LOCUS       NM_023959               3339 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1
            motif, 4 (Adamts4), mRNA.
ACCESSION   NM_023959 XM_001053685 XM_341154
VERSION     NM_023959.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3339)
  AUTHORS   Tatar,M., Uslu,S. and Oner,J.
  TITLE     Expression of placental growth factor and a disintegrin and
            metalloprotease with a thrombospondin type motifs 1-4-8 during the
            three trimesters of rat pregnancy at the maternal-fetal interface
  JOURNAL   Anat Histol Embryol 52 (5), 805-814 (2023)
   PUBMED   37424113
  REMARK    GeneRIF: Expression of placental growth factor and a disintegrin
            and metalloprotease with a thrombospondin type motifs 1-4-8 during
            the three trimesters of rat pregnancy at the maternal-fetal
            interface.
REFERENCE   2  (bases 1 to 3339)
  AUTHORS   Tio,L., Martel-Pelletier,J., Pelletier,J.P., Bishop,P.N.,
            Roughley,P., Farran,A., Benito,P. and Monfort,J.
  TITLE     Characterization of opticin digestion by proteases involved in
            osteoarthritis development
  JOURNAL   Joint Bone Spine 81 (2), 137-141 (2014)
   PUBMED   23845380
REFERENCE   3  (bases 1 to 3339)
  AUTHORS   Soteriou,D., Iskender,B., Byron,A., Humphries,J.D.,
            Borg-Bartolo,S., Haddock,M.C., Baxter,M.A., Knight,D.,
            Humphries,M.J. and Kimber,S.J.
  TITLE     Comparative proteomic analysis of supportive and unsupportive
            extracellular matrix substrates for human embryonic stem cell
            maintenance
  JOURNAL   J Biol Chem 288 (26), 18716-18731 (2013)
   PUBMED   23658023
REFERENCE   4  (bases 1 to 3339)
  AUTHORS   Py,B.F., Gonzalez,S.F., Long,K., Kim,M.S., Kim,Y.A., Zhu,H.,
            Yao,J., Degauque,N., Villet,R., Ymele-Leki,P., Gadjeva,M.,
            Pier,G.B., Carroll,M.C. and Yuan,J.
  TITLE     Cochlin produced by follicular dendritic cells promotes
            antibacterial innate immunity
  JOURNAL   Immunity 38 (5), 1063-1072 (2013)
   PUBMED   23684986
REFERENCE   5  (bases 1 to 3339)
  AUTHORS   Funck-Brentano,T., Lin,H., Hay,E., Ah Kioon,M.D., Schiltz,C.,
            Hannouche,D., Nizard,R., Liote,F., Orcel,P., de Vernejoul,M.C. and
            Cohen-Solal,M.E.
  TITLE     Targeting bone alleviates osteoarthritis in osteopenic mice and
            modulates cartilage catabolism
  JOURNAL   PLoS One 7 (3), e33543 (2012)
   PUBMED   22432033
REFERENCE   6  (bases 1 to 3339)
  AUTHORS   Sone,S., Nakamura,M., Maruya,Y., Takahashi,I., Mizoguchi,I.,
            Mayanagi,H. and Sasano,Y.
  TITLE     Expression of versican and ADAMTS during rat tooth eruption
  JOURNAL   J Mol Histol 36 (4), 281-288 (2005)
   PUBMED   16200461
  REMARK    GeneRIF: This study suggests that dental pulp cells, odontoblasts,
            cementoblasts, cementocytes, periodontal ligament cells,
            osteoblasts and osteocytes may be involved in both production and
            degradation of versican with secreting ADAMTS1, ADAMTS4 and
            ADAMTS5.
REFERENCE   7  (bases 1 to 3339)
  AUTHORS   Somerville,R.P., Longpre,J.M., Apel,E.D., Lewis,R.M., Wang,L.W.,
            Sanes,J.R., Leduc,R. and Apte,S.S.
  TITLE     ADAMTS7B, the full-length product of the ADAMTS7 gene, is a
            chondroitin sulfate proteoglycan containing a mucin domain
  JOURNAL   J Biol Chem 279 (34), 35159-35175 (2004)
   PUBMED   15192113
REFERENCE   8  (bases 1 to 3339)
  AUTHORS   Wang,P., Tortorella,M., England,K., Malfait,A.M., Thomas,G.,
            Arner,E.C. and Pei,D.
  TITLE     Proprotein convertase furin interacts with and cleaves pro-ADAMTS4
            (Aggrecanase-1) in the trans-Golgi network
  JOURNAL   J Biol Chem 279 (15), 15434-15440 (2004)
   PUBMED   14744861
REFERENCE   9  (bases 1 to 3339)
  AUTHORS   Yamanishi,Y., Boyle,D.L., Clark,M., Maki,R.A., Tortorella,M.D.,
            Arner,E.C. and Firestein,G.S.
  TITLE     Expression and regulation of aggrecanase in arthritis: the role of
            TGF-beta
  JOURNAL   J Immunol 168 (3), 1405-1412 (2002)
   PUBMED   11801682
REFERENCE   10 (bases 1 to 3339)
  AUTHORS   Satoh,K., Suzuki,N. and Yokota,H.
  TITLE     ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin
            motifs) is transcriptionally induced in beta-amyloid treated rat
            astrocytes
  JOURNAL   Neurosci Lett 289 (3), 177-180 (2000)
   PUBMED   10961658
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1, CB614460.1, AB042271.1, AB042272.1 and
            AB042273.1.
            
            On or before Dec 17, 2009 this sequence version replaced
            XM_341154.3, XM_001053685.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.653808.1,
                                           SRR26643298.52257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               JAXUCZ010000013.1  86203011-86203223
            214-764             CB614460.1         1-551
            765-1143            AB042271.1         87-465
            1144-2508           AB042272.1         1-1365
            2509-2556           AB042273.1         73-120
            2557-3339           JAXUCZ010000013.1  86211718-86212500
FEATURES             Location/Qualifiers
     source          1..3339
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..3339
                     /gene="Adamts4"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif, 4"
                     /db_xref="GeneID:66015"
                     /db_xref="RGD:621242"
     CDS             1..2556
                     /gene="Adamts4"
                     /EC_number="3.4.24.82"
                     /note="ADAM-TS4; ADAM-TS 4; aggrecanase-1; Aggrecanase;
                     ADAMTS-4; a disintegrin-like and metallopeptidase
                     (reprolysin type) with thrombospondin type 1 motif, 4; a
                     disintegrin and metallopeptidase with thrombospondin
                     motifs 4"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 4"
                     /protein_id="NP_076449.1"
                     /db_xref="GeneID:66015"
                     /db_xref="RGD:621242"
                     /translation="MASIHPSCSTGTMSRMGLHPRRGLTGHRLRRLQPCLPPRTVPFS
                     GLERWQQLLLLASLLPLAWSASPLPREEEIVFPEKLNGSSIIPGSGVPARLLYRLPAF
                     GEILLLELEQDPGVQVEGLTVQYLGQAPEMLGGAEPGTYLTGTINGDPESVASLHWDR
                     GALLGVLQYRGAELHLQPLEGGALNSAGGPGAHILRRKSPASNRGPICNVKAPSGSPS
                     PISRRNKRFASLSRFVETLVVADDKMAAFHGAGLKHYLLTVMAAAAKAFKHPSIRNPV
                     NLVVTRLVILGSGQEVPQVGPSAAQTLRSFCTWQKGLNPPNDSDPDHFDTAILFTRQD
                     LCGVSTCDALGMAGVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCA
                     NLNGQGSSSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPV
                     TFPGKDYDADRQCQLTFGPDSSHCPQLPPPCAALWCFGHLNGHAMCQTKHSPWADGTP
                     CGPAQACMGGRCLHVDQLKDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTKPVP
                     RNGGKYCEGRRTPFRSCNTKNCPHGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRY
                     TGVAPRDQCKLTCQARALGYYYVLEPRVADGTPCSPDSSSVCVQGRCIHAGCDRIIGS
                     KKKFDKCMVCGGNGSSCSKQSGSFKKFRYGYSDVVTIPAGRTHILVRQQGGSGLKSIY
                     LALKLADGSYALNGEYTLMPSSTDVVLPGAVSLRYSGRTAASETLSGHGPLAQPLTLQ
                     VLVAGNPQNVRLRYSFFVPRPVPSTPRPPPQNWLQRRAEILEILRKRTWAGRK"
     exon            1..675
                     /gene="Adamts4"
                     /inference="alignment:Splign:2.1.0"
     exon            676..999
                     /gene="Adamts4"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1132
                     /gene="Adamts4"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1303
                     /gene="Adamts4"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1590
                     /gene="Adamts4"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1777
                     /gene="Adamts4"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1953
                     /gene="Adamts4"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2129
                     /gene="Adamts4"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..3339
                     /gene="Adamts4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcctcaa tccatcccag ctgcagcact ggtaccatgt ccaggatggg cttgcatccc
       61 aggaggggct tgactgggca cagactgcga agactccaac cctgcctgcc gccccgcact
      121 gtgcctttct ctggtttgga gcggtggcag cagctgctgc tgctggcctc cctcctgcct
      181 ttagcctggt cagccagccc cctcccccga gaggaggaga tcgtgtttcc agagaagctc
      241 aacggcagta gtatcatacc tggctcaggc gtccctgcca ggctgctgta ccgattacca
      301 gcctttgggg agatattgtt actagaacta gagcaggatc ctggggtgca ggtagagggg
      361 ctgacagtac agtacctggg ccaggcacct gagatgctgg gtggggcaga gccaggtacc
      421 tacctgactg gcaccatcaa tggagatccg gagtcggtgg cgtctctgca ctgggacagg
      481 ggagccctat tgggggtatt gcagtaccgg ggggccgaac tccacctcca gcctctggaa
      541 ggaggcgccc ttaactctgc tgggggacca ggggctcaca tcctacgccg gaagagtcct
      601 gccagcaacc gaggtcccat atgcaacgtc aaggctcctt ctgggagccc cagtcccatt
      661 tcccgcagaa acaagcgctt cgcttcgctg agtagattcg tggagacact ggtggtggca
      721 gatgacaaga tggcagcatt ccacggggca gggttaaagc actacctgct gacggtcatg
      781 gccgccgctg ccaaagcctt taagcatcca agcatccgaa accctgtcaa cttggtggtg
      841 actcgtctag taatcctggg gtcgggccag gaagtgcccc aagtggggcc aagtgccgcc
      901 cagaccctac gcagcttctg cacctggcag aaaggcctaa accctccgaa cgactcagat
      961 cctgaccact ttgacacggc cattctgttc acccggcagg acctgtgtgg ggtctccacc
     1021 tgtgacgctc tgggtatggc tggtgtgggc acagtgtgtg acccagctag gagctgtgct
     1081 attgtggagg acgatgggct ccagtcggcc ttcaccgccg ctcatgaact gggccatgtc
     1141 ttcaacatgc tccatgataa ctccaaaccg tgtgctaatt tgaatgggca ggggagttcc
     1201 tctcgccatg tcatggctcc tgtcatggct cacgtggacc ctgaagagcc ctggtccccc
     1261 tgcagtgccc gattcatcac tgacttcctg gacaatggct atggacactg cctcttagac
     1321 aaaccagagg ctcccctgca tctgccagtg acttttcctg gcaaggacta tgatgctgac
     1381 cgccagtgcc aactgacctt tggtcctgac tcaagccatt gtccacagct gccaccgccc
     1441 tgtgctgccc tctggtgctt tggccacctc aatggccatg ccatgtgtca gactaagcac
     1501 tcaccctggg ccgatggtac tccctgcgga cctgcacagg cctgtatggg tggccgctgt
     1561 ctccacgtgg accagctcaa ggacttcaat attcctcagg ctggaggctg gggtccctgg
     1621 ggaccatggg gtgactgctc caggacttgt ggaggtggtg tccaattctc ctcccgggac
     1681 tgcacaaagc ctgtcccccg gaatggtgga aagtattgtg agggccgccg taccccgttc
     1741 cgctcctgta acactaagaa ctgcccacat ggctcagcat tgaccttccg tgaagagcag
     1801 tgtgctgcct acaaccaccg aaccgacctc ttcaagagtt ttccggggcc catggactgg
     1861 gttccgcgct acacaggtgt agcccctcga gaccagtgca aactcacctg ccaggcccgg
     1921 gcactgggct actactatgt actggagcca cgggtggcag atggaactcc ctgttcccca
     1981 gactcttcct ctgtctgtgt ccagggccgc tgtatccacg ctggctgtga tcgaatcatt
     2041 ggctccaaaa agaaatttga caagtgcatg gtgtgcggtg ggaatggctc tagctgcagc
     2101 aagcagtcag gctccttcaa aaaattcagg tacggataca gcgatgtggt cacgatccct
     2161 gcgggacgca cccatatcct tgtacggcag cagggaggat ctggcctcaa gagcatctac
     2221 ctggccctga agctagcaga tggttcttac gccctcaatg gtgaatacac gctgatgccc
     2281 tcctcaacag atgtggtact tcctggggca gtcagcttgc gctatagcgg acgcacggca
     2341 gcctcagaga cactgtctgg acatgggccg ctggcccagc ccttgacgct gcaagttctg
     2401 gtggctggca acccacagaa tgtacgtctg cggtacagtt tctttgtccc gcggccagtc
     2461 ccttcaacgc cacgccctcc tccccaaaac tggctgcaac gcagggcaga gattctggag
     2521 atccttcgga agcgaacctg ggcaggccgg aaataacctc actgtcccgg ctgccctttt
     2581 ggggcgccgg ggcctcggac tcatctggga gaatgagcgg gcttctgcag ctgcctcgtg
     2641 ctaaaacaca gtagggaggt gtagagggtg agacctgctt gcctctctgc cccaaaccgc
     2701 aggctggccc tgccctggct tcctgccctg ggaggcagtg atgtgttggt gaatggaaag
     2761 gagcctacct gacagtaccc catctattta actgccccct ctaccctgca ggtcacagga
     2821 gggagcgggg aagacagggt ggggtcctgg gccccagttg tatttattta gtatttattc
     2881 acttttattt agcaccaggg aaggggacta ggaatgggga aactcaccca ttataggccc
     2941 atcctagcta tgaaatccag ggtgttggtg acaaatataa gtgtgtgtgc gcgttcgcgt
     3001 ggtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt tatgtatgag
     3061 gtacaacctg ccctactttc ctcttttcct gatttttccc ctgggaaaag gagagtcaaa
     3121 ggtaggattg ccttcaggga gtaagggatc atcacgtttt tttttttaaa ttgaagtttg
     3181 ctatttatct gctgtttttg gagtcagaca aatgtgggcc atactttggc cccgcatctt
     3241 tgaacattcc ttttctcatg tgccaataat aatacctccc ttagaaatct gttgtaagga
     3301 ttaaataatg taaataaaga actagcatca tgcctccca
//
