LOCUS       NM_020303               2591 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 5 (Adam5), mRNA.
ACCESSION   NM_020303 XM_344538
VERSION     NM_020303.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2591)
  AUTHORS   Rosselot,C., Kierszenbaum,A.L., Rivkin,E. and Tres,L.L.
  TITLE     Chronological gene expression of ADAMs during testicular
            development: prespermatogonia (gonocytes) express fertilin beta
            (ADAM2)
  JOURNAL   Dev Dyn 227 (3), 458-467 (2003)
   PUBMED   12815633
REFERENCE   2  (bases 1 to 2591)
  AUTHORS   Frayne,J., Jury,J.A., Barker,H.L. and Hall,L.
  TITLE     Rat MDC family of proteins: sequence analysis, tissue distribution,
            and expression in prepubertal and adult rat testis
  JOURNAL   Mol Reprod Dev 48 (2), 159-167 (1997)
   PUBMED   9291465
REFERENCE   3  (bases 1 to 2591)
  AUTHORS   Cho,C., Primakoff,P., White,J.M. and Myles,D.G.
  TITLE     Chromosomal assignment of four testis-expressed mouse genes from a
            new family of transmembrane proteins (ADAMs) involved in cell-cell
            adhesion and fusion
  JOURNAL   Genomics 34 (3), 413-417 (1996)
   PUBMED   8786143
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091169.1.
            
            [WARNING] On Mar 18, 2025 this sequence was replaced by
            NM_020303.2.
            
            On Mar 26, 2005 this sequence version replaced XM_344538.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2591
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..2591
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="ADAM metallopeptidase domain 5"
                     /db_xref="GeneID:498654"
                     /db_xref="RGD:621471"
     exon            1..109
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            110..189
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            190..245
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..2341
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /note="a disintegrin and metalloprotease domain (ADAM) 5;
                     tMDC II; a disintegrin and metalloprotease domain 5;
                     transmembrane metalloproteinase-like, disintegrin-like,
                     and cysteine-rich protein II; a disintegrin and
                     metallopeptidase domain 5"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 5"
                     /protein_id="NP_064699.1"
                     /db_xref="GeneID:498654"
                     /db_xref="RGD:621471"
                     /translation="MKTPISSILKSNGLGIFLYRSFITSTAVSYTYDRQDVRHSQSLS
                     SLKNCNYNGYVAGFPNSIVSLTVCSGLRGMIQFENVSYGIEPVETLSGFIHVIYENTN
                     QQAKIPDLGENQTYSWSDELDYQFRSNMKKSGFAVLRPRYIKTDIVVDKKLFDYMGSD
                     TRVVLQKVIQIIGFINTMFSKLKLTVLINSVEIWSKENRIDFPEAPENLLVQFLHWKH
                     KYRPQHISYLLAFVEHPASTGALYPGNLCKPIYGAAIALYPKGLSLESYSVIVLQLLS
                     IGIGLTYDNADSCHCTGDVCLMTPKAIYSGGVKDFSTCSLDDFKYLSTQDLECLQDLP
                     MERQKKKPSRPRRICGNGILEMNEQCDCGTLKNCTHKKCCDPMSCRLKSKAVCGSGEC
                     CGQDCKVKPVNVLCRKSKNECDFEEYCNGNDAYCVPDTFARNGQYCDSGQAFCYSGLC
                     MTSNNQCMNLLGKYVRGASFACYEEFNSRNDRFGNCIRKFCSFENSLCGKLVCTWPFK
                     RLLMKDNMSAAYGQIRDDLCISLYKGGRPLKTTLSTYSDMSERDETFVKDGTICGPDM
                     FCLETQCKETRFLVDFQQCNTSRDCNDHGVCNNFNHCHCDKGYNPPYCESVKGQFGSI
                     DDGHKYYIDEGKSAKQQNRGIHPKQQLQLILYITLPLIMIISAVFIKQSKLSRLCGRE
                     RSEGTSCITEDSVSNTKMTTNEGSTLH"
     exon            246..349
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            350..426
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            427..604
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            605..670
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            671..742
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            743..900
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            901..982
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1119
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1309
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1405
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1601
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1692
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1909
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..1996
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2111
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2274
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2328
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2523
                     /gene="Adam5"
                     /gene_synonym="tMDCII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccacctgcct ggccagatgc tcctcagcta agctccagga ccaccaaggg agccatgttc
       61 ctccttcttt tgctggttgt gcatcttaat gggctgcagg caggccaaca tcctcagaaa
      121 accatcctgc aaacaactgt tcctgaaaag atctcatcac cagatgtgga aacagatcca
      181 gaaaaccata tggcttatct tattacaata aatgaaaacc cccatttcat ccatcttaaa
      241 aagcaatggt ttggggatct ttttgtatag atcgtttata acttcaactg cagtgagtta
      301 tacatatgac agacaagatg ttcggcattc tcagtctttg tcatctctga aaaattgcaa
      361 ttacaacgga tacgttgcag gttttccaaa ttctatcgtg tcgctcaccg tttgctcagg
      421 actcagggga atgatacaat ttgaaaatgt ctcctatgga atcgaacctg tggaaaccct
      481 gtcaggattt atacacgtga tctatgagaa cacaaatcag caagctaaga ttcctgactt
      541 aggagagaat cagacgtaca gttggtctga tgaattagat tatcaattcc gaagcaacat
      601 gaagaaatcc ggatttgccg tgttacggcc acggtacatt aagacggata tcgtcgtgga
      661 taaaaagctg tttgattaca tgggctccga cactagggtc gtgctacaga aagtcattca
      721 gatcatcggt ttcattaaca ctatgttctc caagttgaaa ctgacggttt taataaattc
      781 cgttgaaatc tggtcgaagg aaaacagaat tgatttccca gaggcacctg aaaacttact
      841 ggtccagttt ttacattgga aacataagta tagaccgcag cacatttcat acttactggc
      901 atttgtggag catcctgctt ccacgggagc cctctatccg gggaatctgt gcaaaccgat
      961 ctatggtgct gccattgccc tgtaccctaa aggtttgtca ctagagtcct acagcgtcat
     1021 cgtcctacaa ctactgagca tcggtatagg cttaacctat gacaacgctg acagctgcca
     1081 ctgtacagga gacgtctgcc tgatgacgcc caaggcaata tattctgggg gtgtgaagga
     1141 cttcagtact tgtagcttgg atgacttcaa atacctgtca acacaagacc ttgaatgtct
     1201 ccaggacttg cctatggaaa gacaaaagaa gaagccttcc aggccaagga gaatctgtgg
     1261 caacgggata ttggaaatga acgagcagtg tgactgtggc actttgaaga attgtacaca
     1321 caaaaaatgc tgtgacccca tgtcgtgccg actgaagtcc aaagccgtgt gtggctccgg
     1381 ggagtgctgt ggtcaggact gcaaggtaaa accggttaat gtactctgta gaaagtcgaa
     1441 gaatgaatgt gactttgagg agtactgtaa cggaaatgac gcttactgtg tccctgacac
     1501 gttcgcacgc aacgggcagt actgcgactc agggcaagcc ttctgctaca gtggtctttg
     1561 tatgacgagt aataatcaat gcatgaactt gctcgggaaa tatgtgagag gagcttcctt
     1621 cgcatgctat gaagagttca attccagaaa cgatagattt ggcaactgta ttagaaagtt
     1681 ttgtagtttc gaaaattctc tctgtgggaa gttggtctgt acctggccat tcaagaggct
     1741 gctcatgaaa gacaatatgt ctgcggctta tggacaaatc cgagacgatt tatgcatctc
     1801 tctgtataaa ggagggaggc cacttaagac aacattgtca acatattccg atatgtcaga
     1861 aagagacgaa acatttgtaa aagacggcac aatctgtggt cctgatatgt tttgtttgga
     1921 aacacagtgc aaagaaacga gatttttggt ggattttcaa cagtgcaata cttcccgaga
     1981 ttgcaatgac catggggttt gcaacaactt taatcattgt cattgtgata aaggatataa
     2041 ccctccctat tgtgagtcag taaaaggaca gtttggaagc attgatgacg gccacaaata
     2101 ttacattgac gaagggaaaa gcgctaagca gcagaatcgt ggtattcacc caaagcagca
     2161 actccagctt attctgtata taacgctgcc cttgattatg attatctcgg ctgtatttat
     2221 aaagcaaagc aaactgagtc ggctatgcgg cagagaaaga agcgaaggca ccagctgtat
     2281 aacagaagac agtgtgagta acaccaagat gaccaccaac gaaggaagca cccttcacta
     2341 accacctcaa gtgttgccac ccaaaaagaa gatagtctgg attaaccacg ggaaactggc
     2401 attttgagca agaggaaggg gaaaaaacca cccccaaacc aacccacagc ttctctccca
     2461 cttctgcaga gataaatgag gactctaaac catgaactaa taaatcagcg gtggctgaac
     2521 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2581 aaaaaaaaaa a
//
