LOCUS       NM_001191944            3882 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1
            motif, 18 (Adamts18), mRNA.
ACCESSION   NM_001191944 XM_574244
VERSION     NM_001191944.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3882)
  AUTHORS   Xu,B., Zhang,J.E., Ye,L. and Yuan,C.W.
  TITLE     The progression of obstructive renal fibrosis in rats is regulated
            by ADAMTS18 gene methylation in the embryonic kidney through the
            AKT/Notch pathway
  JOURNAL   J Biochem Mol Toxicol 38 (1), e23628 (2024)
   PUBMED   38229317
  REMARK    GeneRIF: The progression of obstructive renal fibrosis in rats is
            regulated by ADAMTS18 gene methylation in the embryonic kidney
            through the AKT/Notch pathway.
REFERENCE   2  (bases 1 to 3882)
  AUTHORS   Aldahmesh,M.A., Alshammari,M.J., Khan,A.O., Mohamed,J.Y.,
            Alhabib,F.A. and Alkuraya,F.S.
  TITLE     The syndrome of microcornea, myopic chorioretinal atrophy, and
            telecanthus (MMCAT) is caused by mutations in ADAMTS18
  JOURNAL   Hum Mutat 34 (9), 1195-1199 (2013)
   PUBMED   23818446
REFERENCE   3  (bases 1 to 3882)
  AUTHORS   Li,Z., Nardi,M.A., Li,Y.S., Zhang,W., Pan,R., Dang,S., Yee,H.,
            Quartermain,D., Jonas,S. and Karpatkin,S.
  TITLE     C-terminal ADAMTS-18 fragment induces oxidative platelet
            fragmentation, dissolves platelet aggregates, and protects against
            carotid artery occlusion and cerebral stroke
  JOURNAL   Blood 113 (24), 6051-6060 (2009)
   PUBMED   19218546
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Jul 17, 2010 this sequence version replaced XM_574244.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.76587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000019.1  58748850-58748939   c
            91-181              JAXUCZ010000019.1  58748657-58748747   c
            182-498             JAXUCZ010000019.1  58745206-58745522   c
            499-781             JAXUCZ010000019.1  58680336-58680618   c
            782-975             JAXUCZ010000019.1  58678039-58678232   c
            976-1059            JAXUCZ010000019.1  58677636-58677719   c
            1060-1219           JAXUCZ010000019.1  58675761-58675920   c
            1220-1325           JAXUCZ010000019.1  58673692-58673797   c
            1326-1463           JAXUCZ010000019.1  58668883-58669020   c
            1464-1617           JAXUCZ010000019.1  58666010-58666163   c
            1618-1713           JAXUCZ010000019.1  58657109-58657204   c
            1714-1862           JAXUCZ010000019.1  58653591-58653739   c
            1863-2035           JAXUCZ010000019.1  58646796-58646968   c
            2036-2166           JAXUCZ010000019.1  58641942-58642072   c
            2167-2290           JAXUCZ010000019.1  58640603-58640726   c
            2291-2535           JAXUCZ010000019.1  58639996-58640240   c
            2536-2677           JAXUCZ010000019.1  58612980-58613121   c
            2678-2804           JAXUCZ010000019.1  58611836-58611962   c
            2805-3009           JAXUCZ010000019.1  58608315-58608519   c
            3010-3192           JAXUCZ010000019.1  58605644-58605826   c
            3193-3396           JAXUCZ010000019.1  58603892-58604095   c
            3397-3544           JAXUCZ010000019.1  58601925-58602072   c
            3545-3882           JAXUCZ010000019.1  58597745-58598082   c
FEATURES             Location/Qualifiers
     source          1..3882
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..3882
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif, 18"
                     /db_xref="GeneID:361412"
                     /db_xref="RGD:1560118"
     CDS             1..3660
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /note="a disintegrin-like and metallopeptidase (reprolysin
                     type) with thrombospondin type 1 motif, 18; A disintegrin
                     and metalloproteinase with thrombospondin motifs 18"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 18 precursor"
                     /protein_id="NP_001178873.1"
                     /db_xref="GeneID:361412"
                     /db_xref="RGD:1560118"
                     /translation="MECALLFLCALRAAGPGPPWGPAGLARLAKALQLCCLCCASVAV
                     ALASDSGSSGGSGLNDDYVFVVPVEVDSGGSYISHDILHNRKRRSAHGASSSVHYRFS
                     AFGQDLHLELKPSALLSSHFIVQVLGKDGASETREPAVVQQCLYQGFIRNDSLSSVAV
                     STCAGLSGLIRTRDNEFLISPLPQLLAQQHNYSLPAGHHPHVLYKRTAEKRVRRYQDY
                     PASQRTYPGHSPSHTPPASQSQETEYRHRRWQKQHFCGRRKKYAPKPPAEDAYLRFDE
                     YGGAGRPRRSARKSQKGLNVETLVVADAKMVEKHGKDDVTTYILTVMNMVSSLFKDGT
                     IGSDINIVVVSLILLEDEPGGLLINHHADQSLNSFCQWQSALVGKNGKRHDHAILLTG
                     FDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMVHDGE
                     GNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQTGQYKYP
                     DKLPGQIYDADTQCKWQFGAKAKLCSLGVMKDICKSLWCHRVGHRCETKFMPAAEGTV
                     CGLSMWCRQGQCVRLGDLGPRPIHGQWSAWSKWSECSRTCGGGVKYQERHCSNPKPQY
                     GGKYCPGSSRIYKLCNINPCHENSLDFRAQQCAEYNNKPFRGWLYRWRPYTKVEEEDR
                     CKLYCKAENFEFFFAMSGKVKDGTPCSPHRNDVCIDGICEPVGCDHELGSKAVSDACG
                     VCKGDNSTCKFYKGLYLSQHKANEYYPVVTIPAGARSIEIQELELSSSYLAVRSLSQK
                     YYLTGGWNIDWPGDFTFAGTTFEYQRPFNRPERLYAPGPTNETLVFEILTQGKNPGIT
                     WKYALPKVMNVTQPAAKRHHHTWRTVQSDCSVTCGGGYISIKAICLRDQNTQVNSSFC
                     SVRTKPATEPKLCNAFSCPAYWLPGEWSTCSKSCAGGQQSRKIRCVQKKPFQKEEAVL
                     HSLCPVSTPTQVQVCNSHACPPEWSPGPWSQCSKTCGRGVRRREVLCTSPAAETLPES
                     LCSSSPKPEAQEGCVLGRCPKNNRLQWIASAWTECSATCGLGVRKREFKCMEKTLQGK
                     LMTFPERRCRNIKKPNLELEETCNRRACPVYSMAAGWYSSPWQQCTVTCGGGVQTRSV
                     HCMQQGRPSSSCLLHQKPPVLRACNTNFCPVPEKRDDPSCVDFFSWCRLVPQHGVCNH
                     KFYGKQCCRSCSRKS"
     exon            1..90
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            91..181
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            182..498
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            499..781
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            782..975
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1059
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1219
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1325
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1463
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1617
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1713
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1862
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..2035
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2166
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2290
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2535
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2677
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2804
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..3009
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3192
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3396
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..3544
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
     exon            3545..3882
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagtgcg ccctcctgtt cctgtgcgcc ctccgggccg ccggtcctgg gccgccgtgg
       61 gggcccgcgg gactggcgcg tctggccaag gcgctccagc tgtgctgcct ctgctgtgct
      121 tcggtggccg tcgccttagc cagtgacagc ggcagcagcg gtggcagcgg attaaatgat
      181 gattacgtct ttgtcgtgcc agtagaagtg gactcgggcg ggtcatatat ttcgcacgac
      241 attttgcaca acaggaaaag gcgatcggca cacggtgcca gcagctccgt gcactaccgc
      301 ttttcagcat ttggacagga tctacactta gagcttaagc cctcggcgct tttgagcagt
      361 cactttatag tccaggtact tggaaaggat ggtgcttcag agactcggga gcctgcggtg
      421 gtacagcagt gtttgtatca gggatttatc agaaatgaca gcctgtcctc tgttgctgtg
      481 tctacgtgtg ccggcttgtc aggtctgata aggacacgag acaatgaatt cctcatctca
      541 ccgctacctc agctgctggc ccagcaacac aactacagct tgcctgcagg ccaccatcct
      601 cacgtcctgt acaaaaggac agcagagaag agggtcagga ggtatcaaga ctaccctgcc
      661 tcccagcgga catatcctgg tcactcccca agtcacaccc cccctgcctc ccagagccaa
      721 gagacagagt accgccatcg aaggtggcaa aagcagcatt tttgtggacg acgcaagaaa
      781 tatgccccca aacctcctgc agaagatgcc tatctacgtt ttgatgaata tggaggcgca
      841 ggacggccca gacgatcagc cagaaagtct caaaagggtc tcaacgtgga gaccctcgtg
      901 gtggcagatg caaagatggt ggagaagcac ggcaaggatg acgtcactac gtacatcctc
      961 acagtcatga acatggtttc tagcctgttc aaagatggga ccattggaag tgacataaac
     1021 attgtggttg tgagcctaat tctgttggaa gacgaacctg gaggattgct gatcaatcac
     1081 catgcagacc agtctctaaa tagcttctgt caatggcagt cagcccttgt gggaaagaac
     1141 ggcaagagac acgaccatgc catcctcctc acaggatttg acatttgttc ctggaagaac
     1201 gaaccgtgtg acaccctagg atttgcacct atcagtggga tgtgcagtaa ataccgaagc
     1261 tgtaccatca atgaagacac aggacttggc cttgccttca ccattgcaca tgagtcaggg
     1321 cacaactttg gcatggttca tgatggcgaa ggcaacccct gcaggaaggc ggaaggcaac
     1381 atcatgtccc ccacgctgac cggaaacaat ggggtgtttt catggtcctc ctgcagccgt
     1441 cagtatctaa agaaattcct cagtacacca caggctggct gtctggtgga tgagcccaag
     1501 caaacgggac agtataaata tccggacaaa ctcccaggac agatttatga tgccgacacg
     1561 cagtgtaagt ggcaatttgg agccaaagcc aagctgtgca gccttggggt tatgaaggac
     1621 atttgcaagt cgctctggtg ccaccgcgtg ggccacagat gtgaaaccaa gttcatgcct
     1681 gcagccgagg ggaccgtctg tggcttgagc atgtggtgtc ggcaaggcca atgtgtaagg
     1741 cttggagatc tcgggccccg gcccatccac ggccagtggt ctgcctggtc gaagtggtca
     1801 gaatgttctc gaacatgcgg tggaggagtc aagtaccagg agagacactg tagtaacccc
     1861 aagcctcagt atggtgggaa gtactgtcca ggatctagcc gcatctacaa gctgtgcaac
     1921 attaaccctt gtcatgagaa tagcttggat ttccgtgccc agcaatgtgc agagtataac
     1981 aacaagccct tccggggatg gttgtaccgt tggagaccct atacaaaagt tgaagaggaa
     2041 gatcgatgta aactctactg caaggctgag aactttgagt tttttttcgc catgtctggc
     2101 aaggtgaaag acgggacgcc ttgctcccca cacagaaatg atgtctgcat cgacgggatt
     2161 tgtgaacctg tgggatgcga ccatgaactt ggctctaagg cagtgtcaga tgcatgcggt
     2221 gtttgcaaag gcgataactc gacttgcaag ttttataaag gcctgtacct cagtcagcac
     2281 aaagccaacg agtattatcc tgtggtcact atccccgctg gggcccgaag cattgaaatt
     2341 caggagttgg agctttcttc cagctatctt gctgttcgaa gcctcagtca aaagtattac
     2401 ctcacagggg gctggaacat cgactggcct ggggacttca ccttcgccgg caccacattt
     2461 gaataccagc gtccctttaa ccgccctgaa cgactgtacg cgccaggacc cacaaatgag
     2521 acgctggtct ttgaaattct gacccaaggc aagaaccccg ggatcacttg gaagtacgca
     2581 cttcccaagg tcatgaatgt aactcagcca gcggccaaga gacaccacca cacctggcgc
     2641 acagtacagt ctgactgctc ggtcacctgc ggcggaggtt acataagcat caaggccatt
     2701 tgcttacgag atcaaaacac ccaagtcaat tcctcattct gcagtgtaag aaccaagcca
     2761 gcaacggaac ccaagctatg caatgctttc tcctgcccag cctattggtt gccaggtgag
     2821 tggagtacat gcagcaagtc ctgtgccggg ggccagcaga gccgcaagat ccggtgtgtg
     2881 cagaagaagc ccttccagaa agaggaggct gtgctgcatt ctctctgtcc agtgagcacg
     2941 cctacccagg ttcaagtctg caacagccat gcctgccctc cagagtggag ccccgggccc
     3001 tggtctcagt gttccaagac ctgtggccgg ggagtgagga gacgtgaggt cctctgtaca
     3061 agccctgcag ccgagacact ccccgagagc ctgtgttcca gcagccccaa acccgaggca
     3121 caggagggct gtgtgctggg acggtgcccc aagaacaaca gactgcagtg gatcgcctct
     3181 gcctggactg agtgttctgc aacctgtggc ttgggtgtga ggaagagaga attcaagtgc
     3241 atggagaaga ccctgcaggg aaagctgatg acgttcccag agcggagatg tcgcaacatt
     3301 aagaagccaa acctggaact ggaagaaacc tgcaaccgaa gggcttgccc agtatacagc
     3361 atggcggcag gctggtattc gtccccgtgg caacagtgca ctgtaacctg tgggggaggg
     3421 gtccagaccc gatctgtcca ctgcatgcag caaggccggc cttcctcaag ttgtctgctc
     3481 catcagaagc ctccggtgct aagagcctgt aataccaact tctgtccagt tcctgaaaag
     3541 agagatgatc cgtcgtgtgt ggatttcttc agctggtgtc gcctggtccc tcagcacgga
     3601 gtctgcaacc acaaatttta tggaaaacag tgctgtcgat catgctcaag gaagagctga
     3661 tctcagggtc tcctcatccc cctcagacca ggacctgacc cgtccatctc caggtcttca
     3721 tatcaagact acaaaccaca gaggaattgc cacggggttt aaaaaactgg acagatagcc
     3781 accggcctcc ttagttgagc cctggaaaca catggtactc tccaacactt gacagtgaga
     3841 cgcgatgaca aatctaactt aaaaggaaaa aaaaaaaaaa aa
//
