LOCUS       NM_001395113            2843 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 33 (Adam33), mRNA.
ACCESSION   NM_001395113 XM_039104998
VERSION     NM_001395113.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2843)
  AUTHORS   Duan,Y., Long,J., Chen,J., Jiang,X., Zhu,J., Jin,Y., Lin,F.,
            Zhong,J., Xu,R., Mao,L. and Deng,L.
  TITLE     Overexpression of soluble ADAM33 promotes a hypercontractile
            phenotype of the airway smooth muscle cell in rat
  JOURNAL   Exp Cell Res 349 (1), 109-118 (2016)
   PUBMED   27720670
  REMARK    GeneRIF: soluble ADAM33 overexpression altered the mechanical
            behaviors of airway smooth muscle cells.
REFERENCE   2  (bases 1 to 2843)
  AUTHORS   Lin,F., Song,A., Wu,J., Jiang,X., Long,J., Chen,J., Duan,Y., Shi,Y.
            and Deng,L.
  TITLE     ADAM33 protein expression and the mechanics of airway smooth muscle
            cells are highly correlated in ovalbumin-sensitized rats
  JOURNAL   Mol Med Rep 8 (4), 1209-1215 (2013)
   PUBMED   23934418
  REMARK    GeneRIF: ADAM33 is a mediator of airway smooth muscle cell
            dysfunction in asthma.
REFERENCE   3  (bases 1 to 2843)
  AUTHORS   Vergara,C.I., Acevedo,N., Jimenez,S., Martinez,B., Mercado,D.,
            Gusmao,L., Barnes,K.C. and Caraballo,L.
  TITLE     A Six-SNP haplotype of ADAM33 is associated with asthma in a
            population of Cartagena, Colombia
  JOURNAL   Int Arch Allergy Immunol 152 (1), 32-40 (2010)
   PUBMED   19940503
REFERENCE   4  (bases 1 to 2843)
  AUTHORS   Wang,X., Li,L., Xiao,J., Jin,C., Huang,K., Kang,X., Wu,X. and Lv,F.
  TITLE     Association of ADAM33 gene polymorphisms with COPD in a
            northeastern Chinese population
  JOURNAL   BMC Med Genet 10, 132 (2009)
   PUBMED   20003279
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2843)
  AUTHORS   Pabst,S., Pizarro Touron,C., Gillissen,A., Lennarz,M., Tuleta,I.,
            Nickenig,G., Skowasch,D. and Grohe,C.
  TITLE     ADAM33 gene polymorphisms in chronic obstructive pulmonary disease
  JOURNAL   Eur J Med Res 14 Suppl 4 (Suppl 4), 182-186 (2009)
   PUBMED   20156753
REFERENCE   6  (bases 1 to 2843)
  AUTHORS   Qiu,Y.M., Luo,Y.L., Lai,W.Y., Qiu,S.J. and Wu,Y.X.
  TITLE     [Association of polymorphism of Met764Thr locus allele in ADAM33
            gene with bronchial asthma and lung function of asthmatic subjects]
  JOURNAL   Zhonghua Jie He He Hu Xi Za Zhi 30 (7), 518-521 (2007)
   PUBMED   17961406
REFERENCE   7  (bases 1 to 2843)
  AUTHORS   Foley,S.C., Mogas,A.K., Olivenstein,R., Fiset,P.O., Chakir,J.,
            Bourbeau,J., Ernst,P., Lemiere,C., Martin,J.G. and Hamid,Q.
  TITLE     Increased expression of ADAM33 and ADAM8 with disease progression
            in asthma
  JOURNAL   J Allergy Clin Immunol 119 (4), 863-871 (2007)
   PUBMED   17339047
REFERENCE   8  (bases 1 to 2843)
  AUTHORS   Wang,P., Liu,Q.J., Li,J.S., Li,H.C., Wei,C.H., Guo,C.H. and
            Gong,Y.Q.
  TITLE     Lack of association between ADAM33 gene and asthma in a Chinese
            population
  JOURNAL   Int J Immunogenet 33 (4), 303-306 (2006)
   PUBMED   16893396
REFERENCE   9  (bases 1 to 2843)
  AUTHORS   Cheng,L., Enomoto,T., Hirota,T., Shimizu,M., Takahashi,N.,
            Akahoshi,M., Matsuda,A., Dake,Y., Doi,S., Enomoto,K., Yamasaki,A.,
            Fukuda,S., Mao,X.Q., Hopkin,J.M., Tamari,M. and Shirakawa,T.
  TITLE     Polymorphisms in ADAM33 are associated with allergic rhinitis due
            to Japanese cedar pollen
  JOURNAL   Clin Exp Allergy 34 (8), 1192-1201 (2004)
   PUBMED   15298558
REFERENCE   10 (bases 1 to 2843)
  AUTHORS   Becker,K.G., Barnes,K.C., Bright,T.J. and Wang,S.A.
  TITLE     The genetic association database
  JOURNAL   Nat Genet 36 (5), 431-432 (2004)
   PUBMED   15118671
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jun 3, 2021 this sequence version replaced XM_039104998.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.13267.1,
                                           SRR26643299.16048.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               JAXUCZ010000003.1  138736207-138736347 c
            142-221             JAXUCZ010000003.1  138733922-138734001 c
            222-298             JAXUCZ010000003.1  138731433-138731509 c
            299-377             JAXUCZ010000003.1  138729900-138729978 c
            378-454             JAXUCZ010000003.1  138729660-138729736 c
            455-644             JAXUCZ010000003.1  138729327-138729516 c
            645-710             JAXUCZ010000003.1  138729051-138729116 c
            711-782             JAXUCZ010000003.1  138728895-138728966 c
            783-949             JAXUCZ010000003.1  138728638-138728804 c
            950-1034            JAXUCZ010000003.1  138728429-138728513 c
            1035-1177           JAXUCZ010000003.1  138728210-138728352 c
            1178-1355           JAXUCZ010000003.1  138727614-138727791 c
            1356-1445           JAXUCZ010000003.1  138727416-138727505 c
            1446-1641           JAXUCZ010000003.1  138727065-138727260 c
            1642-1750           JAXUCZ010000003.1  138726843-138726951 c
            1751-1949           JAXUCZ010000003.1  138726549-138726747 c
            1950-2027           JAXUCZ010000003.1  138726382-138726459 c
            2028-2136           JAXUCZ010000003.1  138726201-138726309 c
            2137-2281           JAXUCZ010000003.1  138725978-138726122 c
            2282-2352           JAXUCZ010000003.1  138724714-138724784 c
            2353-2843           JAXUCZ010000003.1  138724046-138724536 c
FEATURES             Location/Qualifiers
     source          1..2843
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2843
                     /gene="Adam33"
                     /note="ADAM metallopeptidase domain 33"
                     /db_xref="GeneID:311425"
                     /db_xref="RGD:1305278"
     exon            1..141
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2378
                     /gene="Adam33"
                     /note="a disintegrin and metalloprotease domain 33;
                     disintegrin and metalloproteinase domain-containing
                     protein 33; a disintegrin and metallopeptidase domain 33"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 33 precursor"
                     /protein_id="NP_001382042.1"
                     /db_xref="GeneID:311425"
                     /db_xref="RGD:1305278"
                     /translation="MGSGCRCGRPGGSPMLLLLLLLLPACPLLSARMFPGNAGGELVT
                     PHWVLDGKTWLKVTLKEQISKPDSGLVALKAEGQDLLLELEKNHRLLAPGYTETYYSR
                     DGQPIVLSPNHTDHCHYQGCVRGFRESWVVLSTCSGMSGLIVLSSKVSYYLHPWMPGD
                     TKDFPTHKIFRVEQLFTWRGARKDKNSQFKAGMARLPHVPHRRMRREARRSPKYLELY
                     IVADHALFLLQRQNLNHTRQRLLEIANCVDQILRTLDIQLVLTGLEVWTEQDHSRITQ
                     DANETLWAFLQWRRGLWVRRPHDSTQLLTGRTFQGTTVGLAPVEGMCHAESSGGVSTD
                     HSELPIGTAATMAHEIGHSLGLHHDPEGCCMEADAEQGGCVMEAATGHPFPRVFSACS
                     RRQLRTFFRKGGGACLSNVSAPGLLVLPSRCGNGFVEAEEECDCGSGQKRPDPCCFAH
                     NCSLRAGAQCAQGDCCARCLLKPAGTPCRPAANDCDLPEFCTGTSPHCPADVYLLDGS
                     PCAEGRGYCLDGWCPTLEKQCQQLWGPGSQPAPEPCFQQMNSVGNSQGNCGQDSKGSF
                     LPCTQRDAQCGKLLCQGGKPNPLVPHVVTVDSTILLKGRQVLCRGAFVLPDTHLDQLG
                     LGLVEPGTRCGPRMVCQERHCQNATSQELERCSSGCHNRGVCNSNRNCHCAAGWAPPF
                     CDKPGLGGSVDSGPAQSANPDAFPLAMLLSFLLPLLPGAGLAWCYYQLPTLCQQPGRC
                     CRRDALCNRDQPLGSVHPVEFGSIITGEPSPPNPEESELT"
     exon            142..221
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            222..298
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            299..377
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            378..454
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            455..644
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            645..710
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            711..782
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            783..949
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1034
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1177
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1355
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1445
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1641
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1750
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1949
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2027
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2136
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2281
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2352
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2843
                     /gene="Adam33"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacagcaag agtgggaggc aaaggcactc cagccatggg ctcggggtgc cggtgcggga
       61 gaccaggggg gtctcccatg ctgctattgc tgctgctgtt gcttcccgcg tgtcctctgc
      121 tgagcgctcg gatgtttcca ggaaatgctg gtggagagct agtcactccc cactgggttt
      181 tggatgggaa aacgtggctc aaggtcaccc tgaaagagca gatctccaag cctgactcag
      241 ggctggtggc tttaaaggct gaaggccagg atctcctgct tgaattggag aagaaccaca
      301 ggcttctggc cccaggatac acagaaacct actacagccg ggatgggcag cccatagtgc
      361 tgtcccccaa ccacacggat cattgccact atcaggggtg tgtgaggggc ttccgggaat
      421 cctgggtagt cctcagcacc tgctcgggga tgagtggcct tattgtgctt agcagcaaag
      481 tgagctatta tctacacccc tggatgcctg gggacaccaa ggacttccca acccacaaga
      541 tcttccgggt ggaacaattg ttcacctgga gaggggcccg gaaagacaag aactcccaat
      601 tcaaagcagg aatggcccgt cttcctcatg tcccccacag acggatgagg cgagaggctc
      661 gcaggagtcc caagtacctg gaactgtaca tagtggctga ccacgccctg ttcttgcttc
      721 agcgtcagaa tttgaaccac acaagacagc gcctcctgga aattgccaat tgcgtggacc
      781 agattctcag gactctggat attcagttgg tgttgaccgg gctggaagtg tggacggagc
      841 aggatcatag ccgcatcacg caggacgcaa acgaaacgct ctgggctttc ctacagtggc
      901 gccgtgggct gtgggtcagg agaccacacg actccacgca actgctcacg ggccgcactt
      961 tccagggtac cacggtgggc ctggcgcctg tggagggcat gtgccacgca gagagctccg
     1021 gaggtgtgag cacagaccac tcggaactcc ccatcggcac agcagccacc atggcccacg
     1081 agataggcca cagcctaggc ctccaccatg acccagaggg ctgctgcatg gaggcagacg
     1141 cagaacaagg aggctgcgtc atggaagcag ctacagggca tcctttcccg cgcgtcttca
     1201 gcgcctgcag ccgccgccag ctgcgcacct tcttccgcaa agggggcggt gcgtgcctct
     1261 ctaacgtctc ggctcccggg ctcctggtgc tgcccagccg ctgcggaaac ggcttcgtgg
     1321 aagcagaaga agagtgcgac tgcggttctg gccagaagcg cccagatccc tgctgctttg
     1381 cccacaactg ttccctgcgt gccggggcgc aatgcgccca gggtgattgc tgtgcgcggt
     1441 gcctgctaaa gcccgcaggc acaccttgtc gtcccgccgc gaacgactgc gacctccccg
     1501 agttctgcac cggcacctcc cctcattgtc ccgcagatgt ttacctactg gatggctcac
     1561 cctgcgctga gggtcgtggc tattgcctag atggctggtg tcccacgctg gagaagcagt
     1621 gccagcagct atgggggcct ggatcccagc cggctcctga gccatgtttc cagcagatga
     1681 actccgtggg gaattcacag gggaactgtg gccaggacag taagggtagc ttcctgccct
     1741 gcacacagag ggacgctcag tgtgggaagt tgctgtgcca gggagggaag ccaaacccac
     1801 tagtgccgca cgtagtgact gtggattcca caattctgct aaagggccgc caagtgcttt
     1861 gccggggagc tttcgtactc cctgatactc atctggacca gcttggcttg ggtctggtgg
     1921 agccaggcac ccgctgtgga cctagaatgg tgtgccagga gaggcactgt cagaatgcta
     1981 cctcccagga gttggagcgt tgctcgagtg gctgccataa ccgtggggtt tgcaatagca
     2041 atcgtaactg tcactgtgct gcaggctggg ctccaccctt ctgtgacaag cctggcttgg
     2101 gtggtagtgt ggatagtggc cctgcacagt ctgcgaatcc agatgccttc ccattggcca
     2161 tgctactcag ctttctgctg cctctacttc ctggggctgg cctagcctgg tgctactacc
     2221 agctcccaac actctgtcag caaccaggac ggtgctgcag gagggacgcc ctatgtaata
     2281 gggaccaacc tctgggcagt gttcaccctg tggagtttgg ctccatcatc actggagagc
     2341 cctcgccccc gaaccctgag gagtctgagc ttacctagga gctgcctgcc ctctgaggct
     2401 tgtgccgtgc agacctgccc gatccctacg gtaggtgaag caccccaggc cctcccattg
     2461 cccagtcacc aatctgtctc agtttgttgc ctactcctca gatttatggg ctataaataa
     2521 ggaaacaggc atgggcctca gagaagccat tgtcatggag accaggatgc tggaagcccc
     2581 cttaagggca gggaaggcag accctgtggt tcttaggacg aatgtgtcct gccacataac
     2641 ttgcagcctc tgggcccagt cctcagtgac tcagtgcact ctcatacttc cgatggccgg
     2701 atgctgagct ccctactcac cacaggaacc cagagccatc tcatgatgta tcccacctgc
     2761 cgggagagcc gtgctattct gaaatgtcac aatgtatcta gtaacagtaa atccacaagc
     2821 tctatcagcg ctgttggctg tga
//
