LOCUS       NM_001108544            6308 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1
            motif, 6 (Adamts6), mRNA.
ACCESSION   NM_001108544 XM_001072537 XM_008760707 XM_342184
VERSION     NM_001108544.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6308)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1 and CN542748.1.
            
            On or before Aug 30, 2019 this sequence version replaced
            XM_008760707.2, NM_001108544.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. The extent of this transcript is
            supported by orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000002.1  37155288-37155400
            114-478             JAXUCZ010000002.1  37158087-37158451
            479-647             JAXUCZ010000002.1  37177006-37177174
            648-859             JAXUCZ010000002.1  37183603-37183814
            860-943             JAXUCZ010000002.1  37184521-37184604
            944-1089            JAXUCZ010000002.1  37185476-37185621
            1090-1133           JAXUCZ010000002.1  37211248-37211291
            1134-1239           JAXUCZ010000002.1  37215320-37215425
            1240-1386           JAXUCZ010000002.1  37241971-37242117
            1387-1528           JAXUCZ010000002.1  37255056-37255197
            1529-1636           JAXUCZ010000002.1  37270442-37270549
            1637-1782           JAXUCZ010000002.1  37280144-37280289
            1783-1846           JAXUCZ010000002.1  37282566-37282629
            1847-1949           JAXUCZ010000002.1  37294864-37294966
            1950-2083           JAXUCZ010000002.1  37308703-37308836
            2084-2207           JAXUCZ010000002.1  37310485-37310608
            2208-2288           JAXUCZ010000002.1  37311444-37311524
            2289-2452           JAXUCZ010000002.1  37322430-37322593
            2453-2591           JAXUCZ010000002.1  37323650-37323788
            2592-2721           JAXUCZ010000002.1  37336661-37336790
            2722-2926           JAXUCZ010000002.1  37345476-37345680
            2927-3103           JAXUCZ010000002.1  37351548-37351724
            3104-3260           JAXUCZ010000002.1  37354167-37354323
            3261-6290           JAXUCZ010000002.1  37364043-37367072
            6291-6308           CN542748.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..6308
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q13"
     gene            1..6308
                     /gene="Adamts6"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif, 6"
                     /db_xref="GeneID:361886"
                     /db_xref="RGD:1307678"
     exon            1..113
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..3370
                     /gene="Adamts6"
                     /note="a disintegrin-like and metalloprotease (reprolysin
                     type) with thrombospondin type 1 motif, 6; a
                     disintegrin-like and metallopeptidase (reprolysin type)
                     with thrombospondin type 1 motif, 6"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 6 precursor"
                     /protein_id="NP_001102014.2"
                     /db_xref="GeneID:361886"
                     /db_xref="RGD:1307678"
                     /translation="MEISWKTFTWILSLIMASSEFYSDHRLSYSSQEEFLTYLEHYQL
                     TIPIRVDQNGAFLSFTVKNDKHSRRRRSMDLLDPQQAVSKLFFKLSAYGKHFHLNLTL
                     NTNFVSKHFTVEYWGKDGPQWKHDFLDNCHYTGYLQDQHSTTKVALSNCVGLHGIIAT
                     EDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSTLQQRHIYDHSHCGVSDLTGSGKP
                     WWLNKTSSFPSLPPINDTHNHHRQRRSVSTERFVETLVVADKMMVGYHGRKDIEHYIL
                     SVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILS
                     HQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINED
                     IGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSACSRD
                     YITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCKYGEVCR
                     ELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGSWSL
                     WGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQC
                     ADFDSMPFRGKHYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDI
                     CINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYLEVVQIPR
                     GSVHIEVREVSMSKNYIALKSEGDDYYINGAWTIDWPRKFDVSGTAFHYKRPTDEPES
                     LEALGPTSENLIVMVLLQEQNLGIRYKFNVPIVRTGSGDNEVGFMWTHQPWAECSATC
                     AGGVQKQEVVCKRLDDNSIVQNNFCDPDSKPPENQRACSTEPCPPEWFIGDWLECSKT
                     CDGGMRTRAVLCIRKVGPSEEETLDYSDCLTHRPVEKESCNNQSCPPQWVALDWSECT
                     PKCGSGFKHRIVLCKSSDLSKTFPAAQCPEESKPPARIRCSLGRCPPPRWVTGDWGQC
                     SAQCGLGQQMRTVQCLSYTGQASVDCPEAVRPPSMQQCDSKCDSTPLSSTEECKDVNK
                     VAYCPLVLKFKFCSRAYFRQMCCKTCQGH"
     exon            114..478
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            479..647
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            648..859
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            860..943
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1089
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1133
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1239
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1386
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1528
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1636
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1782
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1846
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1949
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2083
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2207
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2288
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2452
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2591
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2721
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2926
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..3103
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3260
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..6291
                     /gene="Adamts6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcagctttc caaattatgg aaatttcgtg gaaaacgttc acttggattc tgagcctcat
       61 catggcctca tcggagtttt atagtgacca cagactttca tatagttctc aagaggaatt
      121 cctgacttac cttgaacact accagctaac tattccaata agagttgatc aaaatggagc
      181 ttttctcagc tttactgtga aaaatgataa acactcaagg agaagacgga gtatggacct
      241 tcttgatcca cagcaggcag tgtctaaatt attttttaaa ctttcagcct atggcaagca
      301 ctttcaccta aacttgactc tcaatacaaa ttttgtgtcc aaacatttta cagtagagta
      361 ttgggggaaa gatggacccc aatggaaaca tgactttcta gacaactgtc actacacagg
      421 atacttacaa gatcaacata gtacaactaa ggtggcatta agcaactgtg ttggattgca
      481 tggtattatt gctacagaag atgaagaata ttttattgaa cctctaaaga atactacaga
      541 ggattccaaa cactttagtt atgaaaatgg tcaccctcat gtgatttaca aaaagtctac
      601 tcttcagcag cggcatatct atgatcattc tcactgtgga gtttcagatc tcacaggaag
      661 tggcaaacct tggtggctga ataagacatc ttcttttcct tccttaccac caatcaatga
      721 cacacacaat catcacagac agagaagatc tgtgagcact gagagatttg tggagacact
      781 agtagtggca gacaaaatga tggtgggcta ccatggccgt aaagacattg aacattatat
      841 tttgagcgtg atgaatattg ttgccaaact ttaccgtgac tccagtctag gaaacgttgt
      901 gaatattata gtggcccgct taattgttct cacagaagat cagccaaact tggagataaa
      961 ccatcatgca gacaagtccc tcgatagctt ctgtaaatgg cagaaatcca ttctctccca
     1021 ccaaagtgat ggaaacacca ttccagaaaa tgggattgcc caccacgata atgcagttct
     1081 tattactaga tatgacatct gcacttataa aaataagccc tgtggaacac tgggcttggc
     1141 ctctgtggct ggaatgtgcg agcctgaaag gagctgcagc attaatgaag acattggcct
     1201 ggggtcggcc tttaccattg cacatgagat tggtcacaat tttggtatga accatgatgg
     1261 aattggaaat tcttgtggga cgaaaggtca tgaggcagca aaacttatgg cagctcatat
     1321 cacagcaaat accaatccct tctcctggtc tgcctgcagc agagactaca tcaccagctt
     1381 tctagattca ggccgtggta cttgccttga taatgagcct ccaaagcgtg actttcttta
     1441 cccagctgtg gccccaggtc aggtgtatga tgctgacgaa cagtgccgtt tccagtacgg
     1501 agcaacgtcc cgccaatgca aatatgggga agtgtgtaga gagctctggt gtctcagcaa
     1561 aagcaaccgc tgtgtcacca acagtattcc agctgctgag gggaccctgt gccagacggg
     1621 gaacattgaa aaggggtggt gttatcaggg agattgtgtt ccttttggca cttggcccca
     1681 gagcatagat gggggctggg gttcctggtc cctgtggggc gagtgcagca ggacctgtgg
     1741 aggaggagtc tcttcatccc tcagacactg tgacagccca gcaccttctg gaggtggaaa
     1801 atattgcctt ggggaaagga aacgctaccg ctcttgcaac acagatccat gccctttggg
     1861 ttcccgagat tttcgagaaa aacagtgtgc agactttgac agtatgcctt tccggggaaa
     1921 gcattataac tggaaaccct atactggagg tggggtaaaa ccttgtgcat taaactgcct
     1981 ggctgaaggc tacaatttct acacggagcg agcccctgct gtgatagatg ggacccagtg
     2041 caatgcggac tcactggaca tctgtatcaa cggagagtgc aagcacgtag gttgtgataa
     2101 tattttggga tctgatgcta gggaagatag gtgccgagtc tgtggtgggg acggaagcac
     2161 ctgtgatgcc attgaagggt tcttcaatga ctcattgccc agaggaggtt atttggaagt
     2221 ggttcagata ccaagaggct ctgttcacat tgaagtaaga gaagtttcca tgtcaaaaaa
     2281 ttacattgct ttaaaatctg aaggggatga ttactatatt aatggtgcct ggactattga
     2341 ctggcctagg aaatttgatg tttctgggac agcttttcac tacaagagac caacagatga
     2401 accagaatcc ttggaagctc tgggacccac ctctgagaac ctcattgtaa tggttctcct
     2461 ccaagaacag aatttgggaa ttaggtacaa gttcaatgtt cccatcgttc gtactggcag
     2521 tggagataat gaagttggct tcatgtggac tcaccagccc tgggccgagt gctctgctac
     2581 ttgtgctgga ggtgtccaaa aacaagaagt ggtctgtaaa agattggatg acaactccat
     2641 tgtccagaac aatttctgtg accctgacag taaaccaccg gaaaatcaaa gagcctgcag
     2701 cactgagcct tgcccacctg aatggttcat tggtgactgg ctagagtgca gcaagacttg
     2761 tgatggtggg atgcgcacaa gggccgtgct ctgcatcagg aaagttggac cttctgagga
     2821 ggaaacactg gactacagtg actgtttaac acaccggcct gtggagaaag agtcctgcaa
     2881 caaccagtca tgtccacctc agtgggtagc tttggactgg tctgaatgta ctccaaaatg
     2941 tggttcagga ttcaagcatc ggattgttct gtgcaagagc agtgaccttt ctaaaacgtt
     3001 cccagctgcg caatgtccag aggagagcaa gcctcctgct cgcatccgct gtagtctggg
     3061 ccgctgccct cctccccgct gggtgacagg agactggggc cagtgctctg ctcagtgcgg
     3121 ccttggacag cagatgcgca ctgtccagtg cctctcctat actggacagg catctgttga
     3181 ctgcccagaa gctgttcggc ctccatccat gcagcagtgt gacagcaaat gtgatagcac
     3241 ccctctctcc agtactgaag agtgcaaaga tgtgaacaaa gtggcatatt gcccactggt
     3301 gctgaagttc aagttctgca gccgcgcata cttcagacag atgtgttgta agacctgcca
     3361 aggacactga cccgcagaga gccagacagt cctgtcattt catcatggaa acccgtccgt
     3421 caacgagagc cacccagagg aagcggatgg atgttcttac aaaagcatta ccctgtggaa
     3481 aatgtaacca ctggtcagcc ccagctgaca ggatttcaat attattttaa cttctgtgaa
     3541 gtgggattta ttgatccaaa gtgctggaca cggtatcagg agggagatct gagagatcca
     3601 aacaacacag gaaactcact tactgtggaa cgtttgtgtt ctttcgagta aatctaacag
     3661 cctgtttacc tccttggacc attaagataa tttttattat ggacttagca atgacactga
     3721 atccatttgt atttaagact gtttaaaatg tagttattat gacttggtta actatgaaag
     3781 tagaagagag tcagaattct taagtcatag cttaaaaata tttactaccc tttatcgcac
     3841 cacaatagca ccaaacttaa attataaaat gggctttaaa ctgtaattta agaaacaact
     3901 ataaatcaaa agtaatgaaa gtttgtatta tttttctctg tcccacttac tttccttagg
     3961 agtaacccct gttctgaaca ctgctgtgag ccctgtataa actccagtaa cagtgagggc
     4021 ttggcttgaa gccgcgcagc cattgctgca gctgcgcatg tctataaact cagtggccag
     4081 cttgccgtcg tgcaagtgaa gctgagattt ccattaaaac tttaagagag aaacatttca
     4141 atttcatgca gaagccagac ctaggctatg gcagagactg aagcaccatg ccctttgcag
     4201 ccatcacgtg gggtgccgta ctcgagtcac ccggactcct tagtgtttac atccccacca
     4261 gccacagatc agcttctgcc ctactgggct gttgcatgca tggtaagctc atggcgacaa
     4321 tgccatggga aagataagct cgctcagtaa cagccacttg ctgacagcac gatgggttcc
     4381 agatgtccct tctttgatat ggtagaaggg catttattta tatgagagca agtgtatacg
     4441 tgtgtgtatg tgtgtgtgtg tgcagacact cctgagtggg ggaaacaggt gagtttgctt
     4501 gcatataaat gtgctgtttc tgtgagtttt aaagtcgggg aggataacaa ccaaagaaga
     4561 aaagctccac gaagagagat cacaatataa atttaaaagt cacttgacca catcattttt
     4621 acagatagtc tcaatggcaa ttaaatgtga aacccagttt cctgggcgtg tcaggttcta
     4681 aaaatcacac tttactgaac tgaaatgact agcctgggtc ttcccatctc caagcttcac
     4741 aagttgccat caaaagattc gacaagtaga tttttaaggg tacttgctta cgctaatact
     4801 tcgtacttga acatttgtaa tttgtagtag gttgttggtg aatgtgcttt ctgtcgagca
     4861 cacctcctta gtccttcaca tgtgtgcccc atacacacag catcgtctaa aacaaactaa
     4921 acacctacat ggtaacaaag agaatatttt catttaagag catgtctcac ttatctacca
     4981 ctgtgctctg aagatagatt ttggtgtgtc acctatgtgg tgaccttaga aaggctgtca
     5041 ccaaaggcct cctcggcttc ttacttgcta tgtacagttg gcctggatgc tagcccacag
     5101 tccagtgtga ccagccatat ctcattccct gcttcttcct cagtatcatc cccacgtttt
     5161 ccagaggagg ccaacacctc catataactg ccctgagaag accagcctga gtgccatcac
     5221 cgccattcca gtaaagtaag gcaacacatg ggagcctggc ccagacttga attcccttgg
     5281 tccttttcaa aggacagtta acttggtgct aatgtgcctg gtaaaatata ggaagactgg
     5341 cgatcgccga ggcagtttac acataggctt gctatccaga tctgatattt tttaatcaac
     5401 tttaatacta actcatgctt atattccaag aagatttcct acagtacttg tagaaagctg
     5461 tatttacctc acttggaagc taacaccgca agggctgact cccaggtact gtgcttagct
     5521 aggataagag atcagcctga gctctccaca ggaagtgcat tggcattgct gacaggctac
     5581 tgccaggggc agcacagcct tccttctgtg ggggaagcaa agcatgggta taacaggatt
     5641 caacattctc aaggagaccc tgaacttaat cctgagcagg ttacacagag cagagagcat
     5701 cttccatagc acagcacacc accactgcta ctgcagccat ctctgtccta caaggtggca
     5761 gggatcagca gcggaggccg ggctgccttg gcaagcactc caagtgttat gagctgtatt
     5821 gactacttag ggtaccaggg tacccatggt taggagcagt gtctgccact ggcataaagg
     5881 cctcccaaaa aaaggaatgt taaatatacc caaatgattg aacccctaaa ggcaggtatg
     5941 acttcccaat agtccattta attaggaatt tatgtatttg agtgaatgtc ttataggtat
     6001 cgttaataat acagaacaaa attacctttg tattattgtg actagttgtt gcttattatt
     6061 ttatactcgg tattaatgtg gtacactgtt actatttttg cttttgtaaa ttatattcta
     6121 atttattgcc atgtttccta acacctgtcc tttattcatt ctcctgctcg taatggaaat
     6181 gaaagtcatt gcaacacttg atggagtgaa atttcatacc aggcacagat gttttttaac
     6241 atagataatt cagtaaataa taaaatcttc agcttgtaaa agtgatgcag aaaaaaaaaa
     6301 aaaaaaaa
//
