LOCUS       XM_039108565            9518 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus ADAM metallopeptidase domain 22
            (Adam22), transcript variant X5, mRNA.
ACCESSION   XM_039108565
VERSION     XM_039108565.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051339.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039108565.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9518
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..9518
                     /gene="Adam22"
                     /note="ADAM metallopeptidase domain 22; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 35 ESTs, 6 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     22 samples with support for all annotated introns"
                     /db_xref="GeneID:57033"
                     /db_xref="RGD:1585016"
     CDS             309..3194
                     /gene="Adam22"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 22 isoform X5"
                     /protein_id="XP_038964493.1"
                     /db_xref="GeneID:57033"
                     /db_xref="RGD:1585016"
                     /translation="MQAVAAAFFWLLCVLGTYPLARCGRAGDASLRELERGDGNRFLE
                     RQSTVPLRLIYRLGGEDETQHEQLNTRVRGDPGGRQPTHVDKASFRVDAFGTSFILDV
                     LLNHELLSSGYVERHIEHGGKVVENKGGEHCYYQGQIRGNPASFVALSTCHGLHGMFY
                     DGNHTYLIEPEENEMSQESQFHSVYKSRLLEFPLDDLPSEFQRINITAPQFTLKPRLK
                     RRKRQLLRFPRNVEEETKYIELMIVNDHLMFKKHRLSVVYTNTYAKSVVNMADVIYKD
                     QLKTRIVLVAMETWAADNKFAISENPLVTLREFMKYRRDFIKEKADAVHLFSGSQFES
                     SRSGAAYIGGICSLLRGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCE
                     DTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIE
                     TGEECDCGTPAECALEGAECCKKCTLTQDSQCSDGLCCKKCKFQPLGTVCREAVNDCD
                     IREICSGNSSQCAPNVHKMDGYSCDGTQGICFGGRCKTRDRQCKYIWGQKVTASDRYC
                     YEKLNIEGTEKGNCGKDKDTWTQCNKRDVLCGFLLCTNIGNIPRLGELDGEITSTLVV
                     QQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPMASFNFSTCLSNKAG
                     TVCSGNGVCSNELKCVCNRHWTGADCGTHFPHNDDAKTGITLSGNGVAGTNIIIGIIA
                     GTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGDGDSFYSDFPPGGSADSASSSK
                     KRSAFLSHFQISTCSITHYSISQNISLFCSRSNGLSHSWSERIPDTKHISDICENGRP
                     RSNSWQGNVGGNKKKIRGKRFRPRSNSTEYLNPWFKRDYNVAKWVEDVNRNTEGPYFR
                     TLSPAKSPSSSTGSIASSRKYPYPMPPLPDEEKTVNRQSARLWETSI"
ORIGIN      
        1 ggtgcgcggc cgggtgcggc gcgaggggca agtgcaccag gcccgctgcg cacccggctc
       61 cgctccccgc tgcgctgctg gccgcccgcc ttggcctccg cctggggatg aggtgggagg
      121 cgctagaagc cacttagcta cagcctggcg cccgatgcgg cgctcgctcg ctgcccacgc
      181 caccgaagcg cccgccaggc acaatgcagc actgaggcag cggcggctgc ggcagcggcg
      241 cgggctggga aagggcggcc gggagcccga gcccggggcc gggaaacgag cagctgagcg
      301 ccgccaccat gcaggcagtg gcggccgcgt tcttctggct gctctgcgtc ttggggacct
      361 accccctggc gcgctgcggt cgggcaggag acgcctcact gagagaactg gagagggggg
      421 acggaaaccg cttcctggag cgccagagca ccgtaccact gcgcctcatc taccgcttgg
      481 gcggcgagga cgaaactcag cacgagcagc tcaacacgcg ggtgcggggc gaccctggcg
      541 gacggcagcc tactcacgtg gacaaggcaa gcttccgggt ggacgccttt ggaacctcct
      601 tcattctcga tgtcctgctg aaccacgagt tgctgtcctc cggttatgta gagagacata
      661 ttgaacacgg aggcaaggtc gtggaaaaca aaggaggaga acactgctat taccagggcc
      721 agattcgagg aaaccctgcc tcctttgttg ccctgtcaac atgccacgga ctccatggga
      781 tgttctatga tgggaaccac acatatctca ttgagcctga agaaaatgag atgtcccaag
      841 agtctcagtt tcactccgtg tacaaatcca ggctgcttga atttcccttg gacgaccttc
      901 catctgaatt tcaacgcata aatatcactg ccccccagtt tacactgaag ccgagactaa
      961 agcggaggaa aagacagctt cttcgatttc ctcggaatgt agaggaggaa actaaataca
     1021 ttgaactgat gatcgtgaat gatcatctca tgtttaaaaa gcaccggctt tctgttgtat
     1081 atacaaatac ctatgcgaag tctgtggtga acatggcgga cgtgatctat aaggaccaac
     1141 ttaagactag gatagtgctg gttgccatgg aaacctgggc tgctgacaac aagttcgcca
     1201 tatctgaaaa cccactggtc accttgcgtg aattcatgaa atacaggagg gattttatca
     1261 aggagaaggc tgacgcagtc catctcttct cgggcagtca atttgagagt agccggagcg
     1321 gggcggctta tattggtggg atttgctcgc tgctgagagg aggaggcgtg aatgaatttg
     1381 gaaaaacgga tttaatggca gttacactcg ctcagtcgct agcccacaat atcggtataa
     1441 tctcagacaa gaggaagtta gcgagtggtg agtgtaaatg tgaggacacc tggtccgggt
     1501 gcatcatggg agacaccggg tactatcttc ctaaaaagtt cactcagtgc aatattgagg
     1561 aatatcatga cttcctgaat agcggtggag gggcctgcct gtttaacaag ccttccaagc
     1621 ttcttgatcc tcccgagtgt ggaaacggct tcattgaaac cggagaggag tgtgattgtg
     1681 gcacccctgc ggaatgtgcc cttgaagggg cagagtgttg taagaaatgc accttgaccc
     1741 aggactctca atgcagtgat ggcctgtgtt gtaaaaagtg caagtttcag cctctgggga
     1801 ccgtgtgccg ggaggcagtg aatgactgtg acatccgtga aatatgttca ggaaattcga
     1861 gccagtgtgc ccccaatgtg cataaaatgg atggatattc gtgtgatggt actcagggaa
     1921 tttgctttgg aggaagatgt aaaaccagag atagacaatg caaatacatc tgggggcaaa
     1981 aggtgactgc atctgacagg tactgctatg agaaactgaa cattgagggg actgagaagg
     2041 gcaactgtgg gaaagacaaa gacacgtgga cacagtgcaa caaacgggat gtgctctgtg
     2101 gtttccttct atgcacaaat attggcaaca tcccaaggct cggagagctc gatggtgaaa
     2161 tcacgtccac actggttgtg cagcaaggaa ggacattaaa ttgcagcggg ggacatgtga
     2221 agcttgaaga agacgtggat cttggctatg tggaagatgg gacgccctgc ggccctcaga
     2281 tgatgtgctt ggaacacagg tgtcttccca tggcttcctt caacttcagc acttgcttaa
     2341 gcaataaagc aggcactgtg tgctcaggaa acggagtttg tagcaatgag ctcaagtgtg
     2401 tgtgcaacag gcactggaca ggtgccgact gtggcaccca ctttcctcac aatgatgatg
     2461 ctaagactgg catcaccctg tctggcaatg gtgttgctgg cactaatatc ataataggaa
     2521 taattgctgg caccatttta gtgctggccc tcatattagg aataacagcc tggggttata
     2581 aaaactaccg agaacagaga cagttacccc agggagatta tgtaaaaaag cctggagatg
     2641 gcgactcttt ttatagcgac tttcctcctg gaggcagcgc agactcagca tctagttcta
     2701 agaagaggtc tgcttttctg tcgcattttc agatttccac ctgctccatc acacattatt
     2761 ccattagtca gaacatttca ttattttgca gcaggtcaaa tggactctct cattcttgga
     2821 gtgaaaggat tccagacaca aaacatattt cagacatctg tgaaaatggg agaccccgaa
     2881 gtaattcctg gcaaggtaac gtgggaggca acaaaaagaa gatcagaggg aaaagattca
     2941 gacctcgctc taattcaact gagtatttaa acccatggtt caaaagagac tataatgtag
     3001 ctaagtgggt agaagatgtg aatagaaaca ctgaaggacc gtactttagg accctgtcac
     3061 ctgccaagtc tccttcttca tcaactgggt ctattgcctc cagcagaaaa tacccatacc
     3121 cgatgccccc gcttccggat gaggagaaga cggtgaaccg acagagtgcc aggctgtggg
     3181 agacatccat ttaagaacaa ctgtttacat gtgacacatc gaaactgttt acttctactt
     3241 ttatagaaac ccagccaccc acaatcactg caaatctgca tctgcttttc ggacgatttc
     3301 aagaccctct tgcgatgcca gaggagagga agccacgggt catacctgga tagcatactt
     3361 tctttttctt tttcttttct ttttcttttt ttttgtcatt ggcttaaggt ttaaccaaat
     3421 ggtaaagaga attactggaa cgtcacgctg caacatggaa ccatttatgg cctggcattg
     3481 atatgttaat tgataatctg catggcagaa atatgtagac catcaataaa actaacccac
     3541 acgacccaac gttagcaggt tttcccgagg ggacagaagt ggattcagaa ctgagcattc
     3601 tgaatcacat cctcattgca agcagtaacg cccgtatgca tgaagcttct gtttatcgtt
     3661 ttccatatgc aaggaaacaa cctctcctaa tagaaactag catgcagggg ctgaggcata
     3721 taggactctt ctgcaggacc gcaggactgt aaagcttcca gaagccaata tcccatatgc
     3781 tacctttaaa catgtatttt tatttttttt tacttttcat atttatatta gcatacaggg
     3841 acgactgtac atatgtaaac atttttaaaa cttaagaagt aactgttaac cgtaagtgta
     3901 ttttttgcca aatgcctaca aacagtcagt cacgatccta tcgctgtcct ccatccagtg
     3961 tcttcgaagt ataagtggat gatattgtaa atagagtggt cagtgctgta agagtatctc
     4021 tccccaaccg gtgtttgtct aaaacgtgca atttcccttt tcaaagtgtg tacagtctgg
     4081 aagaggtttt cttgagcaag acatccaaat gctcaaactt ctagcctctg catcttgccg
     4141 aaggaagagt ccagatgtga ggtagccatg ccgctccagg acaccctgga gccgacaggc
     4201 tctctgggat tctgccagcc catccactcc atatctaaga cacatggtgc ctgtcacagt
     4261 agctgttctc aaccagtacc agggcatatc aactaatctt acctggaggt catggagtcc
     4321 ccttctctcc agaaagtgtc ttctgtgatt ggcaagatgt accaaagaca tggagcacag
     4381 agtagagcgt tccctcttga ccaaggcctg aggcttgtct ggtctgaagt ttgggttcct
     4441 tgacagaatc cttttagcca ttcttatatg tgaaaggaat gacttgcttc cacaatttta
     4501 acatgtttca tcactagggt gtaaatccca gcaggttgtt ctgtctggct ttgaacaaga
     4561 tggtgtacgg aagcctgaac aaggcataaa aaaattaagt aaagctacac agaggcagtg
     4621 actgcaaagg taaccataag cccgcagagg aaagagcctg tgttttgggc cctataacct
     4681 ttgattcact agaaaaaaaa tgagtatttt atgtgaaatc ttgtcattta caacgaaaca
     4741 ttaatacctg tttcaatgca atgttcagtg ttcaatgcaa aaagaaagtc cctctaatga
     4801 gatctgaggt tgggaggccc agtcacgtga cctcctacgg aacactcttc tgatttccct
     4861 cttcttcttg ctgttttatg tgaggaatga aatcatcaga caagaactca gaaatggact
     4921 ctacatttga tttcttccag atgcgtccag ggacacaatt tgttccaact ctgtgtagaa
     4981 ttgtcctaga tacccaaact gaagggacag gctagaaggc agtggtatat tcagctcatg
     5041 tcttttgcaa tggtccactc ttctaaaaca ctctgaaggt gttaggaaac caatttaatc
     5101 aggcaaaatt aaacagtgaa aaaccatttt ccatgacagg caaagatata ggttgccgat
     5161 ggctcaataa agcagtctca gataaaggca tggatgagtg ttgaacaatg tctccacata
     5221 gcttaaggta aggacggaag gacagacaga tgacggatga aaaagatgta gcaaaatgaa
     5281 gtgacttttg gacaagaaca cttcaaatgt gcactgaatg tttcttggta tcgagtgtat
     5341 aaaaggctaa tgtaatataa ggtttatttt ggctacagaa gaaaaaagtt tatatagctt
     5401 cgaatgaaag gtgcctcatg taaatatgcc gtgtagttaa tagttcgtta gataagctct
     5461 aacctgaaag aattcacaaa tggttagcca gtgagctggt tatctgtcta cctactggtc
     5521 tttccttacc ttctcagttg ctttcacctg gagttatgat tgaaaatcaa tatcattatc
     5581 atgtgccttt ggggagaaac ggttgctccg gcttgtaatc atcttcagat gaaacaggag
     5641 gaaaaggctt tgcttaactc gcagagtgat tttagaaatg taacggcttt agtgttctaa
     5701 tctgggtctc tgtcttccat gtctgagcat tcttagagtt gtttgtggaa ttcacagact
     5761 ttagtcttga tgggtagcct cgagaagtat gcgtcattcc atttaactac acgtgactgc
     5821 attcactgag gtagacagag tagacctgtg gaatcaaacc caagcacagt gactatttca
     5881 tcctcaaatg tgtattttga agaggaactt tgaggctcca cggtggtttg aatcgtgcga
     5941 ctaatattcg tacttcccag tgtggtgtgg ggtcatcact acacagagaa gaaagcgatg
     6001 tgttcattgg atgtcgtttc tctttctcat gatctcggca tcaaatagga ctgcagatag
     6061 cccggatgcc ggagatgtcc cattaagcag atcatttctg ttccaatgaa aaggaacatc
     6121 caagtctttg cactgtgtta gcaggggagg cctgcagtag cagaatcctt aaagaatgaa
     6181 ctggccagat tcactcttcc cgggcacttt ccttagatgc aagtcttccc ccggaataag
     6241 cgagatagaa gatgactcat gcacagtctg cagagggaaa tccgtgctgc tgagatgggg
     6301 cggcatgaaa tttcttagtg ttctgcagtg cctggctttg aagaacaaaa gccaatcacc
     6361 ccaggcccct acttagatgc taactgacaa gtaacctctt cacagttacc cagcaaacat
     6421 tactggggat aggaaaccag ggcttaggat gttgtcttag caggtaagag gggtgctctt
     6481 ttcacatctc ctcctggctc cacaaggctt ttagaataac gtttgcacag gtcagtccaa
     6541 tgtagtcttc atgcatgaga gattggtggc atgtctaaaa gaagccagtg tgaagataaa
     6601 attaaatatt ctctgtcctc cgcgggcatg gatggggagt ggaagatggc tgtgttttcc
     6661 agcacagatc cacatgcttt ccctctgtta aacaccttgc gtatctgcct gacttcattc
     6721 tgccttttgc cctagacttc agactttctg tagtgactct acctgttgcc cttttcagac
     6781 tttgtcttct tcttcttctt tttttttttc tttttgtacc cttaagccag gcaaagtgtg
     6841 atacctctac ttgcttcttg caaatttcag tttgtccact tcactctgtg agttttctgt
     6901 tgccctatag tcccatctta accttaggtc tagacagtgc tttagagaag ccctgctctg
     6961 aagatgagat tactttttaa tcttacttag atgcaaagga agggaaggct gtttggcagg
     7021 ttgcagcgca taaagagaag gggacagagt ctggaactga tgggaggaag gagaagccag
     7081 gcctagctgc acagccacgc agggcaccgc tggctgctgc tattggctgc catgtttgaa
     7141 gcattcatct gagcagtggc aagtttgctt gagcactgag acacttggac tcccattagc
     7201 agcacattct ctacgtctta tgctcctcct tgtctgtttt gttttcttct atagctgtca
     7261 cctgcttccc ttccctcccc accccctgcc tcaaaggcag tcaaatctaa tttttcattc
     7321 ttattctact agctctgtgt gaaaagctga catttctgta gaagagggcc taattggggg
     7381 gctcaagtac tgagtttctt cctgtgggat agttaagact acgctgactt cagaggcagg
     7441 gtcctttctc tgggtgtggg agcacagggg actggggttc tagactcgcc ttattgtatt
     7501 gcagagaact cagttgacgt ttgtgagaag agctgaggca ggagtccatc tggctgtgtg
     7561 tgagcagcgt gcggtaaaag tgccttggcc gctccctgtt ggcacttggc ttacagcata
     7621 tgctcttcag gacagacact ttcagctcaa agagtttccc tagcacagct gcaggtacag
     7681 aacaaaattg tcccagactt ggagagcaga aggtagtatt tccatgccta ttttactcat
     7741 ggttttctgg tcctcaacat ggagcaccta aagtccggca gctgaaaatc aaaactttta
     7801 tcggaccatt attggttctg tccttcaaat ccatggctat tatattggat ggctgcatcg
     7861 agaaccttcc tactcccaaa gttccctgtt cgggatctgt gcagcacttt tcctcttgat
     7921 cagaagcatc ccctatcata cagaacagga ccttctcggg ctaaaatgag aattgggaga
     7981 accacaggaa cacagagcgg gggaggttgt ctttcatttc ctttcaatat gctggtctga
     8041 ttgtgcacct tggaaagtca ctaagagatg gctctcaggg tataaatctc aggaagttaa
     8101 taagcagcac agagttttga gagatcctgg gtcatttcat cccagcctag gagcacagtg
     8161 gccatcccac acaaagcgtg cagaggactc aggaaggtca ccagctatgc tgcagggaac
     8221 tactgctgcc aagagcacac atgggctttg cagttttttg tagtcttgct ttggaagtat
     8281 tttactgtct ggtgtccctt gcattgttca cagacctgtg tcatactggg aggggcttca
     8341 gaagcagtag gtagcctgtg ggatcaaatt caagcaaaat gcattttatt gtttcatttt
     8401 acgaaaaggc atacagtgag acaaaggagt ctttggccac cagtttctat gttcatgagc
     8461 tagtctcccc gacatgtatg aagatgcatg tgtatgcaca tcctgcattc aacttacaac
     8521 attttgggtc atggtttgtt ttgatcgttg agttttaaaa taatgaaaat atcccaagtc
     8581 tttaaatata gcggtgctaa gttttatcag ctaacacaat ccagaaagtg ctgaaatgaa
     8641 ttcagacact tagaagtaac acaagggttc ctgttaaatt atacacgtgt atcactgcct
     8701 gatttgaaac cccacttttc ctttttaatc cagcacaata tcaaactgtg attctatagc
     8761 tcgtcttttt aacgtctaca aataacccaa aatctttttt gttttatgga aaacttttct
     8821 ttttaacact aactgcaaag tgcttagcaa aaggttcctt ctggataaca gcattattaa
     8881 ttattattat ttattattat tattaattat tcctccttca aattgttgga agacttgccc
     8941 ctccaaacag gcatttccca aagacagttt tcagaaactt cacatttcac ctaacgaaag
     9001 ctgttcatac gttagtctgc attaggtctc tgccaatgtt tcccaggttc acggcccccg
     9061 aggggtgatg gccatctgta gatgatagaa accaccccat gcggacctgt gaatagcatc
     9121 agtgtggttc actttgggta actgggtact cacgtgtata tacttagatc tgcatcattc
     9181 aaacctcctc tctgctactc tgcacgcact tccagctctt acgctatttt aaagttcact
     9241 gggttttggt gatcaccaac agaagtgtaa acgacgattg ctttcatgag caggcgtgat
     9301 ttgttttatg gctgtttaag ttacaaactt gttctcatat tgtaggtgaa tcaaaagcct
     9361 ttctgttttt aaaaggtcac tgtaactcaa gattaaaatt tctcgcacaa ctttattagt
     9421 gttcacttct gaagctaata agacaacgga gttttctatg ttactctcac tgtaacatcg
     9481 actaagtgac tttcaataaa agatttctgt tattttga
//
