LOCUS       NM_001034012            4180 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ADAMTS-like 4 (Adamtsl4), mRNA.
ACCESSION   NM_001034012 XM_227446
VERSION     NM_001034012.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4180)
  AUTHORS   Collin,G.B., Hubmacher,D., Charette,J.R., Hicks,W.L., Stone,L.,
            Yu,M., Naggert,J.K., Krebs,M.P., Peachey,N.S., Apte,S.S. and
            Nishina,P.M.
  TITLE     Disruption of murine Adamtsl4 results in zonular fiber detachment
            from the lens and in retinal pigment epithelium dedifferentiation
  JOURNAL   Hum Mol Genet 24 (24), 6958-6974 (2015)
   PUBMED   26405179
REFERENCE   2  (bases 1 to 4180)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 4180)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   4  (bases 1 to 4180)
  AUTHORS   Liu,J., Guo,Q., Chen,B., Yu,Y., Lu,H. and Li,Y.Y.
  TITLE     Cathepsin B and its interacting proteins, bikunin and TSRC1,
            correlate with TNF-induced apoptosis of ovarian cancer cells OV-90
  JOURNAL   FEBS Lett 580 (1), 245-250 (2006)
   PUBMED   16364318
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099119.1.
            
            On Oct 10, 2005 this sequence version replaced XM_227446.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099119.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4180
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4180
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /note="ADAMTS-like 4"
                     /db_xref="GeneID:310670"
                     /db_xref="RGD:1561012"
     exon            1..316
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            317..528
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             509..3601
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /note="ADAMTS-like protein 4; ADAMTSL-4; thrombospondin
                     repeat protein 1"
                     /codon_start=1
                     /product="ADAMTS-like protein 4 precursor"
                     /protein_id="NP_001029184.1"
                     /db_xref="GeneID:310670"
                     /db_xref="RGD:1561012"
                     /translation="MELWLGRLWLYVMLLLLLLQLCQDQELLGPSLQTPSEEDQVPEG
                     LWGPWGRWASCSQPCGVGVQRRSRTCELHPALSLPPRPPRHPEAPQPRGQGSRPQTPR
                     DPQSLYRPQPRGRGGPLRGPASQVGREETQEPRGAQRFRVRDPIKPGMFGYGRVPFAL
                     PLHRSRRLAHKPGQPKDSSTAEETLPSQPPSTEPASEKHSPHMQPPELRAQSRSPSAE
                     TPRSGTAQTEVPSRTSSAPSDMGIPAPTSSFRDSRSFQGSPEPRMPTSQGAERQPHPF
                     SPVTRSQLSRRHWRPPGSPHRSPDGWLPLTRDSSPHWSLFAPSSPTPECSGESEQMRA
                     CSQEPCPPEQPDPRALQCAAFDSQEFMGQLYQWEPFTEVQGSQRCELNCRPRGFRFYV
                     RHTEKVQDGTLCQPGSLDICVAGHCLSPGCDGILGSGRRPDGCGVCGGDGSTCRLVSG
                     NLTDRGGPLGYQKILWIPAGASHLRISQFRPSSNYLALRGPGGRSIINGNWAVDPPGS
                     YAAVGTVFQYNRPPREEGKGETLSAEGPTTQPVDVYMIFQEDNPGVFYQYVTSAAPES
                     PSTMPPALQLQPEMLRGEPLLPSAPRPVRAPGTLQRQARIPQVPPPTHVRTAMGSSAG
                     YWKQVGHSECSASCGKGVWRPIFLCVSRESGEELDEQSCAVGARPPASPESCHRPPCP
                     PYWEAGEWTSCSRSCGPGTQHRQLLCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRL
                     CGHWEISSPWSQCSVRCGRGQRSRQVRCVGSNGHEVGKQECASGPPPPPSREACDMGP
                     CTTAWFYSDWSSKCSAECGTGIQRRAVVCLRSGETLQGDPEAGSTEQGCPLRSRPPDM
                     RACSLGPCEKTWRWYTGPWSECSSECGSGTQHRDIICVSKLGTKFNVTSPSNCSHLPR
                     PPALQPCQGQACEDQWFSTLWSPCSQSCQGGVQTREVQCLSSNHTLSSRCPPHLRPSR
                     KRPCNSQPCNQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSCAHVLEQSQLEPA
                     "
     exon            529..586
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            587..924
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1522
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1625
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1762
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1967
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2140
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2243
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2429
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2559
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2764
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2941
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3139
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3319
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3320..3464
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3465..4158
                     /gene="Adamtsl4"
                     /gene_synonym="Tsrc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaggcagc tggagagagc gggcgcagag aaggtagagc ctccctgacc cccgcctggg
       61 ctctgactgt cttagaacag tagaccctga ggcgaattcc tggggagggg gtctggtctc
      121 tgggactcca ggtcccatca cccgggcgag ggcttgcgcc aagattccta ttaagtcaca
      181 tagtgaagtt ggaaaacata accgggacct ccctacgcgc tggcgcagcc ggctcttccc
      241 tgaggggctt cgggaggatg cgccccgacg cctgcactct gggatcgcag ggatagtgtg
      301 tccaggaggg atgcgggtcc taaaggggtg gaccactcct cccccacccc tccagactgt
      361 gggtgttgtg ctgagacagc ccttcagtcc cccagatatc tgcaggggta acaccatgct
      421 cctccctcct cagagcaccc tccatccctg atgccagagt agctaccctg tcccttctcc
      481 ccagcccagg ggcagtcaca ggaagagcat ggagctttgg ctgggcaggc tctggctgta
      541 tgtcatgctg ctcttgcttc tccttcagct ctgccaggat caggagctgt tgggtccttc
      601 tcttcagaca ccatcagagg aggaccaggt ccctgagggt ctctggggac cttggggccg
      661 atgggcctcc tgctcccagc cctgtggggt gggggtgcag cgccggagcc gaacatgtga
      721 actgcaccca gccctgtccc tccctccccg acccccaaga catccagaag ccccccagcc
      781 ccggggccag ggttccagac cccagactcc acgggatccc cagtccctgt ataggccaca
      841 gcctcgggga aggggtggcc ctcttcgagg tcctgcttct caagtgggga gagaggagac
      901 ccaggagcct cggggggccc agaggttccg tgttcgagac cctatcaagc cagggatgtt
      961 cggttacggg cgagtgccct ttgctttgcc cctgcaccgg agccgcaggc ttgctcacaa
     1021 acctggacag cccaaggact cctctacagc ggaagagaca cttccatccc agcctccaag
     1081 cacagaacca gcctctgaaa agcacagccc ccacatgcag ccccctgaac tgcgtgccca
     1141 atcccgttcc ccctcagctg aaactccaag gtctggaact gctcagacag aagtgccctc
     1201 cagaaccagt tctgctccct ccgacatggg tatccctgca cccacttcct cctttagaga
     1261 cagtaggtct ttccagggat cccctgagcc acgaatgcca acttcccagg gagcagagcg
     1321 acagccacat cctttctctc ctgtcacccg gagccagctg agccggaggc actggagacc
     1381 tccggggagt cctcacaggt ccccagatgg ctggctgcct ctgacaaggg actccagccc
     1441 acactggagc ctctttgctc ccagtagccc cactccagaa tgttctgggg aaagtgaaca
     1501 gatgagagcc tgcagccaag agccttgccc ccctgagcag ccagacccca gggccctgca
     1561 gtgtgccgcc tttgactccc aggaattcat gggccagctg taccagtggg agcccttcac
     1621 cgaagttcaa ggctcccagc gctgtgaact gaactgccgc ccccgtggct tccgatttta
     1681 tgtccgtcac actgaaaagg tgcaggatgg gaccctgtgt cagcctggat ccctagacat
     1741 ttgtgtggct ggacactgcc tgagccccgg ctgtgatggg atccttggct ctggcaggcg
     1801 tccggatggc tgtggagtct gtgggggtga cggctctacc tgccgtctcg tttcggggaa
     1861 tctcactgac cgagggggcc ccttgggcta tcagaagatc ctgtggattc ctgcgggagc
     1921 ctcccatctt cgcatttccc agttccgacc cagttccaat taccttgcac ttcgagggcc
     1981 tggtggccgc tccattatca atgggaactg ggctgtagat cctccaggat cctacgcggc
     2041 cgtcgggacc gtcttccagt ataaccgtcc tcctcgggag gagggcaagg gggagactct
     2101 gtcagcagaa ggccctacca cccagcctgt ggatgtctat atgatctttc aagaggacaa
     2161 cccaggtgtc ttctatcagt atgtcacctc tgcagcccca gagagccctt ccacaatgcc
     2221 tccagccctt cagcttcagc ctgagatgct gaggggggag cccttactcc cttcagcccc
     2281 ccgcccagtt cgggcaccag gcaccctcca gcgtcaggca cggattcccc aagtgcctcc
     2341 tccgactcat gtcaggacgg ccatgggatc ttcggctggg tactggaagc aggtggggca
     2401 ctctgaatgt tcagcatcct gtggcaaagg tgtttggcgc cccatcttcc tctgcgtttc
     2461 ccgtgagtca ggagaagagt tggatgaaca gagctgtgcc gtgggggcca gacccccagc
     2521 ttcccctgaa tcctgccata gaccaccgtg tcccccatac tgggaggctg gcgagtggac
     2581 gtcctgcagc cgctcctgtg gccctggcac ccagcatcgc cagctgctct gcagacagga
     2641 attcggaggc ggtggctcct cagtgcctcc agagcgttgc ggacatctcc cccggcccaa
     2701 catcacccag tcctgtcagc tgcgcctttg tggccactgg gagattagct ccccctggag
     2761 ccagtgctct gtgcgctgtg gtcgtggtca gaggagccgg caagtgcggt gtgttggaag
     2821 taatggccat gaggtgggca agcaggagtg tgcttccggg cccccgccac ctcccagcag
     2881 agaggcctgt gacatgggcc cctgtaccac agcctggttc tacagtgact ggagttccaa
     2941 gtgctcagcc gagtgtggga caggcatcca gagacgcgct gtggtctgcc ttaggagtgg
     3001 ggagaccctt cagggggacc cagaagcagg aagcactgag cagggttgcc ctctcagaag
     3061 ccgccctcct gacatgcgtg cttgcagttt agggccctgt gaaaagacat ggcgctggta
     3121 caccgggccc tggagtgagt gctcctctga gtgtgggtct ggcacacagc acagagacat
     3181 tatctgtgta tccaaactgg ggaccaaatt caatgtgact tctcccagca actgctccca
     3241 cctacccagg cctcctgccc tgcagccctg tcagggccag gcctgtgagg accaatggtt
     3301 ctctactctc tggagtccgt gttctcaatc ctgtcaagga ggtgtgcaga cgagggaagt
     3361 ccagtgcctg agtagcaacc acactctcag ctcccgatgt cctccgcacc tgcgaccttc
     3421 taggaagcgg ccctgtaaca gccaaccctg caaccagcga ccagatgacc aatgcaagga
     3481 cagttctcca cattgccccc tggtggtaca ggcacggctc tgcgtctacc cctactacac
     3541 agctacctgc tgccgctcct gtgcccatgt cctggagcag tcccaactgg agcctgcttg
     3601 aaatgggtcc aagagacccc tctcttatgg ttttctcgcg ccacccattg agatagccca
     3661 aggagtgtac ctgtccgacc tgggtgtttg ccccctgtga acgtttatca cttcctcaga
     3721 agcaccctga gaaagaatta ggaagtggac agggctggct tctctcatgc ttttctgggc
     3781 tggggagaaa gcaaggttat atttccacac taatctgaga tacatggaga gtgtgtgtcc
     3841 ccagaagttc cagttctgtg ccccaatcct cacaaccacg tcaggcggca catctaactt
     3901 atcttgttcc tatccctgcc tcatctagtc tctgtattcc taccacccag attagcaggg
     3961 gtgggggtca gccactgcta ccctacctta cccgaccgag aaggaccaca cctctccagt
     4021 gtagcgatca gttgtgtcgt gggtggaaat gagaaacatc agcataagac accctagccc
     4081 cagccctcac ttcacactga aaatgatgcc caccccagaa gtaatttatt ttttattaaa
     4141 gttgattgtg acaaataaaa aaaaaaaaaa aaaaaaaaaa
//
