LOCUS       NP_001101903            1211 aa            linear   ROD 03-APR-2024
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 19
            precursor [Rattus norvegicus].
ACCESSION   NP_001101903 XP_001060610 XP_006254817 XP_341620
VERSION     NP_001101903.2
DBSOURCE    REFSEQ: accession NM_001108433.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1211)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Apr 8, 2021 this sequence version replaced
            XP_006254817.1, NP_001101903.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN11044071
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1211
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     Protein         1..1211
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 19 precursor"
                     /note="A disintegrin and metalloproteinase with
                     thrombospondin motifs 19; a disintegrin-like and
                     metallopeptidase (reprolysin type) with thrombospondin
                     type 1 motif, 19"
                     /calculated_mol_wt=131563
     sig_peptide     1..30
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3307
     Region          162..277
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          329..546
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(486..487,490,496)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          563..630
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          <727..793
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          795..904
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          928..980
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          984..1040
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1044..1086
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1095..1147
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..1211
                     /gene="Adamts19"
                     /coded_by="NM_001108433.3:513..4148"
                     /db_xref="GeneID:361332"
                     /db_xref="RGD:1308359"
ORIGIN      
        1 mgpemrltri cccccllyql gflshgtisg mqltpdleew evvfpalwrr eslnatglst
       61 gsadpgsgrs agggsrgqps gssrevrsva rapleeaagg qsepwfaarp lqpgaedeee
      121 lesqelprgs sgdtslpsga papwqpspsp qppsspppaq qeepsteevl lripalsrdl
      181 ylllrrdgrf laqrfaveqw pkpgpdptra tvdprppmps dascfytgtv lrhpgslasf
      241 stcggglmgf iqlnedfifi epfndtmaii ghphrlyrqk rsseervtek saahrhhcgv
      301 isdkgrprsk klaenrrekr ysyklpqdyn ietvvvadpa mvsyhgadaa rrfiltilnm
      361 vfnlfqhksl gvqvnlrvik lillhetpad lyighhgekm lesfckwqhe efgrkndihl
      421 emstswgedv asvdaailit rkdfcvhkde pcdtvgiayl ngmcsekrkc iiaednglnl
      481 aftiahemgh nmginhdndh pscadglhim sgewikgqnl gdvswsrcsk edlerflrsk
      541 asscllhtdp qslssvlvps klpgmaytad eqcqilfgpl asfcqemqhv ictglwcrve
      601 gdtecrtkld ppmdgtdcdp gkwckagect rrtpapehla gewstwsscs rscgsgvssr
      661 erkcpglgse ardcngprkq yricenppcp aglpgfrdwq cqaysvrtsy pkhalqwqav
      721 fdeekpcalf cspvgkeqpv llsekvldgt scgyqgldvc angrcqkagc dgllgslare
      781 dhcgvcngng ksckvikgdf nhtrgagyve vlvipagarr ikvveekpah sylalrdask
      841 qsinsdwkie hsgafslagt tvhyirrglw ekisakgptt tplhllvllf qdqnyglhye
      901 ytvpsdplpd nqsskesgpl fmwthagwgd cnatcggger kttvsctkim nknislvdnk
      961 kckdltkpep qirkcneqpc qtrwmmtewt tcsrtcgkgv qsrqvactrq lengtliraw
     1021 erdcigpkpa tmqrcegqdc mtvweagvws ecsvkcgkgv rhrtvrctnp rkkcvlstrp
     1081 revedcedys kcyvwrvgdw skcsitcgkg mqsrviqcmh kitgrhgnec fssekpaayr
     1141 pchlqpcnek invntitspr laaltfkclg dqwpvycrvi reknlcqdmr wyqrccetcr
     1201 dfyaqklrqk s
//
