LOCUS       XM_006230499            3853 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus ADAM metallopeptidase domain 8
            (Adam8), transcript variant X1, mRNA.
ACCESSION   XM_006230499
VERSION     XM_006230499.4
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051336.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_006230499.5.
            
            On Jan 21, 2021 this sequence version replaced XM_006230499.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3853
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..3853
                     /gene="Adam8"
                     /note="ADAM metallopeptidase domain 8; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 11 ESTs, 2 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     45 samples with support for all annotated introns"
                     /db_xref="GeneID:499285"
                     /db_xref="RGD:1566394"
     CDS             699..3305
                     /gene="Adam8"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 8 isoform X1"
                     /protein_id="XP_006230561.1"
                     /db_xref="GeneID:499285"
                     /db_xref="RGD:1566394"
                     /translation="MLGLWLLSILWTPAVAPGPPLPHVKQYEVVWPRRLAASRSRRSL
                     PSQWGLYPESLSYALGTSEQVFTLHLRKNRDLLGSSYTETYSAANGSEVKEQLHEQDH
                     CLYQGHVEGYEGSAASISTCAGLSGFFRVGSTVHLIEPLDADEEGQHAVYQAKHLEQK
                     AGTCGVSETSLDKLGPRTLEIYRAQPGNWLKPREIRYVELYVVADSQEFQKLGTREAV
                     RQRVLEVVNHVDKLYRELSFRVVLVGLEIWNKDKFYISRYANVTLENFLSWREQNLLG
                     RHPHDNVQLITGVDFIGTTVGLAKVSALCSRHSGAVNQDHTRSAIGVASTMAHELGHN
                     LGMNHDENIPGCYCPIPREGGGCIMTESIGSKFPKTFSRCSQVDLESFVTNHQTGCLT
                     NVPDVNRFVGGPVCGNLFVERGEQCDCGTPQDCQNPCCNATTCQLAKGAECAHGACCH
                     ECKVKPAGELCRPMKDKCDLEEFCDGQKPTCPEDAFQQNGTPCPGGYCFDGSCPTLAQ
                     QCQALWGPGARAASDSCFAFSIPQGCYGSMYPSRINRCGVLFCEGGQKPLERSSCTFS
                     SHHGLCQALQTDSNTNTYEFVLQGTKCEEGKVCMDGNCQDLRVYRSENCSAKCNNHGV
                     CNHKRECHCHAGWAPPYCAQLLADVPVVTESAAVHSTTASGNWRGLNSGTVGLGLATT
                     TSSNPLLESQKSWSSESLPVSVVVVLVILVAAVVIGAGIVIYRKAPKQIQRRSVAPKP
                     TSGLSNPLFYTGDSSLPAKSRPPDPPEMVSTNQPPRPIVKPKRPPPAPPGAMSSPPLP
                     VPVYAPKAPNQLRPDPPTKPLPKLKPKQVKPTFAPPTPPVKPGTGGTVPGVTQQGAGG
                     SKVALKVPIQKR"
ORIGIN      
        1 tacctaggga cagagaagac agaatccagg cctgtacaag gagtccggtg cttctggacc
       61 cctacagtga ggttcggtag gacctcaaag aatcagtcag attcttccct gcatgtccct
      121 ctccaatgag gcctcagaaa cctggtggag ctgggcagag cttaggagta ttggtttgcc
      181 ctgcctgcat ctttcagatg tccaggaagt ctaagggtcc ccttctgaaa tttcagactc
      241 ataagtcact tcccttccaa aagtcatctt cctccagcta gactccaccc aattaacact
      301 cccaaagctc tgtcagggct gagaggcaat cccccaggac tgggagcttg tagaattgta
      361 gctgcccaag ttggtccatt taccctctcc agctcccatt aattttattc aataccatgg
      421 gagatcaata ggagacacaa agctacccag aaaccaactg ggaggggcct ctgtaactcc
      481 agactgccct ggaggcgagt tgctgccagc agggtgttgg tatagaggtg tacacttctt
      541 gccccacctt gctccaccct accccgcccc acagtccagt gattggctag ttctgatcag
      601 tgggaagggc tcaaaagaaa gaaataccag actagtgatc tagagagagt actttgtgga
      661 acctctagct ctagggttag tgtgccccag atcgtgtcat gcttggcctc tggctactca
      721 gcatcttatg gacaccagca gtagcccctg gacctccttt gcctcatgtg aaacagtatg
      781 aggtggtatg gcctcggcgc ctagctgcat cccgctcccg cagaagcctg ccctcccagt
      841 ggggcttgta cccagagagt ctgagctatg ctcttgggac cagtgagcaa gttttcaccc
      901 tgcaccttcg aaagaacagg gacttgctgg gctcaagcta cacagagacc tactcagctg
      961 ccaatggctc tgaggtgaag gagcagctgc acgagcagga ccattgcctc taccagggcc
     1021 atgtggaagg gtatgagggc tcagctgcca gtattagcac ctgtgccggc ctcagcggct
     1081 ttttccgagt cgggtccact gtccacttga ttgagcctct ggatgctgac gaagaggggc
     1141 agcatgcagt gtaccaggca aagcatctgg aacagaaggc tgggacctgt ggggtcagcg
     1201 aaaccagcct ggataaacta gggcctcgga ccttagaaat ctacagggct cagcccggga
     1261 actggctaaa acctagagaa atccgctatg tggagttgta tgtggttgca gacagccaag
     1321 agttccagaa gctggggacc agagaggctg tgcgtcagcg agtgctggag gttgtaaacc
     1381 atgtggacaa gctttatcgg gaactcagtt tccgagttgt cctagtgggc ctggagatct
     1441 ggaacaagga caaattctac atcagccgtt atgccaatgt cacactggag aacttcttgt
     1501 cctggaggga gcagaacttg ctagggcggc acccacatga caatgtgcaa cttatcacgg
     1561 gggttgattt cattgggacc actgttggac tggctaaggt atctgccctg tgttcccgtc
     1621 actcaggagc tgtgaatcag gaccacacca ggagcgccat tggtgtagca tctaccatgg
     1681 cccatgagct gggccacaac ctgggcatga accatgatga aaacattcca ggatgctact
     1741 gtcctatacc acgtgagggt ggtggctgca tcatgactga aagcattggc tccaagttcc
     1801 ccaagacatt cagcaggtgc agccaggttg acctagagtc attcgtgaca aatcaccaga
     1861 caggctgcct gaccaatgtt ccagatgtca accggttcgt gggtggccct gtgtgtggaa
     1921 acctatttgt ggaacgtgga gagcagtgtg actgtggtac acctcaggat tgtcaaaacc
     1981 cctgctgcaa tgccaccact tgccagctgg ccaagggggc agagtgtgcc catggtgcct
     2041 gttgtcatga atgcaaggtg aagccagctg gtgagctgtg tcgtcctatg aaggacaaat
     2101 gtgacctgga ggagttctgt gatggccaga agccaacatg tcctgaagat gccttccaac
     2161 agaatggtac cccctgtcca gggggctact gctttgacgg gagctgcccc acactggcac
     2221 agcagtgcca ggctctgtgg gggccaggtg cccgggcagc atccgactcc tgctttgcct
     2281 ttagcattcc tcagggctgc tatgggagta tgtaccctag caggatcaac cgatgtgggg
     2341 tgctgttctg tgagggaggc cagaaacctc ttgaacgttc ctcctgcact ttctcttccc
     2401 accatggact ctgccaagct ctccagactg acagcaacac taacacctac gagttcgtac
     2461 tccagggcac caagtgtgag gagggaaagg tttgcatgga tggaaactgc caggacctcc
     2521 gtgtatacag atctgaaaat tgctctgcta aatgcaacaa ccatggggtt tgcaaccaca
     2581 agagggagtg ccactgtcac gcgggctggg ccccacccta ctgtgcacag ctgctggcag
     2641 atgtaccagt ggtcactgag tctgcagctg tccacagcac cacagcctcg gggaactggc
     2701 ggggcctcaa cagtggcact gtggggctgg gactcgccac taccacgtct tctaacccac
     2761 tgctggagag ccagaagagc tggtcatccg agagcctccc agtcagtgtg gttgtggtct
     2821 tggtgatcct ggtggctgcc gtggtcatcg gggcaggcat cgtcatctac cgaaaggccc
     2881 caaaacaaat ccagaggagg agtgtggcac ccaagcctac ctcagggctc tccaaccccc
     2941 tattctacac aggggacagc agcctgccag ctaagagcag gcctccagac cctcctgaga
     3001 tggtttctac caaccaaccc ccaagaccta tagtgaaacc aaagaggcct ccccctgcac
     3061 ctccaggtgc catgtccagt ccaccgctcc cagttcctgt ttatgcccca aaggcaccaa
     3121 accagcttag acctgatcct cccaccaagc ctctcccaaa gctaaaaccc aagcaggtca
     3181 agccaacctt tgcaccccca acaccaccag tcaagcctgg gaccggaggg actgtgcctg
     3241 gagtgactca gcagggagct ggtgggtcaa aggttgctct gaaggtcccc atccagaaaa
     3301 ggtgaccagc tagggcaccc cagggccatc gtagtcttgt ggaagtttgg agataccact
     3361 gttcctctaa acgagcttct tcagcaacag cccccgccca ggctggacct gcatacagtg
     3421 ttcctacctc aggaataatc tctctctctg tggctcttgc tgttcagctg ccctcctgaa
     3481 ccagtatcca ttctctcact ggccttggcc agcttagacc ttatgtctat gtgtgctagt
     3541 tgctcggcag ggccagcatc gcctgcagtg agcgtgagca aatctgtctt tctctgggtg
     3601 gacagaatgc caggagtccc ctcccagcaa cttctgcacc agccctcaca cagtgacccc
     3661 tccccaaggc acagttccta tatcttcatc ccactcatgt atgagactta ggaaggaaaa
     3721 gccgacgacg ttcttggggt gttgggacag aagttgccgt catttccggg ttgaaagaga
     3781 atagttgttg aaactatgac taaacactat tcattaataa agattctatt ttatcagtaa
     3841 agtatagatc aca
//
