LOCUS       NP_076449                851 aa            linear   ROD 01-APR-2024
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 4
            [Rattus norvegicus].
ACCESSION   NP_076449 XP_001053685 XP_341155
VERSION     NP_076449.1
DBSOURCE    REFSEQ: accession NM_023959.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 851)
  AUTHORS   Tatar,M., Uslu,S. and Oner,J.
  TITLE     Expression of placental growth factor and a disintegrin and
            metalloprotease with a thrombospondin type motifs 1-4-8 during the
            three trimesters of rat pregnancy at the maternal-fetal interface
  JOURNAL   Anat Histol Embryol 52 (5), 805-814 (2023)
   PUBMED   37424113
  REMARK    GeneRIF: Expression of placental growth factor and a disintegrin
            and metalloprotease with a thrombospondin type motifs 1-4-8 during
            the three trimesters of rat pregnancy at the maternal-fetal
            interface.
REFERENCE   2  (residues 1 to 851)
  AUTHORS   Tio,L., Martel-Pelletier,J., Pelletier,J.P., Bishop,P.N.,
            Roughley,P., Farran,A., Benito,P. and Monfort,J.
  TITLE     Characterization of opticin digestion by proteases involved in
            osteoarthritis development
  JOURNAL   Joint Bone Spine 81 (2), 137-141 (2014)
   PUBMED   23845380
REFERENCE   3  (residues 1 to 851)
  AUTHORS   Soteriou,D., Iskender,B., Byron,A., Humphries,J.D.,
            Borg-Bartolo,S., Haddock,M.C., Baxter,M.A., Knight,D.,
            Humphries,M.J. and Kimber,S.J.
  TITLE     Comparative proteomic analysis of supportive and unsupportive
            extracellular matrix substrates for human embryonic stem cell
            maintenance
  JOURNAL   J Biol Chem 288 (26), 18716-18731 (2013)
   PUBMED   23658023
REFERENCE   4  (residues 1 to 851)
  AUTHORS   Py,B.F., Gonzalez,S.F., Long,K., Kim,M.S., Kim,Y.A., Zhu,H.,
            Yao,J., Degauque,N., Villet,R., Ymele-Leki,P., Gadjeva,M.,
            Pier,G.B., Carroll,M.C. and Yuan,J.
  TITLE     Cochlin produced by follicular dendritic cells promotes
            antibacterial innate immunity
  JOURNAL   Immunity 38 (5), 1063-1072 (2013)
   PUBMED   23684986
REFERENCE   5  (residues 1 to 851)
  AUTHORS   Funck-Brentano,T., Lin,H., Hay,E., Ah Kioon,M.D., Schiltz,C.,
            Hannouche,D., Nizard,R., Liote,F., Orcel,P., de Vernejoul,M.C. and
            Cohen-Solal,M.E.
  TITLE     Targeting bone alleviates osteoarthritis in osteopenic mice and
            modulates cartilage catabolism
  JOURNAL   PLoS One 7 (3), e33543 (2012)
   PUBMED   22432033
REFERENCE   6  (residues 1 to 851)
  AUTHORS   Sone,S., Nakamura,M., Maruya,Y., Takahashi,I., Mizoguchi,I.,
            Mayanagi,H. and Sasano,Y.
  TITLE     Expression of versican and ADAMTS during rat tooth eruption
  JOURNAL   J Mol Histol 36 (4), 281-288 (2005)
   PUBMED   16200461
  REMARK    GeneRIF: This study suggests that dental pulp cells, odontoblasts,
            cementoblasts, cementocytes, periodontal ligament cells,
            osteoblasts and osteocytes may be involved in both production and
            degradation of versican with secreting ADAMTS1, ADAMTS4 and
            ADAMTS5.
REFERENCE   7  (residues 1 to 851)
  AUTHORS   Somerville,R.P., Longpre,J.M., Apel,E.D., Lewis,R.M., Wang,L.W.,
            Sanes,J.R., Leduc,R. and Apte,S.S.
  TITLE     ADAMTS7B, the full-length product of the ADAMTS7 gene, is a
            chondroitin sulfate proteoglycan containing a mucin domain
  JOURNAL   J Biol Chem 279 (34), 35159-35175 (2004)
   PUBMED   15192113
REFERENCE   8  (residues 1 to 851)
  AUTHORS   Wang,P., Tortorella,M., England,K., Malfait,A.M., Thomas,G.,
            Arner,E.C. and Pei,D.
  TITLE     Proprotein convertase furin interacts with and cleaves pro-ADAMTS4
            (Aggrecanase-1) in the trans-Golgi network
  JOURNAL   J Biol Chem 279 (15), 15434-15440 (2004)
   PUBMED   14744861
REFERENCE   9  (residues 1 to 851)
  AUTHORS   Yamanishi,Y., Boyle,D.L., Clark,M., Maki,R.A., Tortorella,M.D.,
            Arner,E.C. and Firestein,G.S.
  TITLE     Expression and regulation of aggrecanase in arthritis: the role of
            TGF-beta
  JOURNAL   J Immunol 168 (3), 1405-1412 (2002)
   PUBMED   11801682
REFERENCE   10 (residues 1 to 851)
  AUTHORS   Satoh,K., Suzuki,N. and Yokota,H.
  TITLE     ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin
            motifs) is transcriptionally induced in beta-amyloid treated rat
            astrocytes
  JOURNAL   Neurosci Lett 289 (3), 177-180 (2000)
   PUBMED   10961658
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1, CB614460.1, AB042271.1, AB042272.1 and
            AB042273.1.
            
            On or before Dec 17, 2009 this sequence version replaced
            XP_341155.3, XP_001053685.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.653808.1,
                                           SRR26643298.52257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..851
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     Protein         1..851
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 4"
                     /EC_number="3.4.24.82"
                     /note="ADAM-TS4; ADAM-TS 4; aggrecanase-1; Aggrecanase;
                     ADAMTS-4; a disintegrin-like and metallopeptidase
                     (reprolysin type) with thrombospondin type 1 motif, 4; a
                     disintegrin and metallopeptidase with thrombospondin
                     motifs 4"
                     /calculated_mol_wt=91767
     Region          73..195
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          232..439
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(375..376,379,385)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          453..521
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          545..589
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          592..699
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          701..816
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     CDS             1..851
                     /gene="Adamts4"
                     /coded_by="NM_023959.1:1..2556"
                     /db_xref="GeneID:66015"
                     /db_xref="RGD:621242"
ORIGIN      
        1 masihpscst gtmsrmglhp rrgltghrlr rlqpclpprt vpfsglerwq qllllasllp
       61 lawsasplpr eeeivfpekl ngssiipgsg vparllyrlp afgeilllel eqdpgvqveg
      121 ltvqylgqap emlggaepgt yltgtingdp esvaslhwdr gallgvlqyr gaelhlqple
      181 ggalnsaggp gahilrrksp asnrgpicnv kapsgspspi srrnkrfasl srfvetlvva
      241 ddkmaafhga glkhylltvm aaaakafkhp sirnpvnlvv trlvilgsgq evpqvgpsaa
      301 qtlrsfctwq kglnppndsd pdhfdtailf trqdlcgvst cdalgmagvg tvcdparsca
      361 iveddglqsa ftaahelghv fnmlhdnskp canlngqgss srhvmapvma hvdpeepwsp
      421 csarfitdfl dngyghclld kpeaplhlpv tfpgkdydad rqcqltfgpd sshcpqlppp
      481 caalwcfghl nghamcqtkh spwadgtpcg paqacmggrc lhvdqlkdfn ipqaggwgpw
      541 gpwgdcsrtc gggvqfssrd ctkpvprngg kycegrrtpf rscntkncph gsaltfreeq
      601 caaynhrtdl fksfpgpmdw vprytgvapr dqckltcqar algyyyvlep rvadgtpcsp
      661 dsssvcvqgr cihagcdrii gskkkfdkcm vcggngsscs kqsgsfkkfr ygysdvvtip
      721 agrthilvrq qggsglksiy lalkladgsy alngeytlmp sstdvvlpga vslrysgrta
      781 asetlsghgp laqpltlqvl vagnpqnvrl rysffvprpv pstprpppqn wlqrraeile
      841 ilrkrtwagr k
//
