LOCUS       NP_942056                927 aa            linear   ROD 31-MAR-2024
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 5
            precursor [Rattus norvegicus].
ACCESSION   NP_942056 XP_221699
VERSION     NP_942056.2
DBSOURCE    REFSEQ: accession NM_198761.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 927)
  AUTHORS   Zhou,X., Luo,D., Sun,H., Qi,Y., Xu,W., Jin,X., Li,C., Lin,Z. and
            Li,G.
  TITLE     MiR-132-3p regulates ADAMTS-5 expression and promotes chondrogenic
            differentiation of rat mesenchymal stem cells
  JOURNAL   J Cell Biochem 119 (3), 2579-2587 (2018)
   PUBMED   28980719
  REMARK    GeneRIF: MiR-132-3p promotes rat mesenchymal stem cell chondrogenic
            differentiation, possibly mediated by targeting ADAMTS-5
REFERENCE   2  (residues 1 to 927)
  AUTHORS   Bauters,D., Cobbaut,M., Geys,L., Van Lint,J., Hemmeryckx,B. and
            Lijnen,H.R.
  TITLE     Loss of ADAMTS5 enhances brown adipose tissue mass and promotes
            browning of white adipose tissue via CREB signaling
  JOURNAL   Mol Metab 6 (7), 715-724 (2017)
   PUBMED   28702327
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 927)
  AUTHORS   Liu,Y.D., Liao,L.F., Zhang,H.Y., Lu,L., Jiao,K., Zhang,M.,
            Zhang,J., He,J.J., Wu,Y.P., Chen,D. and Wang,M.Q.
  TITLE     Reducing dietary loading decreases mouse temporomandibular joint
            degradation induced by anterior crossbite prosthesis
  JOURNAL   Osteoarthritis Cartilage 22 (2), 302-312 (2014)
   PUBMED   24316289
REFERENCE   4  (residues 1 to 927)
  AUTHORS   Dancevic,C.M., Fraser,F.W., Smith,A.D., Stupka,N., Ward,A.C. and
            McCulloch,D.R.
  TITLE     Biosynthesis and expression of a disintegrin-like and
            metalloproteinase domain with thrombospondin-1 repeats-15: a novel
            versican-cleaving proteoglycanase
  JOURNAL   J Biol Chem 288 (52), 37267-37276 (2013)
   PUBMED   24220035
REFERENCE   5  (residues 1 to 927)
  AUTHORS   Feng,Z.Y., He,Z.N., Zhang,B. and Chen,Z.
  TITLE     Osteoprotegerin promotes the proliferation of chondrocytes and
            affects the expression of ADAMTS-5 and TIMP-4 through MEK/ERK
            signaling
  JOURNAL   Mol Med Rep 8 (6), 1669-1679 (2013)
   PUBMED   24126801
  REMARK    GeneRIF: OPG regulated the proliferation of chondrocytes via
            MEK/ERK signaling, and directly affected chondrocytes by
            influencing the expression profile of ADAMTS-5 and TIMP-4.
REFERENCE   6  (residues 1 to 927)
  AUTHORS   Appleton,C.T., Pitelka,V., Henry,J. and Beier,F.
  TITLE     Global analyses of gene expression in early experimental
            osteoarthritis
  JOURNAL   Arthritis Rheum 56 (6), 1854-1868 (2007)
   PUBMED   17530714
  REMARK    GeneRIF: Dysregulated genes expressed in rats with
            surgically-induced osteoarthritis included Mmp13, Adamts5, Ptges,
            Cxcr4, Ccl2, and Col2a1.
REFERENCE   7  (residues 1 to 927)
  AUTHORS   Mitani,H., Takahashi,I., Onodera,K., Bae,J.W., Sato,T.,
            Takahashi,N., Sasano,Y., Igarashi,K. and Mitani,H.
  TITLE     Comparison of age-dependent expression of aggrecan and ADAMTSs in
            mandibular condylar cartilage, tibial growth plate, and articular
            cartilage in rats
  JOURNAL   Histochem Cell Biol 126 (3), 371-380 (2006)
   PUBMED   16583222
  REMARK    GeneRIF: ADAMTS-5 mainly contributed to ECM metabolism in growth
            plate and condylar cartilage during growth. ADAMTS-1 and ADAMTS-4
            may be involved in ECM turn over in articular cartilage.
REFERENCE   8  (residues 1 to 927)
  AUTHORS   Sone,S., Nakamura,M., Maruya,Y., Takahashi,I., Mizoguchi,I.,
            Mayanagi,H. and Sasano,Y.
  TITLE     Expression of versican and ADAMTS during rat tooth eruption
  JOURNAL   J Mol Histol 36 (4), 281-288 (2005)
   PUBMED   16200461
  REMARK    GeneRIF: This study suggests that dental pulp cells, odontoblasts,
            cementoblasts, cementocytes, periodontal ligament cells,
            osteoblasts and osteocytes may be involved in both production and
            degradation of versican with secreting ADAMTS1, ADAMTS4 and
            ADAMTS5.
REFERENCE   9  (residues 1 to 927)
  AUTHORS   Malfait,A.M., Liu,R.Q., Ijiri,K., Komiya,S. and Tortorella,M.D.
  TITLE     Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation
            in osteoarthritic cartilage
  JOURNAL   J Biol Chem 277 (25), 22201-22208 (2002)
   PUBMED   11956193
REFERENCE   10 (residues 1 to 927)
  AUTHORS   Yamanishi,Y., Boyle,D.L., Clark,M., Maki,R.A., Tortorella,M.D.,
            Arner,E.C. and Firestein,G.S.
  TITLE     Expression and regulation of aggrecanase in arthritis: the role of
            TGF-beta
  JOURNAL   J Immunol 168 (3), 1405-1412 (2002)
   PUBMED   11801682
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Dec 7, 2020 this sequence version replaced NP_942056.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228283.1, AY382879.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     Protein         1..927
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 5 precursor"
                     /note="A disintegrin and metalloproteinase with
                     thrombospondin motifs 5; a disintegrin-like and
                     metallopeptidase (reprolysin type) with thrombospondin
                     type 1 motif, 5 (aggrecanase-2)"
                     /calculated_mol_wt=99246
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2530
     Region          61..181
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          268..470
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(407..408,411,417)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          484..551
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          567..619
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          625..728
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          730..849
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          876..927
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..927
                     /gene="Adamts5"
                     /coded_by="NM_198761.2:398..3181"
                     /db_xref="GeneID:304135"
                     /db_xref="RGD:735196"
ORIGIN      
        1 mrlewaslll lllllcascl alaadnpaaa paqdktrqpr aaaaaaqpdq rqweetqerg
       61 hpqplarqrr ssglvqnidq lysgggkvgy lvyaggrrfl ldlerddtvg aaggivtagg
      121 lsassghrgh cfyrgtvdgs prslavfdlc ggldgffavk harytlkpll rgswaeserv
      181 ygdgssrilh vytregfsfe alpprtscet paspsgaqes psvhsssrrr telapqlldh
      241 safspagnag pqtwwrrrrr sisrarqvel llvadssmak mygrglqhyl ltlasianrl
      301 yshasienhi rlavvkvvvl tdkslevskn aattlknfck wqhqhnqlgd dheehydaai
      361 lftredlcgh hscdtlgmad vgticspers cavieddglh aaftvaheig hllglshdds
      421 kfceenfgst edkrlmssil tsidaskpws kctsatitef lddghgncll dvprkqilgp
      481 eelpgqtyda tqqcnltfgp eysvcpgmdv carlwcavvr qgqmvcltkk lpavegtpcg
      541 kgriclqgkc vdktkkkyys tsshgnwgsw gpwgqcsrsc gggvqfayrh cnnpaprnsg
      601 ryctgkraiy rscsvipcpp ngksfrheqc eakngyqsda kgvktfvewv pkyagvlpad
      661 vckltcrakg tgyyvvfspk vtdgtecrpy snsvcvrgrc vrtgcdgiig sklqydkcgv
      721 cggdnssctk iigtfnkksk gytdvvripe gathikvrqf kakdqtrfta ylalkkktge
      781 ylingkymis tsetiiding tvmnysgwsh rddflhgmgy satkeilivq ilatdptkal
      841 dvrysffvpk kttqkvnsvi shssnkvglh spqlqwvtgp wlacsrtcdt gwhtrtvqcq
      901 dgnrklakgc ilsqrpsafk qcllkkc
//
