LOCUS       NM_138906               2508 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 6A (Adam6), mRNA.
ACCESSION   NM_138906
VERSION     NM_138906.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2508)
  AUTHORS   Marcello MR, Jia W, Leary JA, Moore KL and Evans JP.
  TITLE     Lack of tyrosylprotein sulfotransferase-2 activity results in
            altered sperm-egg interactions and loss of ADAM3 and ADAM6 in
            epididymal sperm
  JOURNAL   J Biol Chem 286 (15), 13060-13070 (2011)
   PUBMED   21339297
REFERENCE   2  (bases 1 to 2508)
  AUTHORS   Han C, Choi E, Park I, Lee B, Jin S, Kim DH, Nishimura H and Cho C.
  TITLE     Comprehensive analysis of reproductive ADAMs: relationship of ADAM4
            and ADAM6 with an ADAM complex required for fertilization in mice
  JOURNAL   Biol Reprod 80 (5), 1001-1008 (2009)
   PUBMED   19129510
REFERENCE   3  (bases 1 to 2508)
  AUTHORS   Rosselot C, Kierszenbaum AL, Rivkin E and Tres LL.
  TITLE     Chronological gene expression of ADAMs during testicular
            development: prespermatogonia (gonocytes) express fertilin beta
            (ADAM2)
  JOURNAL   Dev Dyn 227 (3), 458-467 (2003)
   PUBMED   12815633
REFERENCE   4  (bases 1 to 2508)
  AUTHORS   Frayne J, Jury JA, Barker HL and Hall L.
  TITLE     Rat MDC family of proteins: sequence analysis, tissue distribution,
            and expression in prepubertal and adult rat testis
  JOURNAL   Mol Reprod Dev 48 (2), 159-167 (1997)
   PUBMED   9291465
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Y09111.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: Y09111.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2508
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2508
                     /gene="Adam6"
                     /gene_synonym="Adam6a; TMDCIV"
                     /note="ADAM metallopeptidase domain 6A"
                     /db_xref="GeneID:192271"
                     /db_xref="RGD:621472"
     exon            1..2489
                     /gene="Adam6"
                     /gene_synonym="Adam6a; TMDCIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..2294
                     /gene="Adam6"
                     /gene_synonym="Adam6a; TMDCIV"
                     /note="tMDC IV; a disintegrin and metallopeptidase domain
                     6; a disintegrin and metalloproteinase domain 6; a
                     disintegrin and metallopeptidase domain 6A"
                     /codon_start=1
                     /product="ADAM metallopeptidase domain 6A precursor"
                     /protein_id="NP_620261.1"
                     /db_xref="GeneID:192271"
                     /db_xref="RGD:621472"
                     /translation="MLSLTWGMKLVERSVVPRVLLLLFALWLLLLVPVRCSEGHPTWR
                     YISSEVVIPRKEIYHSKGIQTQGRLSYSLRFRGQRHIIHLRRKTLIWPRHLLLTTQDD
                     QGALQMDYPFFPVDCYYFGYLEGIPQSMVTVNTCYGGLEGIMMLDDLAYEIKPLNDSQ
                     GFEHIVSQIVSEPDVTGPTNTWKRLNLNTGPPLSRTEYANGTPRMSSKNYASHPAAIK
                     GQFQATNSIYKESNNIDTAARYLFELLSITDSFLITIHMRYYAILLTVFTESDPFALE
                     YTVPGGSIYNYYVSNFFNRLRPDASTVLNKDGPSDNDFHPVEQSLCTPAGLTIVGQHR
                     RSFLALSVMITNRIAMSLGIKADDETYCICHRRTTCIMYKNPEITDAFSNCSLVQINQ
                     ILNTPGTMSCLFYDHHVYHNITKTYRFCGNFKIDIGEQCDCGSHKACYADPCCGSNCK
                     LTAGSICDKELCCANCTYSPSGTLCRPIQNICDLPEYCSGNNIFCPADTYLQDGTPCS
                     EEGYCYKGNCTDRSVQCKEIFGMNAKGANIKCYDINKQRFRFGHCTRAQESLMFNACS
                     DHDKLCGRLQCTNVTNLPFLQEHVSFHQSVISGFTCFGLDEHRGTETTDAGLVKHGTP
                     CSQTNFCDRGACNGSLSRLDYDCTPEKCNFRGVCNNHRHCHCHLGWKPPLCREEGPSG
                     STDSGSPPKERRTIKQSREPLLYLRMLFGRLYLFIVSLLFGVATRAGVIKVFKFEDLQ
                     AALRAAQAKAT"
     regulatory      2467..2472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam6"
                     /gene_synonym="Adam6a; TMDCIV"
     polyA_site      2486
                     /gene="Adam6"
                     /gene_synonym="Adam6a; TMDCIV"
ORIGIN      
        1 ggcagtggcc acagcagagg aatatagctt cacccaggat gttatctctg acctggggta
       61 tgaagctagt ggaaagatct gtggtcccca gggtcctcct cttgctcttt gcactctggc
      121 tgctcctcct ggttccagtc cggtgttctg aaggccaccc cacttggcgc tacatctcat
      181 cagaggtggt tattcctcgg aaggagatct accacagcaa aggaattcaa acacaaggac
      241 ggctctccta tagcttgcgt tttaggggcc agagacatat catccacctg cgaagaaaga
      301 cactaatttg gcccagacac ttgttgctga caactcagga tgaccaagga gccttacaga
      361 tggattaccc ttttttccct gtagattgtt actattttgg ctacctagag ggaatccctc
      421 aatccatggt cactgtgaat acttgctatg gaggcctgga agggatcatg atgttggatg
      481 accttgccta tgaaatcaaa cccctcaacg attcacaggg gtttgaacac attgtttctc
      541 agatagtatc agagcctgat gtaacagggc ctacaaatac atggaaacgc ttgaacctta
      601 atacaggtcc tcccttatcc aggacagagt atgccaatgg aactcccaga atgtctagta
      661 agaactacgc ttcacatcca gctgctataa aaggccaatt ccaagcaact aattctatat
      721 ataaggaaag caacaatatt gatactgcgg ccaggtattt gtttgagctc cttagtataa
      781 cggacagctt tctgatcact attcatatgc ggtactatgc tattctctta actgtgttta
      841 ccgagagcga tccatttgca ctagagtata cggtaccagg gggctctatt tataactatt
      901 atgtgtctaa cttttttaat cggttgaggc ctgatgcatc aaccgtactt aataaagatg
      961 ggccctcgga taacgacttt catccagttg aacagagttt atgtactccc gcaggcctga
     1021 cgattgttgg tcaacacaga cgaagttttc tagctctatc tgttatgatc accaatcgta
     1081 ttgcgatgtc tttaggtata aaagctgatg atgagactta ctgcatctgc cacagaagga
     1141 ccacttgcat tatgtacaaa aaccctgaaa taacagatgc tttcagcaat tgctcccttg
     1201 tgcagataaa ccagatactg aatacccctg gtacaatgtc atgccttttc tatgaccacc
     1261 atgtttatca taatataaca aaaacctaca ggttttgtgg aaacttcaag atagatatcg
     1321 gtgagcagtg tgactgtggc tcacataagg catgttacgc agatccctgc tgcggaagta
     1381 attgcaagtt aactgctggt agcatttgtg ataaagaatt atgctgtgca aactgcacct
     1441 acagtccttc tgggacactc tgcagaccga tccagaacat atgtgatctt ccagaatact
     1501 gtagtgggaa taatatcttt tgccctgcag acacttatct gcaagatggg acgccatgct
     1561 cagaagaggg gtactgctat aaaggcaact gcacagatcg cagtgtgcag tgcaaggaaa
     1621 tctttggtat gaatgctaag ggtgctaata tcaagtgcta tgacatcaac aaacaacggt
     1681 ttcgatttgg gcactgcact agagcacaag agagcctcat gtttaatgct tgctctgatc
     1741 atgataaact gtgtggaagg ctgcagtgta ccaacgtcac caatcttcca ttcctgcagg
     1801 aacatgtttc attccatcaa tcggttatct ctgggtttac ctgctttggg cttgatgaac
     1861 atcgtgggac agaaacaacg gatgctgggc tggtgaaaca tggtacccct tgctcccaaa
     1921 ctaacttctg cgatcgagga gcttgcaatg gaagtttatc tcggttggat tatgactgca
     1981 ccccagaaaa atgcaatttt agaggagtgt gtaataatca tcggcattgc cattgtcatt
     2041 taggttggaa acctcctctg tgcagagagg aggggcctag cgggagcacg gacagtgggt
     2101 cccctccgaa ggaaaggcgc acaataaaac agagcagaga accactgtta tatttaagaa
     2161 tgctctttgg tcgtctttat ttattcattg tctcgctgct ctttggagtg gccactcgcg
     2221 caggagttat taaggtcttt aagtttgaag acttgcaagc tgctctgcgg gctgcacaag
     2281 ccaaggcgac ttaaagatga acgaggtcct cgtaagataa agagaatgca aaaatgcatg
     2341 tcaagagggg acaaggtaga actccagtcc acagttctgg agagccttca tctatatcgt
     2401 ggggacgcaa gaggttttgg atttggatac cacctgacat tggtgggtta ctgatgctca
     2461 cactcgaata aatctttcaa aaccgcaaaa aaaaaaaaaa aaaaaaaa
//
