LOCUS       NM_001106810            6064 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1
            motif, 15 (Adamts15), mRNA.
ACCESSION   NM_001106810 XM_001055387 XM_235976
VERSION     NM_001106810.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6064)
  AUTHORS   Dancevic CM, Fraser FW, Smith AD, Stupka N, Ward AC and McCulloch
            DR.
  TITLE     Biosynthesis and expression of a disintegrin-like and
            metalloproteinase domain with thrombospondin-1 repeats-15: a novel
            versican-cleaving proteoglycanase
  JOURNAL   J Biol Chem 288 (52), 37267-37276 (2013)
   PUBMED   24220035
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474007.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001055387.1, XM_235976.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN11044071,
                              SAMN16093044 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6064
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..6064
                     /gene="Adamts15"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif, 15"
                     /db_xref="GeneID:300474"
                     /db_xref="RGD:1309770"
     exon            1..1278
                     /gene="Adamts15"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..3174
                     /gene="Adamts15"
                     /note="A disintegrin and metalloproteinase with
                     thrombospondin motifs 15; a disintegrin-like and
                     metallopeptidase (reprolysin type) with thrombospondin
                     type 1 motif, 15"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 15 precursor"
                     /protein_id="NP_001100280.1"
                     /db_xref="GeneID:300474"
                     /db_xref="RGD:1309770"
                     /translation="MLLLGISILALAWRPASSSEPEWEVVVPIRRDPDINGRHYYRRG
                     TEDSGDQGLIFQITAFQQDFYLHLTPDAQFLAPAFATEYLGVPLQRLTGSSLDLRRCF
                     YSGYVNAEPDSFAAVSLCGGLRGAFGYQGAEYVISPLPNTSAPEAQRHSQGAHLLQRR
                     GAPVGPSGDPTSRCGVASGWNPAILRALDPYKPRRTGVGESHNRRRSGRAKRFVSIPR
                     YVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLGDRD
                     TGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMAD
                     VGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSP
                     TLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPITLPEDLPGTSYSLSQQCEL
                     AFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKFCLKGACVERH
                     NPNKYRVDGSWAKWEPYGPCSRTCGGGVQLARRQCSNPTPANGGKYCEGVRVKYRSCN
                     LEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANG
                     TGYFYVLAPKVVDGTLCTPDSTSVCVQGKCIKAGCDGNLGSKKKFDKCGVCGGDNKSC
                     KRVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGH
                     FVVSAVERDLVVKGSVLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSF
                     YLPKEPREDKSSRPKDPRGPPVLRNSVLSLSNQVEQPDNRPPARWVAGNWGPCSVSCG
                     SGLQKRAVDCRDSPGQQGISACDVDHRPVEKRACGEPCPTWELGNWSPCSKSCGRGFK
                     RRPLKCVGHGGRLLARDQCDLRRKPQELDFCVLRPC"
     exon            1279..1411
                     /gene="Adamts15"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1579
                     /gene="Adamts15"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1863
                     /gene="Adamts15"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2041
                     /gene="Adamts15"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2223
                     /gene="Adamts15"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2399
                     /gene="Adamts15"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..6064
                     /gene="Adamts15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcaccgcga acggctacgg ttcgcagagc agcccgccac ctcgcgtcac ttctccaccg
       61 caaattttcg cctgtgcact tgacagcgat cctactagag ctcccagagc gcgttttgct
      121 tagggaggaa caggtaggag gcgcgggctg ccctgtgcac gctcgctgtt ctgggaggag
      181 tctcccggac ttggttggct gtcctttctg ggaactgccc attgtcccgg gcgttggtgt
      241 gtgggctaca aggggacagt gcttgccgtg ggagccgggc taagtttcat cccagagcgc
      301 gtctgtgcgc ggcccggcgc catgcttcta ctgggcatct caatcctggc tcttgcctgg
      361 cgacctgcta gcagctccga gccagagtgg gaggtggtcg ttccaatccg acgggacccg
      421 gacatcaatg gccgccacta ctacaggagg ggtacggagg actccgggga tcagggtctc
      481 atttttcaga tcacagcttt tcagcaggac ttttatctac acctgacgcc agatgcccag
      541 ttcctggctc ccgcctttgc tactgagtat ctaggtgtcc ccctgcagag gctcactggc
      601 agctctctag acctgcgacg ctgcttctat tccgggtatg tgaacgcgga gccagactcc
      661 tttgctgctg taagcctatg cgggggtctc cgcggagcct ttggctacca aggtgcggag
      721 tatgtcatta gccctctgcc caacaccagc gcgcctgagg cgcagcgtca tagccagggc
      781 gcacaccttc tccagcgccg gggtgctccc gtagggcctt ccggagaccc tacctctcgc
      841 tgcggggtgg cctcgggctg gaaccccgcc atcctgaggg ccttggaccc ttataaacca
      901 cggcggacgg gcgtgggcga aagccacaac cggcgcaggt ctgggcgcgc caagcgcttc
      961 gtgtctatac cacggtacgt ggagacactg gtggtggcgg acgagtcaat ggtcaagttt
     1021 cacggcgcgg atttggaaca ttatctgctg acgctgctgg ccacggcggc gcgactctac
     1081 cgccacccca gcatcctcaa ccctatcaac atcgttgtgg tcaaggtgtt actcttagga
     1141 gatcgtgaca ctgggcccaa ggtcacaggc aacgcggccc tgactctgcg caacttctgt
     1201 gcctggcaga aaaagttgaa caaagtgagc gacaagcacc ccgagtactg ggacacagcc
     1261 atcctcttca ccagacagga cctatgcggg gctaccacct gtgacacctt gggcatggct
     1321 gatgtgggca ccatgtgtga tcccaagaga agctgctctg tcatcgagga cgatgggctt
     1381 ccgtcggcct tcaccactgc ccatgagctg ggccatgtgt tcaacatgcc ccatgacaac
     1441 gtgaaggtgt gtgaggaggt gtttgggaag ctcagagcca accacatgat gtctccgaca
     1501 ctcatccaga tcgaccgtgc caacccctgg tcagcctgca gtgctgccat tatcaccgac
     1561 ttcctggaca gcgggcacgg tgactgcctc ctggaccagc ccagcaagcc catcaccctg
     1621 cctgaggacc tgccaggcac aagctacagt ttgagccaac agtgcgagct ggcctttggg
     1681 gtgggctcta agccctgccc atatatgcag tactgtacaa agctgtggtg caccggcaag
     1741 gccaaggggc agatggtgtg ccagactcgc cacttcccct gggcagatgg caccagctgt
     1801 ggtgagggca agttctgcct caagggagcc tgcgtggaga gacacaaccc aaacaagtac
     1861 cgggtggacg gctcttgggc caagtgggag ccttatggtc cctgctcgcg cacctgcggt
     1921 gggggcgtgc agctggcccg gaggcagtgc agcaacccta cccctgccaa cggcgggaag
     1981 tactgcgagg gagtgagagt gaaataccga tcttgcaact tggagccctg ccccagctca
     2041 gcctctggca agagcttccg ggaagagcag tgtgaggctt tcaatggcta caaccacagt
     2101 accaacaggc tcactttagc tgtggcatgg gtacccaagt actccggcgt gtcaccacgt
     2161 gacaagtgta agctcatctg ccgagccaat ggtactggct acttctatgt gctagcacct
     2221 aaggtggtgg atggtacgct gtgtactccc gactccacct cggtctgtgt ccaaggcaag
     2281 tgcatcaagg ctggctgtga tgggaacctg ggctccaaga agaaatttga caaatgtggc
     2341 gtgtgtggtg gagacaataa gagctgcaag agggtgacag gactcttcac caagcctatg
     2401 cacggctaca attttgtagt ggccatccct gcaggcgcct ccagcattga catccgccag
     2461 cgtggttaca aggggctcat tggggatgac aactatctgg ccctgaagaa cagccaaggc
     2521 aaatacctgc tcaatgggca ctttgtggta tctgctgtag agagggacct ggtggtaaag
     2581 ggcagtgtgc tacgctatag tggcactggc actgcggtgg agagcctgca ggcgtctcga
     2641 cccatcctgg agccactaac cgtggaggtc ctgtccgtgg ggaagatgac accgccccgt
     2701 gtacgttatt ccttctatct gcccaaagag cctcgggagg acaaatcctc tcgccccaag
     2761 gaccctcggg gtcccccagt gttgcgcaac agtgttctca gcctttccaa ccaagtagag
     2821 cagccagaca acaggcctcc tgcgcgctgg gtggcaggca actgggggcc ttgctcggtg
     2881 agctgtggca gtggcctaca gaagcgagca gtggactgcc gggactcccc agggcagcaa
     2941 ggaatctctg cttgtgatgt agaccatcgg ccagtggaga agcgagcctg tggtgagccc
     3001 tgcccaacct gggagctcgg caactggtcg ccctgttcta agagctgtgg ccgtggattt
     3061 aagaggcgtc cgctcaagtg tgtgggccat ggaggcaggc tgctggctcg ggaccagtgt
     3121 gacctacgcc gcaagcccca ggaattagac ttctgtgtct tgagaccctg ctgaggggta
     3181 ctgtttcttc tactcctcta ttctaaaccc gctgctgtgc tggtgctgtg gtcagctgga
     3241 gcagaggaca gcggccagtg gtctgtgtca cagtgtcact cacatccaga atgaggacca
     3301 tgggtctggg cgagaggttc cttcctcctt ggactcggca gggggaagct aactaatgca
     3361 cagtctacct catgccctgc tcctcgggcc cagttgtggg gagaggcttc aagagatggg
     3421 tgctgggcag aaggtgctga aggccagctt ccaaggaacc tggaagttgg gtgccttcca
     3481 ggcagaactt cagggacctt ggcccccata atggaggtca caggctgctg gaagagccat
     3541 ggcctgcagc ttggcaccct caggtgatcc caggagctct gagcagtccc tgaacaaggc
     3601 aggggtctgg tggtgatttc caccttcttt gttttttgac tgatgtggac ctaacagtaa
     3661 aactgttcag gggttactag aagccaaagg gacaatgaga ttgggttcat ttgggcgcaa
     3721 ctttcctgtt tgctcatctt cagtcttgat cctccttgga agatcagcac tttgtaatct
     3781 ggatggccag ggcattagac cagctgggga agcctcgttg tggcccctga tgctttgaag
     3841 gcagcccgag aaactacagg gaccatttgt tggtcaagag agagcaacta tgtcaaacag
     3901 atacttgtca tgtcaaaggg gaaatgattt ggtggctgaa gcaaggaaca aaaaagctta
     3961 gagggctctt ctctcagtag ggttagaggg tggaggtgtt gaccttcaag aatgtcatcc
     4021 tgggatagcg aaaaggagtt ctgacacttt tgtcatctag cgaggaacat gtaaggaggc
     4081 tgatgatgcc ctagtgacct tccaaagtga ccatagccct gtacccactg agggggagtg
     4141 gtggtgcctg ggagtgtgag gtgctgagtg tccacgtgct ggcaggtcag cattccgctc
     4201 gctcgggcgg ctcctgctgt ctcctgtggg catgctacat tacatctccc agccttcatc
     4261 tctctggtag gtaaacgggg ctcattgttt gctacctcag atcacgctct ctaggacaga
     4321 agaaacctgg tgcttctacc agtctcagct ggatgtgccc aaccataaag atgggtttgt
     4381 gtgtggcttt cctgcttccc acagcctggc tatcatctgg ggccctaaat acgaagacag
     4441 gagtcaggta gagtgtcttt ttccctcagg ttccttggga tcaggtctta ggaaacgcta
     4501 agagtcaata ccctgacctt gagacactcg gaagccaccg gttgggacta ctggagaccc
     4561 atctgtcatc cttgtagaca tgacagtgaa atagaaatcc aggcatttct tatagcaggg
     4621 tatttttttt gaagacctgg aagctccagt gtatacaggg catcttcaaa gaatcagcag
     4681 tgcatccagg acctcagtgg agggttagat ggagacgaga ccaaaaccct tgtcttcaca
     4741 tggaggatag cagtctttgt caatcctttt acatgtttcc agggagtcaa aatccacaca
     4801 gcagccagtg ggcctgtttt gcccctagag cagtagttct caacctccta atgttgcaac
     4861 ctttaataca gttcctcatg ttgtggtgac cctcaaccat aaaagtattt tcattgttac
     4921 ttcataactc attttgctac tgttatgaat cttaacgtaa atttctgtgt tttccgatgg
     4981 tcttagtcaa cccctgtgaa aaggttgatt gtcctccaaa ggggccgcat gacccacagg
     5041 ttgagaacta ctactctaga ctgttattct aaccctgctc tgtctctggg ctggagacct
     5101 aggacagagc tcctacagtg ggcgaagggc atgtgaccct ttgaggctgg gctgtgaagg
     5161 acagcattgg ggtgggtggg ggtggggtgg gaggaatgag tacttcagag ctgtagagac
     5221 aaaaggtccc caaggcctga ggctaaaggg gagccttgct agctgaggag agcatggtac
     5281 ccagtgcttg gtgcattctt tccctgtgag gagaggtagt gctgggctgg gtagaagagg
     5341 tagaggtaca ggcaggtggg cagtgaggtg ccctcaccga ggtgactggc ctctaacaga
     5401 gtagcattgc tgtcagctgt tttacaagtc atttcaagga gggttggcca ctcttgttcc
     5461 tgatacatgc caggtgttca cactcttttt ctgtcacaat agttttaatt ttttttttat
     5521 tttttaaact tcttcttttt aagagaagta tgacgaagac agctttgtaa gttcgtcttg
     5581 cctttgtaca tcttctgtca accccttgct gagcagagat ggggcgaggg cacaggtttc
     5641 taatgatgga ataaaaagtc aaagtgatgt ctcacaacta taggggagga cgttctgggg
     5701 ggctccagga acgtcttcat caggttatgg accagtaaga ctttggtttg ggatccccta
     5761 gtctcttctg cctattgtgt gcactgattg gaggatttag acccaaatac cctcctttta
     5821 tggaccatgt catgttgggg agggggctga aaggagccca gtttggaagt cggctcctgg
     5881 agactctaga caccaatgct agaggctctt cccctatggg ttaactactt ttgcattttg
     5941 tgtactgcag aaggatgaga gggtctgggg actggctgag cgtgtatact gtgtatacat
     6001 gggagctggc tgctgaggtg acagcaacct actcctaata aagttggatg tctttaaaac
     6061 ttgc
//
