LOCUS       NM_001014772            3094 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 9 (Adam9), mRNA.
ACCESSION   NM_001014772 XM_224964
VERSION     NM_001014772.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3094)
  AUTHORS   Goel,K., Egersdorf,N., Gill,A., Cao,D., Collum,S.D., Jyothula,S.S.,
            Huang,H.J., Sauler,M., Lee,P.J., Majka,S., Karmouty-Quintana,H. and
            Petrache,I.
  TITLE     Characterization of pulmonary vascular remodeling and
            MicroRNA-126-targets in COPD-pulmonary hypertension
  JOURNAL   Respir Res 23 (1), 349 (2022)
   PUBMED   36522710
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3094)
  AUTHORS   Wang,L., Hu,J., Zhao,Y., Lu,X., Zhang,Q. and Niu,Q.
  TITLE     Effects of aluminium on beta-amyloid (1-42) and secretases
            (APP-cleaving enzymes) in rat brain
  JOURNAL   Neurochem Res 39 (7), 1338-1345 (2014)
   PUBMED   24792732
REFERENCE   3  (bases 1 to 3094)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 3094)
  AUTHORS   English,W.R., Corvol,P. and Murphy,G.
  TITLE     LPS activates ADAM9 dependent shedding of ACE from endothelial
            cells
  JOURNAL   Biochem Biophys Res Commun 421 (1), 70-75 (2012)
   PUBMED   22480688
REFERENCE   5  (bases 1 to 3094)
  AUTHORS   Lizama,C., Rojas-Benitez,D., Antonelli,M., Ludwig,A. and
            Moreno,R.D.
  TITLE     Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced
            apoptosis of germ cells in rat spermatogenesis
  JOURNAL   J Cell Physiol 227 (2), 829-838 (2012)
   PUBMED   21503882
REFERENCE   6  (bases 1 to 3094)
  AUTHORS   Mahimkar,R.M., Baricos,W.H., Visaya,O., Pollock,A.S. and
            Lovett,D.H.
  TITLE     Identification, cellular distribution and potential function of the
            metalloprotease-disintegrin MDC9 in the kidney
  JOURNAL   J Am Soc Nephrol 11 (4), 595-603 (2000)
   PUBMED   10752518
REFERENCE   7  (bases 1 to 3094)
  AUTHORS   Howard,L., Nelson,K.K., Maciewicz,R.A. and Blobel,C.P.
  TITLE     Interaction of the metalloprotease disintegrins MDC9 and MDC15 with
            two SH3 domain-containing proteins, endophilin I and SH3PX1
  JOURNAL   J Biol Chem 274 (44), 31693-31699 (1999)
   PUBMED   10531379
REFERENCE   8  (bases 1 to 3094)
  AUTHORS   Roghani,M., Becherer,J.D., Moss,M.L., Atherton,R.E.,
            Erdjument-Bromage,H., Arribas,J., Blackburn,R.K., Weskamp,G.,
            Tempst,P. and Blobel,C.P.
  TITLE     Metalloprotease-disintegrin MDC9: intracellular maturation and
            catalytic activity
  JOURNAL   J Biol Chem 274 (6), 3531-3540 (1999)
   PUBMED   9920899
REFERENCE   9  (bases 1 to 3094)
  AUTHORS   Izumi,Y., Hirata,M., Hasuwa,H., Iwamoto,R., Umata,T., Miyado,K.,
            Tamai,Y., Kurisaki,T., Sehara-Fujisawa,A., Ohno,S. and Mekada,E.
  TITLE     A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and
            PKCdelta are involved in TPA-induced ectodomain shedding of
            membrane-anchored heparin-binding EGF-like growth factor
  JOURNAL   EMBO J 17 (24), 7260-7272 (1998)
   PUBMED   9857183
REFERENCE   10 (bases 1 to 3094)
  AUTHORS   Weskamp,G., Kratzschmar,J., Reid,M.S. and Blobel,C.P.
  TITLE     MDC9, a widely expressed cellular disintegrin containing
            cytoplasmic SH3 ligand domains
  JOURNAL   J Cell Biol 132 (4), 717-726 (1996)
   PUBMED   8647900
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001014772.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY953138.1, SRR26643296.35777.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JAXUCZ010000016.1  73725339-73725462
            125-222             JAXUCZ010000016.1  73735083-73735180
            223-281             JAXUCZ010000016.1  73736557-73736615
            282-360             JAXUCZ010000016.1  73738041-73738119
            361-437             JAXUCZ010000016.1  73743675-73743751
            438-633             JAXUCZ010000016.1  73744649-73744844
            634-699             JAXUCZ010000016.1  73746248-73746313
            700-771             JAXUCZ010000016.1  73748301-73748372
            772-941             JAXUCZ010000016.1  73749242-73749411
            942-1023            JAXUCZ010000016.1  73750154-73750235
            1024-1157           JAXUCZ010000016.1  73751155-73751288
            1158-1329           JAXUCZ010000016.1  73764753-73764924
            1330-1422           JAXUCZ010000016.1  73767330-73767422
            1423-1618           JAXUCZ010000016.1  73768270-73768465
            1619-1724           JAXUCZ010000016.1  73773919-73774024
            1725-1908           JAXUCZ010000016.1  73776943-73777126
            1909-1989           JAXUCZ010000016.1  73780018-73780098
            1990-2095           JAXUCZ010000016.1  73780495-73780600
            2096-2228           JAXUCZ010000016.1  73782846-73782978
            2229-2403           JAXUCZ010000016.1  73785495-73785669
            2404-2471           JAXUCZ010000016.1  73789593-73789660
            2472-3094           JAXUCZ010000016.1  73802932-73803554
FEATURES             Location/Qualifiers
     source          1..3094
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..3094
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /note="ADAM metallopeptidase domain 9"
                     /db_xref="GeneID:290834"
                     /db_xref="RGD:621473"
     exon            1..124
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..2565
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /note="a disintegrin and metalloproteinase domain 9
                     (meltrin gamma); a disintegrin and metallopeptidase domain
                     9 (meltrin gamma); disintegrin and metalloproteinase
                     domain-containing protein 9"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 9 precursor"
                     /protein_id="NP_001014772.2"
                     /db_xref="GeneID:290834"
                     /db_xref="RGD:621473"
                     /translation="MGPRALSPLASLRLRWLLACGLLGPVLEAGRPDSEQTVHLSSYE
                     IVTPWRLSRERREALRPSSKQISYVIQAQGKQHIIHLERNTDLLPNDFVVYTYDEEGS
                     LLSDHPNVQSHCHYRGYVEGVPNSTVAVSACFGLRGLLHLENASFGIEPLHNSSHFEH
                     VFYPMDDVHQEPLRCGVSNRDTEQEATQGEEEEHPSVTQLLRRRRAVLPQTRYVELFI
                     VVDKERYNMMGRNQTAVREEMIRLANYLDSMYIMLNIRIVLVGLEIWTDRNPINIIGG
                     AGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFG
                     QITVETFASIVAHELGHNLGMNHDDGRECFCAAKSCIMNSGASGSRNFSSCSAEDFEK
                     LTLNKGGSCLLNIPKPDEAYSAPSCGNKLVDPGEECDCGTPKECELDPCCEGSTCKLK
                     SFAECAYGDCCKDCQFLPGGSMCRGKTSECDVPEYCNGSSQFCPPDVFIQNGYPCWNS
                     KAYCYNGVCQYYDAQCQVIFGSKAKAAPRDCFIEVNSKGDRFGNCGVSGSNYKTCATG
                     NALCGKLQCENVQEMPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCD
                     AGKICRNFQCVNASVLNYDCDIQGKCHGHGVCNSNKNCHCEDGWAPPHCDTKGYGGSV
                     DSGPTYNAKSTALRDGLLVFFFLIIPLVAAAFFLFIKRDELRKTFRKKRSQMSDGRNQ
                     ANASRPPGDPSVSRPPGGPSVSRPPGGPNVSRPPGGPNVSRPPGGPSVSRPPPVHGNR
                     FPVPTYAIKQPPQFPSRPPPPQPKIPSQGNLIPARPAPAPPLYSSLT"
     exon            125..222
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            223..281
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            282..360
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            361..437
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            438..633
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            634..699
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            700..771
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            772..941
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1023
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1157
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1329
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1422
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1618
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1724
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1908
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1989
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2095
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2228
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2403
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2471
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..3094
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgagccgaac ctgccgaagc cctagccatg gggccgcgcg cgctctcgcc cctcgcctct
       61 ctgcgactaa ggtggctgct ggcgtgtggc ttgctgggcc cagtcctcga ggccgggcgg
      121 ccagactctg aacagaccgt ccatctttct tcttatgaaa ttgtaactcc ttggagatta
      181 agtagagaaa gaagggaagc tctgaggccc agttcaaaac agatctctta tgtcatccag
      241 gcccaaggaa aacagcatat tattcacttg gaaagaaaca cagacctttt acctaacgac
      301 tttgtagttt atacctacga cgaggagggc tccctactct ctgaccatcc caacgtacag
      361 agtcattgcc attaccgagg ctatgtggag ggagtgccca attccaccgt tgctgtgagt
      421 gcctgctttg gactcagagg attgctgcat ttggagaatg ccagttttgg aatcgaacct
      481 ctgcacaaca gctcacactt tgagcacgtg ttttacccaa tggatgatgt ccaccaggag
      541 cctctgagat gtggcgtctc taacagggac acagagcagg aagccaccca gggggaagag
      601 gaagagcacc cgagcgtgac tcagctgctg cgaagaagaa gagctgttct cccgcagacc
      661 cgctacgtgg agctgttcat tgttgtagac aaggaaaggt acaacatgat gggaaggaac
      721 cagactgctg tgagagaaga gatgattcgc ttagcaaact acctggatag catgtacatc
      781 atgttaaaca ttcgaattgt gctagttgga ctagaaattt ggacagatag aaatcctatc
      841 aatataattg gaggagctgg agatgtattg ggcaactttg tacagtggcg ggaaaagttt
      901 cttataacac gtcggagaca tgacagtgca cagttggttt tgaagaaagg ctttggtgga
      961 actgcaggaa tggcatttgt aggaacagta tgttcaagga gccacgcagg tgggattaat
     1021 gtgtttgggc aaatcaccgt ggagacattt gcgtccattg ttgctcatga actgggacat
     1081 aaccttggga tgaatcatga tgatgggaga gagtgtttct gtgcagcaaa gagctgtatc
     1141 atgaattcag gagcatcagg gtccaggaac ttcagcagtt gcagtgcaga ggactttgag
     1201 aaattaactt tgaacaaggg aggaagctgc ctgctcaaca tcccgaagcc tgacgaggcc
     1261 tacagcgcgc cctcctgtgg taacaagctg gtggaccccg gggaggagtg tgactgtggc
     1321 acaccaaagg aatgtgagtt ggatccatgc tgtgaaggaa gcacttgtaa gctcaagtca
     1381 tttgctgagt gtgcatatgg cgactgttgt aaagattgcc agttccttcc aggaggctct
     1441 atgtgcagag ggaagaccag tgagtgtgat gtccctgagt actgcaatgg ctcctctcag
     1501 ttctgcccac ccgatgtctt cattcagaac ggctatcctt gttggaatag caaagcctac
     1561 tgttacaatg gcgtgtgcca gtattatgac gctcagtgcc aggtcatctt tggttcaaaa
     1621 gctaaggctg ccccaagaga ttgcttcatt gaagtgaatt ctaaaggtga cagatttggc
     1681 aactgtggtg tctccggcag taattacaaa acgtgtgcca cagggaacgc gttgtgtgga
     1741 aagcttcagt gtgagaacgt gcaggagatg ccggtgttcg gaatcgtgcc agctatcatt
     1801 cagacaccca gccgaggcac caaatgttgg ggtgtggatt tccagcttgg ttccgatgtc
     1861 ccagacccag ggatggtgaa tgaaggcaca aaatgtgatg ctgggaagat ttgtaggaat
     1921 tttcagtgtg taaatgcttc tgtcctgaat tatgactgtg acattcaggg aaaatgtcac
     1981 ggccatgggg tatgtaacag caataagaat tgtcactgtg aagatggctg ggctccccca
     2041 cactgtgaca ccaaaggata tggagggagt gtggacagtg ggccgacgta caatgcaaag
     2101 agcacggccc tgagggatgg acttctggtc ttcttcttcc taatcatccc cctggttgcg
     2161 gctgcctttt tcctcttcat caagagagat gaactgagga aaaccttcag gaagaagaga
     2221 tcacaaatgt cagatggcag aaatcaagca aatgcctcta gaccgccagg ggaccccagt
     2281 gtctccagac caccaggggg tccaagtgtc tccagaccac cagggggccc aaatgtctcc
     2341 agaccaccag ggggcccaaa tgtctccaga ccaccagggg gcccgagtgt ctccagacca
     2401 ccacccgtgc atggaaacag attcccagta ccaacctatg ccatcaagca gccaccacag
     2461 tttccatcaa ggccacctcc accacaaccg aaaatacctt ctcagggaaa cttgattccg
     2521 gcccggccag ctcctgcacc tcctttatat agctccctca cctgacagca gagtcttatt
     2581 tttcaaaagt cttcagggaa ctgagcaaat gtggtttttt ttttctgatg ttttcttgaa
     2641 aagcctttct cttccagccg tgaatgaaca caaattacca caaaacaagc tttattaaca
     2701 cagaagccca gtggggttgg agaaatacag gaacgctgca ggcactccgg ggatttaaaa
     2761 cgaatgttcc catcatttaa atgttttcta tggccatttg tgaatttaat gcactcgatg
     2821 tggattaagt tattttgaac acgttactgt aatgattctc aaattaactg cattagtgta
     2881 agacttgtca tcatgcgctt aaatgtgatc ctgacctttt gaccccagtt accatttgaa
     2941 cgtgtattaa cttaggaaga ctaattgcca ataacatttg cattttcacc ttgcatggat
     3001 taacagtcat ttatgtggac ttaggtctct tagtacacag agaagcaggt acctggaagg
     3061 agaatgcata cacgggaact acagttgcca gatc
//
