LOCUS       XM_006232774            6039 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus adenosine deaminase, RNA-specific
            (Adar), transcript variant X1, mRNA.
ACCESSION   XM_006232774
VERSION     XM_006232774.4
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051337.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_006232774.5.
            
            On Jan 21, 2021 this sequence version replaced XM_006232774.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6039
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..6039
                     /gene="Adar"
                     /note="adenosine deaminase, RNA-specific; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 3 mRNAs, 104 ESTs, 5 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 119 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:81635"
                     /db_xref="RGD:71099"
     CDS             215..3766
                     /gene="Adar"
                     /codon_start=1
                     /product="double-stranded RNA-specific adenosine deaminase
                     isoform X1"
                     /protein_id="XP_006232836.1"
                     /db_xref="GeneID:81635"
                     /db_xref="RGD:71099"
                     /translation="MEEAEAAGDCRGLHLFTGVFPHQTQPCLDPSYEHSKWRYLQPRG
                     SESYLRSFQLQQIEFLKGRLPEAPLIGAQTQSLPTFLPGHWPRFPGPPAQGKQPEIWG
                     FPRSVTLRNQGFHIGPPLPPPHSRGPPWRGAEGLCSHFQELSISQNPEQKVLNRLEEL
                     GEGKATTAYALARELRTPKKDINRILYSLERKGKLHRGVGKPPLWSLVPLSQACTQPP
                     RAVNSDKEVPRGEPDLDSEDGDPASDLEGPSELLDMAEIKEKICDYLFNVSKSSALNL
                     AKNIGLAKARDVNAVLIDLERQGDVYREGATPPIWYLTDKKRERLQMKRSTHSGPAAT
                     PAAVSEATQSTSFPTCHPPQSGGSSSMATSKRVENGQEPVTKYESRHEARPGPVRLRP
                     HAYHNGPSRAGYVASENGPWATDDIPDNLNSIHTAPGEFRAIMEMPSFYSPTLPRCSP
                     YKKLTECQLKNPVSGLLEYAQFTSQTCDFNLIEQSGPSHEPRFKFQVVINGREFPPAE
                     AGSKKVAKQDAAVKAMAILLREAKAKDSGQPEELSNCPMEEDPEKPAESQPPSSSATS
                     LFSGKSPVTTLLECMHKLGNSCEFRLLSKEGPAHDPKFQYCVAVGAQTFPSVSAPSKK
                     VAKQMAAEEAMKALQEEAANSADDQSGGANTDSLDESVAPNKIRRIGELVRYLNTNPV
                     GGLLEYARSHGFAAEFKLIDQSGPPHEPKFVYQAKVGGRWFPAVCAHSKKQGKQDAAD
                     AALRVLIGESEKAEQLGFAEVTPVTGASLRRTMLLLSRSPDAHPKTLPLTGSTFHDQI
                     AMLSHRCFNALTNSFQPSLLGRKILAAIIMKRDPEDMGVVVSLGTGNRCVKGDSLSLK
                     GETVNDCHAEIISRRGFIRFLYSELMKYNHHTAKNSIFELARGGEKLQIKKTVSFHLY
                     ISTAPCGDGALFDKSCSDRAVESTESRHYPVFENPKQGKLRTKVENGEGTIPVESSDI
                     VPTWDGIRLGERLRTMSCSDKILRWNVLGLQGALLTHFLQPVYLKSVTLGYLFSQGHL
                     TRAICCRVTRDGNAFEDGLRYPFIVNHPKVGRVSVYDSKRQSGKTKETSVNWCLADGY
                     DLEILDGTRGTVDGPGKELSRVSKKNIFLQFKKLCSFRARRDLLQLSYGEAKKAARDY
                     DLAKNYFKKSLRDMGYGNWISKPQEEKNFYLCPVPND"
ORIGIN      
        1 atctgcgccc taaccattga ttcctgactg aaggtggagg actacgcgtt gggaccaacc
       61 ggaaaagctg agactactga ctgccctaag tcatggcttt gtggctagct gctttctagc
      121 atggcagatc actcactgtg gacagaagga gaggagctct ggggctggac aggctgtctc
      181 ctgggatggc agtgcacact gattctctat aaccatggag gaagcagaag cagcaggtga
      241 ctgccgtggg ctccacttgt ttacaggggt gttccctcac cagacacagc cctgcttgga
      301 ccctagctat gagcacagca agtggagata cctgcagcca cgtgggtcgg agtcttacct
      361 taggagtttc cagctccagc agatagagtt tctcaaaggg cggctcccag aagcaccctt
      421 gattggagca cagacccagt cactaccgac attcctccca ggacactggc caaggttccc
      481 agggccacct gcccaaggaa aacaaccgga aatctggggg tttcccagga gtgtgactct
      541 cagaaatcag gggttccata taggaccccc acttcctcct ccacacagca ggggtccgcc
      601 atggagaggt gctgaaggtc tttgctcaca cttccaggag ctgagcatca gtcagaatcc
      661 agagcagaag gtcctaaacc gcctggaaga gcttggtgag gggaaggcca ccactgccta
      721 cgcgctagcc agagagctca ggacccccaa aaaggacatc aatcgtatat tgtactcctt
      781 agaaaggaag ggaaagctgc atagaggagt ggggaagcct cctttgtgga gccttgtgcc
      841 cttaagtcag gcttgcactc agccccctag agctgtgaat tcagacaagg aagtccctcg
      901 aggagagccc gatttggaca gtgaggacgg agaccctgcc tctgacttag aaggaccttc
      961 tgagcttctt gatatggctg aaattaagga gaaaatctgt gactatctgt tcaatgtgtc
     1021 aaagtcctct gccctgaacc tggctaagaa cattggcctc gccaaggccc gagatgtgaa
     1081 tgcagtgttg attgacttag aaaggcaagg cgatgtctac agggaagggg ccactcctcc
     1141 catctggtac ttgacggaca agaagcgtga gaggctgcag atgaagagaa gtacacacag
     1201 tggtcctgca gctaccccag cagctgtctc agaagccact caaagcacct cattccctac
     1261 ctgccaccca ccccaatcag gtggctcaag cagcatggca acctccaaaa gagtggaaaa
     1321 cgggcaggag cctgtgacaa agtatgaaag taggcacgag gcccgaccag gaccagtacg
     1381 actgcggcct catgcttatc acaacggccc ctctagagca gggtatgttg cctctgaaaa
     1441 tggcccgtgg gccacagatg acatcccaga taacttgaat agtatccaca cagcaccagg
     1501 tgagtttcga gccatcatgg agatgccctc cttctacagc cctaccttgc cacggtgttc
     1561 accctacaag aagctaactg agtgccagct gaagaaccct gtcagcgggt tgttagagta
     1621 tgctcagttc actagtcaga cctgtgattt caacctgata gagcagagtg gaccgtccca
     1681 tgaacctcga tttaaattcc aggttgtcat caatggtcga gagtttcccc cagctgaggc
     1741 tggcagcaag aaagttgcta agcaggacgc agcagtgaaa gccatggcga ttctgcttcg
     1801 ggaagccaaa gccaaagaca gtggacagcc agaagaattg tccaactgtc ccatggagga
     1861 agacccagag aagccagcag agtcccagcc ccccagctcc tcagcaacat ccttgttctc
     1921 tgggaagagc ccagttacta cactgcttga gtgtatgcac aagctaggga actcctgtga
     1981 atttcgtctc ctgtccaaag aaggccctgc tcatgacccc aagttccagt actgtgtggc
     2041 agtaggagcc cagactttcc cctctgtgag tgcccccagc aagaaagtag caaagcagat
     2101 ggccgcagag gaagccatga aagctctgca agaggaggcg gccaattccg ctgatgacca
     2161 gtctggaggt gcgaacacag actcacttga tgaatctgtg gctcccaaca agatccggag
     2221 gatcggtgag ctcgtaaggt acctgaacac caaccctgtg ggtggcttgt tggagtacgc
     2281 ccgctctcat ggctttgctg ctgagttcaa gctcattgac cagtctggac ctcctcatga
     2341 acccaagttt gtttaccaag caaaagttgg gggccgctgg tttccagccg tgtgtgcaca
     2401 cagcaagaaa cagggcaagc aagacgcagc ggatgcagcc cttcgtgtct tgatcgggga
     2461 gagcgagaag gcagagcagt tgggtttcgc agaggtaacc ccagtaaccg gggccagtct
     2521 cagaagaact atgctactcc tttccaggtc cccagatgca catccaaaga cacttcctct
     2581 cactggtagc accttccacg accagatagc tatgctgagc cacagatgct tcaacgctct
     2641 gaccaacagt ttccagccct ccctgctcgg ccgcaagatc ctggctgcta ttattatgaa
     2701 gagagatcct gaggacatgg gtgttgttgt cagtttgggg actgggaatc gctgtgtgaa
     2761 aggggactct ctcagcctga aaggagagac tgtcaatgac tgccatgctg aaatcatctc
     2821 ccggagaggc ttcatcaggt ttctctacag tgagctgatg aagtacaacc accacactgc
     2881 caagaacagc atattcgagc tggccagggg aggagagaag ctccagataa aaaagacggt
     2941 ttcttttcac ctctacatca gcacggcacc atgtggagat ggagccctct ttgacaaatc
     3001 ctgcagtgac cgtgctgtgg aaagcacaga gtcccgccat taccctgtct ttgaaaatcc
     3061 caagcaaggc aagcttcgca ccaaggtgga gaatggggaa ggcacaattc ctgtggagtc
     3121 cagtgacatt gtacccacgt gggatggcat ccggcttggg gaaagactcc gtaccatgtc
     3181 ctgtagtgac aaaatcctac gctggaatgt gctaggcctg caaggggcgc tgttgacaca
     3241 cttcctacag cctgtgtacc tgaaatctgt gacattaggt taccttttca gccaagggca
     3301 tctgacccgt gctatttgct gccgtgtgac cagagatggg aatgcatttg aggatggact
     3361 acgttatccc tttattgtca accaccccaa ggtcggccga gtcagtgtgt atgattccaa
     3421 aaggcagtcc ggaaagacca aagagacaag cgtcaactgg tgcttggctg atggctatga
     3481 cctggagatc ctggatggca ccaggggcac cgtggatgga ccagggaaag agttgtcgcg
     3541 ggtgtctaag aagaatattt tccttcagtt taagaagctc tgctccttcc gagcccgcag
     3601 agatttgctg cagctctcct atggggaggc caagaaagct gcccgtgact acgacttagc
     3661 caagaactac ttcaagaaaa gcctgaggga catgggctat gggaattgga tcagcaaacc
     3721 ccaggaggaa aagaactttt atctctgtcc agtgcccaat gactgatagt ggggtgtgtt
     3781 cccatggggt cagagggagg tcatagcatt cctcatcaca ttgggccaga gtttaggggc
     3841 cttttttaac cccctccccc ccatttttta atggagaaac cataatagat ggtaaagacc
     3901 tttggttccc attaatcctg cttgctttgg gatttcgagg tggggtctgg ccaagttccc
     3961 acctcccttt tcccaaggga agaggccgag attaaaggaa gaggaagcac taccattcca
     4021 catgtagcat agacagttct tgatcacatg gagcctgggc cccttgggct tagttctgtg
     4081 gagtttttct catctccttt tcctttgctt cactggcctc ttgtgggttt gatcccatcc
     4141 ccatcagttc tctgtaaatc atgtcaggga cttaatgatg tcacctgtag atgtgcaggt
     4201 ccccgttctg tcccccttcc tcctaggatg ccttcctgtg aggtttctgc ttacccaccc
     4261 cagaggatag atagaggcaa acaaaggatg ggtgaactgt ttacaagggc aggagtcgaa
     4321 aagtgtgtca ggggttgtag ggcaacagga atgtggtaag atgtggttgg acaggcaaac
     4381 cctacctagt aatgggccgt gctggcccgc caaggcagtt cccctcctgg gcagctggga
     4441 agttggaagt cagccatggg actgaggaag gtgcccaagc cgagcaagac ccagcagggg
     4501 cccacaaagc actgaccaga gtgcatcacc actcctcgga atgtagctac accgccatcc
     4561 gtcctccatg gagcatcccc agaagctggc tctgtccccc gtgggtatgg ggacacaggc
     4621 cccagggact ggtgaaagcc aaggacaagt cctggagggc agattatctt tgtccagacg
     4681 gagcaaaagt aaatgcaaaa cgtcaacgtt ggtccgttgg ggttcttctc atgcacagat
     4741 acagcagaag ttgacaaagc cttgtataaa attgtttcta aaaagccaga ggtgttgatt
     4801 ctgaactgca tcgcagactt gagatgcaaa tatatttttc cattagtgaa tgtacttcat
     4861 tatatcagat agcttcagaa gctggttcac aggcagggca caaggcctgg aatcttctat
     4921 cctgctcctt tgagaatctt catatacata aaagtgttgt agatggcagg gcaggctagc
     4981 ctcccaccct ggggtgggct tctttgactc ctccccctct gacagtgatt tgtggctatg
     5041 tgggagcctt agtctttgta gagtctgact ctagcctcaa atcaaccaga cagttcgacc
     5101 ctgctccatt ctgcccctcc aggaccgagc ccacctcttt cctctgaatg ctgcggctcc
     5161 ctctggagac agctgccagt gtgctcagca gcttcctgca ctcccttgct tacgcctcag
     5221 tgttgcctgg ctcccccacc ctccggccca ctgccaacag caaacatcac attcacacta
     5281 agtctaatga ctactgccta ctcaacccat gatcaaatct ggatcccaca ggaacttagg
     5341 acttaacaat atactgggga tgtctgcaca gcaccaaatc atcctgcaga actgctggtg
     5401 tctgcagaag cgagagcagc accatgcttg tgtcagctgg aggcatgtta ccttctggca
     5461 cccgcatctg aagcagaacc actgtggccc caagcctggc aggaagcttt agatctgggg
     5521 tctaaaggcc agagacgttc cctttgattc ctagggttcc tctggtcctt tctgggtatt
     5581 cacacagacc cctatctaga aaacttgtgg ttctgggttc ctgtgggtgg aggagagcaa
     5641 ggtatccctg tgctgtgtgt gcttgctgaa gcgagccact ggtatctgca tcccacccca
     5701 cccctgcctc cagtcctgct ggccaagggc agagctccca ctgtgtttcc ttcacctttt
     5761 tgtgtgatct ttaaaaagca gggcctccct ccacaacgtc tcttaataat ttctgtagtt
     5821 gatttgtctg aactgtggct gtcttgcatt ctttgaataa tcacgtttaa gaattgtcaa
     5881 tgcttgaaac tatttcctgt actcaagttg aagggacttt gttggcctag tagggcagtg
     5941 gccaggcata gcctccgcgc tgtgatggat gcagtccctt cttgtgtccc tatacaagtg
     6001 acagtataca ttcctcagaa taaaaacgct gaagcatca
//
