LOCUS       XM_039108561            9566 bp    mRNA    linear   ROD 22-FEB-2024
DEFINITION  PREDICTED: Rattus norvegicus ADAM metallopeptidase domain 22
            (Adam22), transcript variant X1, mRNA.
ACCESSION   XM_039108561
VERSION     XM_039108561.1
DBLINK      BioProject: PRJNA1074393
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_086022) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_036323735.1-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/09/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9566
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /bio_material="RGD 61498"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /sex="male"
                     /tissue_type="kidney, spleen, liver"
                     /geo_loc_name="USA: Wisconsin, Milwaukee"
                     /lat_lon="43.05 N 88.04 W"
                     /collected_by="Rebecca Schilling, Melinda Dwinell"
     gene            1..9566
                     /gene="Adam22"
                     /gene_synonym="MDC2"
                     /note="ADAM metallopeptidase domain 22; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 EST, 637 long SRA reads, 9 Proteins"
                     /db_xref="GeneID:57033"
                     /db_xref="RGD:1585016"
     CDS             309..3242
                     /gene="Adam22"
                     /gene_synonym="MDC2"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 22 isoform X1"
                     /protein_id="XP_038964489.1"
                     /db_xref="GeneID:57033"
                     /db_xref="RGD:1585016"
                     /translation="MQAVAAAFFWLLCVLGTYPLARCGRAGDASLRELERGDGNRFLE
                     RQSTVPLRLIYRLGGEDETQHEQLNTRVRGDPGGRQPTHVDKASFRVDAFGTSFILDV
                     LLNHELLSSGYVERHIEHGGKVVENKGGEHCYYQGQIRGNPASFVALSTCHGLHGMFY
                     DGNHTYLIEPEENEMSQESQFHSVYKSRLLEFPLDDLPSEFQRINITAPQFTLKPRLK
                     RRKRQLLRFPRNVEEETKYIELMIVNDHLMFKKHRLSVVYTNTYAKSVVNMADVIYKD
                     QLKTRIVLVAMETWAADNKFAISENPLVTLREFMKYRRDFIKEKADAVHLFSGSQFES
                     SRSGAAYIGGICSLLRGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCE
                     DTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIE
                     TGEECDCGTPAECALEGAECCKKCTLTQDSQCSDGLCCKKCKFQPLGTVCREAVNDCD
                     IREICSGNSSQCAPNVHKMDGYSCDGTQGICFGGRCKTRDRQCKYIWGQKVTASDRYC
                     YEKLNIEGTEKGNCGKDKDTWTQCNKRDVLCGFLLCTNIGNIPRLGELDGEITSTLVV
                     QQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPMASFNFSTCLSNKAG
                     TVCSGNGVCSNELKCVCNRHWTGADCGTHFPHNDDAKTGITLSGNGVAGTNIIIGIIA
                     GTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGDGDSFYSDFPPGGSADSASSSK
                     KRSAFLSHFQISTCSITHYSISQNISLFCSRSNGLSHSWSERIPDTKHISDICENGRP
                     RSNSWQGNVGGNKKKIRGKRFRPRSNSTEREPQAPEPGHSLAQTSPGISPGGSDSPQT
                     GSLDHSTQDGQHQENRTLSPAKSPSSSTGSIASSRKYPYPMPPLPDEEKTVNRQSARL
                     WETSI"
     polyA_site      9566
                     /gene="Adam22"
                     /gene_synonym="MDC2"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 ggtgcgcggc cgggtgcggc gcgaggggca agtgcaccag gcccgctgcg cacccggctc
       61 cgctccccgc tgcgctgctg gccgcccgcc ttggcctccg cctggggatg aggtgggagg
      121 cgctagaagc cacttagcta cagcctggcg cccgatgcgg cgctcgctcg ctgcccacgc
      181 caccgaagcg cccgccaggc acaatgcagc actgaggcag cggcggctgc ggcagcggcg
      241 cgggctggga aagggcggcc gggagcccga gcccggggcc gggaaacgag cagctgagcg
      301 ccgccaccat gcaggcagtg gcggccgcgt tcttctggct gctctgcgtc ttggggacct
      361 accccctggc gcgctgcggt cgggcaggag acgcctcact gagagaactg gagagggggg
      421 acggaaaccg cttcctggag cgccagagca ccgtaccact gcgcctcatc taccgcttgg
      481 gcggcgagga cgaaactcag cacgagcagc tcaacacgcg ggtgcggggc gaccctggcg
      541 gacggcagcc tactcacgtg gacaaggcaa gcttccgggt ggacgccttt ggaacctcct
      601 tcattctcga tgtcctgctg aaccacgagt tgctgtcctc cggttatgta gagagacata
      661 ttgaacacgg aggcaaggtc gtggaaaaca aaggaggaga acactgctat taccagggcc
      721 agattcgagg aaaccctgcc tcctttgttg ccctgtcaac atgccacgga ctccatggga
      781 tgttctatga tgggaaccac acatatctca ttgagcctga agaaaatgag atgtcccaag
      841 agtctcagtt tcactccgtg tacaaatcca ggctgcttga atttcccttg gacgaccttc
      901 catctgaatt tcaacgcata aatatcactg ccccccagtt tacactgaag ccgagactaa
      961 agcggaggaa aagacagctt cttcgatttc ctcggaatgt agaggaggaa actaaataca
     1021 ttgaactgat gatcgtgaat gatcatctca tgtttaaaaa gcaccggctt tctgttgtat
     1081 atacaaatac ctatgcgaag tctgtggtga acatggcgga cgtgatctat aaggaccaac
     1141 ttaagactag gatagtgctg gttgccatgg aaacctgggc tgctgacaac aagttcgcca
     1201 tatctgaaaa cccactggtc accttgcgtg aattcatgaa atacaggagg gattttatca
     1261 aggagaaggc tgacgcagtc catctcttct cgggcagtca atttgagagt agccggagcg
     1321 gggcggctta tattggtggg atttgctcgc tgctgagagg aggaggcgtg aatgaatttg
     1381 gaaaaacgga tttaatggca gttacactcg ctcagtcgct agcccacaat atcggtataa
     1441 tctcagacaa gaggaagtta gcgagtggtg agtgtaaatg tgaggacacc tggtccgggt
     1501 gcatcatggg agacaccggg tactatcttc ctaaaaagtt cactcagtgc aatattgagg
     1561 aatatcatga cttcctgaat agcggtggag gggcctgcct gtttaacaag ccttccaagc
     1621 ttcttgatcc tcccgagtgt ggaaacggct tcattgaaac cggagaggag tgtgattgtg
     1681 gcacccctgc ggaatgtgcc cttgaagggg cagagtgttg taagaaatgc accttgaccc
     1741 aggactctca atgcagtgat ggcctgtgtt gtaaaaagtg caagtttcag cctctgggga
     1801 ccgtgtgccg ggaggcagtg aatgactgtg acatccgtga aatatgttca ggaaattcga
     1861 gccagtgtgc ccccaatgtg cataaaatgg atggatattc gtgtgatggt actcagggaa
     1921 tttgctttgg aggaagatgt aaaaccagag atagacaatg caaatacatc tgggggcaaa
     1981 aggtgactgc atctgacagg tactgctatg agaaactgaa cattgagggg actgagaagg
     2041 gcaactgtgg gaaagacaaa gacacgtgga cacagtgcaa caaacgggat gtgctctgtg
     2101 gtttccttct atgcacaaat attggcaaca tcccaaggct cggagagctc gatggtgaaa
     2161 tcacgtccac actggttgtg cagcaaggaa ggacattaaa ttgcagcggg ggacatgtga
     2221 agcttgaaga agacgtggat cttggctatg tggaagatgg gacgccctgc ggccctcaga
     2281 tgatgtgctt ggaacacagg tgtcttccca tggcttcctt caacttcagc acttgcttaa
     2341 gcaataaagc aggcactgtg tgctcaggaa acggagtttg tagcaatgag ctcaagtgtg
     2401 tgtgcaacag gcactggaca ggtgccgact gtggcaccca ctttcctcac aatgatgatg
     2461 ctaagactgg catcaccctg tctggcaatg gtgttgctgg cactaatatc ataataggaa
     2521 taattgctgg caccatttta gtgctggccc tcatattagg aataacagcc tggggttata
     2581 aaaactaccg agaacagaga cagttacccc agggagatta tgtaaaaaag cctggagatg
     2641 gcgactcttt ttatagcgac tttcctcctg gaggcagcgc agactcagca tctagttcta
     2701 agaagaggtc tgcttttctg tcgcattttc agatttccac ctgctccatc acacattatt
     2761 ccattagtca gaacatttca ttattttgca gcaggtcaaa tggactctct cattcttgga
     2821 gtgaaaggat tccagacaca aaacatattt cagacatctg tgaaaatggg agaccccgaa
     2881 gtaattcctg gcaaggtaac gtgggaggca acaaaaagaa gatcagaggg aaaagattca
     2941 gacctcgctc taattcaact gagagggagc cccaagcacc tgagcctggg cactccctcg
     3001 cccagacatc cccaggcata agcccagggg gctctgacag cccccagaca gggagtctgg
     3061 atcacagcac ccaagatggc caacatcaag aaaacaggac cctgtcacct gccaagtctc
     3121 cttcttcatc aactgggtct attgcctcca gcagaaaata cccatacccg atgcccccgc
     3181 ttccggatga ggagaagacg gtgaaccgac agagtgccag gctgtgggag acatccattt
     3241 aagaacaact gtttacatgt gacacatcga aactgtttac ttctactttt atagaaaccc
     3301 agccacccac aatcactgca aatctgcatc tgcttttcgg acgatttcaa gaccctcttg
     3361 cgatgccaga ggagaggaag ccacgggtca tacctggata gcatactttc tttttctttt
     3421 tcttttcttt ttcttttttt ttgtcattgg cttaaggttt aaccaaatgg taaagagaat
     3481 tactggaacg tcacgctgca acatggaacc atttatggcc tggcattgat atgttaattg
     3541 ataatctgca tggcagaaat atgtagacca tcaataaaac taacccacac gacccaacgt
     3601 tagcaggttt tcccgagggg acagaagtgg attcagaact gagcattctg aatcacatcc
     3661 tcattgcaag cagtaacgcc cgtatgcatg aagcttctgt ttatcgtttt ccatatgcaa
     3721 ggaaacaacc tctcctaata gaaactagca tgcaggggct gaggcatata ggactcttct
     3781 gcaggaccgc aggactgtaa agcttccaga agccaatatc ccatatgcta cctttaaaca
     3841 tgtattttta ttttttttta cttttcatat ttatattagc atacagggac gactgtacat
     3901 atgtaaacat ttttaaaact taagaagtaa ctgttaaccg taagtgtatt ttttgccaaa
     3961 tgcctacaaa cagtcagtca cgatcctatc gctgtcctcc atccagtgtc ttcgaagtat
     4021 aagtggatga tattgtaaat agagtggtca gtgctgtaag agtatctctc cccaaccggt
     4081 gtttgtctaa aacgtgcaat ttcccttttc aaagtgtgta cagtctggaa gaggttttct
     4141 tgagcaagac atccaaatgc tcaaacttct agcctctgca tcttgccgaa ggaagagtcc
     4201 agatgtgagg tagccatgcc gctccaggac accctggagc cgacaggctc tctgggattc
     4261 tgccagccca tccactccat atctaagaca catggtgcct gtcacagtag ctgttctcaa
     4321 ccagtaccag ggcatatcaa ctaatcttac ctggaggtca tggagtcccc ttctctccag
     4381 aaagtgtctt ctgtgattgg caagatgtac caaagacatg gagcacagag tagagcgttc
     4441 cctcttgacc aaggcctgag gcttgtctgg tctgaagttt gggttccttg acagaatcct
     4501 tttagccatt cttatatgtg aaaggaatga cttgcttcca caattttaac atgtttcatc
     4561 actagggtgt aaatcccagc aggttgttct gtctggcttt gaacaagatg gtgtacggaa
     4621 gcctgaacaa ggcataaaaa aattaagtaa agctacacag aggcagtgac tgcaaaggta
     4681 accataagcc cgcagaggaa agagcctgtg ttttgggccc tataaccttt gattcactag
     4741 aaaaaaaatg agtattttat gtgaaatctt gtcatttaca acgaaacatt aatacctgtt
     4801 tcaatgcaat gttcagtgtt caatgcaaaa agaaagtccc tctaatgaga tctgaggttg
     4861 ggaggcccag tcacgtgacc tcctacggaa cactcttctg atttccctct tcttcttgct
     4921 gttttatgtg aggaatgaaa tcatcagaca agaactcaga aatggactct acatttgatt
     4981 tcttccagat gcgtccaggg acacaatttg ttccaactct gtgtagaatt gtcctagata
     5041 cccaaactga agggacaggc tagaaggcag tggtatattc agctcatgtc ttttgcaatg
     5101 gtccactctt ctaaaacact ctgaaggtgt taggaaacca atttaatcag gcaaaattaa
     5161 acagtgaaaa accattttcc atgacaggca aagatatagg ttgccgatgg ctcaataaag
     5221 cagtctcaga taaaggcatg gatgagtgtt gaacaatgtc tccacatagc ttaaggtaag
     5281 gacggaagga cagacagatg acggatgaaa aagatgtagc aaaatgaagt gacttttgga
     5341 caagaacact tcaaatgtgc actgaatgtt tcttggtatc gagtgtataa aaggctaatg
     5401 taatataagg tttattttgg ctacagaaga aaaaagttta tatagcttcg aatgaaaggt
     5461 gcctcatgta aatatgccgt gtagttaata gttcgttaga taagctctaa cctgaaagaa
     5521 ttcacaaatg gttagccagt gagctggtta tctgtctacc tactggtctt tccttacctt
     5581 ctcagttgct ttcacctgga gttatgattg aaaatcaata tcattatcat gtgcctttgg
     5641 ggagaaacgg ttgctccggc ttgtaatcat cttcagatga aacaggagga aaaggctttg
     5701 cttaactcgc agagtgattt tagaaatgta acggctttag tgttctaatc tgggtctctg
     5761 tcttccatgt ctgagcattc ttagagttgt ttgtggaatt cacagacttt agtcttgatg
     5821 ggtagcctcg agaagtatgc gtcattccat ttaactacac gtgactgcat tcactgaggt
     5881 agacagagta gacctgtgga atcaaaccca agcacagtga ctatttcatc ctcaaatgtg
     5941 tattttgaag aggaactttg aggctccacg gtggtttgaa tcgtgcgact aatattcgta
     6001 cttcccagtg tggtgtgggg tcatcactac acagagaaga aagcgatgtg ttcattggat
     6061 gtcgtttctc tttctcatga tctcggcatc aaataggact gcagatagcc cggatgccgg
     6121 agatgtccca ttaagcagat catttctgtt ccaatgaaaa ggaacatcca agtctttgca
     6181 ctgtgttagc aggggaggcc tgcagtagca gaatccttaa agaatgaact ggccagattc
     6241 actcttcccg ggcactttcc ttagatgcaa gtcttccccc ggaataagcg agatagaaga
     6301 tgactcatgc acagtctgca gagggaaatc cgtgctgctg agatggggcg gcatgaaatt
     6361 tcttagtgtt ctgcagtgcc tggctttgaa gaacaaaagc caatcacccc aggcccctac
     6421 ttagatgcta actgacaagt aacctcttca cagttaccca gcaaacatta ctggggatag
     6481 gaaaccaggg cttaggatgt tgtcttagca ggtaagaggg gtgctctttt cacatctcct
     6541 cctggctcca caaggctttt agaataacgt ttgcacaggt cagtccaatg tagtcttcat
     6601 gcatgagaga ttggtggcat gtctaaaaga agccagtgtg aagataaaat taaatattct
     6661 ctgtcctccg cgggcatgga tggggagtgg aagatggctg tgttttccag cacagatcca
     6721 catgctttcc ctctgttaaa caccttgcgt atctgcctga cttcattctg ccttttgccc
     6781 tagacttcag actttctgta gtgactctac ctgttgccct tttcagactt tgtcttcttc
     6841 ttcttctttt tttttttctt tttgtaccct taagccaggc aaagtgtgat acctctactt
     6901 gcttcttgca aatttcagtt tgtccacttc actctgtgag ttttctgttg ccctatagtc
     6961 ccatcttaac cttaggtcta gacagtgctt tagagaagcc ctgctctgaa gatgagatta
     7021 ctttttaatc ttacttagat gcaaaggaag ggaaggctgt ttggcaggtt gcagcgcata
     7081 aagagaaggg gacagagtct ggaactgatg ggaggaagga gaagccaggc ctagctgcac
     7141 agccacgcag ggcaccgctg gctgctgcta ttggctgcca tgtttgaagc attcatctga
     7201 gcagtggcaa gtttgcttga gcactgagac acttggactc ccattagcag cacattctct
     7261 acgtcttatg ctcctccttg tctgttttgt tttcttctat agctgtcacc tgcttccctt
     7321 ccctccccac cccctgcctc aaaggcagtc aaatctaatt tttcattctt attctactag
     7381 ctctgtgtga aaagctgaca tttctgtaga agagggccta attggggggc tcaagtactg
     7441 agtttcttcc tgtgggatag ttaagactac gctgacttca gaggcagggt cctttctctg
     7501 ggtgtgggag cacaggggac tggggttcta gactcgcctt attgtattgc agagaactca
     7561 gttgacgttt gtgagaagag ctgaggcagg agtccatctg gctgtgtgtg agcagcgtgc
     7621 ggtaaaagtg ccttggccgc tccctgttgg cacttggctt acagcatatg ctcttcagga
     7681 cagacacttt cagctcaaag agtttcccta gcacagctgc aggtacagaa caaaattgtc
     7741 ccagacttgg agagcagaag gtagtatttc catgcctatt ttactcatgg ttttctggtc
     7801 ctcaacatgg agcacctaaa gtccggcagc tgaaaatcaa aacttttatc ggaccattat
     7861 tggttctgtc cttcaaatcc atggctatta tattggatgg ctgcatcgag aaccttccta
     7921 ctcccaaagt tccctgttcg ggatctgtgc agcacttttc ctcttgatca gaagcatccc
     7981 ctatcataca gaacaggacc ttctcgggct aaaatgagaa ttgggagaac cacaggaaca
     8041 cagagcgggg gaggttgtct ttcatttcct ttcaatatgc tggtctgatt gtgcaccttg
     8101 gaaagtcact aagagatggc tctcagggta taaatctcag gaagttaata agcagcacag
     8161 agttttgaga gatcctgggt catttcatcc cagcctagga gcacagtggc catcccacac
     8221 aaagcgtgca gaggactcag gaaggtcacc agctatgctg cagggaacta ctgctgccaa
     8281 gagcacacat gggctttgca gttttttgta gtcttgcttt ggaagtattt tactgtctgg
     8341 tgtcccttgc attgttcaca gacctgtgtc atactgggag gggcttcaga agcagtaggt
     8401 agcctgtggg atcaaattca agcaaaatgc attttattgt ttcattttac gaaaaggcat
     8461 acagtgagac aaaggagtct ttggccacca gtttctatgt tcatgagcta gtctccccga
     8521 catgtatgaa gatgcatgtg tatgcacatc ctgcattcaa cttacaacat tttgggtcat
     8581 ggtttgtttt gatcgttgag ttttaaaata atgaaaatat cccaagtctt taaatatagc
     8641 ggtgctaagt tttatcagct aacacaatcc agaaagtgct gaaatgaatt cagacactta
     8701 gaagtaacac aagggttcct gttaaattat acacgtgtat cactgcctga tttgaaaccc
     8761 cacttttcct ttttaatcca gcacaatatc aaactgtgat tctatagctc gtctttttaa
     8821 cgtctacaaa taacccaaaa tcttttttgt tttatggaaa acttttcttt ttaacactaa
     8881 ctgcaaagtg cttagcaaaa ggttccttct ggataacagc attattaatt attattattt
     8941 attattatta ttaattattc ctccttcaaa ttgttggaag acttgcccct ccaaacaggc
     9001 atttcccaaa gacagttttc agaaacttca catttcacct aacgaaagct gttcatacgt
     9061 tagtctgcat taggtctctg ccaatgtttc ccaggttcac ggcccccgag gggtgatggc
     9121 catctgtaga tgatagaaac caccccatgc ggacctgtga atagcatcag tgtggttcac
     9181 tttgggtaac tgggtactca cgtgtatata cttagatctg catcattcaa acctcctctc
     9241 tgctactctg cacgcacttc cagctcttac gctattttaa agttcactgg gttttggtga
     9301 tcaccaacag aagtgtaaac gacgattgct ttcatgagca ggcgtgattt gttttatggc
     9361 tgtttaagtt acaaacttgt tctcatattg taggtgaatc aaaagccttt ctgtttttaa
     9421 aaggtcactg taactcaaga ttaaaatttc tcgcacaact ttattagtgt tcacttctga
     9481 agctaataag acaacggagt tttctatgtt actctcactg taacatcgac taagtgactt
     9541 tcaataaaag atttctgtta ttttga
//
