LOCUS       NP_001101347            1880 aa            linear   ROD 03-APR-2024
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 9
            precursor [Rattus norvegicus].
ACCESSION   NP_001101347 XP_001076761 XP_232202
VERSION     NP_001101347.1
DBSOURCE    REFSEQ: accession NM_001107877.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1880)
  AUTHORS   Dancevic,C.M., Fraser,F.W., Smith,A.D., Stupka,N., Ward,A.C. and
            McCulloch,D.R.
  TITLE     Biosynthesis and expression of a disintegrin-like and
            metalloproteinase domain with thrombospondin-1 repeats-15: a novel
            versican-cleaving proteoglycanase
  JOURNAL   J Biol Chem 288 (52), 37267-37276 (2013)
   PUBMED   24220035
REFERENCE   2  (residues 1 to 1880)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (residues 1 to 1880)
  AUTHORS   Kern,C.B., Wessels,A., McGarity,J., Dixon,L.J., Alston,E.,
            Argraves,W.S., Geeting,D., Nelson,C.M., Menick,D.R. and Apte,S.S.
  TITLE     Reduced versican cleavage due to Adamts9 haploinsufficiency is
            associated with cardiac and aortic anomalies
  JOURNAL   Matrix Biol 29 (4), 304-316 (2010)
   PUBMED   20096780
REFERENCE   4  (residues 1 to 1880)
  AUTHORS   Koo,B.H., Coe,D.M., Dixon,L.J., Somerville,R.P., Nelson,C.M.,
            Wang,L.W., Young,M.E., Lindner,D.J. and Apte,S.S.
  TITLE     ADAMTS9 is a cell-autonomously acting, anti-angiogenic
            metalloprotease expressed by microvascular endothelial cells
  JOURNAL   Am J Pathol 176 (3), 1494-1504 (2010)
   PUBMED   20093484
REFERENCE   5  (residues 1 to 1880)
  AUTHORS   Reid,M.J., Cross,A.K., Haddock,G., Allan,S.M., Stock,C.J.,
            Woodroofe,M.N., Buttle,D.J. and Bunning,R.A.
  TITLE     ADAMTS-9 expression is up-regulated following transient middle
            cerebral artery occlusion (tMCAo) in the rat
  JOURNAL   Neurosci Lett 452 (3), 252-257 (2009)
   PUBMED   19348733
  REMARK    GeneRIF: study indicates that ADAMTS-9 expression is modulated in
            response to cerebral ischaemia in vivo
REFERENCE   6  (residues 1 to 1880)
  AUTHORS   Silver,D.L., Hou,L., Somerville,R., Young,M.E., Apte,S.S. and
            Pavan,W.J.
  TITLE     The secreted metalloprotease ADAMTS20 is required for melanoblast
            survival
  JOURNAL   PLoS Genet 4 (2), e1000003 (2008)
   PUBMED   18454205
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 1880)
  AUTHORS   Somerville,R.P., Longpre,J.M., Jungers,K.A., Engle,J.M., Ross,M.,
            Evanko,S., Wight,T.N., Leduc,R. and Apte,S.S.
  TITLE     Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS
            subfamily related to Caenorhabditis elegans GON-1
  JOURNAL   J Biol Chem 278 (11), 9503-9513 (2003)
   PUBMED   12514189
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473957.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_232202.4, XP_001076761.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5756307, SAMEA5760384
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1880
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     Protein         1..1880
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 9 precursor"
                     /note="A disintegrin and metalloproteinase with
                     thrombospondin motifs 9; a disintegrin-like and
                     metalloprotease (reprolysin type) with thrombospondin type
                     1 motif, 9"
                     /calculated_mol_wt=208544
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2273
     Region          49..208
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          294..497
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(435..436,439,445)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          512..566
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          557..609
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          614..718
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          720..837
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          851..897
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          905..959
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          967..1019
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1022..1074
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1077..1131
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1152..1205
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1208..1261
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1294..1345
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1348..1401
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1407..1450
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1463..1516
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1521..1574
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1578..1637
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1643..1695
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1698..1868
                     /region_name="GON"
                     /note="GON domain; pfam08685"
                     /db_xref="CDD:462559"
     CDS             1..1880
                     /gene="Adamts9"
                     /coded_by="NM_001107877.1:338..5980"
                     /db_xref="GeneID:312566"
                     /db_xref="RGD:1306889"
ORIGIN      
        1 mqlvswatll tllvpdlvem rspdsaaavr kdrlhprqvk lleslseyei aspirvnplg
       61 epfptnvhfk rrrrsinsas dpwpafasss sssstssqeh yrlkafgqqf lfnltahtgf
      121 iaplftvtll gepgvnqskl yseeemelrh cfykghvntk sehtavislc sgmmgtfrsh
      181 dgdyfiepll svdeqedeee qnkphviyrr nnpqrepstg khacdtselk nsyskdkrkt
      241 rlrkrrkrns laddvaalkr gmatkafsgy nnrtngtrdr rnhkrtkrfl syprfvevmv
      301 vadhrmvlyh gsnlqhyilt lmsivasiyk dssignlini vivnlvvihn eqegpsinfn
      361 aqttlknfcq wqhsknhlgg iqhdtavlvt redicraqdk cdtlglaelg ticdpyrscs
      421 isedsglsta ftiahelghv fnmphddsnk ckeegvkspq hvmaptlnfy tnpwmwskcs
      481 rkyitefldt gygecllnep qsrtyplpsq lpgllynvnk qcelifgpgs qvcpymhckf
      541 gfcvpkemeg paidgswgsw shfgacsrtc gggirtaire cnrpepkngg rycvgrrmkf
      601 kscntepcpk hkrdfreeqc ayfdgkhfni ngllpsvrwv pkysgilmkd rcklfcrvag
      661 ntayyqlrdr vidgtpcgqd tndicvqglc rqagcdhiln skarkdkcgi cggdnssckt
      721 vagtfntvhy gyntvvripa gatsldvrqh sfsgkseddn ylalsnsrge fllngdfvvs
      781 mskrevrvgs amieysgsdn vverlncsdr ieeelllqvl svgklynpdv rysfnipied
      841 rsqqfywnsh gpwqacskpc qgerrrklvc tresdqltvs dqrcdrlpqp gpvteacgtd
      901 cdlrwhiask secsaqcglg yrtldihcak ysrvdgktek vddsfcgsqp rpsnqekcsg
      961 ecstggwrys awtecskscd ggtqrrraic vntrndvldd skcaqqekvi vqrcnefscp
     1021 hwktgewsec lvtcgkghkh rqvwcqfged rlsdrmcdpe akpepmqmcq qpecaawqag
     1081 pwgqcsvtcg qgyqlravkc imgtymsvvd dndcnaatrp tdtqdcelss chpsiltlep
     1141 rrhvhgvprt qwrfgswtpc satcgkgtrm ryvscrdedg svadesacat lpkpvakeec
     1201 svtpcgqwka ldwsscsmtc gqgkatrqvv cvnysdhvid qsecdpdyip etdqdcsmsp
     1261 cpqwtgsayp fqnedfrprs dspsrthvlg gnqwrtgpwg acsstcaggs qrrvvvcqde
     1321 ngytatdcve rikpdeqrac esgpcpqway gswgectklc gggmrtrlvv cqrangdrfp
     1381 dlscevldkp pdreqcntha cpqdaawstg pwsscsvscg rghkhrnvyc lakdgshles
     1441 dyckhlpkph ghrrcrggrc prwkagawsq csvscgqgvq qrhvgcqigt hktaresecs
     1501 sysrpeserv cqaspcplyt wraeqwqqct ktcgegsryr qvvcvaedqs evhsahcdsd
     1561 qrppdrescs lqpceyvwit gewsecsvtc gkgyrqrlvs cseiytgken yeysyqttvn
     1621 cpgtqppsvh pcylrdcpvs atwrvgnwgs csvscgmgvm hrsvqcltne dqpshlcptd
     1681 ikpeerktch nvyncelpqn ckevkklnsa svdgeyflav rgkplkvfca gmhsdypkey
     1741 vtlahgdsen fsevyghrlh nptecpyngs rrddchcrkd ytaagfssfq kiridltsmq
     1801 iittdlefar tseghpvpfa tagdcysaak cpqgrfsinl ygtglsltes arwtsqgnya
     1861 vsdikkspvr lciawgmvlv
//
