LOCUS       NM_001393708            6308 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 23 (Adam23),
            transcript variant 2, mRNA.
ACCESSION   NM_001393708
VERSION     NM_001393708.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6308)
  AUTHORS   Hivert B, Marien L, Agbam KN and Faivre-Sarrailh C.
  TITLE     ADAM22 and ADAM23 modulate the targeting of the Kv1
            channel-associated protein LGI1 to the axon initial segment
  JOURNAL   J Cell Sci 132 (2) (2019)
   PUBMED   30598502
  REMARK    GeneRIF: ADAM22 and ADAM23 also associate with Caspr2 and TAG-1
            (also known as CNTN2) to be selectively targeted to different
            axonal sub-regions. Hence, the combinatorial expression of
            Kv1-associated CAMs may be critical to tune intrinsic excitability
            in physiological and epileptogenic contexts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6308)
  AUTHORS   Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S
            and Russo T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   3  (bases 1 to 6308)
  AUTHORS   Fukata Y, Lovero KL, Iwanaga T, Watanabe A, Yokoi N, Tabuchi K,
            Shigemoto R, Nicoll RA and Fukata M.
  TITLE     Disruption of LGI1-linked synaptic complex causes abnormal synaptic
            transmission and epilepsy
  JOURNAL   Proc Natl Acad Sci U S A 107 (8), 3799-3804 (2010)
   PUBMED   20133599
REFERENCE   4  (bases 1 to 6308)
  AUTHORS   Sagane K, Yamazaki K, Mizui Y and Tanaka I.
  TITLE     Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23
  JOURNAL   Gene 236 (1), 79-86 (1999)
   PUBMED   10433968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000214.1 and BF543743.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001393708.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132283,
                              SAMD00132286 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-510               JACYVU010000214.1  20857540-20858049
            511-728             JACYVU010000214.1  20859318-20859535
            729-805             JACYVU010000214.1  20889410-20889486
            806-869             JACYVU010000214.1  20927302-20927365
            870-952             JACYVU010000214.1  20936336-20936418
            953-1016            JACYVU010000214.1  20937833-20937896
            1017-1089           JACYVU010000214.1  20941795-20941867
            1090-1163           JACYVU010000214.1  20942635-20942708
            1164-1229           JACYVU010000214.1  20944414-20944479
            1230-1301           JACYVU010000214.1  20950472-20950543
            1302-1465           JACYVU010000214.1  20952774-20952937
            1466-1550           JACYVU010000214.1  20953752-20953836
            1551-1641           JACYVU010000214.1  20954697-20954787
            1642-1690           JACYVU010000214.1  20956689-20956737
            1691-1790           JACYVU010000214.1  20958702-20958801
            1791-1862           JACYVU010000214.1  20962088-20962159
            1863-1952           JACYVU010000214.1  20962754-20962843
            1953-2033           JACYVU010000214.1  20964167-20964247
            2034-2084           JACYVU010000214.1  20970216-20970266
            2085-2148           JACYVU010000214.1  20970880-20970943
            2149-2254           JACYVU010000214.1  20973401-20973506
            2255-2374           JACYVU010000214.1  20974616-20974735
            2375-2426           JACYVU010000214.1  20977588-20977639
            2427-2432           BF543743.1         74-79
            2433-2543           JACYVU010000214.1  20977645-20977755
            2544-2655           JACYVU010000214.1  20980390-20980501
            2656-2746           JACYVU010000214.1  20993684-20993774
            2747-6308           JACYVU010000214.1  21001048-21004609
FEATURES             Location/Qualifiers
     source          1..6308
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..6308
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /note="ADAM metallopeptidase domain 23"
                     /db_xref="GeneID:301460"
                     /db_xref="RGD:1305739"
     exon            1..510
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..2795
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     disintegrin and metalloproteinase domain-containing
                     protein 23; a disintegrin and metallopeptidase domain 23"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 23 isoform 2"
                     /protein_id="NP_001380637.1"
                     /db_xref="GeneID:301460"
                     /db_xref="RGD:1305739"
                     /translation="MKPPGSSSRRPPLTGCSLPGASRGPGRCPAGPVPARAPPCRLLL
                     VLLLLPALAASSRPRARGAAALSALHWNETAENSPGVVADEDSTLQQNGSRNTSYSSA
                     VQKEITLPSRLVYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFIL
                     DLILNNGLLSSDYVEIHYEDGKQMYSKGGEHCYYHGSIRGVKDSRVALSTCNGLHGMF
                     EDDTFVYMIEPLELTHDEKSTGRPHIIQKTLAGQYSKQMKNLSTDGSDQWPLLPELQW
                     LRRRKRAVNPSRGVFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYK
                     EQLNTRVVLVAVETWTEKDQIDITINPVQMLHEFSKYRQRIKQHADAVHLISRVTFHY
                     KRSSLSYFGGVCSRVKGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKCECIE
                     SWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEA
                     GEECDCGFHVECYGVCCKKCSLSNGAHCSDGPCCNNTSCLFQSRGYECRDAVNSCDIT
                     EYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKASGSDKFCYE
                     KLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQ
                     GRVIDCSGAHVVLDDDTDVGYVEDGTPLCPSMMCLDRKCLQIQALNMSSCPLDSKGKV
                     CSGHGVCSNEATCICDFTWAGTDCSIRDPVRNPNPPKDEGPKGPSATNLIIGSIAGAI
                     LVAAIVLGGTGWGFKNVKKRRFDPTQQGPI"
     exon            511..728
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            729..805
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            806..869
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            870..952
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1016
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1089
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1163
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1229
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1301
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1465
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1550
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1641
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1690
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1790
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1862
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1952
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2033
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2084
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2148
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2254
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2374
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2543
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2655
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2746
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..6308
                     /gene="Adam23"
                     /gene_synonym="MDC3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcatcctcag gcccggcagc aacccccgca gtcactggtg cggccgcgcc cgctactggg
       61 agggtgcagc cgctggggga ggctccaagt tggcggagcg gcggggaccc cctctgcggg
      121 ccgctccccg aaaggcggaa agagtcgagg agggcgcgcc gccgtccccg agaccccaac
      181 ccctgacccc tgcccgcggc cgcagcatgc gcgcccagcc ggcgtgaccg gctccgcccg
      241 cagccgcccc gcagcccagc ccggcgctct cgcgggtcac tcggaccggc gcccgggagc
      301 gatgagccat gaagccgccc ggcagcagct cccggcggcc gcccctgacg ggctgcagcc
      361 tgcccggcgc ctcccgcggc cccggccgct gccccgccgg cccggtgccg gcccgcgcgc
      421 cgccctgccg cctgctcctc gtccttctcc tgctgcctgc gctcgccgcc tcgtcccggc
      481 cccgtgcccg gggggccgct gcgctcagcg ctctgcattg gaatgaaact gcagaaaaca
      541 gcccgggagt tgtggcagat gaagacagca cattgcaaca gaatggcagc agaaatacca
      601 gctacagcag tgcagtgcag aaagaaatca cactgccctc aagactggtg tattacatca
      661 accaggactc agaaagccct tatcatgttc ttgacacaaa ggccagacac caacagaaac
      721 acaataaggc tgtccatctg gcccaggcaa gcttccagat cgaagccttt ggctccaagt
      781 tcattcttga cctcatactg aacaatggtt tactatcttc ggactacgtg gagatccact
      841 atgaggacgg gaagcagatg tactctaagg gcggagagca ctgctactac catgggagca
      901 tcagaggtgt caaggactcc agggtggctc tgtcgacctg caatggactc catggcatgt
      961 ttgaggatga cactttcgtg tatatgatag agcctctgga gctgactcat gatgagaaaa
     1021 gcactggccg accacacata atccagaaaa ccttggcagg acaatattct aagcagatga
     1081 agaatctcag cacagatggc agtgaccagt ggcctttgct acctgaatta cagtggctga
     1141 gaagaaggaa aagagcagtt aatccatcgc gaggtgtgtt tgaagaaatg aagtatttgg
     1201 agcttatgat tgttaacgat cacaagacgt ataagaagca ccgctcttct cacgcgcata
     1261 cgaacaactt cgcaaagtct gtggtcaacc ttgtagattc tatttacaag gaacagctca
     1321 acaccagggt tgtcctggtg gctgtagaga cctggaccga gaaggatcaa attgacatca
     1381 ccatcaaccc cgtgcagatg cttcatgagt tctccaagta ccggcaacgt atcaaacagc
     1441 atgcagacgc ggtccacctt atctcgcgtg tgacattcca ttataagaga agcagtctga
     1501 gttacttcgg aggtgtgtgt tcccgcgtaa aaggggttgg tgtgaatgag tacggtcttc
     1561 caatggcagt ggcacaagtg ttatcgcaga gcctggctca aaaccttgga atccagtggg
     1621 aaccttcgag caggaagcca aaatgtgaat gcatagagtc ctggggcggc tgcatcatgg
     1681 aagaaacagg ggtgtcccac tctcgaaagt tctcaaagtg cagcattttg gagtacagag
     1741 actttttaca gagaggaggc ggagcgtgtc ttttcaatag gccgactaag ctgtttgagc
     1801 ccacggaatg tggaaacgga tatgtggaag ccggggagga atgcgattgt ggtttccatg
     1861 tggaatgcta cggagtttgc tgtaagaaat gctctctctc caacggggcc cactgcagtg
     1921 acggcccctg ttgtaacaac acctcgtgtc tttttcagtc acgagggtac gaatgtcggg
     1981 atgccgtgaa cagctgtgat ataacggagt actgcaccgg agactctggc cagtgcccgc
     2041 cgaatctgca taaacaagat ggctacgcct gcaatcaaaa tcagggtcgc tgctacaatg
     2101 gcgagtgcaa gacaagggac aaccaatgcc agtacatctg ggggacaaag gcttcggggt
     2161 cagacaagtt ctgctatgaa aagctgaaca cagaaggcac cgagaagggc aattgtggca
     2221 aggatggaga ccggtggatt cagtgcagca aacatgatgt gttctgtgga tttctgcttt
     2281 gcaccaatct tacccgagct ccgcgtattg gtcaacttca aggagagatc atcccgactt
     2341 ccttctacca tcaaggccga gttattgact gcagtggtgc tcacgtagtt ttagacgatg
     2401 atacagatgt gggctatgta gaagatggga ctccattgtg cccctccatg atgtgcttag
     2461 atcggaagtg cctacagatt caagccctaa atatgagcag ctgcccactt gactccaagg
     2521 gtaaagtctg ctcaggccat ggggtgtgta gcaacgaagc cacctgcatc tgtgacttca
     2581 cttgggcagg cacagactgc agcatccggg atccagttcg gaaccccaac cccccaaagg
     2641 atgaaggacc taagggtcct agcgccacca atctcataat aggctccatc gctggtgcca
     2701 tcctggtagc agctattgtc cttgggggca caggctgggg atttaaaaac gtcaagaaga
     2761 ggagattcga tcccactcag caaggcccca tctgaatcag ctgcactgga ggagtgccac
     2821 cttgcactgt ggggttctgg caatgacatg ctttccacca tgctgctgga actcttaagt
     2881 ctgtaaacaa gaccattggg tggtaatgac tacagagctc aaatctgagg acggggatgg
     2941 ggtacaacac aacagtccct tttggaaata acttcaagta accccctcta tcacctgtca
     3001 ataaagggga ggggttaaag accacgtcat tataaaaaaa ctgttcagaa tcctttattt
     3061 ttctttcttt ttaactaaag gagaagggag cagcaacaag tgcaataaaa gaacaaatcg
     3121 ccagtgaccc cccccttagc ctgctgacac ttaatatctt ctaaaggatt tggcatgatt
     3181 ttttttcctt ttactatcaa agacaaactc cagcggcatg aagatccaat tttggaaagg
     3241 gtaaaaactg catggcatat ataacaacaa gctagcaagc cagccttcag caaatcctac
     3301 cgtggaaatc ccgaggggaa gatgacagac gaccacacag acgctgcctg gctttggatt
     3361 aatgccttcc cactcctcca cctccgtcct ggcccacctt ttccctccat gcccctcggc
     3421 ccactctgga ccggccgtgg cagcactcat ctggactgtg ttcttgatgc cctgtaccca
     3481 ttatttctct cctggaccaa gcatcctttg gaaatgggat ctggaacttg aacagtgcta
     3541 ttgtacagtt cttttataaa tgtagatatg gaagtgaggt tttgacacgc cattttcgct
     3601 tgtctctatg gaaatgtttt cctcgcaaag atactctcta tactttgttg cttgctccac
     3661 atcttcttta tctttctttt tcctcttgtt ttcctccttt gtctctgtcc tctcttataa
     3721 catatccact tgcttaacaa gacagacgta gccacagatg cagggagttt gggcacaaat
     3781 ctagaatgtt tgaaaccaaa tattaaaaaa aacctagggg gctggggggg ggaccacaaa
     3841 acaacccata acaagaacac aaaatatgta agtgtgagtg tatatgtact gatgacccta
     3901 acatgtttga tgtcatcata agcacatgta tataccgtag ggaaaccgag acccttctca
     3961 agttaatcac agaagtgcca aactcatcat tctcgcttct ggtttcgaca gttctctttc
     4021 cctgtcataa atgtgaaagg aggaggaact taaagcctta aataaagaat taataacttt
     4081 taaatgctgg aagcttggag acagttcagc tttccattct gttcatctgt atctatttaa
     4141 ttttttttga taaatttcat ttatgcttcc tcttcctgcc tcagagcctg tgtgacagag
     4201 cccagtgtag acagcaggtc atctctgatc atttctgcat ggtggtttcg ggactctccc
     4261 gacctctgtg ttttgctgga ccatggactc tgggttgtga tgggattcca ctatgtctga
     4321 gtccatacgc ttcttttttc ccccaagtgg ccagggagat agagtcttgg cattcccaag
     4381 gctgagtttc cctcatcttc ccccattgca attctaaggg aacaggctat tgaggaggtc
     4441 ctctcctagg tttgctttgg acatacagat atacagtgaa aacccatcaa ggactcgacc
     4501 tgccagagag ccctacttct tcactggccc acttttagca agaacatcca gatgaactat
     4561 gcatttcttc ctggcgttga ggtactttta catttagctc ttagcccctc tctggcaaga
     4621 cttaagtttt acattttcct cgactgggag gaggatttcc taatgggctt catgaaactg
     4681 gactttccct cttcccccaa agatatcttt aattgttgac atttcaccct cacagagtag
     4741 aaaccttgat tgctatgtac aaccccagac cataacttaa catcctaacc ttcagatggc
     4801 tttctgagaa acaggtgcta tgtaggtatg cagtctgtcg cttgaacttg ctgtttgttt
     4861 ctatagtaat aacagggctc tctgaaggcg agttggcctt atttctggtt ccagaagaca
     4921 cgggttgtat ccctttactt aatggcagtg gttcagttgg aggaaggtca gaggaaactc
     4981 agatggtatc tcttcctgtt gttgcaatgt ttcggggtcc acttcactat gagataccaa
     5041 gcagctgcca acctcactgt actcatttca ttactattcc cgaggcacca tggtgagttt
     5101 ttccaacata aaaccatgtc agttacaaaa cagatctccc ttgataactt tggaacattt
     5161 cacaaacaac attgtaaatg tgcgatgtta tgttttaaat cagaccacag tggtccccaa
     5221 atattatgta catatgacaa atgccagtgt aactttttgt tacgctgaca gtttcatagg
     5281 taaaccaacc tatgctccaa tgttaaatta cgtgtgtata tgtgaaatac acaagcatta
     5341 agctaagtgt gtatggacac gagggtagtg caatcatact gtataaaatg ggccagaatc
     5401 attttcagtg gtgttaggtc atgtagtttc agactcgttg ctgcattttc tcttgcacat
     5461 gccatccatt tgcttattct tgggcgtgag tactccttat taatttgaat tcaaagcaca
     5521 agcctcccct tgttcaacat tgcccaacga gagtgtcaag tgatggccaa gttcccactt
     5581 cacctgctct acttttactg cgacactgac gaggaggtgt gcgctgacct cattgctcac
     5641 ccgggatagt gcatgaaccc actgaattag acctacttct accagctaag tgagcagtac
     5701 cataggtgca tgtttcaaca ggagtcacat agagtgctgg agttttgcca agtgatgtgt
     5761 tttctttttt tccttttctt atttctcttt ctttctttct tcctttcttt cttccttcct
     5821 ttctttcttt tttttttact atgcaaagat gggaaatgca caaacctcca agacatgtct
     5881 gaagaacttt acaatacttg aatcctttct ttaattatcc catcacattg ttatggtcac
     5941 tgacacttcc attgttgttt ttcctttctt ttgttccctt caactccaat ggtttgtgat
     6001 ttttaaatgc acaacccgaa cttttgtttg aagttaaatt ctaaccctct ttgctgcctg
     6061 tgagcaaaga ttccatcatg cttatatgca tcttttggtt gactgtgcat taaaagtttt
     6121 attattgtag gatgtcgcgg ttttgtgctt tgactggtgt ttcttaactc tcgtttcttc
     6181 tgtgttttct tgcattattg gtcaagtggc tatgtgcctg ggatttggca gtctcaatca
     6241 aaggttcact gcaaactgaa gcagccaatg gagcaaaata aactttctgg ttaatggtta
     6301 atgttctg
//
