LOCUS       NM_001389237            5124 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1
            motif, 14 (Adamts14), mRNA.
ACCESSION   NM_001389237 XM_006256449
VERSION     NM_001389237.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5124)
  AUTHORS   Vistnes,M., Aronsen,J.M., Lunde,I.G., Sjaastad,I., Carlson,C.R. and
            Christensen,G.
  TITLE     Pentosan polysulfate decreases myocardial expression of the
            extracellular matrix enzyme ADAMTS4 and improves cardiac function
            in vivo in rats subjected to pressure overload by aortic banding
  JOURNAL   PLoS One 9 (3), e89621 (2014)
   PUBMED   24595230
  REMARK    GeneRIF: discovered that myocardial mRNA and protein levels of
            ADAMTS1 and -4, and mRNA levels of versican, aggrecan, and ADAMTS8
            increased after AB, and TNF-alpha and IL-1beta synergistically
            increased mRNA of versican and ADAMTS4
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5124)
  AUTHORS   Rodriguez-Lopez,J., Pombo-Suarez,M., Loughlin,J., Tsezou,A.,
            Blanco,F.J., Meulenbelt,I., Slagboom,P.E., Valdes,A.M.,
            Spector,T.D., Gomez-Reino,J.J. and Gonzalez,A.
  TITLE     Association of a nsSNP in ADAMTS14 to some osteoarthritis
            phenotypes
  JOURNAL   Osteoarthritis Cartilage 17 (3), 321-327 (2009)
   PUBMED   18790654
REFERENCE   3  (bases 1 to 5124)
  AUTHORS   Goertsches,R., Comabella,M., Navarro,A., Perkal,H. and Montalban,X.
  TITLE     Genetic association between polymorphisms in the ADAMTS14 gene and
            multiple sclerosis
  JOURNAL   J Neuroimmunol 164 (1-2), 140-147 (2005)
   PUBMED   15913795
REFERENCE   4  (bases 1 to 5124)
  AUTHORS   Colige,A., Vandenberghe,I., Thiry,M., Lambert,C.A., Van Beeumen,J.,
            Li,S.W., Prockop,D.J., Lapiere,C.M. and Nusgens,B.V.
  TITLE     Cloning and characterization of ADAMTS-14, a novel ADAMTS
            displaying high homology with ADAMTS-2 and ADAMTS-3
  JOURNAL   J Biol Chem 277 (8), 5756-5766 (2002)
   PUBMED   11741898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Dec 1, 2020 this sequence version replaced XM_006256449.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-267               JAXUCZ010000020.1  29762416-29762682   c
            268-659             JAXUCZ010000020.1  29760424-29760815   c
            660-816             JAXUCZ010000020.1  29737344-29737500   c
            817-1007            JAXUCZ010000020.1  29733265-29733455   c
            1008-1091           JAXUCZ010000020.1  29718846-29718929   c
            1092-1239           JAXUCZ010000020.1  29718297-29718444   c
            1240-1345           JAXUCZ010000020.1  29715810-29715915   c
            1346-1489           JAXUCZ010000020.1  29714059-29714202   c
            1490-1622           JAXUCZ010000020.1  29712967-29713099   c
            1623-1736           JAXUCZ010000020.1  29711754-29711867   c
            1737-1885           JAXUCZ010000020.1  29709642-29709790   c
            1886-2061           JAXUCZ010000020.1  29706081-29706256   c
            2062-2195           JAXUCZ010000020.1  29702902-29703035   c
            2196-2319           JAXUCZ010000020.1  29702459-29702582   c
            2320-2400           JAXUCZ010000020.1  29701348-29701428   c
            2401-2564           JAXUCZ010000020.1  29696108-29696271   c
            2565-2733           JAXUCZ010000020.1  29693976-29694144   c
            2734-2866           JAXUCZ010000020.1  29693450-29693582   c
            2867-3074           JAXUCZ010000020.1  29691290-29691497   c
            3075-3204           JAXUCZ010000020.1  29689779-29689908   c
            3205-3315           JAXUCZ010000020.1  29688948-29689058   c
            3316-5124           JAXUCZ010000020.1  29685876-29687684   c
FEATURES             Location/Qualifiers
     source          1..5124
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..5124
                     /gene="Adamts14"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif, 14"
                     /db_xref="GeneID:309837"
                     /db_xref="RGD:1308899"
     exon            1..267
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..3797
                     /gene="Adamts14"
                     /note="A disintegrin and metalloproteinase with
                     thrombospondin motifs 14; a disintegrin-like and
                     metallopeptidase (reprolysin type) with thrombospondin
                     type 1 motif, 14"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 14 precursor"
                     /protein_id="NP_001376166.1"
                     /db_xref="GeneID:309837"
                     /db_xref="RGD:1308899"
                     /translation="MARLRALLHCLLPWYCALCAAAGSQTPDPRLSGKLHDYVVTVPC
                     STDFQGRFLSHVVSAPAAASSRSHLRVARSPLSLERETPRPRHHFLYFNVTVFGKLLH
                     LRLQPNRRLVAPGAPVEWQEDFRELFRQPLQRECVYTGGVTGMPGAAVAISNCDGLAG
                     LIRTDNSDFFIEPLERGQQEKEAGGRTHVVYRREAVQREWTEPHGDLHNEAFGLGDLP
                     NVLDLVGDQLGDTERKRRHAKPGSYSIEVLLAVDDSVVRFHGREHTQNYVLTLMNIVD
                     EIYHDESLGAHVNIALVRLIMVGYRQSLSLIERGNPARSLEQVCRWAHSQQRQDPSHT
                     EHHDHVIFLTRQNFGPSGYAPVTGMCHPLRSCALNHEDGFSSAFVVAHETGHVLGMEH
                     DGQGNGCDDETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYNCLLDDPFERTWP
                     QPPELPGIDYSMDEQCRFDFGTGYHTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPL
                     DGTECAPGKWCFKGHCVWKSPEQTYGQDGGWSSWTNFGSCSRSCGGGVRSRSRSCDNP
                     PPAYGGRLCSGPMFEYQICNSEDCPGPFEDFRAQQCAKRNSYYTHQDAKHSWLPYEPD
                     SEAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPFGCDKEVGSMK
                     TDDKCGVCGGDNSHCRTVKGTLGKASKQAAALKQVQIPAGARHIQIELLEKAPRRIAV
                     KNQVTGSFILNPKGKEASSRTFTALGLEWEHAAEDTKDSLKTNGPLPEAIAVLVLPPA
                     EGKPRGSLAYKYVIHEDLLPLIGSNNVLLEEMDSYEWALKSWSPCSKACGGGIQFTKY
                     GCRHRRDHHMVQRHLCDHKKRPKAIRRRCNQHPCPQPTWVTEEWGACSRSCGKLGLQT
                     RGVQCLLPLSNGTHKAMPAKACLGNRPEAKRPCLRVPCPAQWRTGAWSQCSATCGKGI
                     QQRQVVCRNSSSALGPCEGVKPDTVRICSQPACGGDLQNSTVNAEVQDPVTKMGPWEP
                     QSRPLTPMNRISTMEPCVGDRSVFCRMEVLDRYCTIPGYLRLCCESCIKKASSSNASL
                     ASLPTFSTPGSLLPEPTATQEDMESTRGPTRLEDHRQSQPTQLSGAVDRISSVTQHLV
                     TPQMLSPKASESNSPATPQGPPWGRTQTAVPTSEGQGQSREEPGHSGTSLPTTSPVT"
     exon            268..659
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            660..816
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1007
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1091
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1239
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1345
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1489
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1622
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1736
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1885
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2061
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2195
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2319
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2400
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2564
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2733
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..2866
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..3074
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3204
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3315
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..5124
                     /gene="Adamts14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgctgagt ccctgcggct ccgaacagcg cgggcggaca gagcggccgc cgccggagcc
       61 agcagcgagg gcgccgtgcc gggggacccg gaccgggcca gcgggaggcg gaggctgcct
      121 gctggtctgc gatctggcag tcccaggact cgggttcctg ccggtccctg aacccgcgca
      181 gccacatggc tcggctccgc gctctgctcc actgcctgct gccctggtac tgcgcgcttt
      241 gcgccgccgc cggcagtcag accccagacc cacgcctctc tgggaaactt catgactatg
      301 tcgtgactgt gccctgcagc acggatttcc agggacgatt cttgtcccac gtggtgtctg
      361 ctcccgcagc tgcctcctcc cggagccacc tccgggtggc tcgaagtccc ctgagcctgg
      421 aaagagagac accacgtcca aggcaccatt tcctctactt caatgtgact gtctttggga
      481 agttgctcca cttgaggctg cagcccaacc ggaggttggt ggcaccaggg gccccggtgg
      541 aatggcagga ggactttcgg gaactcttcc gccaaccctt gcagcgggag tgtgtgtaca
      601 ccggaggtgt cactggaatg cctggggcag ctgtagccat cagcaattgt gacggattgg
      661 ctggcctcat ccgcacagac aactcagact tcttcattga gcctctggag cgagggcagc
      721 aggagaaaga ggctggcggg aggacccacg tggtataccg ccgggaagcc gtccagaggg
      781 agtggacaga gcctcatggg gacctccaca atgaagcctt cggccttggt gaccttccca
      841 atgtgctgga tctggtaggg gaccagctgg gtgacacaga gcggaagcgg cgacacgcca
      901 agcctggcag ctacagcatc gaggtgctgc tggcagtgga cgactcggtg gttcgcttcc
      961 acggcaggga gcacacgcag aactacgtgc tcacgctcat gaacatcgtg gatgaaatct
     1021 accatgatga atcgctgggg gcccacgtga acattgccct tgtccgcctg atcatggtgg
     1081 gctaccgaca gtccctgagc ctgatcgagc gagggaaccc agcacgcagc ctggagcagg
     1141 tgtgtcgctg ggcacactcc cagcagcgcc aggaccctag ccacactgaa catcacgacc
     1201 acgtcatctt cctcacccgc cagaacttcg gcccctcagg gtacgcacct gttactggca
     1261 tgtgccaccc cctaaggagc tgtgccctca accacgagga tggcttctcc tcagcttttg
     1321 tcgtggctca tgagacaggt catgtgcttg gcatggagca tgatggccaa ggcaatggct
     1381 gtgatgacga gaccagtctg ggcagcgtca tggcgcccct ggttcaggct gccttccacc
     1441 gctttcattg gtctcgctgc agcaagctgg aactcagccg ttacctccca tcctacaatt
     1501 gcctccttga tgaccccttc gagcgcacct ggccccagcc cccggaactg cccgggatcg
     1561 actactccat ggacgagcag tgccggttcg actttggcac tgggtaccac acctgcttgg
     1621 ctttcagaac ctttgaaccc tgcaagcagc tgtggtgcag ccaccccgac aacccatact
     1681 tctgcaagac caagaagggg cctccactgg atgggacaga gtgtgcacca ggcaagtggt
     1741 gcttcaaagg ccattgtgtc tggaagtcgc cagagcagac ttatggccag gacggaggct
     1801 ggagctcctg gaccaacttc ggctcatgtt ctcggtcatg cggaggtggg gtgcggtccc
     1861 gaagccggag ctgcgacaac cctcctccag cctatggagg tcgcctgtgc tcagggccca
     1921 tgtttgagta ccagatctgc aacagtgagg actgtcctgg gcccttcgag gacttccggg
     1981 cccagcagtg tgccaagcga aactcctact atacccacca ggatgccaag cacagctggt
     2041 tgccctatga gccggacagt gaggcccaga agtgcgagct catttgtcag tcggcagaca
     2101 ccggagacgt ggtgtttatg aaccaagtgg tgcatgatgg gacgcgctgc agttaccgag
     2161 atccttacag tgtctgtgcc cgtggagagt gcgtgccctt tggttgcgac aaggaggtgg
     2221 gatccatgaa gacggatgac aagtgcggtg tctgcggtgg ggacaactct cactgcagga
     2281 ctgtgaaggg gacactggga aaggcctcca agcaagcagc ggctctcaaa caggtgcaga
     2341 tcccggcggg cgccaggcac attcagattg agttgctgga gaaggctccc cgccgtattg
     2401 cggtgaagaa tcaggtgact ggaagcttca tcctcaaccc caagggcaag gaggcctcta
     2461 gcaggacatt cactgcgctg ggcctggaat gggagcacgc agcggaggac accaaggata
     2521 gcctcaagac caacggaccc ttgcctgaag ccatcgccgt cctggttctc cccccggctg
     2581 agggtaaacc ccgaggtagc ctggcctaca agtatgtcat ccacgaggac ctgctgcccc
     2641 tcattgggag caataatgtg ctcctggaag agatggacag ctatgagtgg gctctcaaga
     2701 gctggtctcc ctgcagcaag gcctgtggag gaggaatcca gttcactaaa tacggctgcc
     2761 ggcaccgcag ggaccaccac atggtgcagc ggcacctgtg tgaccataaa aagaggccca
     2821 aggctattcg acggcgttgc aaccagcacc cgtgtcccca gcccacgtgg gtgacagaag
     2881 agtggggtgc ctgcagccgg agctgtggga agctggggct gcagaccagg ggggtgcagt
     2941 gcctgctgcc tctctccaac ggcacccata aggccatgcc agccaaggct tgcctaggta
     3001 accggccaga ggccaagagg ccatgcctcc gtgtgccctg cccagcccag tggcggactg
     3061 gagcctggtc ccagtgctct gccacctgtg gaaaaggcat ccagcaacgg caggtcgtgt
     3121 gcaggaacag ctccagtgcc ctcgggccat gtgagggggt caagccggac accgtgcgga
     3181 tctgcagcca gccagcctgt ggaggagatc tccagaactc tacagtgaat gcagaggtcc
     3241 aggaccctgt gactaaaatg ggaccctggg aaccccaatc caggcccctg actcccatga
     3301 acaggatctc aacaatggag ccctgtgtgg gagacagatc cgtcttctgc cggatggaag
     3361 tgctggaccg ttactgcacc atccctggct acctccggct gtgttgtgag tcttgcataa
     3421 agaaggcctc gagctccaat gccagcctgg cctcactacc caccttctcc acccctggga
     3481 gtctcttgcc agaacccacg gccacccagg aggacatgga atctacaagg gggccaacca
     3541 gactggaaga tcatcggcaa agccagccca cacagctctc aggggcggtg gacaggatct
     3601 cctcagtaac tcagcatctg gtcacccccc agatgctaag ccctaaagcc tctgagagca
     3661 attctcccgc caccccacag ggcccacctt ggggccggac ccaaacagct gtgccaacct
     3721 ctgagggtca aggacagtcc agggaggaac caggacattc aggcaccagc cttcccacaa
     3781 cctccccagt gacatgaacc cgtccctctg gtcatgttga cactctgcgt ggggtcccag
     3841 tgatcctaga tcagaggact caagcacggg acaggaagta tcacaggttc ccttttaaat
     3901 tatttgccct ctagttctgt ttggggctgt gacactcttt actcccatga cagggttgtg
     3961 gggaaaggga gatcagggac tgccctaacc agaaatacct cagccagcag agccggggct
     4021 ccacttccaa gagttttcta cgattcgtcc ttctaggctc agtaatgccc catcccacag
     4081 ccactgggcc tgacaaggct gaatctcagg caggggcctg tcagaggttc ttgcttgttc
     4141 gtgacttctg actaccaggg aggcctgaac agccacacac acataccccc aaaacaaaga
     4201 agggctcagg aggtagggcc acacacaaag cagacatggg aagggtctgg gatggacgca
     4261 gaggtgaggc ttcacagctg cagggttggg caggggagag ttcttctcag gcctggttct
     4321 tgtcagctga gggctgctaa tccccggcag aaatcagttc acctttgcca gtcatagggt
     4381 cacttttgtg gcccactctg tagatgtcac tgctggtgac tctaggtaac aggctggcct
     4441 cccagtgtca cacccaaacc accagaggaa gaggcccgga tacacagctt caacatccag
     4501 aagtttccaa gctggggctt gatccctggt tggacgagga acggtgactt cagccatcac
     4561 tcaggcttgc aggaggtcca gcttgaaagg tggccactgg agagatgtca cctccaagac
     4621 tgtccccctt agccatcact ctctgctgac gcttactcct ggtggagtta ggggtggggt
     4681 tggttcttcc cttatgactt aagctgggcc caaatgtgtg gtgcttagaa ggtcagtcag
     4741 gtgggtcaca tagccaacga ctagagaatc cactcagctg gaccgtgcgg aaggtctggg
     4801 caggatgcca gctgctgttg ctcccaggtt agggcaggga gggtgcatag agaagcttcc
     4861 acggtcttaa ggctctcagg aaattgccta gatcctcatt ttgagggtca gtggcggagg
     4921 tgcttgtctc tctgccttcc tcaactggag gaaggaaagt cgctgacctg gaagctccgt
     4981 ggggagcagg gatgctggga actctgcatg ctcctcccac tcccgcttcc cgctttacag
     5041 gtggctgggg ctacccggag tcaagtcatg tgtggaccgg cctgaagatt ctgattttta
     5101 aaatgttacc tatttattag tatt
//
