LOCUS       NM_020301               3584 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 7 (Adam7), mRNA.
ACCESSION   NM_020301
VERSION     NM_020301.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3584)
  AUTHORS   Choi,H., Han,C., Jin,S., Kwon,J.T., Kim,J., Jeong,J., Kim,J.,
            Ham,S., Jeon,S., Yoo,Y.J. and Cho,C.
  TITLE     Reduced Fertility and Altered Epididymal and Sperm Integrity in
            Mice Lacking ADAM7
  JOURNAL   Biol Reprod 93 (3), 70 (2015)
   PUBMED   26246218
REFERENCE   2  (bases 1 to 3584)
  AUTHORS   Oh,J., Woo,J.M., Choi,E., Kim,T., Cho,B.N., Park,Z.Y., Kim,Y.C.,
            Kim,D.H. and Cho,C.
  TITLE     Molecular, biochemical, and cellular characterization of epididymal
            ADAMs, ADAM7 and ADAM28
  JOURNAL   Biochem Biophys Res Commun 331 (4), 1374-1383 (2005)
   PUBMED   15883027
  REMARK    GeneRIF: ADAM7, but not ADAM28, is transferred from the epididymis
            to the sperm surface and redistributed in the sperm head during
            acrosome reaction
REFERENCE   3  (bases 1 to 3584)
  AUTHORS   Yang,L.T., Nichols,J.T., Yao,C., Manilay,J.O., Robey,E.A. and
            Weinmaster,G.
  TITLE     Fringe glycosyltransferases differentially modulate Notch1
            proteolysis induced by Delta1 and Jagged1
  JOURNAL   Mol Biol Cell 16 (2), 927-942 (2005)
   PUBMED   15574878
REFERENCE   4  (bases 1 to 3584)
  AUTHORS   Perry,A.C., Jones,R., Barker,P.J. and Hall,L.
  TITLE     A mammalian epididymal protein with remarkable sequence similarity
            to snake venom haemorrhagic peptides
  JOURNAL   Biochem J 286 (Pt 3) (Pt 3), 671-675 (1992)
   PUBMED   1417724
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Nov 26, 2020 this sequence version replaced NM_020301.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X66140.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760434,
                                           SAMN14984019 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                JAXUCZ010000015.1  47057484-47057581   c
            99-202              JAXUCZ010000015.1  47056430-47056533   c
            203-279             JAXUCZ010000015.1  47047203-47047279   c
            280-358             JAXUCZ010000015.1  47045851-47045929   c
            359-435             JAXUCZ010000015.1  47043885-47043961   c
            436-625             JAXUCZ010000015.1  47042721-47042910   c
            626-679             JAXUCZ010000015.1  47040981-47041034   c
            680-751             JAXUCZ010000015.1  47038917-47038988   c
            752-921             JAXUCZ010000015.1  47037278-47037447   c
            922-1006            JAXUCZ010000015.1  47034563-47034647   c
            1007-1134           JAXUCZ010000015.1  47032720-47032847   c
            1135-1309           JAXUCZ010000015.1  47030720-47030894   c
            1310-1399           JAXUCZ010000015.1  47029264-47029353   c
            1400-1595           JAXUCZ010000015.1  47027907-47028102   c
            1596-1698           JAXUCZ010000015.1  47027393-47027495   c
            1699-1885           JAXUCZ010000015.1  47026284-47026470   c
            1886-1966           JAXUCZ010000015.1  47024328-47024408   c
            1967-2045           JAXUCZ010000015.1  47017008-47017086   c
            2046-2151           JAXUCZ010000015.1  47016434-47016539   c
            2152-2251           JAXUCZ010000015.1  47015965-47016064   c
            2252-2314           JAXUCZ010000015.1  47013223-47013285   c
            2315-2371           JAXUCZ010000015.1  47011592-47011648   c
            2372-3584           JAXUCZ010000015.1  47009176-47010388   c
FEATURES             Location/Qualifiers
     source          1..3584
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..3584
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /note="ADAM metallopeptidase domain 7"
                     /db_xref="GeneID:29641"
                     /db_xref="RGD:62032"
     exon            1..98
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..2416
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /note="disintegrin and metalloproteinase domain-containing
                     protein 7; a disintegrin and metalloprotease domain 7; a
                     disintegrin and metallopeptidase domain 7; a disintegrin
                     and metalloprotease domain (ADAM) 7; epididymal apical
                     protein I"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 7 precursor"
                     /protein_id="NP_064697.2"
                     /db_xref="GeneID:29641"
                     /db_xref="RGD:62032"
                     /translation="MFPTGIFLMSVLISQMQGRGIVGVEGQELVHPKKLSLLQKRDLE
                     RIHDSDTPEEYEEELLYEIKLGRKTLTLHLLKAREFLALNYSETYYNIKREMVTRHPQ
                     ILDHCFYQGSIIHEFDSAASISTCNGLRGFFRVNDQRYLIEPVKYSDEGDHLVFKYNV
                     KAPYATNYSCEGLNFTKKSTLIDAKNIEEHKVEDYHKEKFIELFVVADEFVYRRNSKP
                     QNKLRKRIWGMVNFVNMIYKALNIRVTLTGMEIWSAGDEIEIVSNLESTLLHFSTWQE
                     TVLKKRKDFDHVILLSGKWLYTSMQGIAYPGGICQTLRSCSVVKDLLPDVNIIGNRMA
                     HQLGHSLGMRHDDFPCTCPLGKCVMGAGSIPAIKFSKCSQTQYQQFLKNQKPACILNN
                     PLPEEFNDYPFCGNKKVDEGEECDCGPVQECTNPCCDAHKCVLKPGFTCVEGECCESC
                     QMKKEGVICRPAKNECDISEVCTGYSPECPKDESQANGFPCKNGEGYCFMGLCPTRDD
                     QCAELFSGGAEESHSLCYRMNQKGNRFGYCKNKDNTFVPCEEKDLKCGKIYCTGGRRS
                     AHLGEDKTYNLKNVKQNISIKCKTMFLYHNSRDMGLVNSGTKCGEGMVCSNGECIEME
                     KAYNSTICSSLCDENDVDDNEPDCQCEEGPIITEWGEALNLTSVSIMVVVLVMVIIGV
                     GLVILLIRYQKCIKMKQVQSSSREIRGIENKVYFPDEHQTRSEPIFTDIYPLHNTAES
                     LERVPSTFSSPHYITLKSVSKDPRGIADPKQNDNMNLNLDSQSDCTRLG"
     exon            99..202
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            203..279
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            280..358
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            359..435
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            436..625
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            626..679
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            680..751
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            752..921
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1006
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1134
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1309
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1399
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1595
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1698
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1885
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1966
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2045
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2151
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2251
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2314
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2371
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..3584
                     /gene="Adam7"
                     /gene_synonym="ADAM; ADAM 7; EAP; EAP I; EAPI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagaacaag gagtagggtg aagcttttct cagataaccc ttcagaatgt ttcccacagg
       61 tatatttttg atgagtgtcc ttatttctca gatgcaagga agagggattg ttggagtaga
      121 gggtcaagaa ctggttcatc ctaaaaagct atccctgcta cagaaacggg atcttgaacg
      181 catccatgac tctgatacac cggaggaata tgaagaagaa ttgttgtatg aaataaaatt
      241 ggggagaaaa actttaaccc ttcaccttct gaaagcaagg gaattcctcg ctctaaatta
      301 cagtgagaca tactacaaca taaagagaga aatggtcacc aggcatccac agatcttgga
      361 tcactgtttt taccaaggct ccatcataca tgaatttgat tctgcggcaa gcatcagcac
      421 ttgtaatggt ctgagaggct tcttcagggt aaatgaccag cggtacctca ttgaaccagt
      481 aaaatactca gatgagggag atcatttggt gttcaaatac aatgtcaagg caccttatgc
      541 taccaattac tcctgtgaag ggctgaattt taccaagaag tctactctga tagatgctaa
      601 gaatatagaa gagcataaag tagaagacta tcacaaagaa aagttcattg aattgtttgt
      661 tgttgctgat gaatttgtgt accgcaggaa cagtaaaccc caaaacaagt taagaaaacg
      721 aatttggggg atggtcaatt ttgtcaacat gatttataaa gccttgaaca ttcgtgtgac
      781 tttgactggc atggaaatat ggtcggctgg agatgagata gaaatagtgt ccaatctaga
      841 aagtacctta ttgcattttt cgacttggca agaaacagtt ctcaaaaaga ggaaggactt
      901 tgatcatgtg attttactga gtgggaagtg gctctacaca tctatgcaag gaattgctta
      961 cccaggaggg atatgtcaga cccttcgttc atgcagtgtt gttaaggatc ttctgccaga
     1021 tgtaaatata attggcaaca ggatggcaca tcagctggga cacagcctgg gcatgcggca
     1081 tgatgacttt ccatgcacct gtcctttggg gaaatgtgtg atgggtgcag gaagcatccc
     1141 tgcaataaaa ttcagcaaat gcagccaaac ccaataccag caatttctga agaatcagaa
     1201 accagcatgc atactcaaca acccacttcc ggaagaattc aatgattatc cgttctgtgg
     1261 gaacaagaag gtggatgagg gagaagagtg tgactgtggg ccagttcagg aatgcaccaa
     1321 tccttgctgt gatgcacaca aatgtgtcct gaagccagga ttcacttgtg tagaaggaga
     1381 gtgctgtgaa tcatgtcaga tgaagaagga aggggttata tgcagaccag caaagaatga
     1441 atgtgatatt tcggaagtgt gtactggcta ctcccctgag tgtcctaaag acgagtccca
     1501 agccaacggg tttccttgca agaatggaga aggctactgc tttatggggc tgtgtcccac
     1561 tcgggatgac cagtgcgcag agttgttcag tggtggagct gaagagagtc acagcctttg
     1621 ctacaggatg aatcaaaagg gaaacagatt tggatactgc aaaaataagg acaacacgtt
     1681 tgttccctgt gaagagaaag atctcaaatg tggaaagata tactgcaccg gaggccggcg
     1741 ttcagcacac cttggagagg ataaaaccta taaccttaag aatgtgaagc agaatatctc
     1801 catcaaatgc aaaaccatgt ttttatacca caattctaga gacatgggcc tggtgaattc
     1861 tggaacaaaa tgtggtgagg gaatggtttg cagcaatggc gaatgtatag aaatggagaa
     1921 ggcctacaac tcaaccatct gctcttccct gtgtgatgaa aatgatgtgg atgacaatga
     1981 acctgactgc cagtgtgaag aaggaccaat aattacagag tggggagaag ccttaaacct
     2041 taccagtgtc tccatcatgg tcgttgtgct tgtcatggtt attattggtg ttggacttgt
     2101 catattacta atccgttacc agaaatgcat taagatgaag caagttcaaa gctcttctag
     2161 agaaatacgg ggcatagaga ataaagtata ctttcctgat gagcatcaga cgaggagtga
     2221 gccaatcttc acagatatct atcccctaca taatacggca gagtcattgg aaagagttcc
     2281 ttccaccttt tcaagtcctc actacatcac cctgaaatct gtcagcaagg acccaagagg
     2341 aattgcagac cctaagcaaa atgataacat gaatttgaac ctggatagcc aaagcgactg
     2401 cacaagactg ggctaaagat cctccatgca gatcatcact gccttgatgt ctgctaaaca
     2461 gatttcagtt gtttgccaaa tatcccttac ctggatagaa aatgttcaag agaaatagtt
     2521 tcttcctgtc aatattaagt catagaaccc acaatctata gcacacacat aatccccaca
     2581 aaaatgaata tgaactttcc aatgggcttt aatttaatgc ccaaatagga agtctctctg
     2641 ctctagtaat ttcctatgta atattaatct tgtaatttta taataatcaa agcttgtgat
     2701 catttagagt ttcacataca aggaacagat aaggctagtg gttggttact ttgttaagat
     2761 cattttaaaa gcacttactt tcaggtcaga tgttgtggcc cagacctata atccctagag
     2821 gttgagatag gaggatcaca ggttcagggt ctacatgggc tgcagagaaa gatcatgtca
     2881 agtctggaca acttggtgag aactctttaa aaaaatcata aaatttaaaa ttgcaccaga
     2941 aatgttaagg aacagctgtt ggtggagcag aatgggagac accctgggtt caaccccgag
     3001 aattaaaaaa acaaaacaaa acaaagcaaa caaacaaaac agaaagatca aaacagatga
     3061 cagtgtgcct actttgattt gcaaactata tcactgaagt ctgctttcaa tgaaattatc
     3121 ttctatggaa gggccaagga ggttagggca gggcagagag ttatagtagc tgattagaag
     3181 agggaggaac aaaagaatgg cctcctagac tatagcacca gcactgtcac aaagcatctc
     3241 atccattgcc cagggtgtag aggcctgtgc aagctttggg ttcctaggcc tgcctttcta
     3301 gatttctata ataagccaag aaaatgacag ggcttttaaa atattcactc cacttccttg
     3361 tgagtcctca ggaaacacag atgggggtgt gcttagtgtt cattttcttt actgcagaac
     3421 actgcattcc catggatttg ttgccttgcg ttgggttgtt tccttataca gatgtctgtg
     3481 ggtggaagca ctctctctca ctgactctgt tttcttaatg ggagctgtta agtcttttaa
     3541 atctatagat aattttcccc catccttaaa taaagatctc aaac
//
