LOCUS       NP_001014772             845 aa            linear   ROD 03-APR-2024
DEFINITION  disintegrin and metalloproteinase domain-containing protein 9
            precursor [Rattus norvegicus].
ACCESSION   NP_001014772 XP_224964
VERSION     NP_001014772.2
DBSOURCE    REFSEQ: accession NM_001014772.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 845)
  AUTHORS   Goel,K., Egersdorf,N., Gill,A., Cao,D., Collum,S.D., Jyothula,S.S.,
            Huang,H.J., Sauler,M., Lee,P.J., Majka,S., Karmouty-Quintana,H. and
            Petrache,I.
  TITLE     Characterization of pulmonary vascular remodeling and
            MicroRNA-126-targets in COPD-pulmonary hypertension
  JOURNAL   Respir Res 23 (1), 349 (2022)
   PUBMED   36522710
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 845)
  AUTHORS   Wang,L., Hu,J., Zhao,Y., Lu,X., Zhang,Q. and Niu,Q.
  TITLE     Effects of aluminium on beta-amyloid (1-42) and secretases
            (APP-cleaving enzymes) in rat brain
  JOURNAL   Neurochem Res 39 (7), 1338-1345 (2014)
   PUBMED   24792732
REFERENCE   3  (residues 1 to 845)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (residues 1 to 845)
  AUTHORS   English,W.R., Corvol,P. and Murphy,G.
  TITLE     LPS activates ADAM9 dependent shedding of ACE from endothelial
            cells
  JOURNAL   Biochem Biophys Res Commun 421 (1), 70-75 (2012)
   PUBMED   22480688
REFERENCE   5  (residues 1 to 845)
  AUTHORS   Lizama,C., Rojas-Benitez,D., Antonelli,M., Ludwig,A. and
            Moreno,R.D.
  TITLE     Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced
            apoptosis of germ cells in rat spermatogenesis
  JOURNAL   J Cell Physiol 227 (2), 829-838 (2012)
   PUBMED   21503882
REFERENCE   6  (residues 1 to 845)
  AUTHORS   Mahimkar,R.M., Baricos,W.H., Visaya,O., Pollock,A.S. and
            Lovett,D.H.
  TITLE     Identification, cellular distribution and potential function of the
            metalloprotease-disintegrin MDC9 in the kidney
  JOURNAL   J Am Soc Nephrol 11 (4), 595-603 (2000)
   PUBMED   10752518
REFERENCE   7  (residues 1 to 845)
  AUTHORS   Howard,L., Nelson,K.K., Maciewicz,R.A. and Blobel,C.P.
  TITLE     Interaction of the metalloprotease disintegrins MDC9 and MDC15 with
            two SH3 domain-containing proteins, endophilin I and SH3PX1
  JOURNAL   J Biol Chem 274 (44), 31693-31699 (1999)
   PUBMED   10531379
REFERENCE   8  (residues 1 to 845)
  AUTHORS   Roghani,M., Becherer,J.D., Moss,M.L., Atherton,R.E.,
            Erdjument-Bromage,H., Arribas,J., Blackburn,R.K., Weskamp,G.,
            Tempst,P. and Blobel,C.P.
  TITLE     Metalloprotease-disintegrin MDC9: intracellular maturation and
            catalytic activity
  JOURNAL   J Biol Chem 274 (6), 3531-3540 (1999)
   PUBMED   9920899
REFERENCE   9  (residues 1 to 845)
  AUTHORS   Izumi,Y., Hirata,M., Hasuwa,H., Iwamoto,R., Umata,T., Miyado,K.,
            Tamai,Y., Kurisaki,T., Sehara-Fujisawa,A., Ohno,S. and Mekada,E.
  TITLE     A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and
            PKCdelta are involved in TPA-induced ectodomain shedding of
            membrane-anchored heparin-binding EGF-like growth factor
  JOURNAL   EMBO J 17 (24), 7260-7272 (1998)
   PUBMED   9857183
REFERENCE   10 (residues 1 to 845)
  AUTHORS   Weskamp,G., Kratzschmar,J., Reid,M.S. and Blobel,C.P.
  TITLE     MDC9, a widely expressed cellular disintegrin containing
            cytoplasmic SH3 ligand domains
  JOURNAL   J Cell Biol 132 (4), 717-726 (1996)
   PUBMED   8647900
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NP_001014772.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY953138.1, SRR26643296.35777.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..845
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     Protein         1..845
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 9 precursor"
                     /note="a disintegrin and metalloproteinase domain 9
                     (meltrin gamma); a disintegrin and metallopeptidase domain
                     9 (meltrin gamma); disintegrin and metalloproteinase
                     domain-containing protein 9"
                     /calculated_mol_wt=89312
     sig_peptide     1..29
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3075
     Region          44..163
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          212..406
                     /region_name="Reprolysin"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     pfam01421"
                     /db_xref="CDD:426256"
     Region          423..496
                     /region_name="Disintegrin"
                     /note="pfam00200"
                     /db_xref="CDD:459709"
     Region          500..636
                     /region_name="ACR"
                     /note="ADAM Cysteine-Rich Domain; smart00608"
                     /db_xref="CDD:214743"
     Region          650..673
                     /region_name="EGF_2"
                     /note="EGF-like domain; pfam07974"
                     /db_xref="CDD:400365"
     Region          732..>802
                     /region_name="Pro-rich"
                     /note="Proline-rich protein; pfam15240"
                     /db_xref="CDD:464580"
     CDS             1..845
                     /gene="Adam9"
                     /gene_synonym="MDC9"
                     /coded_by="NM_001014772.2:28..2565"
                     /db_xref="GeneID:290834"
                     /db_xref="RGD:621473"
ORIGIN      
        1 mgpralspla slrlrwllac gllgpvleag rpdseqtvhl ssyeivtpwr lsrerrealr
       61 psskqisyvi qaqgkqhiih lerntdllpn dfvvytydee gsllsdhpnv qshchyrgyv
      121 egvpnstvav sacfglrgll hlenasfgie plhnsshfeh vfypmddvhq eplrcgvsnr
      181 dteqeatqge eeehpsvtql lrrrravlpq tryvelfivv dkerynmmgr nqtavreemi
      241 rlanyldsmy imlnirivlv gleiwtdrnp iniiggagdv lgnfvqwrek flitrrrhds
      301 aqlvlkkgfg gtagmafvgt vcsrshaggi nvfgqitvet fasivahelg hnlgmnhddg
      361 recfcaaksc imnsgasgsr nfsscsaedf ekltlnkggs cllnipkpde aysapscgnk
      421 lvdpgeecdc gtpkeceldp ccegstcklk sfaecaygdc ckdcqflpgg smcrgktsec
      481 dvpeycngss qfcppdvfiq ngypcwnska ycyngvcqyy daqcqvifgs kakaaprdcf
      541 ievnskgdrf gncgvsgsny ktcatgnalc gklqcenvqe mpvfgivpai iqtpsrgtkc
      601 wgvdfqlgsd vpdpgmvneg tkcdagkicr nfqcvnasvl nydcdiqgkc hghgvcnsnk
      661 nchcedgwap phcdtkgygg svdsgptyna kstalrdgll vfffliiplv aaafflfikr
      721 delrktfrkk rsqmsdgrnq anasrppgdp svsrppggps vsrppggpnv srppggpnvs
      781 rppggpsvsr pppvhgnrfp vptyaikqpp qfpsrppppq pkipsqgnli parpapappl
      841 ysslt
//
