LOCUS       NM_001271445            4066 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1
            motif, 10 (Adamts10), mRNA.
ACCESSION   NM_001271445 XM_003750295 XM_003754277
VERSION     NM_001271445.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4066)
  AUTHORS   Wu,H.J., Kuchtey,R.W. and Kuchtey,J.
  TITLE     Optic neuropathy associated with TGFbeta dysregulation in mice with
            a glaucoma-causative mutation of ADAMTS10
  JOURNAL   Matrix Biol 113, 83-99 (2022)
   PUBMED   36216203
REFERENCE   2  (bases 1 to 4066)
  AUTHORS   Wu,H.J., Mortlock,D.P., Kuchtey,R.W. and Kuchtey,J.
  TITLE     Altered Ocular Fibrillin Microfibril Composition in Mice With a
            Glaucoma-Causing Mutation of Adamts10
  JOURNAL   Invest Ophthalmol Vis Sci 62 (10), 26 (2021)
   PUBMED   34424262
REFERENCE   3  (bases 1 to 4066)
  AUTHORS   Kutz,W.E., Wang,L.W., Bader,H.L., Majors,A.K., Iwata,K.,
            Traboulsi,E.I., Sakai,L.Y., Keene,D.R. and Apte,S.S.
  TITLE     ADAMTS10 protein interacts with fibrillin-1 and promotes its
            deposition in extracellular matrix of cultured fibroblasts
  JOURNAL   J Biol Chem 286 (19), 17156-17167 (2011)
   PUBMED   21402694
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Sep 27, 2012 this sequence version replaced
            XM_003750295.1, XM_003754277.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.26817.1,
                                           SRR26643295.27435.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000007.1  15033935-15033991
            58-244              JAXUCZ010000007.1  15039240-15039426
            245-591             JAXUCZ010000007.1  15039606-15039952
            592-748             JAXUCZ010000007.1  15041054-15041210
            749-966             JAXUCZ010000007.1  15042523-15042740
            967-1050            JAXUCZ010000007.1  15047004-15047087
            1051-1196           JAXUCZ010000007.1  15047191-15047336
            1197-1240           JAXUCZ010000007.1  15047836-15047879
            1241-1346           JAXUCZ010000007.1  15048011-15048116
            1347-1493           JAXUCZ010000007.1  15048207-15048353
            1494-1635           JAXUCZ010000007.1  15048495-15048636
            1636-1743           JAXUCZ010000007.1  15052757-15052864
            1744-1889           JAXUCZ010000007.1  15053163-15053308
            1890-1953           JAXUCZ010000007.1  15053402-15053465
            1954-2056           JAXUCZ010000007.1  15054459-15054561
            2057-2190           JAXUCZ010000007.1  15054805-15054938
            2191-2314           JAXUCZ010000007.1  15055021-15055144
            2315-2395           JAXUCZ010000007.1  15058845-15058925
            2396-2559           JAXUCZ010000007.1  15059019-15059182
            2560-2686           JAXUCZ010000007.1  15059273-15059399
            2687-2816           JAXUCZ010000007.1  15059493-15059622
            2817-3021           JAXUCZ010000007.1  15060462-15060666
            3022-3198           JAXUCZ010000007.1  15061004-15061180
            3199-3361           JAXUCZ010000007.1  15061258-15061420
            3362-4066           JAXUCZ010000007.1  15063096-15063800
FEATURES             Location/Qualifiers
     source          1..4066
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..4066
                     /gene="Adamts10"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif, 10"
                     /db_xref="GeneID:314655"
                     /db_xref="RGD:1598320"
     exon            1..57
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            58..244
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..3471
                     /gene="Adamts10"
                     /note="a disintegrin-like and metalloprotease (reprolysin
                     type) with thrombospondin type 1 motif, 10; a
                     disintegrin-like and metalloprotease with thrombospondin
                     type 1 motif, 10; A disintegrin and metalloproteinase with
                     thrombospondin motifs 10"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 10 precursor"
                     /protein_id="NP_001258374.1"
                     /db_xref="GeneID:314655"
                     /db_xref="RGD:1598320"
                     /translation="MASACQILRWALALGLGLTFKVTHAFRSQDELLSSLESYEIAFP
                     TRVDHNGAMLAFSPPALRRQRRGVGAAAESRLFYKVAAPSTHFLLNLTRSPRLLAGHV
                     SVEYWTREGLAWQRAARAHCLYAGHLQGQAGSSHVAISTCGGLHGLIVADDEEYLIEP
                     LQGGPKGRRGPEESGPHVVYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPAR
                     PQGNETERGQLGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQ
                     DSSLGNIVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVSHSGHGNAIPEN
                     GVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSINEDIGLATAFTIAH
                     EIGHTFGMNHDGVGNGCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLG
                     LCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYGEVCSELWCLSKSNRC
                     ITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRSCGGG
                     VSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTNDCPPGSQDFREMQCSEFDSVPFRGK
                     FYTWKTYRGGGVKACSLTCLADGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGC
                     DRVLGSDLREDKCRVCGGDGSACETIEGVFSPALPGTGYEDVVWIPKGSVHIFIQDLN
                     LSLSHLALKGDQESLLLEGLPGTSQPHRLPLAGTTFHLRQGPDQAQSLEALGPINASL
                     IIMVLAQAELPALRYRFNAPIARDALPPYSWHYAPWTKCSAQCAGGSQVQVVECRNQL
                     DSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSRCSRSCDAGVRSRSVVCQRR
                     VSAAEEKALDDSACPQPRPPVLEACQGPMCPPEWAALDWSECTPSCGPGLRHRVVLCK
                     SADQRSTLPPGHCPPAAKPPSTMRCNLRRCPPARWVASEWGECSTQCGLGQQQRTVRC
                     TSHTGQPSRECTEALRPSTMQQCEAKCDSVVPPGDGPEECKDVNKVAYCPLVLKFQFC
                     SRAYFRQMCCKTCQGR"
     exon            245..591
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            592..748
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            749..966
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1050
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1196
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1240
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1346
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1493
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1635
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1743
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1889
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..1953
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2056
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2190
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2314
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2395
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2559
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2686
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2816
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..3021
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3198
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            3199..3361
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..4066
                     /gene="Adamts10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgcgggg cggtgagtct gtgcggctac ggcagaccgg aggctccagg cacgcagggg
       61 accagtgatg ctgcccagac tgtgaacagg ggaggcagca ctgtaggggc tgccagcagc
      121 cggggctggg gagagacatg tggacacgta gcccctatgg cttctgcctg ccagatcctc
      181 cgctgggccc ttgccctggg gctgggcctc acattcaagg tcacgcatgc cttcagatct
      241 caagatgagc tcctgtccag tttggagagc tatgagattg ccttcccaac tcgagtggac
      301 cacaacgggg caatgctggc cttctcacca cctgccctcc ggaggcagcg tcggggtgta
      361 ggggctgcag ctgagtcccg tctattctac aaggtggccg cacccagcac tcacttcctg
      421 ctgaacctga cccgcagccc ccgtctcctg gcagggcacg tctcggtgga atactggaca
      481 cgggaaggcc tagcctggca gagggctgcc cgggcccact gcctctacgc tggccacttg
      541 caaggccagg ctggtagctc ccatgtggcc atcagcacct gtgggggcct gcatggcctg
      601 attgtggcag atgacgaaga gtacctgatt gagcccctgc aaggtggacc caaaggtcgc
      661 cgtggcccag aagagagtgg cccccacgta gtatacaagc gttcctctct gcgtcacccc
      721 catctggaca cagcctgtgg agtgagagat gagaaaccat ggaagggtcg tccatggtgg
      781 ttgcgcaccc tgaagccacc gcctgccagg ccccagggga atgaaactga gcgaggccag
      841 ctgggcctga agcgatcagt cagccgagag cgctatgtgg agaccctggt ggtggccgac
      901 aagatgatgg tggcctacca tgggcggaga gatgtggagc aatatgtgtt ggccatcatg
      961 aatattgttg ccaaactttt ccaggactcg agtctgggaa acatcgtcaa catcctcgtc
     1021 actcgcctta tcctgctcac agaggaccag cccaccctgg agatcaccca tcatgctggg
     1081 aagtcactgg acagcttctg taagtggcag aaatcaatcg tgagccacag tggccatggc
     1141 aacgccatcc cagagaacgg tgtggcaaac catgacacag ctgtgctcat cacacgctat
     1201 gacatctgca tctacaagaa caaaccctgc ggcactctag gcctggcccc tgtgggtgga
     1261 atgtgtgagc gtgagaggag ctgcagcatc aatgaagata ttggcctggc cacagctttc
     1321 accattgccc acgagatcgg gcacacattc ggcatgaacc acgatggtgt gggaaacggc
     1381 tgcggggctc gaggtcagga ccctgcaaag ctcatggctg cccatatcac catgaagact
     1441 aatccattcg tgtggtcatc atgcagtcga gattacatca ccagctttct ggactcaggc
     1501 ctggggcttt gcttgaacaa ccggcctccc agacaggact tcgtgtaccc aacggtggct
     1561 cctggccagg cctatgatgc tgatgagcag tgccgattcc agcatggagt caaatcgcgt
     1621 cagtgtaaat acggggaggt ctgcagtgaa ctgtggtgtc tgagcaagag caatcggtgc
     1681 atcaccaata gcatcccagc tgctgaggga acactgtgcc aaacacacac tatcgacaaa
     1741 gggtggtgct acaaacgagt gtgtgtcccc tttgggtctc gaccagaggg tgtagacggg
     1801 gcctggggcc catggactcc atggggtgac tgcagcaggt catgtggcgg tggtgtgtca
     1861 tcttccagtc gtcactgcga cagtcccagg ccaaccattg ggggcaagta ctgtctgggc
     1921 gagagacgga ggcaccggtc ctgcaacacc aatgactgtc cacctggctc ccaggacttc
     1981 agagaaatgc agtgctctga atttgacagt gttcctttcc gtggaaaatt ctacacatgg
     2041 aagacgtacc gaggaggggg cgtgaaggcc tgctcgctga cttgcctagc agatggcttc
     2101 aacttttaca cggagagagc agcagctgtg gtggatggaa caccctgccg ccctgacaca
     2161 gtggacattt gtgtcagcgg cgagtgcaag catgtgggct gtgacagggt cctgggttct
     2221 gatctccgag aggacaaatg cagagtgtgt gggggtgacg gcagtgcctg tgagaccatt
     2281 gagggggtct tcagcccagc tttgccagga actgggtatg aggacgtcgt ctggatcccc
     2341 aaaggctcag tccacatttt catccaagat ctgaacctgt cccttagtca cctggcccta
     2401 aagggggacc aggagtctct gctactggag gggctacctg ggacctccca acctcaccgc
     2461 cttcccctgg ctgggaccac atttcatcta cggcagggac cagaccaggc ccagagccta
     2521 gaagccctgg gacccattaa tgcatctctc atcatcatgg tgctggccca ggcagagttg
     2581 cctgctctcc gctaccgctt caatgcaccc attgcccggg atgcactgcc tccctactcc
     2641 tggcactatg ccccctggac caaatgctca gctcagtgtg caggcggcag ccaggtccaa
     2701 gtggtggagt gccgaaatca gctggacagc tcagcagtgg ccccacacta ctgcagtgcc
     2761 cacagcaaat tacccaagag gcagcgtgcc tgcaacacag aaccatgccc accagattgg
     2821 gttgtaggta actggtcccg ctgcagccgt agctgtgatg ctggtgtgcg tagccgctca
     2881 gtggtgtgcc aacgccgagt gtctgctgca gaggagaaag ccttagatga cagcgcctgt
     2941 ccacagccac gcccacctgt gctggaggcc tgccaaggcc caatgtgccc ccctgagtgg
     3001 gcagccctgg actggtctga gtgtacccca agttgtgggc ctggtctccg ccaccgagtg
     3061 gtcctttgta agagtgcaga tcaacgatcc actctgcccc ctgggcactg ccctcctgca
     3121 gccaagccac catctactat gagatgcaac ttgcgccgct gccctcccgc ccgctgggtg
     3181 gccagtgagt ggggtgagtg ttccacacag tgtggcctcg gccagcagca gcgcacagtg
     3241 cgttgcacca gccacactgg ccagccatct cgagagtgca ctgaggccct gcggccgtcc
     3301 accatgcagc agtgtgaggc caagtgtgac agtgtggtgc cgcctggaga tggcccagaa
     3361 gaatgcaagg atgtgaacaa ggtggcttac tgccccctgg tgctcaaatt tcagttctgt
     3421 agccgagcct acttccgcca gatgtgctgc aaaacctgcc aaggccgcta gggtacctgg
     3481 aaccaacctg gagcacaggc tgaggcaggg gaaatcccac tggagagggc ctgagggggg
     3541 atgggagggc tgggattgaa gggtgagacg cagttgaaag ttatttattg ggtaacccct
     3601 acagggctcc tggctagggg gtggagaaga gctggctacc cagggaccct cttcagtgtc
     3661 ttgccaagtt gacaatgaaa ggagaggact gccccttgtc gcacacactt ttaagtccct
     3721 aacactcccc caccctttga tcggaatatg tactgtgaag agtgggggtg gggagagggt
     3781 atgctggtac cctgcccccc agcactgttc tatccctaca ctctgagctg ggggaattta
     3841 tatctgctat ggggggagtg ggcttgatac cacctccctg tcaccctccc ccagactgac
     3901 caaggggaag atctacccca acctctgccc tgcctgccca gggggggagt ccaacatcca
     3961 ggccatcccc catcatggtg ctaacaagcc ctgccctggg gcccacacac tcctcaccaa
     4021 gaagccttcc attaataaag ttctgtcttg tgtagatttc cgctca
//
