LOCUS       NM_001106420            8572 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1
            motif, 12 (Adamts12), mRNA.
ACCESSION   NM_001106420 XM_001059671 XM_226837
VERSION     NM_001106420.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8572)
  AUTHORS   Yang,S., Zhou,X., Jia,Z., Zhang,M., Yuan,M., Zhou,Y., Wang,J. and
            Xia,D.
  TITLE     Epigenetic regulatory mechanism of ADAMTS12 expression in
            osteoarthritis
  JOURNAL   Mol Med 29 (1), 86 (2023)
   PUBMED   37400752
  REMARK    GeneRIF: Epigenetic regulatory mechanism of ADAMTS12 expression in
            osteoarthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8572)
  AUTHORS   Arning,A., Hiersche,M., Witten,A., Kurlemann,G., Kurnik,K.,
            Manner,D., Stoll,M. and Nowak-Gottl,U.
  TITLE     A genome-wide association study identifies a gene network of ADAMTS
            genes in the predisposition to pediatric stroke
  JOURNAL   Blood 120 (26), 5231-5236 (2012)
   PUBMED   22990015
REFERENCE   3  (bases 1 to 8572)
  AUTHORS   Moncada-Pazos,A., Obaya,A.J., Llamazares,M., Heljasvaara,R.,
            Suarez,M.F., Colado,E., Noel,A., Cal,S. and Lopez-Otin,C.
  TITLE     ADAMTS-12 metalloprotease is necessary for normal inflammatory
            response
  JOURNAL   J Biol Chem 287 (47), 39554-39563 (2012)
   PUBMED   23019333
  REMARK    Erratum:[J Biol Chem. 2018 Jul 20;293(29):11648. PMID: 30030383]
REFERENCE   4  (bases 1 to 8572)
  AUTHORS   Zhang,Q., Huang,M., Wang,X., Xu,X., Ni,M. and Wang,Y.
  TITLE     Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage
            differentiation
  JOURNAL   J Orthop Res 30 (8), 1238-1243 (2012)
   PUBMED   22247065
REFERENCE   5  (bases 1 to 8572)
  AUTHORS   Yu,H. and Zhu,Y.
  TITLE     Expression of ADAMTS-7 and ADAMTS-12 in the nucleus pulposus during
            degeneration of rat caudal intervetebral disc
  JOURNAL   J Vet Med Sci 74 (1), 9-15 (2012)
   PUBMED   21869572
  REMARK    GeneRIF: ADAMTS-7 and ADAMTS-12 expression were dramatically
            increased during disc degeneration.
REFERENCE   6  (bases 1 to 8572)
  AUTHORS   Beristain,A.G., Zhu,H. and Leung,P.C.
  TITLE     Regulated expression of ADAMTS-12 in human trophoblastic cells: a
            role for ADAMTS-12 in epithelial cell invasion?
  JOURNAL   PLoS One 6 (4), e18473 (2011)
   PUBMED   21494557
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8572)
  AUTHORS   Luan,Y., Kong,L., Howell,D.R., Ilalov,K., Fajardo,M., Bai,X.H., Di
            Cesare,P.E., Goldring,M.B., Abramson,S.B. and Liu,C.J.
  TITLE     Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage
            oligomeric matrix protein by alpha-2-macroglobulin
  JOURNAL   Osteoarthritis Cartilage 16 (11), 1413-1420 (2008)
   PUBMED   18485748
REFERENCE   8  (bases 1 to 8572)
  AUTHORS   Llamazares,M., Obaya,A.J., Moncada-Pazos,A., Heljasvaara,R.,
            Espada,J., Lopez-Otin,C. and Cal,S.
  TITLE     The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties
            through modulation of the Ras-dependent ERK signalling pathway
  JOURNAL   J Cell Sci 120 (Pt 20), 3544-3552 (2007)
   PUBMED   17895370
REFERENCE   9  (bases 1 to 8572)
  AUTHORS   Liu,C.J., Kong,W., Xu,K., Luan,Y., Ilalov,K., Sehgal,B., Yu,S.,
            Howell,R.D. and Di Cesare,P.E.
  TITLE     ADAMTS-12 associates with and degrades cartilage oligomeric matrix
            protein
  JOURNAL   J Biol Chem 281 (23), 15800-15808 (2006)
   PUBMED   16611630
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001106420.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.7501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-366               JAXUCZ010000002.1  61759987-61760352
            367-734             JAXUCZ010000002.1  61766525-61766892
            735-885             JAXUCZ010000002.1  61850564-61850714
            886-1082            JAXUCZ010000002.1  61908862-61909058
            1083-1166           JAXUCZ010000002.1  61911164-61911247
            1167-1291           JAXUCZ010000002.1  61923924-61924048
            1292-1441           JAXUCZ010000002.1  61927033-61927182
            1442-1585           JAXUCZ010000002.1  61941146-61941289
            1586-1730           JAXUCZ010000002.1  61942473-61942617
            1731-1823           JAXUCZ010000002.1  61943748-61943840
            1824-1969           JAXUCZ010000002.1  61944617-61944762
            1970-2139           JAXUCZ010000002.1  61948923-61949092
            2140-2273           JAXUCZ010000002.1  61955997-61956130
            2274-2394           JAXUCZ010000002.1  61970851-61970971
            2395-2639           JAXUCZ010000002.1  61981546-61981790
            2640-2778           JAXUCZ010000002.1  61982721-61982859
            2779-2905           JAXUCZ010000002.1  61988647-61988773
            2906-3116           JAXUCZ010000002.1  61996796-61997006
            3117-4223           JAXUCZ010000002.1  62007142-62008248
            4224-4376           JAXUCZ010000002.1  62016113-62016265
            4377-4556           JAXUCZ010000002.1  62025517-62025696
            4557-4700           JAXUCZ010000002.1  62028898-62029041
            4701-4860           JAXUCZ010000002.1  62033628-62033787
            4861-8572           JAXUCZ010000002.1  62051005-62054716
FEATURES             Location/Qualifiers
     source          1..8572
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..8572
                     /gene="Adamts12"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif, 12"
                     /db_xref="GeneID:294809"
                     /db_xref="RGD:1307323"
     exon            1..366
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..5039
                     /gene="Adamts12"
                     /note="A disintegrin and metalloproteinase with
                     thrombospondin motifs 12; a disintegrin-like and
                     metallopeptidase (reprolysin type) with thrombospondin
                     type 1 motif, 12"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 12 precursor"
                     /protein_id="NP_001099890.2"
                     /db_xref="GeneID:294809"
                     /db_xref="RGD:1307323"
                     /translation="MPCAQGNWMAKLSMVAQLLNFGAFCHGRQAQPWPVRFPDPKQEH
                     FIKSLPEYHIVSPVQVDASGHFLSYGLHHPVTGSRKKRAAGGSGDQVYYRISHEEKNL
                     FFNLTVNWEFLSNGYVVERRYGNLSHVKMAASSGQPCHLRGTVLQQGPTIRMGTAALS
                     ACQGLTGFFHLPHGDFFIEPVKKHPLTEEGYQPHVIYRRQSYRVPETKEPTCGLKDSL
                     DNSVKQELQREKWERKNWPSRSLSRRSISKERWVETLVVADTKMVEYHGSENVESYIL
                     TIMNMVTGLFHNPSIGNAVHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINP
                     KSDLNPVHHDVAVLITRKDICAGVNRPCETLGLSQLSGMCQPHRSCNINEDSGLPLAF
                     TIAHELGHSFGIQHDGKENDCEPVGRHPYIMSQQIQYDPTPLTWSKCSKEYITRFLDR
                     GRGFCLDDVPRKKGLKSNVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCSVK
                     GFCRSKLDAAADGTRCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGA
                     QSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSDTPTFRQMQCSEFDTVPYKNQF
                     YRWFPVFNPAHPCELYCRPIDEQFSERMLEAVIDGTPCFEGGNSRNVCINGICKRVGC
                     DYEIDSNATEDRCGVCLGDGSACQTVKKVFRQKEGSGYIDIGLIPKGARDIRVMEIKA
                     AGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLERLMAPGPTNESVW
                     LQLLFQVTNPGIKYEYTVRKDGLDNDVEKLLYFWQFGRWTECSVTCGTGIRRQTAHCV
                     KKGHGIVKTTFCNPETQPSVRQKKCYEKDCPPRWWAGEWEACSMTCGPYGEKKRTVLC
                     IQTMGSDEQALPATDCQHLLKPKTLVSCNRDILCPSDWTVGNWSECSVSCGGGVRIRS
                     VTCAKNLNEPCDKTRKPNSRALCGLQQCPFSRRVLKPNKDTVPSGKNPTTSEHDHFKP
                     IPASTSRPTPLSTPTVPESVSTSTPTINSLGSTITSQEEPDGIGWQNNSTQAEEDSHI
                     PTSVGSTSQTPLTSWSWSMQPDDENVSSSAIGPTSESDFWATTSDSGLSSSNAMTWQV
                     TPFYSTATTEPEVEIHSGSGEDSDQPLNKEENNSVLWNKIRVPERDAPMEMDAEIPLG
                     PPPTSYVTEESSWPPFSTMMKSSLPAWSFKNETPRDEGMITEKSGNIPLPLGGDHQTT
                     SPEKLGNNDQLASANSTNPTQGSGPVLTEEDASTLIEEGFLLNASNYKHLMKDHSPAH
                     WIVGNWSKCSTTCGLGAYWRSVECSTGMNADCAAIQRPDPAKKCHLRPCAGWRVGNWS
                     KCSRNCSGGFKIREVQCMDGVDHHRSLRPFHCQFLAGVPPPLSMSCNLEPCEEWKVEP
                     WSQCSRSCGGGVQERGVFCPGGLCDWTKRPASTVPCNRHLCCHWATGNWELCTTSCGG
                     GSQKRTVHCIPSENSTTEDQDQCFCDHQARPPEFQNCNQQACRKSADLTCTKDRLSTS
                     FCQTLKSMKKCSVPSVRVQCCLSCPQTQSIHTQRQRKQQMLQNHDTL"
     exon            367..734
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            735..885
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1082
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1166
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1291
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1441
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1585
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1730
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1823
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1969
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2139
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2273
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2394
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2639
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2778
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2905
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..3116
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..4223
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..4376
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            4377..4556
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            4557..4700
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            4701..4860
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
     exon            4861..8572
                     /gene="Adamts12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaaagcag aagctgtcag ctcattcact cccctttcag gaaagggaga gcagagaagt
       61 tctctggtcc tgtctacttc aaaaggccac tagagctctt gggcagctag cgggccgctc
      121 ccttcccacg cctggaccat gctccgctgc ggcttcctgc gcggccacgg gcgaggactc
      181 ggtatctgca gctgagagct aacactgttt tgacttttct tctccccaac aaccgaacca
      241 tgccatgtgc tcaggggaac tggatggcaa agctctccat ggtggcccag cttcttaact
      301 ttggggcttt ttgccatggg agacaagctc agccctggcc ggttcgcttc ccagacccga
      361 agcaagaaca ttttatcaag tccctgccag aataccacat agtgagtcct gtccaagtag
      421 atgccagtgg ccactttctg tcctatggcc tgcatcaccc tgtcactggc agcaggaaga
      481 agagagctgc aggtggttct ggggaccagg tgtactacag gatttcacac gaagaaaaaa
      541 acctgttttt caatctgaca gtcaactggg aatttctttc caatggctat gtcgtggaga
      601 ggagatatgg gaacctttcc catgtgaaga tggcggcttc ctcagggcag ccctgccatc
      661 tcaggggcac agttctgcaa cagggcccca caatcaggat ggggacagca gctcttagtg
      721 cctgccaagg actgactgga tttttccatc taccacatgg agactttttc attgagcctg
      781 ttaaaaagca tccactgacc gaggaaggtt accagcctca tgtcatatac aggaggcaga
      841 gctacagagt tccagagaca aaggagccca cctgcggatt aaaggacagc cttgataact
      901 ctgtgaagca agagctccag cgggagaagt gggagaggaa gaactggcca agcagaagcc
      961 tctcccgacg ctccataagc aaggagagat gggtggagac cctcgtggta gctgacacga
     1021 agatggtaga gtaccatgga agtgagaacg tggagtcgta catcctcact atcatgaata
     1081 tggtcactgg gttgtttcat aacccaagca ttggaaacgc agtgcacatt gttgtggttc
     1141 ggctcattct acttgaagaa gaggagcaag gattgaaaat agttcaccat gcagagaaga
     1201 cactgtccag cttctgcaag tggcagaaga gcatcaatcc caagagtgac ctcaaccctg
     1261 tccatcatga tgtggctgtc cttatcacca gaaaggacat ctgtgctggt gtcaatcgcc
     1321 cttgtgagac tctggggctg tcccagctgt caggaatgtg ccagcctcac aggagctgta
     1381 acatcaacga agactccggt ctccccctgg ctttcaccat tgcgcatgaa cttgggcaca
     1441 gcttcggcat ccaacatgat gggaaggaaa atgactgtga gcccgtgggc agacacccat
     1501 acatcatgtc ccaacaaatt cagtatgacc caactccact gacatggtcg aaatgcagca
     1561 aggagtacat cactcgcttc ttggaccgag gcagggggtt ctgtcttgat gacgtcccca
     1621 gaaagaaagg cttaaagtcc aatgtcattg cccctggagt gatttatgat gttcatcacc
     1681 agtgccagct ccaatacggc ccaaatgcta cattctgcca ggaagtggaa aatgtttgcc
     1741 agacactgtg gtgctcagtg aaaggcttct gtcgctctaa gctggatgct gctgcagatg
     1801 ggacacgttg tggtgagaag aagtggtgta tggctggaaa gtgtatcaca gtggggaaga
     1861 aaccagagag catccctgga ggctggggac gctggtcacc ctggtcacac tgttcgagga
     1921 catgtggggc aggagctcag agcgcagaga ggctctgcaa caacccagaa ccaaagtttg
     1981 gagggaaata ctgcaccgga gaaagaaaac gctatcgctt atgcaatgtc cacccctgcc
     2041 gctcagacac tccaactttc cgacagatgc agtgcagtga atttgacaca gtcccctaca
     2101 aaaaccaatt ctaccgctgg ttcccagtgt ttaatccagc acatccttgt gagctgtact
     2161 gcagacccat agatgaacag ttttctgaga gaatgctgga agccgtcatt gatggcaccc
     2221 cgtgctttga aggtggcaac agcagaaatg tctgtattaa tggcatatgt aagagggttg
     2281 gctgtgacta tgagattgat tccaatgcta cagaggatcg ctgtggcgtg tgccttggag
     2341 atggctctgc ctgccagact gtgaagaagg tgtttagaca gaaggaagga tccggttaca
     2401 ttgacatcgg acttattccc aaaggtgcaa gggatataag agtgatggaa atcaaggcag
     2461 ccggcaattt cctggccatt aggagtgaag atccagaaaa atattacctc aacggaggat
     2521 ttatcatcca gtggaatgga aactataaac tggcagggac cgtcttccag tatgacagga
     2581 aaggagatct ggagagactt atggctccag gccccaccaa cgagtcagtg tggctccagc
     2641 tactattcca ggtgactaac cccggtatca agtatgagta cacagtccgg aaagatggcc
     2701 ttgacaatga tgtggagaag ttgctgtact tctggcaatt tggccgctgg acagagtgca
     2761 gtgtaacatg tggaacaggt atccgccggc agactgctca ttgtgtcaag aagggccatg
     2821 ggatagtgaa aactaccttc tgcaacccag aaacacagcc cagcgtgaga cagaaaaagt
     2881 gctatgaaaa ggactgtcca cccaggtggt gggccggaga gtgggaagca tgttcaatga
     2941 catgtgggcc gtacggagaa aaaaagagaa cagtgctgtg catccagacc atgggctctg
     3001 atgagcaggc tctcccagct acagactgcc agcacctgct gaagcccaag acactggttt
     3061 cctgcaacag agacattctg tgtccatcag attggacagt aggcaactgg agtgagtgct
     3121 ctgtttcctg tggtggtgga gtgcggattc gcagtgtcac atgtgccaag aaccttaatg
     3181 aaccctgtga caagacacgg aaacccaaca gtcgagctct gtgtggcctc cagcagtgcc
     3241 cattcagccg tagagttctg aaacccaata aagatacagt tcccagtggg aaaaatccaa
     3301 caacatcaga acatgaccac ttcaagccca tcccagcatc tacatccagg cccacgccac
     3361 tgtccacacc cacagtgcct gagtctgtga gcacaagtac ccccacaatc aacagccttg
     3421 gctccaccat aacatcccaa gaagaaccag atgggatagg atggcagaat aattcaaccc
     3481 aagctgaaga ggactcccac atccctactt ctgttggaag cacttcccag actcccctca
     3541 cttcctggtc ttggagtatg cagcctgatg atgaaaacgt ttccagttca gctataggtc
     3601 caacttcaga gagtgacttt tgggcaacca caagtgattc tggcttatca tctagcaatg
     3661 ctatgacttg gcaggtaact ccattttata gcactgcgac cacagaaccg gaagtggaga
     3721 tacatagtgg ctcaggggaa gacagtgacc agcctttgaa caaggaggaa aacaactctg
     3781 tgctatggaa caagatcaga gtacctgaac gtgatgctcc catggagatg gatgcagaaa
     3841 taccacttgg acctccacca acatcttatg tgacagaaga gtcctcatgg cctcccttca
     3901 gtacaatgat gaaaagctca ctacctgcct ggtccttcaa aaatgagaca cccagggatg
     3961 aggggatgat cactgaaaaa tcagggaata ttccactccc tcttggagga gaccaccaga
     4021 caacatcccc agagaagtta ggaaacaatg accaactggc atcagcaaat agtacaaatc
     4081 caacccaagg ctctgggcct gtcctgactg aggaagatgc ctccactctg attgaggagg
     4141 gatttttgct aaatgcttcc aattacaagc atctcatgaa ggaccacagc cctgcacact
     4201 ggattgttgg aaattggagt aaatgctcta ccacctgtgg gctgggggcc tactggagga
     4261 gtgtggagtg tagcaccggg atgaacgctg actgcgccgc cattcagagg ccagaccctg
     4321 ctaagaagtg ccacctgcgc ccctgtgctg gctggcgagt gggaaactgg agcaagtgct
     4381 ctcgaaactg cagtggaggt ttcaagattc gtgaggttca gtgcatggac ggcgtggacc
     4441 atcaccggag cctgaggcca tttcactgtc agttcctggc cggcgttcct cctccgctga
     4501 gtatgagctg taatctggag ccttgcgaag agtggaaagt ggaaccctgg agccagtgtt
     4561 ctaggtcctg tggaggcggt gttcaggaga gaggagtgtt ttgcccagga ggtctctgcg
     4621 actggacaaa aagacctgca tccactgtgc cctgcaacag acacctttgc tgtcactggg
     4681 ccactgggaa ctgggaactg tgcaccactt cctgtggtgg tggctctcag aagaggaccg
     4741 ttcattgcat cccttcagaa aacagtacaa ctgaagatca agaccagtgt ttctgtgacc
     4801 accaagccag acccccagaa ttccaaaact gcaaccagca agcctgccgg aagagtgctg
     4861 atttaacttg cacgaaggac agactttcaa ccagcttctg ccagacacta aaatccatga
     4921 agaagtgctc ggtgccatca gtacgagtcc agtgctgtct ctcgtgtcca cagacacaga
     4981 gcatccacac ccagaggcaa agaaaacagc agatgctcca aaatcatgac acgctctagg
     5041 ttcagaaaga agccaccatc atgggcttcc acagcctgat acccaagaac atggtccaga
     5101 aggccacttc actaatattt cactttgtac attctaggtt caactttggg tcataacaaa
     5161 acaaaacgca atgtgtgtgt ctagtcacta aatgtttctc acagaaagct tggggctggc
     5221 tgctccccaa taggaagacg aagtatttga gagaatgatg ctgcagcagt tgagatgagt
     5281 tccttgggaa agtgccagat taggcaagtc tgtgaaaata tgtctttccc cctttaaaga
     5341 tgaaaataga aacctgtttt tttcccaaac tacctcaaga aacagagaca cacttaccca
     5401 ggaaacagat aatcttttaa atttgtcttc atgaatatat cccccttagg tgccttgggt
     5461 agccactgtt taaaagccat gaggcaagtt ttaggaccat ctatctcagt agtcaataag
     5521 gacaggaaaa agatgctagc tatggtgccc tgtctgttct ccatcactgt aggacttcac
     5581 aactggaaac ctagaatctt gggacaaacc atggagattt gagattaagg agacaggggc
     5641 atcagatgca gcctaggggc attagattgg cggtcaagaa gtcatttttt actttacttc
     5701 aatttctatt aaaagtcctt aaaatgcaaa tgaacagaat caacttctag ctagcataag
     5761 aaagaaaatg gtccttgtcc ctcaaacttt actggctttg ttagcttgtc acagaacaaa
     5821 tgtgtgttcc tgtctgccag tgccctgtcc ctttcggagt catgacctca ggtcttccca
     5881 tcatccctgt gcagaaagat tacacacaaa cctgctacaa gtagggttag ggctgtctgc
     5941 acaccctgtt tctctcctga gagaaaaagt gaagttatag gccaaaccac ttttaaaaat
     6001 caggtaaatt gtactaagtc taggaattta gtagaaattt atagtttaga agaaaaaagt
     6061 tctaaaaagt gtgccttagt gtgtctatta gtaactttta aaagagataa agagctgggg
     6121 tagaatgcat atttatcaca gttgtgcaag gctgtaagtt tggtgtctag caacacacgt
     6181 gcatgcgtat acacatacac acagaatcaa aaatggaggc taactaacct tatggagagc
     6241 aagcaagtca agagggtcca gaacactgaa acagaagtga aatagaacac taaaacatgc
     6301 ttgttttaga tatcaccccg cctcactgat gtcagtaggc tgtgagcaca aacgcagagc
     6361 agatttccag gtgagcctgt agactgaacc ttgagtgaaa aatggatgtg tggagagatg
     6421 caagccccag ggaaagaccc cagaaccagc tcttgacagg ataggaggca atgtatgtct
     6481 tccggtggga ctcaaggctt atgcaccaat atgaatcttc attctggagt gcagtgtccc
     6541 tcagctccct gtagttatct gtccattcag cagaatggtg ctattgaact tggtgctaat
     6601 atctagatgg tggcaaagct aacagaatgt taacaaatag tcatgtgaaa ggctaggtgt
     6661 ctatgaactt ccttatagac atatgctttg tgtgagatgg tattgctggc caatgccagt
     6721 tttatttgtt ctgagaccat gaacatagca ttatatagga tgcactttta aactctttca
     6781 agacactagc atggattatt ctgatcgatt cctgtggaaa gtaaaacact gggatttgga
     6841 taaaattcaa ggtataccag aaataggaga aaatacacat ttactgaagc cagggaatta
     6901 tgtatagtta agcatacatt cttgcattct gtctttacat aaacacattg ctggccaatg
     6961 acaatctctg atgaaatagc tattttagag aaatgcttac attaatctgt tagtggcaga
     7021 aatggagaaa aaagtagagg agaacttgac cttctaatga ggaattttgc aagggctagt
     7081 agtataggct ttcaaaagtg ttaattaata agccatgtgt actgttctac agcagaataa
     7141 agaacatgac accagagtcc tgggtatgac caggcttaca aaactcagga acaaacttgg
     7201 atttctactg acctcaacaa actaaaagta ggccagattt tccagtgcaa aaaaaataga
     7261 ccatgtcatt tgggacccat gtggttgagc acaacatgag cctcggggga gagtctggcc
     7321 aggtgctcca ttctagatct ttctccattt tcttaagtac aggaaatagg tctctgatca
     7381 tgcatcatgg acatcctctt cttctaccac ggtgagactg tcctatgcca tgtgtcatta
     7441 gtgtttgctg taggagtcat tggtcagctg ctcagctgtg ggctatcagt gtttccatgg
     7501 atctttaatg cttgagatgc tggaagaacc ttgaatagca ggatgacact gacagcaaga
     7561 gctggatagt atcttcacgg ggtcaaatgt gaaggcttgg tttatttcat ccatctcctc
     7621 cttcacatca acaccttgaa ggtgtgaaca agaagctcag caagagacac tagagtcgta
     7681 ctctgagcca gacagatcca ccatggagcc ttgtacttac attcatcatg ttgggtttac
     7741 attgcttttc agagtgatag acttagttct tctccaaaaa gttataagct acttaatttt
     7801 aacatcagaa aagtgttatg ccataagaaa acaatattcc tagaaacttt atagtgaaca
     7861 ctttgttcaa gtcatgaatc atgtcctgta acaaaggatt gctttccttt gcaggaataa
     7921 ctattgagtc ataggtcttc ctaaacaaga gcacaggcac tttcctctgg tctcctgaga
     7981 cagcatgtct tcgctggctg tccaatgcaa tgctctgaga gtcttttgag caaccgccac
     8041 caagaatctg aagcaatttg agagattaca taatttcaga ccctaatttc ccatccagtt
     8101 agctgaagtt ctctgacagc tacatattgc aaacctagaa aagtgcaaag tcttagtttt
     8161 ctcctttctc acttcaagat gaagctctgg gacagctttt ctggtgctca atccacagtg
     8221 atccactctc acaggccaca tgtcttgagt ttcctggtgc tataaccaat ctaatacatt
     8281 tgatgctact cctgttgtta atgcaagtat tttttttaat tcaagtattt ttttaagttc
     8341 tgtcactaaa aataatgtga tgggggaaaa tgcatttctc cctaccattg tcctccaaaa
     8401 taatggcgtg acataacatg gctaactcat tgtctcccct gtgtttctat attgctgctt
     8461 caccagctga ttcctacact cctcctgtac cccattagta agtacctcag tattaaaacc
     8521 agattgtaat cacaggctgt ctctgtgtgg catcaataaa tggccaaacc ca
//
