctac tggggtcatg tggcattggg aaattggaat taggaagcct ctgacccgtc
     5821 agggaccatg aatgagggag ttcgtcccat ggtctgaccg atcatggctg gctcctcagt
     5881 gcactttccg ctcagccgct gggggaatgt ccacatctct gtggtagtac ctgttcgttc
     5941 tgtttgctgt ttgaatggca agtgcccagc ctcagaagca cttaattgtc gccacagcag
     6001 gcgctgatgg tacacaagga actgatgggc cattctactg aatggaacgc agtaggttaa
     6061 aagcacagtt tgaggaatgt tcacggaata agcccctaaa agctgttagc ttttccaggc
     6121 tttgggttat gtacttttaa tttgatttta gagtttggac actttacatg aatgtaattc
     6181 agccaagaaa cgtgttgcta agatacaatc ctcagtgttc tctgtatgta tatttatgta
     6241 tataccacat gttacagcct gcatgagctt cctcacaccg agcccagccg gaactgagca
     6301 tgaaatgctg tcacatgtag acaaaggact gagatgttct caataaagac taagacgttt
     6361 cactaaaaaa aaaaaaaaaa aa
//
