LOCUS       NM_198761               3862 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1
            motif, 5 (Adamts5), mRNA.
ACCESSION   NM_198761 XM_221699
VERSION     NM_198761.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3862)
  AUTHORS   Zhou,X., Luo,D., Sun,H., Qi,Y., Xu,W., Jin,X., Li,C., Lin,Z. and
            Li,G.
  TITLE     MiR-132-3p regulates ADAMTS-5 expression and promotes chondrogenic
            differentiation of rat mesenchymal stem cells
  JOURNAL   J Cell Biochem 119 (3), 2579-2587 (2018)
   PUBMED   28980719
  REMARK    GeneRIF: MiR-132-3p promotes rat mesenchymal stem cell chondrogenic
            differentiation, possibly mediated by targeting ADAMTS-5
REFERENCE   2  (bases 1 to 3862)
  AUTHORS   Bauters,D., Cobbaut,M., Geys,L., Van Lint,J., Hemmeryckx,B. and
            Lijnen,H.R.
  TITLE     Loss of ADAMTS5 enhances brown adipose tissue mass and promotes
            browning of white adipose tissue via CREB signaling
  JOURNAL   Mol Metab 6 (7), 715-724 (2017)
   PUBMED   28702327
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3862)
  AUTHORS   Liu,Y.D., Liao,L.F., Zhang,H.Y., Lu,L., Jiao,K., Zhang,M.,
            Zhang,J., He,J.J., Wu,Y.P., Chen,D. and Wang,M.Q.
  TITLE     Reducing dietary loading decreases mouse temporomandibular joint
            degradation induced by anterior crossbite prosthesis
  JOURNAL   Osteoarthritis Cartilage 22 (2), 302-312 (2014)
   PUBMED   24316289
REFERENCE   4  (bases 1 to 3862)
  AUTHORS   Dancevic,C.M., Fraser,F.W., Smith,A.D., Stupka,N., Ward,A.C. and
            McCulloch,D.R.
  TITLE     Biosynthesis and expression of a disintegrin-like and
            metalloproteinase domain with thrombospondin-1 repeats-15: a novel
            versican-cleaving proteoglycanase
  JOURNAL   J Biol Chem 288 (52), 37267-37276 (2013)
   PUBMED   24220035
REFERENCE   5  (bases 1 to 3862)
  AUTHORS   Feng,Z.Y., He,Z.N., Zhang,B. and Chen,Z.
  TITLE     Osteoprotegerin promotes the proliferation of chondrocytes and
            affects the expression of ADAMTS-5 and TIMP-4 through MEK/ERK
            signaling
  JOURNAL   Mol Med Rep 8 (6), 1669-1679 (2013)
   PUBMED   24126801
  REMARK    GeneRIF: OPG regulated the proliferation of chondrocytes via
            MEK/ERK signaling, and directly affected chondrocytes by
            influencing the expression profile of ADAMTS-5 and TIMP-4.
REFERENCE   6  (bases 1 to 3862)
  AUTHORS   Appleton,C.T., Pitelka,V., Henry,J. and Beier,F.
  TITLE     Global analyses of gene expression in early experimental
            osteoarthritis
  JOURNAL   Arthritis Rheum 56 (6), 1854-1868 (2007)
   PUBMED   17530714
  REMARK    GeneRIF: Dysregulated genes expressed in rats with
            surgically-induced osteoarthritis included Mmp13, Adamts5, Ptges,
            Cxcr4, Ccl2, and Col2a1.
REFERENCE   7  (bases 1 to 3862)
  AUTHORS   Mitani,H., Takahashi,I., Onodera,K., Bae,J.W., Sato,T.,
            Takahashi,N., Sasano,Y., Igarashi,K. and Mitani,H.
  TITLE     Comparison of age-dependent expression of aggrecan and ADAMTSs in
            mandibular condylar cartilage, tibial growth plate, and articular
            cartilage in rats
  JOURNAL   Histochem Cell Biol 126 (3), 371-380 (2006)
   PUBMED   16583222
  REMARK    GeneRIF: ADAMTS-5 mainly contributed to ECM metabolism in growth
            plate and condylar cartilage during growth. ADAMTS-1 and ADAMTS-4
            may be involved in ECM turn over in articular cartilage.
REFERENCE   8  (bases 1 to 3862)
  AUTHORS   Sone,S., Nakamura,M., Maruya,Y., Takahashi,I., Mizoguchi,I.,
            Mayanagi,H. and Sasano,Y.
  TITLE     Expression of versican and ADAMTS during rat tooth eruption
  JOURNAL   J Mol Histol 36 (4), 281-288 (2005)
   PUBMED   16200461
  REMARK    GeneRIF: This study suggests that dental pulp cells, odontoblasts,
            cementoblasts, cementocytes, periodontal ligament cells,
            osteoblasts and osteocytes may be involved in both production and
            degradation of versican with secreting ADAMTS1, ADAMTS4 and
            ADAMTS5.
REFERENCE   9  (bases 1 to 3862)
  AUTHORS   Malfait,A.M., Liu,R.Q., Ijiri,K., Komiya,S. and Tortorella,M.D.
  TITLE     Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation
            in osteoarthritic cartilage
  JOURNAL   J Biol Chem 277 (25), 22201-22208 (2002)
   PUBMED   11956193
REFERENCE   10 (bases 1 to 3862)
  AUTHORS   Yamanishi,Y., Boyle,D.L., Clark,M., Maki,R.A., Tortorella,M.D.,
            Arner,E.C. and Firestein,G.S.
  TITLE     Expression and regulation of aggrecanase in arthritis: the role of
            TGF-beta
  JOURNAL   J Immunol 168 (3), 1405-1412 (2002)
   PUBMED   11801682
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Dec 7, 2020 this sequence version replaced NM_198761.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228283.1, AY382879.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1492              JAXUCZ010000011.1  38532025-38533516   c
            1493-1625           JAXUCZ010000011.1  38519106-38519238   c
            1626-1793           JAXUCZ010000011.1  38509346-38509513   c
            1794-2077           JAXUCZ010000011.1  38495507-38495790   c
            2078-2261           JAXUCZ010000011.1  38494102-38494285   c
            2262-2437           JAXUCZ010000011.1  38493592-38493767   c
            2438-2613           JAXUCZ010000011.1  38491606-38491781   c
            2614-3862           JAXUCZ010000011.1  38486945-38488193   c
FEATURES             Location/Qualifiers
     source          1..3862
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..3862
                     /gene="Adamts5"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif, 5"
                     /db_xref="GeneID:304135"
                     /db_xref="RGD:735196"
     exon            1..1492
                     /gene="Adamts5"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..3181
                     /gene="Adamts5"
                     /note="A disintegrin and metalloproteinase with
                     thrombospondin motifs 5; a disintegrin-like and
                     metallopeptidase (reprolysin type) with thrombospondin
                     type 1 motif, 5 (aggrecanase-2)"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 5 precursor"
                     /protein_id="NP_942056.2"
                     /db_xref="GeneID:304135"
                     /db_xref="RGD:735196"
                     /translation="MRLEWASLLLLLLLLCASCLALAADNPAAAPAQDKTRQPRAAAA
                     AAQPDQRQWEETQERGHPQPLARQRRSSGLVQNIDQLYSGGGKVGYLVYAGGRRFLLD
                     LERDDTVGAAGGIVTAGGLSASSGHRGHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVK
                     HARYTLKPLLRGSWAESERVYGDGSSRILHVYTREGFSFEALPPRTSCETPASPSGAQ
                     ESPSVHSSSRRRTELAPQLLDHSAFSPAGNAGPQTWWRRRRRSISRARQVELLLVADS
                     SMAKMYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLTDKSLEVSKNAATT
                     LKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCA
                     VIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEENFGSTEDKRLMSSILTSIDASKPWS
                     KCTSATITEFLDDGHGNCLLDVPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGM
                     DVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGN
                     WGSWGPWGQCSRSCGGGVQFAYRHCNNPAPRNSGRYCTGKRAIYRSCSVIPCPPNGKS
                     FRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVT
                     DGTECRPYSNSVCVRGRCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIIGTFNKKSK
                     GYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKTGEYLINGKYMISTSETIIDI
                     NGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKALDVRYSFFVPKKTTQKV
                     NSVISHSSNKVGLHSPQLQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCILSQ
                     RPSAFKQCLLKKC"
     exon            1493..1625
                     /gene="Adamts5"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1793
                     /gene="Adamts5"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..2077
                     /gene="Adamts5"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2261
                     /gene="Adamts5"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2437
                     /gene="Adamts5"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2613
                     /gene="Adamts5"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..3862
                     /gene="Adamts5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcgttggg cctctctcct ttattttgta ttcggtagct ctccaactcc tggcttttgc
       61 tcccaccacc accacccttt atttaatttt tttaaatatt tttaattttt ttttcttcct
      121 ccgtctcttg gacctcaatt ccaaacattt tccaaaccaa caaagaaaag ttcgcacgct
      181 ggcaccgcgg ccaggacagc ctggcgctct gctgcgggtt ccccctaccc tttcctggac
      241 acttgactca accttgcaag caagtgtgta gagtgtgtgg gtgtgggagg gtgggtggga
      301 gggtgagccc cccacccccg cccctgaaac ttctatagca aatagcaaac atccagctag
      361 actcagtcgc gcagcccctc ccggcgggca gcgcactatg cggctcgagt gggcgtcctt
      421 gctgctgcta ctgctgctgc tgtgcgcgtc ctgcctggcc ctggccgctg acaaccctgc
      481 cgcggcacct gcccaggata aaaccaggca gcctcgggct gctgcagcgg ctgcccagcc
      541 cgaccagcgg cagtgggagg aaacacagga gcggggccat ccgcaaccct tggccaggca
      601 gcgcaggagc agcgggctgg tgcagaatat agaccaactc tactctggcg gtggcaaagt
      661 gggctacctt gtctacgcgg gcggccggag gttcctgctg gacctggaga gggatgacac
      721 agtgggtgct gctggtggca tcgttactgc aggagggctg agcgcatcct ctggccacag
      781 gggtcactgc ttctacagag gcactgtgga cggcagccct cgatccctag ctgtctttga
      841 cctctgtggg ggtctcgatg gcttcttcgc agtcaagcat gcgcgctaca ctctgaagcc
      901 gctcttgcgt gggtcctggg cagagtccga acgagtttac ggggatgggt cttcacgcat
      961 cctgcatgtc tacacccgcg agggcttcag cttcgaggcc ctgccgccac gcaccagttg
     1021 cgagactcca gcgtccccgt ctggggccca agagagcccc tcggtgcaca gtagttctag
     1081 gcgacgcaca gaactggcac cgcagctgct ggaccattca gctttctcgc cagctgggaa
     1141 cgcgggacct cagacgtggt ggaggcggag gcgccgttcc atctccaggg cccgccaggt
     1201 ggagctcctc ttggtggctg actcttccat ggccaagatg tatgggcggg gcctgcagca
     1261 ttacctgctg accctggcct ctattgccaa ccggctgtac agtcatgcaa gcatcgagaa
     1321 ccacatccgc ctggccgtag tgaaagtggt ggtgctgacc gacaagagtc tggaggtgag
     1381 caagaacgcg gccacgaccc tcaagaactt ttgcaaatgg cagcaccaac acaaccagct
     1441 aggtgatgac catgaggagc actacgatgc agccatcctg ttcaccagag aggatttatg
     1501 tgggcatcat tcatgtgaca ccctgggaat ggcagacgtt gggaccatat gttctccgga
     1561 gcgcagctgc gctgtgattg aagatgatgg cctccatgca gctttcactg tggctcacga
     1621 aattggacat ctacttggcc tctctcacga cgattccaaa ttctgtgaag agaactttgg
     1681 ttctacagaa gacaagcgtt taatgtcttc aatccttacc agcattgatg catccaagcc
     1741 ctggtccaaa tgcacttcag ccacgatcac agaatttctg gatgacggtc atggtaactg
     1801 tttactagat gtaccacgga agcagattct gggccccgag gaactcccag gacagaccta
     1861 tgatgccacc cagcagtgca acttgacatt tgggcctgaa tattctgtgt gccctggcat
     1921 ggatgtctgt gcacggctgt ggtgtgctgt ggtgcgccaa ggccaaatgg tgtgtctgac
     1981 caagaagttg cctgccgtgg agggcactcc ctgtgggaaa ggaagaatct gcctgcaagg
     2041 caaatgtgtg gacaaaacta agaaaaaata ttactcgaca tcaagccatg gaaattgggg
     2101 gtcctggggc ccctggggtc agtgttctcg ctcttgcggg ggaggagtac agtttgccta
     2161 ccgccattgc aataaccccg cacctcgaaa cagtggccgc tactgcacag ggaagagggc
     2221 catataccgt tcctgcagtg tcataccctg cccacctaac ggcaaatctt tccgccacga
     2281 gcagtgtgaa gccaaaaatg gctatcagtc cgatgcaaaa ggagtcaaaa catttgtaga
     2341 atgggttccc aaatacgcag gtgtcctgcc ggcagacgtg tgcaagctta cgtgcagagc
     2401 taagggcact ggctattacg tggtcttttc tccaaaggtt acagatggga cagaatgtag
     2461 accctacagc aactccgtgt gtgtccgagg gaggtgcgtg agaacggggt gtgacggcat
     2521 catcggctca aagctacagt atgacaagtg tggagtgtgt ggaggggata actccagttg
     2581 tacaaagatt attggaacct tcaataaaaa aagcaagggt tatactgacg ttgtgaggat
     2641 ccctgaagga gcaacccaca taaaagtccg acagttcaaa gccaaagacc agactagatt
     2701 cactgcttac ttagccctaa agaagaaaac tggcgagtac cttatcaacg gcaagtacat
     2761 gatctccact tcagagacca tcatcgacat caatggtacc gtcatgaact acagtgggtg
     2821 gagtcacaga gatgattttt tacatgggat gggctattca gccacaaagg aaattctgat
     2881 tgtgcagatc cttgcaacag acccaactaa agcattagac gtccgttaca gcttttttgt
     2941 tcccaagaag accactcaaa aagtgaattc cgtcattagc cacagcagca acaaagtggg
     3001 actacactcc ccgcagctac agtgggtgac aggcccctgg ctggcctgct ctaggacctg
     3061 tgacacaggc tggcacacca ggaccgtgca gtgccaggat ggaaacagga aattagctaa
     3121 gggatgcatt ctctctcaga ggccttctgc gtttaagcaa tgtttgctca agaaatgtta
     3181 gcctgtggtt tagtctaacg cacaaaaata accgggaggt catcacagac gcacttgtgg
     3241 ggaagacaag gcctacccaa agcacagaaa gtcatgccct catgtcccct gtcaccgtga
     3301 gtcgaattat gggcagaatc tgctctctgc gaccaaaaga atgactctat ttggtgcaat
     3361 gaaggtgacc ttgggataac agaaaacatg ggagttatgg aacatccctg ggcctacaca
     3421 aaggaggcac acaatgatga atgtagaagc ggggacatct gaagatggca gagaagtctt
     3481 gtcacctacc tcttatagaa tgtcttcaaa ggcaccgtga tcatggtcat ccgtgacact
     3541 cagcttatct ttactgtctg taaatgcatc tgcccttggt atgtcacttt ataaacttgg
     3601 tcctattaat atatacatat gtgtatgtat atatgtatat gtacatatat atacacatat
     3661 atgtatatat acacatatat atacatatat atatatattg ctacaacaaa atatttgacc
     3721 aaagtaggcc tacagctatt tcaactaata gtttccagaa agagctgtgg aagatttact
     3781 ggaaattaag aacttgctgc tgttaaataa gactttgtat atttctggtc tgcaggagat
     3841 aacattttag ttagaaaaaa aa
//
