LOCUS       NM_020101               1797 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ArfGAP with dual PH domains 2 (Adap2), mRNA.
ACCESSION   NM_020101
VERSION     NM_020101.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1797)
  AUTHORS   Venturin,M., Bentivegna,A., Moroni,R., Larizza,L. and Riva,P.
  TITLE     Evidence by expression analysis of candidate genes for congenital
            heart defects in the NF1 microdeletion interval
  JOURNAL   Ann Hum Genet 69 (Pt 5), 508-516 (2005)
   PUBMED   16138909
REFERENCE   2  (bases 1 to 1797)
  AUTHORS   Hanck,T., Stricker,R., Sedehizade,F. and Reiser,G.
  TITLE     Identification of gene structure and subcellular localization of
            human centaurin alpha 2, and p42IP4, a family of two highly
            homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter
            proteins
  JOURNAL   J Neurochem 88 (2), 326-336 (2004)
   PUBMED   14690521
REFERENCE   3  (bases 1 to 1797)
  AUTHORS   Whitley,P., Gibbard,A.M., Koumanov,F., Oldfield,S., Kilgour,E.E.,
            Prestwich,G.D. and Holman,G.D.
  TITLE     Identification of centaurin-alpha2: a phosphatidylinositide-binding
            protein present in fat, heart and skeletal muscle
  JOURNAL   Eur J Cell Biol 81 (4), 222-230 (2002)
   PUBMED   12018390
  REMARK    GeneRIF: Results describe the cloning, expression and
            characterisation of centaurin-alpha2 from a rat adipocyte cDNA
            library.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_020101.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ238993.1, SRR26643287.25053.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000010.1  65635990-65636134
            146-276             JAXUCZ010000010.1  65636778-65636908
            277-368             JAXUCZ010000010.1  65638751-65638842
            369-445             JAXUCZ010000010.1  65641843-65641919
            446-558             JAXUCZ010000010.1  65644005-65644117
            559-705             JAXUCZ010000010.1  65650708-65650854
            706-789             JAXUCZ010000010.1  65655737-65655820
            790-852             JAXUCZ010000010.1  65658871-65658933
            853-930             JAXUCZ010000010.1  65660546-65660623
            931-1159            JAXUCZ010000010.1  65661501-65661729
            1160-1797           JAXUCZ010000010.1  65662856-65663493
FEATURES             Location/Qualifiers
     source          1..1797
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..1797
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /note="ArfGAP with dual PH domains 2"
                     /db_xref="GeneID:56826"
                     /db_xref="RGD:708487"
     exon            1..145
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1182
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /note="centaurin-alpha-2; cnt-a2; Centaurin-alpha2
                     protein"
                     /codon_start=1
                     /product="arf-GAP with dual PH domain-containing protein
                     2"
                     /protein_id="NP_064486.1"
                     /db_xref="GeneID:56826"
                     /db_xref="RGD:708487"
                     /translation="MGDRERNKKRLLELLQAAGTGNGHCADCGAADPDWASYKLGVFI
                     CLHCSGVHRNFPDISKVKSVRLDFWDDSMVEFMTHNGNLSVKAKFEARVPTFYYVPQA
                     SDCLVLKEQWIRAKYERQEFMAEKAVSPPGDREGFLWKRGRDNSQFLRRRFVLLSREG
                     LLKYYTKEEGKTPKAIINIKDLNATFQTEKIGHPHGLQITYRKEGQTRNLFVYHDSGK
                     EIVDWFNALRAARLQYLKLAFPDLPESELVPLITRNYLKQGFMEKTGPKHREPFKKRW
                     FALDPQERRLLYYKNPLDAFEQGQVFLGSNEQGYEVWEGLPQGIRGNRWKVGLTVITP
                     ERKFVFTCPTEKEQREWLESLRGVLSSPLSPLHLLTTSAKSG"
     exon            146..276
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            277..368
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..445
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            446..558
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            559..705
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            706..789
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..852
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            853..930
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1159
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1797
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaccacag aggtggcggg gctgagcccc gctgagacct ctgggccggc catgggcgac
       61 cgtgaacgca acaagaagcg gttgctggag ctgctgcagg ctgcgggcac tggcaacggg
      121 cactgcgccg actgcggggc agcggatcct gattgggcct cttacaagct gggggttttc
      181 atctgtctcc actgctctgg cgtccatcgc aacttcccag acatcagcaa agttaaatcc
      241 gtgagactgg acttctggga cgacagtatg gtggagttca tgactcacaa tgggaacctc
      301 agtgtgaaag ccaagtttga agctagagtc ccaactttct actacgtccc tcaggccagc
      361 gactgcctgg tcttaaagga acaatggatt cgagctaagt atgaaaggca ggagtttatg
      421 gctgagaaag ctgtctcgcc cccaggtgat cgagaaggct tcctgtggaa gcgaggaagg
      481 gacaactccc agttcctgag gagaaggttt gtccttctgt caagggaagg cctgctgaag
      541 tactacacca aggaagaggg taaaacccca aaggctatca tcaacatcaa ggacttaaat
      601 gccaccttcc agacagagaa gattggacat ccccacgggc tgcagattac ctacaggaag
      661 gagggccaaa ccagaaatct gtttgtatat catgacagtg gaaaggagat agtggattgg
      721 ttcaatgctc tccgtgcagc ccgcctgcaa tacctaaaat tggcctttcc tgatctccca
      781 gagtctgagc tcgtgcctct catcaccagg aactacctca aacaaggctt catggagaag
      841 actggtccaa agcatagaga acccttcaag aaaaggtggt ttgccttgga tcctcaggag
      901 cggaggctgc tgtattataa gaaccccctg gacgcttttg agcagggcca ggtttttctg
      961 ggaagcaatg agcagggata tgaagtatgg gaaggcctgc cccagggcat ccgagggaac
     1021 cgctggaagg tcggactcac ggtcatcact ccggagcgga aattcgtctt cacctgcccc
     1081 acggaaaagg agcagcggga atggctggag agtctgcggg gtgtcctgtc cagtcccttg
     1141 tcgcccctcc acctcctcac cacatcagca aagagtggct gaggcctgag gtgacccatc
     1201 tcggaggatc tggctggcca ctgagcacct gaagtcctgg agaagtgttc acctcagccc
     1261 tggttgtcca gaaggaagtc ctgaggccag cagctgccct tgcctgtgaa ctctgtgaag
     1321 gtgaggttta tcctacgact ccctgggctc cttccagaac atttcccagt cttgaggagt
     1381 tgggaccgag aagaattcag ctctccaagc ttagatgtcc tcataactgc accgaaagtc
     1441 agccatggtg atgcgtgcaa gttgagaggc aggaatgcca tgagcccagt gccaacgtga
     1501 accacccaag gagttcaagt ctagcctgaa ttgcatagca agaccttgtc tcaaacaaca
     1561 aacaaacaaa caaacaaaca aaaacaaaac agaaaaaaca gcagtcagga ggcagagact
     1621 gacggatcca agacagtcac agccaaggct ggttacactg aaaaacactg tctagaaaaa
     1681 ctaagaacaa aaaacagaaa caaaagcaag taagcagggt tggggattta gctcagtggt
     1741 agagcgcttg cctagcaacc gcaaggccct gggttcggtc cccagctccg aaaaaaa
//
