LOCUS       XP_038964489             977 aa            linear   ROD 22-FEB-2024
DEFINITION  disintegrin and metalloproteinase domain-containing protein 22
            isoform X1 [Rattus norvegicus].
ACCESSION   XP_038964489
VERSION     XP_038964489.1
DBLINK      BioProject: PRJNA1074393
DBSOURCE    REFSEQ: accession XM_039108561.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_086022) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_036323735.1-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/09/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..977
                     /organism="Rattus norvegicus"
                     /strain="BN/NHsdMcwi"
                     /bio_material="RGD 61498"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /sex="male"
                     /tissue_type="kidney, spleen, liver"
                     /geo_loc_name="USA: Wisconsin, Milwaukee"
                     /lat_lon="43.05 N 88.04 W"
                     /collected_by="Rebecca Schilling, Melinda Dwinell"
     Protein         1..977
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 22 isoform X1"
                     /calculated_mol_wt=107752
     Region          70..185
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          236..435
                     /region_name="Reprolysin"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     pfam01421"
                     /db_xref="CDD:426256"
     Region          450..523
                     /region_name="Disintegrin"
                     /note="pfam00200"
                     /db_xref="CDD:459709"
     Region          527..668
                     /region_name="ACR"
                     /note="ADAM Cysteine-Rich Domain; smart00608"
                     /db_xref="CDD:214743"
     CDS             1..977
                     /gene="Adam22"
                     /gene_synonym="MDC2"
                     /coded_by="XM_039108561.1:309..3242"
                     /db_xref="GeneID:57033"
                     /db_xref="RGD:1585016"
ORIGIN      
        1 mqavaaaffw llcvlgtypl arcgragdas lrelergdgn rflerqstvp lrliyrlgge
       61 detqheqlnt rvrgdpggrq pthvdkasfr vdafgtsfil dvllnhells sgyverhieh
      121 ggkvvenkgg ehcyyqgqir gnpasfvals tchglhgmfy dgnhtyliep eenemsqesq
      181 fhsvyksrll efplddlpse fqrinitapq ftlkprlkrr krqllrfprn veeetkyiel
      241 mivndhlmfk khrlsvvytn tyaksvvnma dviykdqlkt rivlvametw aadnkfaise
      301 nplvtlrefm kyrrdfikek adavhlfsgs qfessrsgaa yiggicsllr gggvnefgkt
      361 dlmavtlaqs lahnigiisd krklasgeck cedtwsgcim gdtgyylpkk ftqcnieeyh
      421 dflnsgggac lfnkpsklld ppecgngfie tgeecdcgtp aecalegaec ckkctltqds
      481 qcsdglcckk ckfqplgtvc reavndcdir eicsgnssqc apnvhkmdgy scdgtqgicf
      541 ggrcktrdrq ckyiwgqkvt asdrycyekl niegtekgnc gkdkdtwtqc nkrdvlcgfl
      601 lctnignipr lgeldgeits tlvvqqgrtl ncsgghvkle edvdlgyved gtpcgpqmmc
      661 lehrclpmas fnfstclsnk agtvcsgngv csnelkcvcn rhwtgadcgt hfphnddakt
      721 gitlsgngva gtniiigiia gtilvlalil gitawgykny reqrqlpqgd yvkkpgdgds
      781 fysdfppggs adsassskkr saflshfqis tcsithysis qnislfcsrs nglshswser
      841 ipdtkhisdi cengrprsns wqgnvggnkk kirgkrfrpr snsterepqa pepghslaqt
      901 spgispggsd spqtgsldhs tqdgqhqenr tlspakspss stgsiassrk ypypmpplpd
      961 eektvnrqsa rlwetsi
//
