LOCUS       NP_001104525             701 aa            linear   ROD 27-APR-2025
DEFINITION  double-stranded RNA-specific editase 1 isoform 2 [Rattus
            norvegicus].
ACCESSION   NP_001104525
VERSION     NP_001104525.1
DBSOURCE    REFSEQ: accession NM_001111055.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 701)
  AUTHORS   Gurung,S., Evans,A.J., Wilkinson,K.A. and Henley,J.M.
  TITLE     ADAR2-mediated Q/R editing of GluK2 regulates kainate receptor
            upscaling in response to suppression of synaptic activity
  JOURNAL   J Cell Sci 131 (24) (2018)
   PUBMED   30559217
  REMARK    GeneRIF: that activity-dependent regulation of ADAR2 proteostasis
            and GluK2 Q/R editing are key determinants of kainate receptors
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 701)
  AUTHORS   Behm,M., Wahlstedt,H., Widmark,A., Eriksson,M. and Ohman,M.
  TITLE     Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA
            editing during neuronal development
  JOURNAL   J Cell Sci 130 (4), 745-753 (2017)
   PUBMED   28082424
  REMARK    GeneRIF: lower levels of ADAR2 in the nucleus of immature neurons
            than in mature neurons.
REFERENCE   3  (residues 1 to 701)
  AUTHORS   Tariq,A., Garncarz,W., Handl,C., Balik,A., Pusch,O. and
            Jantsch,M.F.
  TITLE     RNA-interacting proteins act as site-specific repressors of
            ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation
  JOURNAL   Nucleic Acids Res 41 (4), 2581-2593 (2013)
   PUBMED   23275536
REFERENCE   4  (residues 1 to 701)
  AUTHORS   Yang,L., Huang,P., Li,F., Zhao,L., Zhang,Y., Li,S., Gan,Z., Lin,A.,
            Li,W. and Liu,Y.
  TITLE     c-Jun amino-terminal kinase-1 mediates glucose-responsive
            upregulation of the RNA editing enzyme ADAR2 in pancreatic
            beta-cells
  JOURNAL   PLoS One 7 (11), e48611 (2012)
   PUBMED   23139803
  REMARK    GeneRIF: The JNK1 pathway may be functionally linked to the
            nutrient-sensing actions of ADAR2-mediated RNA editing in
            professional secretory cells.
REFERENCE   5  (residues 1 to 701)
  AUTHORS   Rueter,S.M., Dawson,T.R. and Emeson,R.B.
  TITLE     Regulation of alternative splicing by RNA editing
  JOURNAL   Nature 399 (6731), 75-80 (1999)
   PUBMED   10331393
REFERENCE   6  (residues 1 to 701)
  AUTHORS   Belcher,S.M. and Howe,J.R.
  TITLE     Characterization of RNA editing of the glutamate-receptor subunits
            GluR5 and GluR6 in granule cells during cerebellar development
  JOURNAL   Brain Res Mol Brain Res 52 (1), 130-138 (1997)
   PUBMED   9450685
REFERENCE   7  (residues 1 to 701)
  AUTHORS   Gerber,A., O'Connell,M.A. and Keller,W.
  TITLE     Two forms of human double-stranded RNA-specific editase 1 (hRED1)
            generated by the insertion of an Alu cassette
  JOURNAL   RNA 3 (5), 453-463 (1997)
   PUBMED   9149227
REFERENCE   8  (residues 1 to 701)
  AUTHORS   Lai,F., Chen,C.X., Carter,K.C. and Nishikura,K.
  TITLE     Editing of glutamate receptor B subunit ion channel RNAs by four
            alternatively spliced DRADA2 double-stranded RNA adenosine
            deaminases
  JOURNAL   Mol Cell Biol 17 (5), 2413-2424 (1997)
   PUBMED   9111310
REFERENCE   9  (residues 1 to 701)
  AUTHORS   O'Connell,M.A., Gerber,A. and Keller,W.
  TITLE     Purification of human double-stranded RNA-specific editase 1
            (hRED1) involved in editing of brain glutamate receptor B pre-mRNA
  JOURNAL   J Biol Chem 272 (1), 473-478 (1997)
   PUBMED   8995285
REFERENCE   10 (residues 1 to 701)
  AUTHORS   Melcher,T., Maas,S., Herb,A., Sprengel,R., Seeburg,P.H. and
            Higuchi,M.
  TITLE     A mammalian RNA editing enzyme
  JOURNAL   Nature 379 (6564), 460-464 (1996)
   PUBMED   8559253
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB576423.1, U43534.1,
            CB720085.1, CB556744.1, CB801553.1, BF388249.1, JAXUCZ010000020.1
            and CK840559.1.
            
            Summary: This gene encodes a double-stranded-RNA-specific adenosine
            deaminase that is involved in editing pre-mRNAs by site-specific
            conversion of adenosine (A) to inosine (I). Substrates for this
            enzyme include ionotropic glutamate receptors (GluR2-6) and
            serotonin receptor (5HT2C). Studies in rodents have shown that this
            protein can modify its own pre-mRNA by A->I editing to create a
            novel acceptor splice site, alternative splicing to which results
            in down regulation of its protein expression. Additional splicing
            events result in transcript variants encoding different isoforms.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2, also referred to as 2a) uses
            an alternate, in-frame donor splice site at one of the internal
            coding exons, compared to transcript variant 1. This results in a
            shorter isoform (2), missing a 10 aa segment found in isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.59584.1,
                                           SRR26643287.36924.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            undergoes RNA editing  :: PMID: 10331393
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..701
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     Protein         1..701
                     /product="double-stranded RNA-specific editase 1 isoform
                     2"
                     /EC_number="3.5.4.37"
                     /note="RNA-editing enzyme 1; double-stranded RNA-specific
                     editase 1; dsRNA adenosine deaminase; RNA-editing
                     deaminase 1; RNA editing deaminase of glutamate receptors;
                     double stranded RNA specific deaminase RED1"
                     /calculated_mol_wt=76744
     Region          1..79
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P51400.1)"
     Region          75..146
                     /region_name="DSRM_RED1_rpt1"
                     /note="first double-stranded RNA binding motif of
                     RNA-editing deaminase 1 (RED1) and similar proteins;
                     cd19895"
                     /db_xref="CDD:380724"
     Site            order(80,83..84,87..88,90,104..105,107,109,126..128,131)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:380724"
     Region          83..88
                     /region_name="Interaction with substrate RNA"
                     /note="propagated from UniProtKB/Swiss-Prot (P51400.1)"
     Region          104..105
                     /region_name="Interaction with substrate RNA"
                     /note="propagated from UniProtKB/Swiss-Prot (P51400.1)"
     Site            149
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P78563; propagated from
                     UniProtKB/Swiss-Prot (P51400.1)"
     Region          176..220
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P51400.1)"
     Region          232..301
                     /region_name="DSRM_RED1_rpt2"
                     /note="second double-stranded RNA binding motif of
                     RNA-editing deaminase 1 (RED1) and similar proteins;
                     cd19898"
                     /db_xref="CDD:380727"
     Site            order(235,237..238,241..242,257..259,261,263,279..282,285)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:380727"
     Region          237..242
                     /region_name="Interaction with substrate RNA"
                     /note="propagated from UniProtKB/Swiss-Prot (P51400.1)"
     Region          259
                     /region_name="Interaction with substrate RNA"
                     /note="propagated from UniProtKB/Swiss-Prot (P51400.1)"
     Region          322..698
                     /region_name="ADEAMc"
                     /note="tRNA-specific and double-stranded RNA adenosine
                     deaminase (RNA-specific editase); smart00552"
                     /db_xref="CDD:214718"
     CDS             1..701
                     /gene="Adarb1"
                     /gene_synonym="Adar2; Red1"
                     /coded_by="NM_001111055.1:373..2478"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:25367"
                     /db_xref="RGD:2033"
ORIGIN      
        1 mdiedeenms ssstdvkenr nldnmppkds stpgpgegip lsnggggsts rkrpleegsn
       61 ghskyrlkkr rktpgpvlpk nalmqlneik pglqymllsq tgpvhaplfv msvevngqvf
      121 egsgptkkka klhaaekalr sfvqfpnase ahlamgrtls vntdftsdqa dfpdtlfngf
      181 etpdkseppf yvgsngddsf sssgdvslsa spvpasltqp plpipppfpp psgknpvmil
      241 nelrpglkyd flsesgesha ksfvmsvvvd gqffegsgrn kklakaraaq salatvfnlh
      301 ldqtpsrqpv lseglqlhlp qvladavsrl vlgkfsdltd nfsspharrk vlsgvvmttg
      361 tdvkdakvis vstgtkcing eymsdrglal ndchaeiisr rsllrflyaq lelylnnked
      421 qkksifqkse rggfrlkdtv qfhlyistsp cgdarifsph epvleepadr hpnrkargql
      481 rtkiesgegt ipvrsnasiq twdgvlqger lltmscsdki arwnvvgiqg allsifvepi
      541 yfssiilgsl yhgdhlsram yqrisniedl pplytlnkpl lsgisnaear qpgkapnfsv
      601 nwtvgdtaie vinattgkde lgrpsrlckh alycrwmrvh gkvpphllrt kitkpttyhe
      661 sklaakeyqa akarlftafi kaglgawvek pteqdqfsft p
//
