LOCUS       NP_001381639            1202 aa            linear   ROD 01-APR-2024
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 3
            isoform 2 precursor [Rattus norvegicus].
ACCESSION   NP_001381639 XP_006250835
VERSION     NP_001381639.1
DBSOURCE    REFSEQ: accession NM_001394710.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1202)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1202)
  AUTHORS   Jeltsch,M., Jha,S.K., Tvorogov,D., Anisimov,A., Leppanen,V.M.,
            Holopainen,T., Kivela,R., Ortega,S., Karpanen,T. and Alitalo,K.
  TITLE     CCBE1 enhances lymphangiogenesis via A disintegrin and
            metalloprotease with thrombospondin motifs-3-mediated vascular
            endothelial growth factor-C activation
  JOURNAL   Circulation 129 (19), 1962-1971 (2014)
   PUBMED   24552833
REFERENCE   3  (residues 1 to 1202)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (residues 1 to 1202)
  AUTHORS   Le Goff,C., Somerville,R.P., Kesteloot,F., Powell,K., Birk,D.E.,
            Colige,A.C. and Apte,S.S.
  TITLE     Regulation of procollagen amino-propeptide processing during mouse
            embryogenesis by specialization of homologous ADAMTS proteases:
            insights on collagen biosynthesis and dermatosparaxis
  JOURNAL   Development 133 (8), 1587-1596 (2006)
   PUBMED   16556917
REFERENCE   5  (residues 1 to 1202)
  AUTHORS   Fernandes,R.J., Hirohata,S., Engle,J.M., Colige,A., Cohn,D.H.,
            Eyre,D.R. and Apte,S.S.
  TITLE     Procollagen II amino propeptide processing by ADAMTS-3. Insights on
            dermatosparaxis
  JOURNAL   J Biol Chem 276 (34), 31502-31509 (2001)
   PUBMED   11408482
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On May 3, 2021 this sequence version replaced XP_006250835.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1202
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     Protein         1..1202
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 3 isoform 2 precursor"
                     /note="a disintegrin-like and metalloprotease (reprolysin
                     type) with thrombospondin type 1 motif, 3; A disintegrin
                     and metalloproteinase with thrombospondin motifs 3"
                     /calculated_mol_wt=132897
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2207
     Region          43..201
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          256..457
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(398..399,402,408)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          472..540
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          554..605
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          611..712
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          714..827
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          849..904
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          909..966
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          970..1015
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1023..1051
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..1202
                     /gene="Adamts3"
                     /coded_by="NM_001394710.1:488..4096"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="GeneID:305253"
                     /db_xref="RGD:1310750"
ORIGIN      
        1 mvflslwlia aslvevrtsa dgqagaeemv qidlptkryr eyelvtpvst nlkghylshi
       61 lsanhkkrsp rdvssnseql ffnvtafgrd fhlrlrpnth fiapgavvew hetaprpgnt
      121 tdprnsrphr ssseggwrse plqtscayvg dimdvpgtsv aisncdglag miksdneeyf
      181 ieplergkqm deengrihiv ykrsamerap rdvsedvyyk esnleglddl gtvysnigqq
      241 lnettrrrrh agendyniev llgvddsvvr fhgkehvqny lltlmnivne iyhdeslgvh
      301 invvlvrmim lgyaksisli ergnpsrsle nvcrwacqqq ksdpnhaehh dhaifltrqd
      361 fgpagmqgya pvtgmchpvr sctlnhedgf ssafvvahet ghvlgmehdg qgnrcgdeta
      421 mgsvmaplvq aafhryhwsr csgqelkryi hsydcllddp fehdwpklpe lpginysmde
      481 qcrfdfgvgy kmctafrtfd pckqlwcshp dnpyfcktkk gppldgteca agkwcykghc
      541 mwknanqqkq dgnwgswtkf gscsrtcgtg vrfrtrqcnn ptpinggqdc pgvnfeyqlc
      601 nteecqkhfe dfraqqcqqr nshfdyqntk hhwlphehpd skkrchlycq sketgdvaym
      661 kqlvhdgtrc sykdpysicv rgecvkvgcd keigsnkved kcgvcggdns hcrtvkgtft
      721 rtprklgylk mfdippgarh vliqedeasp hvlaiknqat ghyilngkge eaksrtfidl
      781 gvewdynied dietlhtdgp lhdpvivlii pqendtrssl tykyiiheds vptinsnnvi
      841 qeeldtfewa lkswsqcskp cgggfqytky gcrrksdskm vhrsfcevnk kpkpirrmcn
      901 iqecthplwa aeawehcsrs cgssgyqlrt vrclqplqdg tnrsvhsryc lgerpesrrp
      961 cnripcpaqw ktgpwnecsv tcgegtevrq vlcrtgdhcd gekpesvrac qlppcndepc
     1021 lgdksifcqm evlarycsip gyselccesc skrsgtlppp ylqeaaeihs daifgpsdlp
     1081 rslvmptpfl pyysgsradk kslssvssva npsayaafrs ssrasvsfpr kkaqeggtkt
     1141 pvsmppsssi ktdhlhsssp gaaapspait dsigaspqtr tpkkdgktis rrhpirstas
     1201 er
//
