LOCUS       NM_024400               4395 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase with thrombospondin type 1
            motif, 1 (Adamts1), mRNA.
ACCESSION   NM_024400
VERSION     NM_024400.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4395)
  AUTHORS   Tatar,M., Uslu,S. and Oner,J.
  TITLE     Expression of placental growth factor and a disintegrin and
            metalloprotease with a thrombospondin type motifs 1-4-8 during the
            three trimesters of rat pregnancy at the maternal-fetal interface
  JOURNAL   Anat Histol Embryol 52 (5), 805-814 (2023)
   PUBMED   37424113
  REMARK    GeneRIF: Expression of placental growth factor and a disintegrin
            and metalloprotease with a thrombospondin type motifs 1-4-8 during
            the three trimesters of rat pregnancy at the maternal-fetal
            interface.
REFERENCE   2  (bases 1 to 4395)
  AUTHORS   Li,M., Liu,Q., Lei,J., Wang,X., Chen,X. and Ding,Y.
  TITLE     MiR-362-3p inhibits the proliferation and migration of vascular
            smooth muscle cells in atherosclerosis by targeting ADAMTS1
  JOURNAL   Biochem Biophys Res Commun 493 (1), 270-276 (2017)
   PUBMED   28890348
REFERENCE   3  (bases 1 to 4395)
  AUTHORS   Roet,K.C., Franssen,E.H., de Bree,F.M., Essing,A.H., Zijlstra,S.J.,
            Fagoe,N.D., Eggink,H.M., Eggers,R., Smit,A.B., van Kesteren,R.E.
            and Verhaagen,J.
  TITLE     A multilevel screening strategy defines a molecular fingerprint of
            proregenerative olfactory ensheathing cells and identifies SCARB2,
            a protein that improves regenerative sprouting of injured sensory
            spinal axons
  JOURNAL   J Neurosci 33 (27), 11116-11135 (2013)
   PUBMED   23825416
REFERENCE   4  (bases 1 to 4395)
  AUTHORS   Oveland,E., Karlsen,T.V., Haslene-Hox,H., Semaeva,E., Janaczyk,B.,
            Tenstad,O. and Wiig,H.
  TITLE     Proteomic evaluation of inflammatory proteins in rat spleen
            interstitial fluid and lymph during LPS-induced systemic
            inflammation reveals increased levels of ADAMST1
  JOURNAL   J Proteome Res 11 (11), 5338-5349 (2012)
   PUBMED   23025351
  REMARK    GeneRIF: A disintegrin and metalloproteinase with thrombospondin
            motifs 1 (ADAMTS1) was detected by proteomics (the pro- region) in
            lymph only after LPS
REFERENCE   5  (bases 1 to 4395)
  AUTHORS   Wang,Y., Huang,C.X., Zhou,Y.F., Cheng,J.S., Wang,H., Wu,W.J.,
            Liao,W.Q., Wen,J.Y., Ke,Y.N. and Zheng,J.G.
  TITLE     ADAMTS-1 expression in rat myocardium after ischemic
            preconditioning: age-associated differences
  JOURNAL   Chin Med J (Engl) 124 (1), 95-99 (2011)
   PUBMED   21362315
  REMARK    GeneRIF: Cardioprotection with IPC is attenuated in the older
            heart. ADAMTS-1 expression induced by IPC is greater in old rats.
            Over-expression of anti-angiogenic factors might be a potential
            mechanism behind reduced protection after IPC associated with
            aging.
REFERENCE   6  (bases 1 to 4395)
  AUTHORS   Diamantis,I., Luthi,M., Hosli,M. and Reichen,J.
  TITLE     Cloning of the rat ADAMTS-1 gene and its down regulation in
            endothelial cells in cirrhotic rats
  JOURNAL   Liver 20 (2), 165-172 (2000)
   PUBMED   10847486
REFERENCE   7  (bases 1 to 4395)
  AUTHORS   Espey,L.L., Yoshioka,S., Russell,D.L., Robker,R.L., Fujii,S. and
            Richards,J.S.
  TITLE     Ovarian expression of a disintegrin and metalloproteinase with
            thrombospondin motifs during ovulation in the gonadotropin-primed
            immature rat
  JOURNAL   Biol Reprod 62 (4), 1090-1095 (2000)
   PUBMED   10727282
REFERENCE   8  (bases 1 to 4395)
  AUTHORS   Vazquez,F., Hastings,G., Ortega,M.A., Lane,T.F., Oikemus,S.,
            Lombardo,M. and Iruela-Arispe,M.L.
  TITLE     METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a
            new family of proteins with angio-inhibitory activity
  JOURNAL   J Biol Chem 274 (33), 23349-23357 (1999)
   PUBMED   10438512
REFERENCE   9  (bases 1 to 4395)
  AUTHORS   Kuno,K. and Matsushima,K.
  TITLE     ADAMTS-1 protein anchors at the extracellular matrix through the
            thrombospondin type I motifs and its spacing region
  JOURNAL   J Biol Chem 273 (22), 13912-13917 (1998)
   PUBMED   9593739
REFERENCE   10 (bases 1 to 4395)
  AUTHORS   Kuno,K., Kanada,N., Nakashima,E., Fujiki,F., Ichimura,F. and
            Matsushima,K.
  TITLE     Molecular cloning of a gene encoding a new type of
            metalloproteinase-disintegrin family protein with thrombospondin
            motifs as an inflammation associated gene
  JOURNAL   J Biol Chem 272 (1), 556-562 (1997)
   PUBMED   8995297
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC080237.1.
            
            On Jun 10, 2007 this sequence version replaced NM_024400.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080237.1, AF149118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788, SAMN16676789
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4395
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..4395
                     /gene="Adamts1"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif, 1"
                     /db_xref="GeneID:79252"
                     /db_xref="RGD:621241"
     exon            1..1111
                     /gene="Adamts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1458
                     /gene="Adamts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1591
                     /gene="Adamts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1759
                     /gene="Adamts1"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..2046
                     /gene="Adamts1"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2233
                     /gene="Adamts1"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2409
                     /gene="Adamts1"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2585
                     /gene="Adamts1"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..4371
                     /gene="Adamts1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctaggcctga gcgcacagcc cggcggagag agcagatcct tgctcagatc cagccctatc
       61 gcggccaagg cggaggacga agagtccagg ctcttattct ggacttgttc cccaattcca
      121 gggcgcttct cgatcctgca gcagcctctt agcggctcca gcagtgcgga gccattaact
      181 actcggtgct ggaataaaaa aattcccgcg cgccggcgca gcctttttct aagtgacccg
      241 gagcttttgg ctgcgagctc tgcaagaact ttcaaatcaa agtgcttgtg aattttaagc
      301 atccggagca ggccaacgaa gctctgcgcg tctaaccgtc taaccagaac aagagttctc
      361 tgcgctgcag tgtgcggtgt catgcagcca gaagtccctt tggggtcagg caagctgaag
      421 ccctgctcag acatggggga catccagcgg gcagcgaagt ttcggagctc tcagtctgca
      481 cacatgctgt tgctactcct cgcttccata acaatgctgc tatgtgtgcg gggcgcacac
      541 gggcgcccca cggaggaaga cgaggagctg gtgctgccct cgctggagcg cgcccggggc
      601 cacggttcca ccacactcct ccgtctggac gcctttggtc agcagctgca tctgaagttg
      661 cagccagaca gcggtttctt agcgcctggc ttcaccctcc agacggtggg gcgcagtcct
      721 gggtccgagg cacagcatct ggaccccact ggggacctgg cccactgctt ctactctggc
      781 acggtgaacg gtgaccccag ctccgccgcc gccctcagcc tctgtgaagg tgtgcgcggt
      841 gccttctacc tacaaggcga ggagttcttc attcagccag cgcctgcggt ggccaccgag
      901 cgcctggtcc ccgccgaacc gaaggaggag tcaatcgcac ctccgcggtt ccacatcctg
      961 aggcgaaggc ggcggggcag cggcggcgca aagtgcggtg tcatggacga agagaccctg
     1021 ccaaccagca actcgggtcg cgaaagccag aacaccccgg accagtggcc tctgcggaac
     1081 cccactcctc agggcgcggg aaagccaaca ggaccaggaa gcataaggaa gaagcgattt
     1141 gtgtccagcc cccgttatgt ggaaaccatg ctcgtggctg accagtccat ggctgacttc
     1201 cacggcagcg gtctaaagca ttaccttcta accctgttct cggtggcagc cagattttac
     1261 aagcacccca gcattaggaa ttcaattagt ctggtggtgg tgaagatctt ggtcatatat
     1321 gaggagcaga agggaccgga agttacttcc aatgccgctc tcacccttag gaatttctgt
     1381 agctggcaga aacagcacaa cagccccagt gaccgggatc cagagcacta tgacacagcg
     1441 attctgttca ccagacagga tttatgtggc tcccacacct gtgacactct cgggatggct
     1501 gatgttggaa ctgtatgtga ccccagcagg agctgttcgg tcatcgaaga tgatggttta
     1561 caggctgcct tcaccacagc ccatgaattg ggccatgtgt ttaacatgcc acacgatgac
     1621 gccaagcact gcgccagctt taatggcgtg agtggggatt cccatctgat ggcctcgatg
     1681 ctctccagct tggaccacag ccagccctgg tctccttgca gtgcctacat ggtcacatca
     1741 ttcctggaca acggccatgg ggaatgtttg atggacaagc cgcagaaccc aatcaagctc
     1801 ccatctgatc ttcccggtac cttgtacgat gccaaccgcc agtgtcagtt taccttcggg
     1861 gaggaatcca cgcactgccc tgatgcagcc agcacatgca gtaccctgtg gtgcactggc
     1921 acctccggtg gcttactggt gtgccaaaca aaacacttcc cttgggcaga tggcaccagc
     1981 tgcggagaag ggaaatggtg tgtcagcggc aagtgtgtga acaagaccga catgaagcac
     2041 tttgctactc ctgttcatgg gagctgggga ccgtggggac catggggaga ctgctcaaga
     2101 acctgtggtg gaggagttca atatacaatg agagaatgtg acaacccggt cccaaagaac
     2161 ggggggaagt actgcgaagg caaacgagtc cgctacaggt cctgtaacat tgaggactgt
     2221 ccagacaata acggaaaaac attcagagag gagcaatgcg aggcgcacaa tgagttttcc
     2281 aaagcttcct ttgggaatga acccacggtg gaatggacac ccaagtatgc tggcgtctcg
     2341 ccaaaggaca ggtgcaagct tacctgcgaa gccaaaggca ttggctactt ctttgtttta
     2401 cagcccaagg tggtagatgg cactccctgt agtccagact ctacttctgt ctgtgtgcaa
     2461 ggacagtgtg tgaaagctgg ctgtgatcgc atcatagact ccaaaaagaa gttcgataag
     2521 tgtggcgttt gtggaggaaa tggctccacg tgcaagaaaa tatcaggaac ggtcactagt
     2581 acaagacctg ggtatcatga cattgtcaca attcctgctg gagccaccaa cattgaagtg
     2641 aaacatcgta atccaagggg gtccagaaac aatggcagct ttctggctat tagagctgca
     2701 gatggtacct atattctgaa tggaaacttc actctgtcca ctctagagca agacctcacc
     2761 tacaaaggta ctgtcttaag atacagtggt tcctcagcag cattggaaag aatccgcagc
     2821 tttagtccac tcaaagaacc cctgaccatc caggttctta tggtgggcca tgctctccga
     2881 cccaaaatca agtacaccta ttttatgaag aagaagacgg agcccttcaa cgctattccc
     2941 acattttcgg agtgggtgat tgaagagtgg ggggagtgct ccaagacatg tggttccggt
     3001 tggcagagga gagtggtaga gtgcagagac attaatggac accctgcttc tgaatgtgcc
     3061 aaagaagtga agccagccag taccagacct tgtgcagacc ttccttgccc acgttggcag
     3121 gtgggggatt ggtcaccatg ttctaaaact tgtgggaagg gttataagaa gagaaccttg
     3181 aaatgtctgt cccatgatgg cggtgtgtta tcaaatgaga gctgtgatcc tttgaagaaa
     3241 ccaaagcatt acattgactt ttgcatactg acacagtgca gttaagaggt tttgaggaca
     3301 atgtagcgtg ggagggctga tacactgaaa gcaagagtgc tggagggatc ctgtgaatca
     3361 aaccagtaaa cagtgaggtg tggcaatgag gtgtgtgtag gggatacatt agcaaaagag
     3421 gtagatccgt acactatcct gccagttaac ttctgatagg gtagttaatg aggaatagta
     3481 gcatctgaaa gaccatacat agcactatga agccccaaag tactattagt attccttttg
     3541 ttacatccac tgcacaaata attttcagag tctggcagaa gcatggctac cctgttgcat
     3601 ggtactaatt aatactttgt atcacagggg ttgggaaagg aaagcagaag aatggtaaga
     3661 ttggatttca aacatggctt acttttttat cactggaggc agggagaagg gtacaaacaa
     3721 gatcattatt caaagtttct ggctgccgtg gtttcaggga aggttgattc ctatcaagag
     3781 tgaaaagttc tgattgctca acatgagaga gagaaagcct cgtctctgtg aaataactct
     3841 tgatttcttc ttagaccatc tccgtttttt aaccataatt cctgttgagg tagtaacaat
     3901 tcacctactt ataaaatgta cattgggtgg gaaaaagtga agtataagag ttacacataa
     3961 aaactcaagg aataagcaac atggctcctg ctttgctttc tcctaaggtt agcctgcctg
     4021 ggatctgtgg acgttaaaga taatccttga ctcacaaaag gcagtaaaac catacatgtc
     4081 atgcaagagt aagaatgggc tatagagatc agggtcccat gagatggggg acacggaggt
     4141 cactcatctc acatgggaga ctgctgcagg atagcaggtc cactcctggc agctggtcca
     4201 acagtcgtat cctggtgaat gtctgttcag ctcttttact gagagagaat atgactgttt
     4261 ccatatgtat atagtaaaat acattactat gatttatatg tactttataa gtattggttt
     4321 gtttgttcct tctaagaagg actatagttt ataataaatg cctataacat aaaaaaaaaa
     4381 aaaaaaaaaa aaaaa
//
