LOCUS       NP_001178873            1219 aa            linear   ROD 09-APR-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 18
            precursor [Rattus norvegicus].
ACCESSION   NP_001178873 XP_574244
VERSION     NP_001178873.1
DBSOURCE    REFSEQ: accession NM_001191944.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1219)
  AUTHORS   Xu,B., Zhang,J.E., Ye,L. and Yuan,C.W.
  TITLE     The progression of obstructive renal fibrosis in rats is regulated
            by ADAMTS18 gene methylation in the embryonic kidney through the
            AKT/Notch pathway
  JOURNAL   J Biochem Mol Toxicol 38 (1), e23628 (2024)
   PUBMED   38229317
  REMARK    GeneRIF: The progression of obstructive renal fibrosis in rats is
            regulated by ADAMTS18 gene methylation in the embryonic kidney
            through the AKT/Notch pathway.
REFERENCE   2  (residues 1 to 1219)
  AUTHORS   Aldahmesh,M.A., Alshammari,M.J., Khan,A.O., Mohamed,J.Y.,
            Alhabib,F.A. and Alkuraya,F.S.
  TITLE     The syndrome of microcornea, myopic chorioretinal atrophy, and
            telecanthus (MMCAT) is caused by mutations in ADAMTS18
  JOURNAL   Hum Mutat 34 (9), 1195-1199 (2013)
   PUBMED   23818446
REFERENCE   3  (residues 1 to 1219)
  AUTHORS   Li,Z., Nardi,M.A., Li,Y.S., Zhang,W., Pan,R., Dang,S., Yee,H.,
            Quartermain,D., Jonas,S. and Karpatkin,S.
  TITLE     C-terminal ADAMTS-18 fragment induces oxidative platelet
            fragmentation, dissolves platelet aggregates, and protects against
            carotid artery occlusion and cerebral stroke
  JOURNAL   Blood 113 (24), 6051-6060 (2009)
   PUBMED   19218546
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Jul 17, 2010 this sequence version replaced XP_574244.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.76587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1219
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     Protein         1..1219
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 18 precursor"
                     /note="a disintegrin-like and metallopeptidase (reprolysin
                     type) with thrombospondin type 1 motif, 18; A disintegrin
                     and metalloproteinase with thrombospondin motifs 18"
                     /calculated_mol_wt=130790
     sig_peptide     1..47
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=4686
     Region          65..204
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          294..495
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(437..438,441,447)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          512..579
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          593..645
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          649..749
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          751..862
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          884..932
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          936..992
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          996..1049
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1057..1116
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1125..1171
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1186..1216
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..1219
                     /gene="Adamts18"
                     /gene_synonym="RGD1560118"
                     /coded_by="NM_001191944.1:1..3660"
                     /db_xref="GeneID:361412"
                     /db_xref="RGD:1560118"
ORIGIN      
        1 mecallflca lraagpgppw gpaglarlak alqlcclcca svavalasds gssggsglnd
       61 dyvfvvpvev dsggsyishd ilhnrkrrsa hgasssvhyr fsafgqdlhl elkpsallss
      121 hfivqvlgkd gasetrepav vqqclyqgfi rndslssvav stcaglsgli rtrdneflis
      181 plpqllaqqh nyslpaghhp hvlykrtaek rvrryqdypa sqrtypghsp shtppasqsq
      241 eteyrhrrwq kqhfcgrrkk yapkppaeda ylrfdeygga grprrsarks qkglnvetlv
      301 vadakmvekh gkddvttyil tvmnmvsslf kdgtigsdin ivvvslille depggllinh
      361 hadqslnsfc qwqsalvgkn gkrhdhaill tgfdicswkn epcdtlgfap isgmcskyrs
      421 ctinedtglg laftiahesg hnfgmvhdge gnpcrkaegn imsptltgnn gvfswsscsr
      481 qylkkflstp qagclvdepk qtgqykypdk lpgqiydadt qckwqfgaka klcslgvmkd
      541 ickslwchrv ghrcetkfmp aaegtvcgls mwcrqgqcvr lgdlgprpih gqwsawskws
      601 ecsrtcgggv kyqerhcsnp kpqyggkycp gssriyklcn inpchensld fraqqcaeyn
      661 nkpfrgwlyr wrpytkveee drcklyckae nfefffamsg kvkdgtpcsp hrndvcidgi
      721 cepvgcdhel gskavsdacg vckgdnstck fykglylsqh kaneyypvvt ipagarsiei
      781 qelelsssyl avrslsqkyy ltggwnidwp gdftfagttf eyqrpfnrpe rlyapgptne
      841 tlvfeiltqg knpgitwkya lpkvmnvtqp aakrhhhtwr tvqsdcsvtc gggyisikai
      901 clrdqntqvn ssfcsvrtkp atepklcnaf scpaywlpge wstcskscag gqqsrkircv
      961 qkkpfqkeea vlhslcpvst ptqvqvcnsh acppewspgp wsqcsktcgr gvrrrevlct
     1021 spaaetlpes lcssspkpea qegcvlgrcp knnrlqwias awtecsatcg lgvrkrefkc
     1081 mektlqgklm tfperrcrni kkpnleleet cnrracpvys maagwysspw qqctvtcggg
     1141 vqtrsvhcmq qgrpssscll hqkppvlrac ntnfcpvpek rddpscvdff swcrlvpqhg
     1201 vcnhkfygkq ccrscsrks
//
