LOCUS       NM_031006               3608 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus adenosine deaminase, RNA-specific (Adar), mRNA.
ACCESSION   NM_031006
VERSION     NM_031006.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3608)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3608)
  AUTHORS   Pujantell,M., Badia,R., Galvan-Femenia,I., Garcia-Vidal,E., de
            Cid,R., Alcalde,C., Tarrats,A., Pinol,M., Garcia,F., Chamorro,A.M.,
            Revollo,B., Videla,S., Pares,D., Corral,J., Tural,C., Sirera,G.,
            Este,J.A., Ballana,E. and Riveira-Munoz,E.
  TITLE     ADAR1 function affects HPV replication and is associated to
            recurrent human papillomavirus-induced dysplasia in HIV coinfected
            individuals
  JOURNAL   Sci Rep 9 (1), 19848 (2019)
   PUBMED   31882741
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3608)
  AUTHORS   Zhang,X., Gao,X., Hu,J., Xie,Y., Zuo,Y., Xu,H. and Zhu,S.
  TITLE     ADAR1p150 Forms a Complex with Dicer to Promote miRNA-222 Activity
            and Regulate PTEN Expression in CVB3-Induced Viral Myocarditis
  JOURNAL   Int J Mol Sci 20 (2), 407 (2019)
   PUBMED   30669342
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3608)
  AUTHORS   Okugawa,Y., Toiyama,Y., Shigeyasu,K., Yamamoto,A., Shigemori,T.,
            Yin,C., Ichikawa,T., Yasuda,H., Fujikawa,H., Yoshiyama,S., Hiro,J.,
            Ohi,M., Araki,T., Kusunoki,M. and Goel,A.
  TITLE     Enhanced AZIN1 RNA editing and overexpression of its regulatory
            enzyme ADAR1 are important prognostic biomarkers in gastric cancer
  JOURNAL   J Transl Med 16 (1), 366 (2018)
   PUBMED   30563560
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3608)
  AUTHORS   Pujantell,M., Franco,S., Galvan-Femenia,I., Badia,R., Castellvi,M.,
            Garcia-Vidal,E., Clotet,B., de Cid,R., Tural,C., Martinez,M.A.,
            Riveira-Munoz,E., Este,J.A. and Ballana,E.
  TITLE     ADAR1 affects HCV infection by modulating innate immune response
  JOURNAL   Antiviral Res 156, 116-127 (2018)
   PUBMED   29906476
REFERENCE   6  (bases 1 to 3608)
  AUTHORS   Desterro,J.M., Keegan,L.P., Lafarga,M., Berciano,M.T., O'Connell,M.
            and Carmo-Fonseca,M.
  TITLE     Dynamic association of RNA-editing enzymes with the nucleolus
  JOURNAL   J Cell Sci 116 (Pt 9), 1805-1818 (2003)
   PUBMED   12665561
REFERENCE   7  (bases 1 to 3608)
  AUTHORS   Shtrichman,R., Heithoff,D.M., Mahan,M.J. and Samuel,C.E.
  TITLE     Tissue selectivity of interferon-stimulated gene expression in mice
            infected with Dam(+) versus Dam(-) Salmonella enterica serovar
            Typhimurium strains
  JOURNAL   Infect Immun 70 (10), 5579-5588 (2002)
   PUBMED   12228285
REFERENCE   8  (bases 1 to 3608)
  AUTHORS   Wang,Q., Khillan,J., Gadue,P. and Nishikura,K.
  TITLE     Requirement of the RNA editing deaminase ADAR1 gene for embryonic
            erythropoiesis
  JOURNAL   Science 290 (5497), 1765-1768 (2000)
   PUBMED   11099415
REFERENCE   9  (bases 1 to 3608)
  AUTHORS   Liu,Y., George,C.X., Patterson,J.B. and Samuel,C.E.
  TITLE     Functionally distinct double-stranded RNA-binding domains
            associated with alternative splice site variants of the
            interferon-inducible double-stranded RNA-specific adenosine
            deaminase
  JOURNAL   J Biol Chem 272 (7), 4419-4428 (1997)
   PUBMED   9020165
REFERENCE   10 (bases 1 to 3608)
  AUTHORS   O'Connell,M.A., Krause,S., Higuchi,M., Hsuan,J.J., Totty,N.F.,
            Jenny,A. and Keller,W.
  TITLE     Cloning of cDNAs encoding mammalian double-stranded RNA-specific
            adenosine deaminase
  JOURNAL   Mol Cell Biol 15 (3), 1389-1397 (1995)
   PUBMED   7862132
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U18942.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U18942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3608
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3608
                     /gene="Adar"
                     /note="adenosine deaminase, RNA-specific"
                     /db_xref="GeneID:81635"
                     /db_xref="RGD:71099"
     exon            1..47
                     /gene="Adar"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..3547
                     /gene="Adar"
                     /EC_number="3.5.4.37"
                     /note="DRADA"
                     /codon_start=1
                     /product="double-stranded RNA-specific adenosine
                     deaminase"
                     /protein_id="NP_112268.1"
                     /db_xref="GeneID:81635"
                     /db_xref="RGD:71099"
                     /translation="MSQGFRGPTGVFPHQTQPCLDPSYEHSKWRYLQPRGSESYLRSF
                     QLQQIEFLKGRLPEAPLIGAQTQSLPPFLPGHWPRFPGPPAQGKQPEIWGFPRSVTLR
                     NQGFHIGPPLPPPHSRGPPWRGAEGLCSHFQELSISQNPEQKVLNRLEELGEGKATTA
                     YALARELRTPKKDINRILYSLERKGKLHRGVGKPPLWSLVPLSQACTQPPRAVNSDKE
                     VPRGEPDLDSEDGDPASDLEGPSELLDMAEIKEKICDYLFNVSKSSALNLAKNIGLAK
                     ARDVNAVLIDLERQGDVYREGATPPIWYLTDKKRERLQMKRSTHSGPAATPAAVSEAT
                     QSTSFPTCHPPQSGGSSSMATSKRVENGQEPVTKYESRHEARPGPVRLRPHAYHNGPS
                     RAGYVASENGPWATDDIPDNLNSIHTAPGEFRAIMEMPSFYSPTLPRCSPYKKLTECQ
                     LKNPVSGLLEYAQFTSQTCDFNLIEQSGPSHEPRFKFQVVINGREFPPAEAGSKKVAK
                     QDAAVKAMAILLREAKAKDSGQPEELSNCPMEEDPEKPAESQPPSSSATSLFSGKSPV
                     TTLLECMHKLGNSCEFRLLSKEGPAHDPKFQYCVAVGAQTFPSVSAPSKKVAKQMAAE
                     EAMKALQEEAANSADDQSGGANTDSLDESVAPNKIRRIGELVRYLNTNPVGGLLEYAR
                     SHGFAAEFKLIDQSGPPHEPKFVYQAKVGGRWFPAVCAHSKKQGKQDAADAALRVLIG
                     ESEKAEQLGFAEVTPVTGASLRRTMLLLSRSPDAHPKTLPLTGSTFHDQIAMLSHRCF
                     NALTNSFQPSLLGRKILAAIIMKRDPEDMGVVVSLGTGNRCVKGDSLSLKGETVNDCH
                     AEIISRRGFIRFLYSELMKYNHHTAKNSIFELARGGEKLQIKKTVSFHLYISTAPCGD
                     GAHFDKSCSDRAVESTESRHYPVFENPKQGKLRTKVENGEGTIPVESSDIVPTWDGIR
                     LGERLRTMSCSDKILRWNVLGLQGALLTHFLQPVYLKSVTLGYLFSQGHLTRAICCRV
                     TRDGNAFEDGLRYPFIVNHPKVGRVSVYDSKRQSGKTKETSVNWCLADGYDLEILDGT
                     RGTVDGPGKELSRVSKKNIFLQFKKLCSFRARRDLLQLSYGEAKKAARDYDLAKNYFK
                     KSLRDMGYGNWISKPQEEKNFYLCPVPND"
     exon            48..1470
                     /gene="Adar"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1654
                     /gene="Adar"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1803
                     /gene="Adar"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1942
                     /gene="Adar"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2127
                     /gene="Adar"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2353
                     /gene="Adar"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2525
                     /gene="Adar"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2619
                     /gene="Adar"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2742
                     /gene="Adar"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2876
                     /gene="Adar"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3059
                     /gene="Adar"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3172
                     /gene="Adar"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3300
                     /gene="Adar"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3608
                     /gene="Adar"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccttgcc ggcggagcta tgtctcaggg gttcagggga cccacagggg tgttccctca
       61 ccagacacag ccctgcttgg accctagcta tgagcacagc aagtggagat acctgcagcc
      121 acgtgggtcg gagtcttacc ttaggagttt ccagctccag cagatagagt ttctcaaagg
      181 gcggctccca gaagcaccct tgattggagc acagacccag tcactaccgc cattcctccc
      241 aggacactgg ccaaggttcc cagggccacc tgcccaagga aaacaaccgg aaatctgggg
      301 gtttcccagg agtgtgactc tcagaaatca ggggttccat ataggacccc cacttcctcc
      361 tccacacagc aggggtccgc catggagagg tgctgaaggt ctttgctcac acttccagga
      421 gctgagcatc agtcagaatc cagagcagaa ggtcctaaac cgcctggaag agcttggtga
      481 ggggaaggcc accactgcct acgcgctagc cagagagctc aggaccccca aaaaggacat
      541 caatcgtata ttgtactcct tagaaaggaa gggaaaactg catagaggag tggggaagcc
      601 tcctttgtgg agccttgtgc ccttaagtca ggcttgcact cagcccccta gagctgtgaa
      661 ttcagacaag gaagtccctc gaggagagcc cgatttggac agtgaggacg gagaccctgc
      721 ctctgactta gaaggacctt ctgagcttct tgatatggct gaaattaagg agaaaatctg
      781 tgactatctg ttcaatgtgt caaagtcctc tgccctgaac ctggctaaga acattggcct
      841 cgccaaggcc cgagatgtga atgcagtgtt gattgactta gaaaggcaag gcgatgtcta
      901 cagggaaggg gccactcctc ccatctggta cttgacggac aagaagcgtg agaggctgca
      961 gatgaagaga agtacacaca gtggtcctgc agctacccca gcagctgtct cagaagccac
     1021 tcaaagcacc tcattcccta cctgccaccc accccaatca ggtggctcaa gcagcatggc
     1081 aacctccaaa agagtggaaa acgggcagga gcctgtgaca aagtatgaaa gtaggcacga
     1141 ggcccgacca ggaccagtac gactgcggcc tcatgcttat cacaacggcc cctctagagc
     1201 agggtatgtt gcctctgaaa atggcccgtg ggccacagat gacatcccag ataacttgaa
     1261 tagtatccac acagcaccag gtgagtttcg agccatcatg gagatgccct ccttctacag
     1321 ccctaccttg ccacggtgtt caccctacaa gaagctaact gagtgccagc tgaagaaccc
     1381 tgtcagcggg ttgttagagt atgctcagtt cactagtcag acctgtgatt tcaacctgat
     1441 agagcagagt ggaccgtccc atgaacctcg atttaaattc caggttgtca tcaatggtcg
     1501 agagtttccc ccagctgagg ctggcagcaa gaaagttgct aagcaggacg cagcagtgaa
     1561 agccatggcg attctgcttc gggaagccaa agccaaagac agtggacagc cagaagaatt
     1621 gtccaactgt cccatggagg aagacccaga gaagccagca gagtcccagc cccccagctc
     1681 ctcagcaaca tccttgttct ctgggaagag cccagttact acactgcttg agtgtatgca
     1741 caagctaggg aactcctgtg aatttcgtct cctgtccaaa gaaggccctg ctcatgaccc
     1801 caagttccag tactgtgtgg cagtaggagc ccagactttc ccctctgtga gtgcccccag
     1861 caagaaagta gcaaagcaga tggccgcaga ggaagccatg aaagctctgc aagaggaggc
     1921 ggccaattcc gctgatgacc agtctggagg tgcgaacaca gactcacttg atgaatctgt
     1981 ggctcccaac aagatccgga ggatcggtga gctcgtaagg tacctgaaca ccaaccctgt
     2041 gggtggcttg ttggagtacg cccgctctca tggctttgct gctgagttca agctcattga
     2101 ccagtctgga cctcctcatg aacccaagtt tgtttaccaa gcaaaagttg ggggccgctg
     2161 gtttccagcc gtgtgtgcac acagcaagaa acagggcaag caagacgcag cggatgcagc
     2221 ccttcgtgtc ttgatcgggg agagcgagaa ggcagagcag ttgggtttcg cagaggtaac
     2281 cccagtaacc ggggccagtc tcagaagaac tatgctactc ctttccaggt ccccagatgc
     2341 acatccaaag acacttcctc tcactggtag caccttccac gaccagatag ctatgctgag
     2401 ccacagatgc ttcaacgctc tgaccaacag tttccagccc tccctgctcg gccgcaagat
     2461 cctggctgct attattatga agagagatcc tgaggacatg ggtgttgttg tcagtttggg
     2521 gactgggaat cgctgtgtga aaggggactc tctcagcctg aaaggagaga ctgtcaatga
     2581 ctgccatgct gaaatcatct cccggagagg cttcatcagg tttctctaca gtgagctgat
     2641 gaagtacaac caccacactg ccaagaacag catattcgag ctggccaggg gaggagagaa
     2701 gctccagata aaaaagacgg tttcttttca cctctacatc agcacggcac catgtggaga
     2761 tggagcccac tttgacaaat cctgcagtga ccgtgctgtg gaaagcacag agtcccgcca
     2821 ttaccctgtc tttgaaaatc ccaagcaagg caagcttcgc accaaggtgg agaatgggga
     2881 aggcacaatt cctgtggagt ccagtgacat tgtacccacg tgggatggca tccggcttgg
     2941 ggaaagactc cgtaccatgt cctgtagtga caaaatccta cgctggaatg tgctaggcct
     3001 gcaaggggcg ctgttgacac acttcctaca gcctgtgtac ctgaaatctg tgacattagg
     3061 ttaccttttc agccaagggc atctgacccg tgctatttgc tgccgtgtga ccagagatgg
     3121 gaatgcattt gaggatggac tacgttatcc ctttattgtc aaccacccca aggtcggccg
     3181 agtcagtgtg tatgattcca aaaggcagtc cggaaagacc aaagagacaa gcgtcaactg
     3241 gtgcttggct gatggctatg acctggagat cctggatggc accaggggca ccgtggatgg
     3301 accagggaaa gagttgtcgc gggtgtctaa gaagaatatt ttccttcagt ttaagaagct
     3361 ctgctccttc cgagcccgca gagatttgct gcagctctcc tatggggagg ccaagaaagc
     3421 tgcccgtgac tacgacttag ccaagaacta cttcaagaaa agcctgaggg acatgggcta
     3481 tgggaattgg atcagcaaac cccaggagga aaagaacttt tatctctgtc cagtgcccaa
     3541 tgactgatag tggggtgtgt tcccatgggg tcagagggag gtcatagcat tcctcatcac
     3601 attgggcc
//
