LOCUS       NM_001394671            2535 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 28 (Adam28),
            transcript variant 1, mRNA.
ACCESSION   NM_001394671
VERSION     NM_001394671.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2535)
  AUTHORS   Walkiewicz,K., Strzelczyk,J., Waniczek,D., Biernacki,K.,
            Muc-Wierzgon,M., Copija,A. and Nowakowska-Zajdel,E.
  TITLE     Adamalysines as Biomarkers and a Potential Target of Therapy in
            Colorectal Cancer Patients: Preliminary Results
  JOURNAL   Dis Markers 2019, 5035234 (2019)
   PUBMED   31565100
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2535)
  AUTHORS   Mochizuki,S., Shimoda,M., Abe,H., Miyamae,Y., Kuramoto,J.,
            Aramaki-Hattori,N., Ishii,K., Ueno,H., Miyakoshi,A., Kojoh,K. and
            Okada,Y.
  TITLE     Selective Inhibition of ADAM28 Suppresses Lung Carcinoma Cell
            Growth and Metastasis
  JOURNAL   Mol Cancer Ther 17 (11), 2427-2438 (2018)
   PUBMED   30190423
REFERENCE   3  (bases 1 to 2535)
  AUTHORS   Sasaki,A., Abe,H., Mochizuki,S., Shimoda,M. and Okada,Y.
  TITLE     SOX4, an epithelial-mesenchymal transition inducer, transactivates
            ADAM28 gene expression and co-localizes with ADAM28 at the invasive
            front of human breast and lung carcinomas
  JOURNAL   Pathol Int (2018) In press
   PUBMED   29882245
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 2535)
  AUTHORS   Wang,J., Li,H., Wang,Y., Wang,L., Yan,X., Zhang,D., Ma,X., Du,Y.,
            Liu,X. and Yang,Y.
  TITLE     MicroRNA-552 enhances metastatic capacity of colorectal cancer
            cells by targeting a disintegrin and metalloprotease 28
  JOURNAL   Oncotarget 7 (43), 70194-70210 (2016)
   PUBMED   27661126
REFERENCE   5  (bases 1 to 2535)
  AUTHORS   Ota,M., Mochizuki,S., Shimoda,M., Abe,H., Miyamae,Y., Ishii,K.,
            Kimura,H. and Okada,Y.
  TITLE     ADAM23 is downregulated in side population and suppresses lung
            metastasis of lung carcinoma cells
  JOURNAL   Cancer Sci 107 (4), 433-443 (2016)
   PUBMED   26800504
REFERENCE   6  (bases 1 to 2535)
  AUTHORS   Verbisck,N.V., Costa,E.T., Costa,F.F., Cavalher,F.P., Costa,M.D.,
            Muras,A., Paixao,V.A., Moura,R., Granato,M.F., Ierardi,D.F.,
            Machado,T., Melo,F., Ribeiro,K.B., Cunha,I.W., Lima,V.C., Maciel
            Mdo,S., Carvalho,A.L., Soares,F.F., Zanata,S., Sogayar,M.C.,
            Chammas,R. and Camargo,A.A.
  TITLE     ADAM23 negatively modulates alpha(v)beta(3) integrin activation
            during metastasis
  JOURNAL   Cancer Res 69 (13), 5546-5552 (2009)
   PUBMED   19549921
REFERENCE   7  (bases 1 to 2535)
  AUTHORS   Oh,J., Woo,J.M., Choi,E., Kim,T., Cho,B.N., Park,Z.Y., Kim,Y.C.,
            Kim,D.H. and Cho,C.
  TITLE     Molecular, biochemical, and cellular characterization of epididymal
            ADAMs, ADAM7 and ADAM28
  JOURNAL   Biochem Biophys Res Commun 331 (4), 1374-1383 (2005)
   PUBMED   15883027
  REMARK    GeneRIF: ADAM7, but not ADAM28, is transferred from the epididymis
            to the sperm surface and redistributed in the sperm head during
            acrosome reaction
REFERENCE   8  (bases 1 to 2535)
  AUTHORS   Goldsmith,A.P., Gossage,S.J. and ffrench-Constant,C.
  TITLE     ADAM23 is a cell-surface glycoprotein expressed by central nervous
            system neurons
  JOURNAL   J Neurosci Res 78 (5), 647-658 (2004)
   PUBMED   15505805
REFERENCE   9  (bases 1 to 2535)
  AUTHORS   Fourie,A.M., Coles,F., Moreno,V. and Karlsson,L.
  TITLE     Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on
            synthetic peptide substrates and in ectodomain cleavage of CD23
  JOURNAL   J Biol Chem 278 (33), 30469-30477 (2003)
   PUBMED   12777399
REFERENCE   10 (bases 1 to 2535)
  AUTHORS   Howard,L., Zheng,Y., Horrocks,M., Maciewicz,R.A. and Blobel,C.
  TITLE     Catalytic activity of ADAM28
  JOURNAL   FEBS Lett 498 (1), 82-86 (2001)
   PUBMED   11389903
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760400
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                JAXUCZ010000015.1  50250433-50250526   c
            95-198              JAXUCZ010000015.1  50245017-50245120   c
            199-275             JAXUCZ010000015.1  50242411-50242487   c
            276-354             JAXUCZ010000015.1  50241403-50241481   c
            355-431             JAXUCZ010000015.1  50240224-50240300   c
            432-624             JAXUCZ010000015.1  50238501-50238693   c
            625-696             JAXUCZ010000015.1  50236142-50236213   c
            697-768             JAXUCZ010000015.1  50235050-50235121   c
            769-938             JAXUCZ010000015.1  50234341-50234510   c
            939-1023            JAXUCZ010000015.1  50231713-50231797   c
            1024-1154           JAXUCZ010000015.1  50230012-50230142   c
            1155-1332           JAXUCZ010000015.1  50220853-50221030   c
            1333-1422           JAXUCZ010000015.1  50219381-50219470   c
            1423-1618           JAXUCZ010000015.1  50217115-50217310   c
            1619-1721           JAXUCZ010000015.1  50210074-50210176   c
            1722-1881           JAXUCZ010000015.1  50207680-50207839   c
            1882-1962           JAXUCZ010000015.1  50204647-50204727   c
            1963-2041           JAXUCZ010000015.1  50204252-50204330   c
            2042-2150           JAXUCZ010000015.1  50197493-50197601   c
            2151-2229           JAXUCZ010000015.1  50189127-50189205   c
            2230-2298           JAXUCZ010000015.1  50188382-50188450   c
            2299-2345           JAXUCZ010000015.1  50187122-50187168   c
            2346-2535           JAXUCZ010000015.1  50185515-50185704   c
FEATURES             Location/Qualifiers
     source          1..2535
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..2535
                     /gene="Adam28"
                     /note="ADAM metallopeptidase domain 28"
                     /db_xref="GeneID:290344"
                     /db_xref="RGD:727820"
     exon            1..94
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2367
                     /gene="Adam28"
                     /note="a disintegrin and metalloproteinase domain 28; a
                     disintegrin and metallopeptidase domain 28; disintegrin
                     and metalloproteinase domain-containing protein 28; a
                     disintegrin and metalloprotease domain 28"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 28 precursor"
                     /protein_id="NP_001381600.1"
                     /db_xref="GeneID:290344"
                     /db_xref="RGD:727820"
                     /translation="MQQWRLLVVWFLLSPVPASAIKELPKAKNYEVVYPIRLHLLHKR
                     ETKEPEPKETFETELRYKMTVNGKVVELYLKKNNKLLAPGYLETYYNSSGNKVTTSPQ
                     IMDSCYYQGHIINEKDSAASISMCQGLRGYFSQADERYFIEPLSSEILDEQAHALFKD
                     DPKEDQENSNCGVDDALWLQGLHQDVVLPATRLIKLNDGMVQEPKKYIEYYVVLDNGE
                     FKKYNKNLDEIRKRVHEMANYVNMLYNKLDAHVALVGMEIWTDEDKIKITPDANTTLE
                     NFSKWRGNDLLKRKHHDVAQLISSTDFSGSTVGLAFMSSMCSPYHSVGIVQDHSNYHL
                     RVAGTMAHEMGHNLGMIHDYLSCKCPSEVCVMEQSLRFHMPTDFSSCSRDNYRRFLEE
                     KLSHCLFNSPLPSDIISTPVCGNQLLEMNEDCDCGTPKECTNKCCDAETCKIKAGFQC
                     ALGECCEKCQLKKPGVVCRAAKDECDLPEMCDGKSSHCPVDRFRVNGFPCQNGHGYCL
                     KGNCPTLQQQCMDMWGPETKVANKSCYKQNEGGSKYGYCHVENGTHMPCKAKDAMCGK
                     LFCEGGSGDLPWKGLTIAFLTCKLFDPEDINQGVDMVANGTKCGNNKVCINAECVDME
                     KTYKSANCSSKCKGHAVCDHELQCQCKEGWAPPDCEDSATVFRVSIMVGVLFPLAAIF
                     VVIAIVIHHQSARRKQRRVQRLPPIKDAKLHKQKCRPQKVKDIQPQEMSQMKKLHVSD
                     LPTEKQEPPPDVLITKPNFPPPPIPVSWDANAKV"
     exon            95..198
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            199..275
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            276..354
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            355..431
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            432..624
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            625..696
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            697..768
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            769..938
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1023
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1154
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1332
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1422
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1618
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1721
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1881
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1962
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2041
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2150
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2229
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2298
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2345
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2535
                     /gene="Adam28"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaggtgtga gcggatgcac ccactgctcc caggatcaca gaatgcagca atggcgactt
       61 ctggtagtct ggttcctcct ttctccagtt ccagcaagtg caataaaaga actccctaaa
      121 gccaagaatt atgaagtggt ttatcccata agacttcatc tgttgcataa aagagagacc
      181 aaagagccag agccaaagga aacatttgaa actgagctca ggtacaaaat gacagtaaac
      241 ggaaaggttg tggagctata cctgaagaag aacaacaagc tcctagcacc tggctacttg
      301 gaaacatact ataattccag tggaaacaag gtcaccacaa gcccgcaaat catggatagc
      361 tgttactacc aaggacacat cataaacgag aaagattcag cagccagcat cagcatgtgt
      421 caagggctac ggggttactt cagtcaagct gatgaaaggt attttattga acctttgagc
      481 tcggagatct tggatgagca ggcacatgca ctcttcaagg atgatcccaa agaagaccag
      541 gagaacagta actgtggagt ggatgatgcg ctatggctcc aaggactgca tcaggatgtg
      601 gtccttcctg ccaccaggtt gattaagctg aatgatggga tggtccaaga acctaagaag
      661 tacatagaat attatgtggt cctggacaat ggtgagttta agaaatacaa taaaaatctt
      721 gatgaaataa gaaagagagt acatgagatg gccaattatg tcaacatgct ttacaataag
      781 cttgatgccc atgtggcctt agttggaatg gaaatctgga ctgatgagga taaaataaag
      841 ataacaccag atgccaacac caccctggaa aacttctcta agtggagggg aaatgatctg
      901 ctaaagcgaa agcaccatga tgttgcccag ctaatctcct caacagattt ttctggttca
      961 acagttggtc tagccttcat gtcttcaatg tgttctcctt accattctgt tggcattgtt
     1021 caggaccaca gtaactacca tcttcgagtc gcaggaacaa tggcacatga aatgggtcac
     1081 aaccttggca tgattcatga ctacttgagt tgtaagtgcc catctgaagt ctgtgtaatg
     1141 gagcagtcac taagattcca catgcctaca gacttcagct cctgcagtcg tgacaattac
     1201 agacgatttc ttgaagagaa attatctcat tgcctcttta atagtccttt gccttcagat
     1261 atcatatcca ccccagtctg tgggaaccag ttattggaaa tgaatgagga ctgtgactgt
     1321 ggcactccca aggagtgtac caacaaatgc tgtgatgcag agacctgtaa aattaaagca
     1381 ggtttccagt gtgctttggg agaatgctgc gagaaatgcc aacttaaaaa gcctggggtt
     1441 gtgtgcagag cagcaaaaga tgagtgtgat ctgcctgaaa tgtgtgatgg taaatccagc
     1501 cactgcccag ttgacagatt cagagtcaat ggcttccctt gccaaaatgg gcatggctac
     1561 tgcttgaagg gcaactgtcc caccctgcag cagcagtgca tggacatgtg gggcccagaa
     1621 accaaggttg caaataagtc atgttacaag cagaatgaag gtgggtcaaa gtacggatac
     1681 tgtcacgtgg agaatggtac ccacatgccc tgcaaagcca aagatgccat gtgtgggaag
     1741 ttgttctgtg agggtgggtc aggtgatctg ccctggaaag gacttacaat agctttcctg
     1801 acatgtaaat tatttgatcc tgaagacatc aatcaaggag tagacatggt ggccaatgga
     1861 accaaatgtg gaaataacaa ggtgtgcatt aatgcagagt gtgtggacat ggagaagaca
     1921 tacaagtcag ccaactgctc ctccaagtgc aaaggccacg cagtgtgtga ccatgagctt
     1981 cagtgtcagt gcaaggaagg atgggcccct cctgactgtg aggattctgc cacagtcttc
     2041 cgcgtctcca tcatggttgg cgtgctcttt cctctggcag ccatatttgt ggtgattgct
     2101 atagtgatcc atcatcaaag tgccagaaga aagcaaagga gagttcagag gctaccaccc
     2161 atcaaggatg ccaagctaca caagcagaag tgtagacccc aaaaggtgaa ggatattcaa
     2221 ccccaggaga tgagtcagat gaaaaagctc catgtgtctg atctgcccac tgaaaagcag
     2281 gagcctccac ctgatgtcct aatcacaaag ccaaatttcc caccgccacc aattcctgtt
     2341 tcctgggacg cgaatgcaaa agtatgaagc aacaactaaa ccagggtcga tgatcagatg
     2401 gtcagagtgg aagcgttgat gttttggaag gaaaggacat gtgcttactt cgttcttact
     2461 agtgctcttg accctcagag attaacatgt tctggtttgt gctatatttt gaagattaaa
     2521 acatttaaga aacac
//
