LOCUS       NM_001393840            5322 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1
            motif, 7 (Adamts7), transcript variant 3, mRNA.
ACCESSION   NM_001393840 XM_006243525
VERSION     NM_001393840.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5322)
  AUTHORS   Ren,W., Liang,L., Li,Y., Wei,F.Y., Mu,N., Zhang,L., He,W., Cao,Y.,
            Xiong,D. and Li,H.
  TITLE     Upregulation of miR-423 improves autologous vein graft restenosis
            via targeting ADAMTS-7
  JOURNAL   Int J Mol Med 45 (2), 532-542 (2020)
   PUBMED   31894258
  REMARK    GeneRIF: Upregulation of miR423 improves autologous vein graft
            restenosis via targeting ADAMTS7.
REFERENCE   2  (bases 1 to 5322)
  AUTHORS   Cai,H., Zhu,X., Li,Z., Zhu,Y. and Lang,J.
  TITLE     lncRNA/mRNA profiling of endometriosis rat uterine tissues during
            the implantation window
  JOURNAL   Int J Mol Med 44 (6), 2145-2160 (2019)
   PUBMED   31638262
  REMARK    GeneRIF: In conclusion, the changes in the expression of lncRNAs,
            mRNAs and proteins (Adamts7, P2ry6, Dlx3 and TP53) may possibly
            affect endometrial receptivity in rats with endometriosis during
            the implantation window, probably resulting in implantation failure
            of the embryo.
REFERENCE   3  (bases 1 to 5322)
  AUTHORS   Wu,W., Wang,H., Yu,C., Li,J., Gao,Y., Ke,Y., Wang,Y., Zhou,Y. and
            Zheng,J.
  TITLE     Association of ADAMTS-7 Levels with Cardiac Function in a Rat Model
            of Acute Myocardial Infarction
  JOURNAL   Cell Physiol Biochem 38 (3), 950-958 (2016)
   PUBMED   26938210
  REMARK    GeneRIF: Study shows that elevated ADAMTS-7 levels may be involved
            in ventricular remodeling after acute myocardial infarction.
REFERENCE   4  (bases 1 to 5322)
  AUTHORS   Zhang,L., Yu,F., Wang,L., Zheng,J., Du,Y., Huang,Y., Liu,B.,
            Wang,X. and Kong,W.
  TITLE     ADAMTS-7 promotes vascular smooth muscle cells proliferation in
            vitro and in vivo
  JOURNAL   Sci China Life Sci 58 (7), 674-681 (2015)
   PUBMED   25921940
  REMARK    GeneRIF: data demonstrates that ADAMTS-7 promotes VSMC
            proliferation both in vitro and in vivo. ADAMTS-7 may therefore
            serve as a novel therapeutic target for atherosclerosis and
            post-angioplasty restenosis
REFERENCE   5  (bases 1 to 5322)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   6  (bases 1 to 5322)
  AUTHORS   Yu,H. and Zhu,Y.
  TITLE     Expression of ADAMTS-7 and ADAMTS-12 in the nucleus pulposus during
            degeneration of rat caudal intervetebral disc
  JOURNAL   J Vet Med Sci 74 (1), 9-15 (2012)
   PUBMED   21869572
  REMARK    GeneRIF: ADAMTS-7 and ADAMTS-12 expression were dramatically
            increased during disc degeneration.
REFERENCE   7  (bases 1 to 5322)
  AUTHORS   Wang,L., Zheng,J., Bai,X., Liu,B., Liu,C.J., Xu,Q., Zhu,Y.,
            Wang,N., Kong,W. and Wang,X.
  TITLE     ADAMTS-7 mediates vascular smooth muscle cell migration and
            neointima formation in balloon-injured rat arteries
  JOURNAL   Circ Res 104 (5), 688-698 (2009)
   PUBMED   19168437
  REMARK    GeneRIF: ADAMTS-7 mediates vascular smooth muscle cell migration
            and neointima formation in balloon-injured rat arteries.
REFERENCE   8  (bases 1 to 5322)
  AUTHORS   Luan,Y., Kong,L., Howell,D.R., Ilalov,K., Fajardo,M., Bai,X.H., Di
            Cesare,P.E., Goldring,M.B., Abramson,S.B. and Liu,C.J.
  TITLE     Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage
            oligomeric matrix protein by alpha-2-macroglobulin
  JOURNAL   Osteoarthritis Cartilage 16 (11), 1413-1420 (2008)
   PUBMED   18485748
REFERENCE   9  (bases 1 to 5322)
  AUTHORS   Liu,C.J., Kong,W., Ilalov,K., Yu,S., Xu,K., Prazak,L., Fajardo,M.,
            Sehgal,B. and Di Cesare,P.E.
  TITLE     ADAMTS-7: a metalloproteinase that directly binds to and degrades
            cartilage oligomeric matrix protein
  JOURNAL   FASEB J 20 (7), 988-990 (2006)
   PUBMED   16585064
  REMARK    GeneRIF: ADAMTS-7 is the first metalloproteinase found to bind
            directly to and degrade COMP
REFERENCE   10 (bases 1 to 5322)
  AUTHORS   Somerville,R.P., Longpre,J.M., Apel,E.D., Lewis,R.M., Wang,L.W.,
            Sanes,J.R., Leduc,R. and Apte,S.S.
  TITLE     ADAMTS7B, the full-length product of the ADAMTS7 gene, is a
            chondroitin sulfate proteoglycan containing a mucin domain
  JOURNAL   J Biol Chem 279 (34), 35159-35175 (2004)
   PUBMED   15192113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 18, 2021 this sequence version replaced XM_006243525.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY327121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-379               JAXUCZ010000008.1  99586631-99587009
            380-735             JAXUCZ010000008.1  99595421-99595776
            736-892             JAXUCZ010000008.1  99597490-99597646
            893-1071            JAXUCZ010000008.1  99598339-99598517
            1072-1155           JAXUCZ010000008.1  99601360-99601443
            1156-1280           JAXUCZ010000008.1  99601723-99601847
            1281-1430           JAXUCZ010000008.1  99602980-99603129
            1431-1577           JAXUCZ010000008.1  99604221-99604367
            1578-1722           JAXUCZ010000008.1  99609675-99609819
            1723-1815           JAXUCZ010000008.1  99610376-99610468
            1816-1961           JAXUCZ010000008.1  99610966-99611111
            1962-2131           JAXUCZ010000008.1  99612333-99612502
            2132-2265           JAXUCZ010000008.1  99612789-99612922
            2266-2386           JAXUCZ010000008.1  99613716-99613836
            2387-2631           JAXUCZ010000008.1  99614892-99615136
            2632-2767           JAXUCZ010000008.1  99615409-99615544
            2768-2894           JAXUCZ010000008.1  99615857-99615983
            2895-3108           JAXUCZ010000008.1  99616392-99616605
            3109-4084           JAXUCZ010000008.1  99616908-99617883
            4085-4302           JAXUCZ010000008.1  99618061-99618278
            4303-4455           JAXUCZ010000008.1  99619162-99619314
            4456-4629           JAXUCZ010000008.1  99619679-99619852
            4630-4776           JAXUCZ010000008.1  99619934-99620080
            4777-4939           JAXUCZ010000008.1  99620989-99621151
            4940-5322           JAXUCZ010000008.1  99623750-99624132
FEATURES             Location/Qualifiers
     source          1..5322
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..5322
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif, 7"
                     /db_xref="GeneID:315879"
                     /db_xref="RGD:1306713"
     exon            1..379
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..5097
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /EC_number="3.4.24.-"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; a disintegrin and metalloproteinase with
                     thrombospondin motifs 7; a disintegrin-like and
                     metallopeptidase (reprolysin type) with thrombospondin
                     type 1 motif, 7"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 7 isoform 3 precursor"
                     /protein_id="NP_001380769.1"
                     /db_xref="GeneID:315879"
                     /db_xref="RGD:1306713"
                     /translation="MHRGLNLLLILCALAPHVLGPASGLPTEGRAGLDIVHPVRVDAG
                     GSFLSYELWPRVLRKRDVSAAQASSAFYQLQYQGRELLFNLTTNPYLLAPGFVSEIRR
                     RSNLSNVHIQTSVPTCHLLGDVQDPELEGGFAAISACDGLRGVFQLSNEDYFIEPLDE
                     VPAQPGHAQPHMVYKHKRSGQQDDSRTSGTCGVQGSPELKHQREHWEQRQQKRRQQRS
                     ISKEKWVETLVVADSKMVEYHGQPQVESYVLTIMNMVAGLYHDPSIGNPIHITVVRLI
                     ILEDEEKDLKITHHADDTLKNFCRWQKNVNMKGDDHPQHHDTAILLTRKDLCATMNHP
                     CETLGLSHVAGLCHPQLSCSVSEDTGLPLAFTVAHELGHSFGIQHDGTGNDCESIGKR
                     PFIMSPQLLYDRGIPLTWSRCSREYITRFLDRGWGLCLDDRPSKGVINFPSVLPGVLY
                     DVNHQCRLQYGPSSAYCEDVDNVCYTLWCSVGTTCHSKMDAAVDGTSCGKNKWCLNGE
                     CVPEGFQPETVDGGWSGWSAWSVCSRSCGVGVRSSERQCTQPVPKNKGKYCVGERKRY
                     RLCNLQACPPDRPSFRHTQCSQFDSMLYKGKLHKWVPVLNDENPCELHCRPFNYSNRE
                     KLRDAVMDGTPCYQGRISRDICIDGICKKVGCDFELDSGAEEDRCGVCRGDGSTCHTV
                     SRTFKEAEGMGYVDVGLIPAGAREILIEEVAEAANFLALRSEDPDKYFLNGGWTIQWN
                     GDYQVAGTTFTYTRKGNWETLTSPGPTTEPVWIQLLFQERNPGVHYKYTIQRASHSEA
                     QPPEFSWHYGPWSKCPVTCGTGVQRQSLYCMEKQAGIVDEGHCDHLSRPRDRKRKCNE
                     EPCPARWWVGDWQPCSRSCGPGGFFRRAVFCTRSVGLDEQRALEPSACGHLPRPLAEI
                     PCYHYVACPSSWGVGNWSQCSVTCGAGIRQRSVLCINNTGVPCDGAERPITETFCFLQ
                     PCQYSTYIVDTGASGSGSSSPELFNEVDFDPHQPVPRPSPASSPKPVSISNAIDEEDP
                     ELDPPGPVFVDDFYYDYNFINFHEDLSYGSFEESHSDLVDIGGQTVPPHIRPTEPPSD
                     SPVPTAGAPGAEEEGIQGSWSPSPLLSEASHSPPVLLENTPVNPLANFLTEEESPIGA
                     PELGLPSVSWPPASVDGMVTSVAPGNPDELLVREDTQSQPSTPWSDRNKLSKDGNPLG
                     PTSPALPKSPFPTQPSSPSNSTTQASLSPDAVEVSTGWNVALDPVLEADLKPVHAPTD
                     PGLLDQIQTPHTEGTQSPGLLPRPAQETQTNSSKDPAVQPLQPSLVEDGAPTDLLPAK
                     NASWQVGNWSQCSTTCGLGAIWRLVRCSSGNDEDCTLSSRPQPARHCHLRPCAAWRAG
                     NWSKCSRNCGGGSATRDVQCVDTRDLRPLRPFHCQPGPTKPPTRQLCGTQPCLPWYTS
                     SWRECSEACGGGEQQRLVTCPEPGLCEESLRPNNTRPCNTHPCTQWVVGPWGQCSAPC
                     GGGVQRRLVKCVNTQTGLAEEDSDLCSHEAWPESSRPCATEDCELVEPSRCERDRLPF
                     NFCETLRLLGRCQLPTIRAQCCRSCPPLSRGVPSRGHQRVARR"
     exon            380..735
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            736..892
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1071
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1155
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1280
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1430
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1577
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1722
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1815
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1961
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2131
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2265
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2386
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2631
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2767
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2894
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3108
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..4084
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            4085..4302
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            4303..4455
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            4456..4629
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            4630..4776
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            4777..4939
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
     exon            4940..5322
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7; ADAMTS7B;
                     COMPase"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgccctg ttccccctcc cgccctccct ccctccttcc ttttctttct ttctttcttt
       61 cttttttttt ttccccccta ggcttctcgc tctctttctt tgcctgggca gctggctgag
      121 ggggcgggcc ttgcagtctt tgttgccgga ggagcgagtg cagctgcccg gcggctagag
      181 tcaggacctg gaccttggga agagtttaaa accagccatg tcctgagtcg gacccaggcc
      241 cggctagggc gcaaaggcgc agactaaggc gtgcacaagg ggtcgtcctg cggccacccc
      301 attctggcca tgcaccgtgg tctgaatctc ctcctgatcc tgtgcgctct ggcgccccac
      361 gtcctcggac ctgcatcagg tctcccaact gagggccggg cgggtttgga catcgtgcac
      421 cctgtgcgag tggatgctgg aggctccttc ctgtcctatg agctgtggcc acgggtgctg
      481 cgtaagcggg atgtgtctgc tgcgcaggcc tcatccgcgt tctaccagct gcagtaccaa
      541 gggcgggagc tgcttttcaa cctgaccacc aacccttatc tcctggctcc cggctttgtg
      601 agtgagatcc gacgtcgcag caacctaagc aacgtgcaca tccaaaccag tgtcccaacc
      661 tgccatttgc ttggcgatgt ccaagaccca gagctggaag gtggctttgc agccatcagc
      721 gcctgtgatg gcctaagagg tgtgttccag ctctccaatg aggactactt cattgagcct
      781 ctggatgaag ttccagctca gcctggacat gcccagcccc atatggtgta caagcacaaa
      841 cgctctgggc agcaggatga ctcaaggact tcaggcacct gtggggtgca agggtcccca
      901 gagctgaagc accagcgaga acattgggaa cagcggcagc agaagcggag gcagcagcga
      961 tcaatcagca aagagaagtg ggtggagacc ctggtagtgg ctgattccaa gatggtggag
     1021 taccacgggc agccgcaagt ggagagctat gtgctgacga tcatgaacat ggtggctgga
     1081 ctgtatcatg atccaagcat tgggaatccc attcacatca ccgttgtgcg ccttattata
     1141 ctggaagacg aggagaagga cttaaagatc acacaccatg ctgatgacac tctgaagaac
     1201 ttctgtaggt ggcagaagaa tgtcaacatg aagggggatg accacccaca gcaccatgac
     1261 actgccatcc tgcttaccag gaaggatttg tgtgcaacca tgaaccaccc ctgtgaaacc
     1321 ttgggcctgt ctcacgtggc tggcttgtgc caccctcagc tcagctgtag tgtcagtgag
     1381 gatactggcc tgcctctggc cttcactgtg gcccatgagc taggacacag ttttggcatt
     1441 cagcatgacg gcaccggcaa tgactgtgaa tccattggga aacggccttt catcatgtct
     1501 ccacagctcc tgtatgacag aggcattcca ctcacctggt cccgctgcag ccgcgagtac
     1561 atcaccaggt tcctcgaccg tgggtggggc ctgtgcttag atgaccgtcc atccaagggt
     1621 gtcattaact tcccctcggt gctgcccggt gtcctgtacg atgtgaacca tcagtgccgc
     1681 cttcagtatg ggccttcttc agcctactgt gaggacgtgg ataatgtctg ctacactctg
     1741 tggtgctcgg tggggaccac ctgtcactcc aagatggatg ctgctgtgga tggtacgagc
     1801 tgtgggaaga acaagtggtg tctcaatgga gagtgcgtcc ctgagggctt ccagcccgag
     1861 acggtggacg gtggctggtc cggttggagt gcctggtctg tctgctcgcg gagctgtggc
     1921 gtgggcgtac ggagttctga acgacagtgc acacagcctg tgcctaagaa caaaggcaag
     1981 tactgtgtgg gggagcggaa gcggtaccgg ctctgcaacc tgcaggcctg cccaccagac
     2041 cgtccctctt tccgccacac ccagtgtagc cagtttgata gcatgctgta caaggggaaa
     2101 ctacacaaat gggtgcctgt gctcaacgac gagaacccat gtgagctgca ctgccggccc
     2161 ttcaactact ccaacagaga gaagctgagg gatgctgtga tggatggcac cccttgctac
     2221 caaggccgca tcagccgtga catctgcatc gatggcattt gcaagaaagt gggctgtgac
     2281 tttgagcttg actctggtgc tgaggaggac cgctgtgggg tgtgccgggg ggatggttct
     2341 acttgccata ccgtgagcag gaccttcaag gaggctgaag gcatggggta tgtggatgta
     2401 gggctgatcc cagctggagc ccgagagatt ctcattgagg aggtggccga ggctgccaac
     2461 ttcctggccc tgcggagtga ggacccagac aagtacttcc tcaatggcgg ctggaccatc
     2521 cagtggaatg gggactacca ggtggcaggc actaccttca cctatacacg caagggcaac
     2581 tgggagaccc tcacatcccc aggccccacc actgagcctg tctggatcca gctgctattc
     2641 caggagagaa accctggggt acactacaag tataccatcc agagggccag ccacagtgaa
     2701 gcccagccac ctgagttctc ctggcactat gggccctgga gcaagtgccc agtcacctgt
     2761 gggacaggtg tgcagaggca gagtttgtac tgcatggaga agcaggcagg aattgtagat
     2821 gagggacact gtgaccatct gagtcggccc cgtgaccgca agaggaaatg caatgaggag
     2881 ccctgtcctg ccaggtggtg ggtaggggac tggcagccgt gttcccgatc ctgtgggcct
     2941 ggaggtttct ttcgccgggc tgtgttctgc acacgtagtg tagggctgga tgagcagcgt
     3001 gcccttgagc catctgcttg tggacatctt ccccgtccct tggctgaaat cccgtgctac
     3061 cattatgttg cctgtccttc ctcctggggt gtggggaact ggtctcagtg ctctgtgaca
     3121 tgtggagctg gcattcggca acgaagtgtc ctctgcatca acaatactgg tgtcccctgt
     3181 gatggagctg agcgaccaat aactgagacc ttttgttttc tgcaaccctg ccagtattcc
     3241 acgtacatag tggacacagg tgcctctggg agcggctcct ccagtcccga gctcttcaat
     3301 gaggttgact tcgacccgca ccagccggtc ccacgccctt ccccagcatc ctcacccaag
     3361 ccagtcagca tcagcaacgc tattgatgag gaagacccgg aactggatcc gccagggcct
     3421 gtgtttgtgg atgatttcta ttatgactac aatttcatta acttccacga agacctgtcc
     3481 tatgggtcct ttgaagaatc ccattcagac ctggttgata ttgggggtca gacagtacca
     3541 cctcacatca gacccactga acccccctca gattctccag tgcctactgc aggagctcct
     3601 ggagctgagg aagagggcat tcagggatct tggtctccta gccctttact cagtgaggct
     3661 agccattccc caccagtatt attagagaat acccctgtga accccttggc caatttcttg
     3721 accgaggaag agagtcccat aggggcccct gaacttgggc tccccagcgt gtcctggccc
     3781 cctgcttcag ttgatggaat ggtgacatct gttgcccctg gaaaccctga tgagttgcta
     3841 gtgagagaag atacgcagag ccagccatcc actccatggt ctgacaggaa caagctttct
     3901 aaagatggta accccttggg tcctacatca cctgcccttc ccaagagccc tttccccacc
     3961 cagccctcat caccctccaa cagtactacc caagcttctc tgagtcctga tgcagtagag
     4021 gtgtcgacag gatggaatgt ggccttggac cctgtgctag aggctgacct gaagcctgta
     4081 cacgcaccaa ctgatccagg actactggac cagatacaga cccctcacac cgaggggacc
     4141 cagagtcctg ggttgttacc tagaccagct caggagactc aaactaacag tagcaaggac
     4201 cctgcagtcc agcctttgca gcccagccta gtggaggacg gcgcccctac agatctgctg
     4261 cctgccaaga atgccagttg gcaagtagga aactggagcc agtgttccac tacctgtggc
     4321 ctgggtgcca tttggaggct tgtgcgctgc agctctggca atgatgaaga ctgcaccctt
     4381 tcaagccgtc cccagccagc ccgccattgt catctgaggc cctgtgctgc ctggcgtgca
     4441 ggcaactgga gtaagtgctc tcgcaactgt ggtggcggtt ccgctaccag ggatgtacag
     4501 tgtgtggaca cacgggatct ccggccattg cggccctttc actgccagcc cgggcctacc
     4561 aagccaccca cccgtcagct ttgtgggacc caaccttgcc tcccctggta cacctcctcc
     4621 tggagagagt gctctgaggc ttgtggtggt ggcgaacagc agcgtctggt gacttgtcca
     4681 gagccaggcc tctgtgagga gtcgctgaga cccaacaaca ccaggccctg caacacccac
     4741 ccctgcacac agtgggtggt agggccctgg ggtcagtgct cagccccctg tggtggtggt
     4801 gttcagcggc gtctggtcaa gtgtgtgaac actcagacag gcttggcaga ggaagacagt
     4861 gacctgtgta gccatgaggc ctggcctgag agctcacggc catgtgccac tgaggactgt
     4921 gaactggttg aaccctcacg ttgtgagcgg gatcgcctgc ccttcaattt ctgtgagacg
     4981 ctgcgtctgt tgggccgctg ccagctgccc accatccgcg ctcagtgctg ccgctcatgt
     5041 cccccactca gccgcggtgt cccttcccga ggccatcaac gggtggccag acgataaacc
     5101 cacgcaccat caggatgcac agaccgaccc atgacacaca gacctcagtg ccccaccaca
     5161 ggctgcggtg gagcccctgc tcctcgtgtc ctaatggtgc taacctcatc cctgcacaat
     5221 ggcaggctgg ggaccccctt tcctttcaga aaaaggtatt tttttattct aacagtttgc
     5281 acatttgtta ttgttttaca taaatgagta tctaccattt tg
//
