LOCUS       NP_001258374            1104 aa            linear   ROD 31-MAR-2024
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 10
            precursor [Rattus norvegicus].
ACCESSION   NP_001258374 XP_003750343 XP_003754325
VERSION     NP_001258374.1
DBSOURCE    REFSEQ: accession NM_001271445.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1104)
  AUTHORS   Wu,H.J., Kuchtey,R.W. and Kuchtey,J.
  TITLE     Optic neuropathy associated with TGFbeta dysregulation in mice with
            a glaucoma-causative mutation of ADAMTS10
  JOURNAL   Matrix Biol 113, 83-99 (2022)
   PUBMED   36216203
REFERENCE   2  (residues 1 to 1104)
  AUTHORS   Wu,H.J., Mortlock,D.P., Kuchtey,R.W. and Kuchtey,J.
  TITLE     Altered Ocular Fibrillin Microfibril Composition in Mice With a
            Glaucoma-Causing Mutation of Adamts10
  JOURNAL   Invest Ophthalmol Vis Sci 62 (10), 26 (2021)
   PUBMED   34424262
REFERENCE   3  (residues 1 to 1104)
  AUTHORS   Kutz,W.E., Wang,L.W., Bader,H.L., Majors,A.K., Iwata,K.,
            Traboulsi,E.I., Sakai,L.Y., Keene,D.R. and Apte,S.S.
  TITLE     ADAMTS10 protein interacts with fibrillin-1 and promotes its
            deposition in extracellular matrix of cultured fibroblasts
  JOURNAL   J Biol Chem 286 (19), 17156-17167 (2011)
   PUBMED   21402694
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Sep 27, 2012 this sequence version replaced
            XP_003750343.1, XP_003754325.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.26817.1,
                                           SRR26643295.27435.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1104
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     Protein         1..1104
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 10 precursor"
                     /note="a disintegrin-like and metalloprotease (reprolysin
                     type) with thrombospondin type 1 motif, 10; a
                     disintegrin-like and metalloprotease with thrombospondin
                     type 1 motif, 10; A disintegrin and metalloproteinase with
                     thrombospondin motifs 10"
                     /calculated_mol_wt=118361
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2672
     Region          40..180
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          239..454
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(392..393,396,402)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          469..537
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          550..602
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          607..705
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          707..818
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          829..884
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          888..944
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          948..1002
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1007..1056
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1070..1102
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..1104
                     /gene="Adamts10"
                     /coded_by="NM_001271445.1:157..3471"
                     /db_xref="GeneID:314655"
                     /db_xref="RGD:1598320"
ORIGIN      
        1 masacqilrw alalglgltf kvthafrsqd ellsslesye iafptrvdhn gamlafsppa
       61 lrrqrrgvga aaesrlfykv aapsthflln ltrsprllag hvsveywtre glawqraara
      121 hclyaghlqg qagsshvais tcgglhgliv addeeyliep lqggpkgrrg peesgphvvy
      181 krsslrhphl dtacgvrdek pwkgrpwwlr tlkppparpq gnetergqlg lkrsvsrery
      241 vetlvvadkm mvayhgrrdv eqyvlaimni vaklfqdssl gnivnilvtr lilltedqpt
      301 leithhagks ldsfckwqks ivshsghgna ipengvanhd tavlitrydi ciyknkpcgt
      361 lglapvggmc ererscsine diglatafti aheightfgm nhdgvgngcg argqdpaklm
      421 aahitmktnp fvwsscsrdy itsfldsglg lclnnrpprq dfvyptvapg qaydadeqcr
      481 fqhgvksrqc kygevcselw clsksnrcit nsipaaegtl cqthtidkgw cykrvcvpfg
      541 srpegvdgaw gpwtpwgdcs rscgggvsss srhcdsprpt iggkyclger rrhrscntnd
      601 cppgsqdfre mqcsefdsvp frgkfytwkt yrgggvkacs ltcladgfnf yteraaavvd
      661 gtpcrpdtvd icvsgeckhv gcdrvlgsdl redkcrvcgg dgsacetieg vfspalpgtg
      721 yedvvwipkg svhifiqdln lslshlalkg dqeslllegl pgtsqphrlp lagttfhlrq
      781 gpdqaqslea lgpinaslii mvlaqaelpa lryrfnapia rdalppyswh yapwtkcsaq
      841 caggsqvqvv ecrnqldssa vaphycsahs klpkrqracn tepcppdwvv gnwsrcsrsc
      901 dagvrsrsvv cqrrvsaaee kalddsacpq prppvleacq gpmcppewaa ldwsectpsc
      961 gpglrhrvvl cksadqrstl ppghcppaak ppstmrcnlr rcpparwvas ewgecstqcg
     1021 lgqqqrtvrc tshtgqpsre ctealrpstm qqceakcdsv vppgdgpeec kdvnkvaycp
     1081 lvlkfqfcsr ayfrqmcckt cqgr
//
