LOCUS       NM_001372015            4980 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1
            motif, 16 (Adamts16), mRNA.
ACCESSION   NM_001372015 XM_003748684 XM_003753157
VERSION     NM_001372015.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4980)
  AUTHORS   Sarila G, Bao T, Abeydeera SA, Li R, Mell B, Joe B, Catubig A and
            Hutson J.
  TITLE     Interplay between collagenase and undescended testes in Adamts16
            knockout rats
  JOURNAL   J Pediatr Surg 55 (9), 1952-1958 (2020)
   PUBMED   32037220
  REMARK    GeneRIF: Interplay between collagenase and undescended testes in
            Adamts16 knockout rats.
REFERENCE   2  (bases 1 to 4980)
  AUTHORS   Abdul-Majeed S, Mell B, Nauli SM and Joe B.
  TITLE     Cryptorchidism and infertility in rats with targeted disruption of
            the Adamts16 locus
  JOURNAL   PLoS One 9 (7), e100967 (2014)
   PUBMED   24983376
  REMARK    GeneRIF: These observations, taken together with our previous
            report of renal abnormalities observed with the same Adamts16mutant
            rats, suggest an important mechanistic link between Adamts16 and
            the functioning of the male genitourinary system.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4980)
  AUTHORS   Jacobi CL, Rudigier LJ, Scholz H and Kirschner KM.
  TITLE     Transcriptional regulation by the Wilms tumor protein, Wt1,
            suggests a role of the metalloproteinase Adamts16 in murine
            genitourinary development
  JOURNAL   J Biol Chem 288 (26), 18811-18824 (2013)
   PUBMED   23661704
  REMARK    Erratum:[J Biol Chem. 2014 Apr 18;289(16):11566]
REFERENCE   4  (bases 1 to 4980)
  AUTHORS   Gopalakrishnan K, Kumarasamy S, Abdul-Majeed S, Kalinoski AL,
            Morgan EE, Gohara AF, Nauli SM, Filipiak WE, Saunders TL and Joe B.
  TITLE     Targeted disruption of Adamts16 gene in a rat genetic model of
            hypertension
  JOURNAL   Proc Natl Acad Sci U S A 109 (50), 20555-20559 (2012)
   PUBMED   23185005
  REMARK    GeneRIF: physiological observations functionally link Adamts16 to
            blood pressure regulation and suggest the vasculature as the
            potential site of action of Adamts16 to lower blood pressure
REFERENCE   5  (bases 1 to 4980)
  AUTHORS   Joe B, Saad Y, Dhindaw S, Lee NH, Frank BC, Achinike OH, Luu TV,
            Gopalakrishnan K, Toland EJ, Farms P, Yerga-Woolwine S,
            Manickavasagam E, Rapp JP, Garrett MR, Coe D, Apte SS, Rankinen T,
            Perusse L, Ehret GB, Ganesh SK, Cooper RS, O'Connor A, Rice T,
            Weder AB, Chakravarti A, Rao DC and Bouchard C.
  TITLE     Positional identification of variants of Adamts16 linked to
            inherited hypertension
  JOURNAL   Hum Mol Genet 18 (15), 2825-2838 (2009)
   PUBMED   19423552
  REMARK    GeneRIF: Genetic variation of Adamts16 is linked to inherited
            hypertension in a rat model.
            Erratum:[Hum Mol Genet. 2011 Nov 1;20(21):4297. Dhindaw, Seema
            [added]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000009.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001372015.3.
            
            On Feb 10, 2021 this sequence version replaced NM_001372015.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMN09345238 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               JACYVU010000009.1  5163421-5163702
            283-385             JACYVU010000009.1  5163813-5163915
            386-714             JACYVU010000009.1  5169737-5170065
            715-976             JACYVU010000009.1  5207869-5208130
            977-1176            JACYVU010000009.1  5210652-5210851
            1177-1260           JACYVU010000009.1  5213120-5213203
            1261-1420           JACYVU010000009.1  5216057-5216216
            1421-1526           JACYVU010000009.1  5217629-5217734
            1527-1664           JACYVU010000009.1  5225213-5225350
            1665-1818           JACYVU010000009.1  5232529-5232682
            1819-1914           JACYVU010000009.1  5234684-5234779
            1915-2063           JACYVU010000009.1  5238545-5238693
            2064-2236           JACYVU010000009.1  5239680-5239852
            2237-2367           JACYVU010000009.1  5241559-5241689
            2368-2491           JACYVU010000009.1  5243194-5243317
            2492-2736           JACYVU010000009.1  5243868-5244112
            2737-2875           JACYVU010000009.1  5254233-5254371
            2876-3002           JACYVU010000009.1  5266995-5267121
            3003-3204           JACYVU010000009.1  5282584-5282785
            3205-3399           JACYVU010000009.1  5282877-5283071
            3400-3624           JACYVU010000009.1  5285348-5285572
            3625-3772           JACYVU010000009.1  5291024-5291171
            3773-4980           JACYVU010000009.1  5292272-5293479
FEATURES             Location/Qualifiers
     source          1..4980
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..4980
                     /gene="Adamts16"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif, 16"
                     /db_xref="GeneID:306664"
                     /db_xref="RGD:1310046"
     exon            1..282
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..3888
                     /gene="Adamts16"
                     /note="A disintegrin and metalloproteinase with
                     thrombospondin motifs 16; a disintegrin-like and
                     metallopeptidase (reprolysin type) with thrombospondin
                     type 1 motif, 16"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 16 precursor"
                     /protein_id="NP_001358944.1"
                     /db_xref="GeneID:306664"
                     /db_xref="RGD:1310046"
                     /translation="MEPRGCFALWVLLLAQLSEQQTPACALGAAAAATERLGDPHPPS
                     SSGSDWLETSEYDLVSAYEVDHSGDYVSYDIMHHQRRRRRAVTQSKGDALHLRLKGPR
                     HDLHLDLKAASNLMAPGFMVQTLGKGGTKSVQMFPAEENCFYQGSLRSQGNSSVALST
                     CQGLLGMIRTKDADYFLKPLPPQLTSKLNRSAQGGSPSHILYKRSTEHQAPRENEVLM
                     ITRKRDLARTHLHHDNFHLGLSRKQHFCGRRKKYMPQPPDDNLYILPDEYKPSSRPKR
                     SLLKSHRNEELNVETLVVVDRKMLQSHGHENITTYVLTILNMVSALFKDGTIGGNINI
                     VIVGLILLEDEQPGLAISHHADRTLTSFCQWQSGLMGKDGARHDHAILLTGLDICSWK
                     NEPCDTLGFAPISGMCSKYRSCTVNEDSGLGLAFTIAHESGHNFGMVHDGEGNMCKKS
                     EGNIMSPTLAGRNGVFSWSSCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGQL
                     YDANTQCKWQFGEKAKLCMLDFRKDICKALWCHRIGRKCETKFMPAAEGTLCGQDMWC
                     RGGQCVKYGDEGPKPTHGHWSDWSPWSPCSRTCGGGVSHRDRLCTNPRPSHGGKFCQG
                     SARTLKLCNSQKCPLDSVGFRAAQCAEYNSKRFRGWLYKWTPYTQVEDQDLCKLYCIA
                     EGFDFFFSLSNKVKDGTPCSEDSRNVCIDGMCEKVGCDNVLGSDATEDSCGVCQGNNS
                     DCVMHRGLYSKNHPTNQYYHVVTIPSGARSIHIYETNISTSYISVRNSVKKYYLNGHW
                     SVDWPGRYKFSGTTFNYRRSYKEPESLTSTGPTNETLIVELLFQGRNPGVAWEFSVPR
                     SGSKRTPPPQPSYSWAILRSECSVSCGGGKMSSKAGCYRDLKVLVNASFCNPKTRPVP
                     ALVPCKVSACPPSWSVGNWSTCSRTCGGGTQSRPVHCTRRAHYREESISASLCPQPAP
                     PLHQACNSQSCPPAWSTGPWAECSRTCGKGWRKRTVACKSTNPSARAQLLHDTACTSE
                     PKPRTHQVCLLKRCHKHKKLQWLVSAWSPCSATCQRGTQHRVLRCAEKYVSGKYRELA
                     SKKCLHLPKPDLELERACGLIPCPKHPPYAASGPPRGSWFASPWSLCTASCGGGVQRR
                     TVQCLLGGQPASDCFLHEKPETSTACNTHFCPIAEKRDTFCRDLFHWCYLVPQHGMCS
                     HRFYSKQCCNTCSKSNL"
     exon            283..385
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            386..714
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            715..976
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1176
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1260
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1420
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1526
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1664
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1818
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1914
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2063
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2236
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2367
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2491
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2736
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2875
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..3002
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3204
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3399
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3624
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            3625..3772
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..4980
                     /gene="Adamts16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catggttgag gcgagtgctc tgccgccccc gccaccattg ccactccacc ccctggtgca
       61 gagcgaagct gcagtgataa ctccgatgtg tgtggtggag tcgctgcctg gaacccctgc
      121 gattttgccg ggtcgatcct ctgcacccta gcacactgct aacaccagtg acccaatcta
      181 gaccactgag ctgagtcctg tgagcccgcg gggcacacag ggatggaacc ccgcggttgc
      241 tttgcgctct gggtgctgtt gctggcgcag ctcagtgagc agcaaacacc tgcgtgcgcc
      301 ctaggagctg cagctgcagc gactgagcgc ctgggagacc ctcatcctcc ctcttcctcc
      361 gggtcggact ggctggaaac cagcgagtat gacctggtgt ctgcctatga ggtagaccac
      421 agcggggatt atgtatccta tgacatcatg catcaccagc ggcgacggag aagagctgtg
      481 acccagtcaa aaggagatgc ccttcatcta cggctgaagg gccccaggca tgacctccac
      541 ctagacctga aagctgccag caacttgatg gctcctggat tcatggtgca aactctgggg
      601 aagggaggca ccaagtctgt acagatgttt ccagcagagg agaactgctt ttatcaaggg
      661 tccttaaggt cccaggggaa ttcttctgtg gccctttcta cctgccaagg tttgttaggc
      721 atgataagaa caaaagacgc tgattacttc ttaaagccgc tgcctccaca actaacaagc
      781 aaactaaaca ggtctgcaca gggcggctct ccttcccata ttctgtacaa gagatccaca
      841 gagcaccagg ctcccagaga aaatgaagtc ctgatgatca ccaggaagcg agatctggca
      901 agaacgcatc tgcaccatga caactttcac cttggcctct cacgaaagca gcatttctgt
      961 ggaagacgca agaaatacat gccccaacct ccggatgata acctctacat cttgcctgat
     1021 gagtacaagc ctagctcccg acccaagcgc tcgctcttga aatcccacag aaatgaagag
     1081 ttgaatgtgg agactctggt ggtggttgac agaaaaatgc tgcaaagcca tggccatgaa
     1141 aatattacga cctatgtgct taccattctc aacatggtgt ctgctttatt caaggatgga
     1201 acaattgggg gaaacatcaa tattgtcatt gtgggactca ttctgctgga agacgaacag
     1261 ccagggctgg cgattagtca ccatgcagac cgcacgttaa ccagcttctg ccagtggcaa
     1321 tctggactga tggggaaaga tggagctcgt catgaccacg ccatcttact gactggtctg
     1381 gacatatgtt cctggaagaa tgaaccctgt gacacattgg gtttcgcacc catcagtggg
     1441 atgtgcagta agtaccgcag ctgcacggtc aacgaagact caggccttgg actggccttc
     1501 accattgctc atgaatctgg acacaacttt ggcatggtcc atgatggaga agggaatatg
     1561 tgcaagaagt ctgagggcaa cataatgtcc ccaacactgg caggacgcaa tggcgtcttc
     1621 tcctggtcct cctgcagtcg tcagtacctg cacaagttct taagcaccgc ccaagcaata
     1681 tgccttgctg accagccgaa gcctgtgaaa gagtacaagt acccggaaaa gctgccagga
     1741 cagttatacg atgcaaatac acagtgcaag tggcagtttg gagagaaagc caagctttgc
     1801 atgctggact tcagaaagga catctgtaag gccttgtggt gccatcggat tggaaggaaa
     1861 tgtgagacta agttcatgcc agcagcagag ggtacactgt gtgggcagga catgtggtgt
     1921 cgtggaggac agtgtgtgaa gtacggtgac gaaggcccca agcctactca cggccattgg
     1981 tcagattggt ccccttggtc cccctgttcc cggacctgtg ggggaggagt ctctcacaga
     2041 gaccgtctct gtaccaatcc cagaccatct catggaggga agttttgcca gggttccgca
     2101 cgcactctga agctttgcaa cagtcagaaa tgccctctgg acagtgtggg cttccgtgct
     2161 gcccagtgtg ctgagtacaa cagcaagcgt ttccgagggt ggctctacaa gtggacgcct
     2221 tacacccaag tggaagatca ggacttatgc aaactctact gtatcgcaga aggatttgat
     2281 ttcttctttt ctttgtcaaa taaagtcaaa gatgggactc catgctcgga ggatagccgt
     2341 aatgtttgta tagatgggat gtgtgagaag gttggctgtg acaatgtcct tggatcggat
     2401 gcaactgagg actcctgtgg ggtctgccag gggaataact cagactgcgt catgcataga
     2461 ggactctaca gtaagaatca ccccaccaac cagtactacc acgtggtaac cattccctct
     2521 ggagctcgga gcattcacat ctatgaaaca aacatctcta cctcctatat ttctgtgcgc
     2581 aattctgtca agaaatatta cctgaatggg cactggagtg tggactggcc agggcgatac
     2641 aagttttcag gtaccacctt caactacaga cgatcctaca aggagcctga gagtttaacc
     2701 tccactggac caaccaacga aacactgatt gtggagcttt tgttccaagg caggaaccct
     2761 ggagtggcct gggaattctc agtgcccagg tcagggtcta aaaggactcc acctccccag
     2821 cccagctact catgggctat cctgcgctct gagtgctctg tctcctgtgg aggaggtaag
     2881 atgagctcaa aggcgggatg ctacagagac ctgaaggttc tggtcaatgc atccttctgc
     2941 aaccccaaga cacgacctgt cccagcactg gtgccctgca aggtgtcagc ttgtcctccc
     3001 agctggtctg tgggaaactg gagcacatgc agccggacat gtggtggggg cacccagagc
     3061 aggcccgtgc actgtacacg gagggcacac taccgtgagg agtccatctc agccagcctg
     3121 tgtccacagc ctgcaccccc ccttcaccaa gcctgcaact ctcagagctg cccacctgct
     3181 tggagcactg ggccctgggc agagtgctca cggacctgtg ggaagggctg gaggaagagg
     3241 acagtggcct gcaagagcac caacccctca gctcgagccc agctgctgca tgacacggcc
     3301 tgcacttcgg aacccaagcc tcggacccac caagtctgcc tgctcaagcg ctgccacaag
     3361 cataagaagc tacagtggct ggtatctgcc tggtccccgt gctctgcgac atgccagaga
     3421 ggaacacagc atagagttct caggtgtgct gagaagtacg tctccggaaa gtaccgagag
     3481 ctggcctcca agaagtgctt gcatctgcca aagcctgacc tggaactgga acgtgcttgc
     3541 ggcctgattc cctgccccaa gcaccctccg tatgctgctt cagggccccc aagaggcagc
     3601 tggtttgcct caccctggtc tctgtgcaca gccagctgtg ggggtggtgt gcagaggaga
     3661 accgtgcagt gtctgctggg gggacagccg gcctcggatt gcttcctgca tgagaaaccc
     3721 gagacctcca cagcgtgcaa cacccatttc tgccctattg cagagaagag agacaccttc
     3781 tgcagagacc tattccactg gtgctacctg gtgccacagc atggcatgtg cagccacagg
     3841 ttctacagca agcagtgctg caacacctgt tccaagtcca acctgtgagc cgagaccagt
     3901 cctggtaaca agatgtcccc gtggcagaga gaggctagct gagagagctg cacagtgtgc
     3961 actgggatgc atccaaaaaa cgacaggagc tggaagaagg acttggtctt ttgacctaga
     4021 gtgaatccat gtgtttctga gcgcgggaac acataattgc acccacaaag gcatgttccg
     4081 ttgtcctggt tgggtgggga agtaggatcc tgcgggctgg cctcctgcac gtagatggga
     4141 gagtcggtgc tatagtgcgt aggaagcagc cccccccccc cctccttcca acgccatgtt
     4201 tatgtccagc caaattaaat tcgaaagaca gccagatcca atctggcaaa tgctggatgt
     4261 gttgcttaga agaaaaagac caagaaatca ggaaaatgtt cgtatctctg tcatccagca
     4321 caccagcctc cctccgtctt tggagaaccc attttcatca cgaaaagttt atggaccttg
     4381 aggagcaggt ataggctagc tccttactgc gccccgtggc tcctggaaca tgtacctggg
     4441 agtgggtggg ggtggggagc tctgatatag ggctttgcat acttggaaat ggataaacaa
     4501 cactcctgct aaggtgcttt ctctacttcc ggtccctggg ctggaggagc aacttcgata
     4561 ctttgtctcc gcctcagctt tttacaggaa gttcctgtct caattgtttt ctcaatgctg
     4621 ttctgtttta aatgagggat cggaaaggca cgttacacta aaatctaggt gtccctggaa
     4681 agtgagggtc cccgggaatc gaattcaatc aagtggccaa agcattgata gtgttaagcc
     4741 cgaggctgtg gtttgtgtgc tgagtggttt taaaatgcat cccatgagtt tgactggttc
     4801 tgagctgaca gccaaggcca atggccttca aaggaaaagc ccagggccac ctccaacctc
     4861 tctacccctc tccctcagta ttggtgctta tctctgcttt tcccacctag ggccttccca
     4921 gtaggaacac agatatttat atttgccgaa attttataat aaattttata ttgtatggtg
//
