LOCUS       NM_020077               2582 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 2 (Adam2), mRNA.
ACCESSION   NM_020077
VERSION     NM_020077.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2582)
  AUTHORS   Zhang,B.J. and Yuan,C.X.
  TITLE     Effects of ADAM2 silencing on isoflurane-induced cognitive
            dysfunction via the P13K/Akt signaling pathway in immature rats
  JOURNAL   Biomed Pharmacother 109, 217-225 (2019)
   PUBMED   30396079
  REMARK    GeneRIF: ADAM2 silencing alleviates isoflurane-induced cognitive
            dysfunction by activating the PI3K/Akt signal pathway.
REFERENCE   2  (bases 1 to 2582)
  AUTHORS   Nishimura,H., Gupta,S., Myles,D.G. and Primakoff,P.
  TITLE     Characterization of mouse sperm TMEM190, a small transmembrane
            protein with the trefoil domain: evidence for co-localization with
            IZUMO1 and complex formation with other sperm proteins
  JOURNAL   Reproduction 141 (4), 437-451 (2011)
   PUBMED   21273369
REFERENCE   3  (bases 1 to 2582)
  AUTHORS   Desiderio,U.V., Zhu,X. and Evans,J.P.
  TITLE     ADAM2 interactions with mouse eggs and cell lines expressing
            alpha4/alpha9 (ITGA4/ITGA9) integrins: implications for
            integrin-based adhesion and fertilization
  JOURNAL   PLoS One 5 (10), e13744 (2010)
   PUBMED   21060781
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2582)
  AUTHORS   Han,C., Choi,E., Park,I., Lee,B., Jin,S., Kim,D.H., Nishimura,H.
            and Cho,C.
  TITLE     Comprehensive analysis of reproductive ADAMs: relationship of ADAM4
            and ADAM6 with an ADAM complex required for fertilization in mice
  JOURNAL   Biol Reprod 80 (5), 1001-1008 (2009)
   PUBMED   19129510
REFERENCE   5  (bases 1 to 2582)
  AUTHORS   Takahashi,E., Sagane,K., Oki,T., Yamazaki,K., Nagasu,T. and
            Kuromitsu,J.
  TITLE     Deficits in spatial learning and motor coordination in
            ADAM11-deficient mice
  JOURNAL   BMC Neurosci 7, 19 (2006)
   PUBMED   16504143
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2582)
  AUTHORS   Rosselot,C., Kierszenbaum,A.L., Rivkin,E. and Tres,L.L.
  TITLE     Chronological gene expression of ADAMs during testicular
            development: prespermatogonia (gonocytes) express fertilin beta
            (ADAM2)
  JOURNAL   Dev Dyn 227 (3), 458-467 (2003)
   PUBMED   12815633
REFERENCE   7  (bases 1 to 2582)
  AUTHORS   Yoshida,T., Kurella,M., Beato,F., Min,H., Ingelfinger,J.R.,
            Stears,R.L., Swinford,R.D., Gullans,S.R. and Tang,S.S.
  TITLE     Monitoring changes in gene expression in renal ischemia-reperfusion
            in the rat
  JOURNAL   Kidney Int 61 (5), 1646-1654 (2002)
   PUBMED   11967014
REFERENCE   8  (bases 1 to 2582)
  AUTHORS   Szpirer,C., Van Vooren,P., Riviere,M., Scohy,S., Collau,G. and
            Szpirer,J.
  TITLE     Localization of 54 rat genes, and definition of new synteny groups
            conserved in the human and the rat
  JOURNAL   Mamm Genome 11 (9), 729-735 (2000)
   PUBMED   10967130
REFERENCE   9  (bases 1 to 2582)
  AUTHORS   Gerst,J.L., Raina,A.K., Pirim,I., McShea,A., Harris,P.L.,
            Siedlak,S.L., Takeda,A., Petersen,R.B. and Smith,M.A.
  TITLE     Altered cell-matrix associated ADAM proteins in Alzheimer disease
  JOURNAL   J Neurosci Res 59 (5), 680-684 (2000)
   PUBMED   10686596
REFERENCE   10 (bases 1 to 2582)
  AUTHORS   McLaughlin,E.A., Frayne,J., Barker,H.L., Jury,J.A., Jones,R.,
            Ford,W.C. and Hall,L.
  TITLE     Cloning and sequence analysis of rat fertilin alpha and
            beta--developmental expression, processing and immunolocalization
  JOURNAL   Mol Hum Reprod 3 (9), 801-809 (1997)
   PUBMED   9358007
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 13, 2023 this sequence version replaced NM_020077.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X99794.1, SRR26643293.60147.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               JAXUCZ010000015.1  44459411-44459516   c
            107-183             JAXUCZ010000015.1  44458993-44459069   c
            184-239             JAXUCZ010000015.1  44456116-44456171   c
            240-318             JAXUCZ010000015.1  44455060-44455138   c
            319-395             JAXUCZ010000015.1  44449982-44450058   c
            396-564             JAXUCZ010000015.1  44449259-44449427   c
            565-621             JAXUCZ010000015.1  44445501-44445557   c
            622-693             JAXUCZ010000015.1  44444356-44444427   c
            694-860             JAXUCZ010000015.1  44443206-44443372   c
            861-942             JAXUCZ010000015.1  44442175-44442256   c
            943-1079            JAXUCZ010000015.1  44439660-44439796   c
            1080-1257           JAXUCZ010000015.1  44438044-44438221   c
            1258-1359           JAXUCZ010000015.1  44434165-44434266   c
            1360-1555           JAXUCZ010000015.1  44432132-44432327   c
            1556-1661           JAXUCZ010000015.1  44428784-44428889   c
            1662-1845           JAXUCZ010000015.1  44425978-44426161   c
            1846-1923           JAXUCZ010000015.1  44423828-44423905   c
            1924-2053           JAXUCZ010000015.1  44423463-44423592   c
            2054-2213           JAXUCZ010000015.1  44420417-44420576   c
            2214-2275           JAXUCZ010000015.1  44418881-44418942   c
            2276-2582           JAXUCZ010000015.1  44418199-44418505   c
FEATURES             Location/Qualifiers
     source          1..2582
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..2582
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /note="ADAM metallopeptidase domain 2"
                     /db_xref="GeneID:56806"
                     /db_xref="RGD:69299"
     exon            1..106
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..2247
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /note="disintegrin and metalloproteinase domain-containing
                     protein 2; PH30; ADAM 2; PH30-beta; fertilin subunit beta;
                     a disintegrin and metalloprotease domain (ADAM) 2; a
                     disintegrin and metallopeptidase domain 2; fertilin beta;
                     A disintegrin and metalloprotease domain 2 (Fertilin
                     beta)"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 2 precursor"
                     /protein_id="NP_064462.2"
                     /db_xref="GeneID:56806"
                     /db_xref="RGD:69299"
                     /translation="MWLLLLLLSGLSRLGGLSEPQTEGTREKLHVQVTVPEKIRSVTS
                     EGYETQVTYSLKIEGKTYILNLMQKAFLPPNFRVYSYDSTGIMRPLEQKFQNICYFQG
                     YIEGYPNSMVIVSTCTGLRGVLQFGNVSYGIEPLESSSGFEHVIYQVEPKKGDTLLYA
                     EKDMDLRDPQYKIRSIKPQRTVSHYLEIHIVVEKQMFEHIGADTAVVTQKIFQLIGLT
                     NAIFAPFNLTVILSSLEFWMDENKISTTGDANKLLYRFLKWKQSYLVLRPHDMAFLLV
                     YRDTTDYVGATYQGKMCDKNYAGGVALHPKAVTLESLAIILVQLLSLSMGVAYDDVNT
                     CQCGVPICVMNPEALHSSGVRSFSNCSMEDFSKFIASQSSHCLQNQPHLQPSYKMAVC
                     GNGELEEGEVCDCGQEGCDDKPPPCCNPTTCQLSEGSTCSTGSCCDASCNLKAKGELC
                     RPANQECDVTEYCNGTSEVCEEDFFVQDGHPCAEQKWICINGTCQSGAQQCRDLFGTD
                     ADYGTKECYSELNSKSDISGSCGITPTGYKDCAPNDRMCGKLICIYQSEDILKMRSAI
                     VIYANISGQICISLEYPPGHKESKKMWVRDGTVCGSGKVCLNQECVEDTFLNYDCTPE
                     KCNHHGVCNNKKHCHCEPTYLPPDCKNTEDTWPGGSVDSGNQQRAESIPARSYVASAY
                     RSKSARWPFFLIIPFYVVILVLIGMLVKVYSQRKKWRMDDFSSEEQFESESESKD"
     exon            107..183
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            184..239
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            240..318
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            319..395
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            396..564
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            565..621
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            622..693
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            694..860
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            861..942
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1079
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1257
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1359
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1555
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1661
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1845
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1923
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2053
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2213
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2275
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2582
                     /gene="Adam2"
                     /gene_synonym="Ftnb; PH-30"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attccccggg gctggggtcc aggaggccag gccatgtggc tcctcttgct tctgctgagt
       61 gggctgagta gacttggagg gcttagcgag ccccaaacag aaggcactcg tgagaaatta
      121 cacgtgcaag tcacggtgcc agagaaaatc cggtccgtca caagtgaagg ctacgaaaca
      181 caggtgacct acagtctcaa aatcgaaggg aaaacataca tcctgaacct aatgcaaaaa
      241 gcgttcttgc ctcccaactt tagagtctac agctatgaca gcacagggat catgaggcct
      301 cttgagcaga agtttcagaa tatctgctac ttccaaggat acattgaagg ttatccaaat
      361 tctatggtga ttgttagcac atgtactgga ctcaggggag tacttcagtt tggaaacgtt
      421 agctacggaa ttgaacccct ggaatcttcc agtggttttg aacatgtaat ctaccaagtg
      481 gaacctaaga aaggagacac attactctat gccgagaagg atatggattt aagagacccg
      541 cagtataaga tacgaagtat caagcctcag cgaaccgtct cgcactatct ggaaatacac
      601 attgtagttg aaaagcagat gtttgagcat attggggctg atacagctgt tgtcactcaa
      661 aagattttcc agttgattgg actgacaaat gctatctttg ccccctttaa tcttacagta
      721 attctgtctt ccctggaatt ttggatggac gaaaacaaaa tctcgaccac gggtgatgct
      781 aacaagttgc tgtacaggtt cctgaagtgg aaacagtcgt acctcgttct gcgaccacat
      841 gacatggcgt ttttactcgt ctacagggac accactgatt atgttggcgc cacctatcaa
      901 gggaagatgt gtgacaagaa ctatgcagga ggcgttgctc tgcaccccaa agccgtaact
      961 ctggaatcac ttgcaattat tttagttcag ctgctgagcc tcagcatggg ggtcgcatat
     1021 gacgatgtga acacgtgcca gtgcggagta cccatctgcg tgatgaaccc cgaagcactt
     1081 cattccagcg gtgtgaggtc cttcagtaac tgcagcatgg aggacttctc caagtttatc
     1141 gcaagtcaaa gctcccactg tcttcagaac cagccacacc tacagccgtc gtacaagatg
     1201 gcagtctgtg ggaatggaga gttggaagaa ggagaagttt gcgactgtgg acaggagggc
     1261 tgtgacgata agcctcctcc atgctgtaat cccaccacct gtcagctgtc agagggctcc
     1321 acttgctcca ccggaagttg ctgcgacgct tcgtgcaatc tgaaggcaaa aggggaactt
     1381 tgcaggcctg ccaatcagga atgtgacgtc acagagtact gcaacggcac ttccgaagtg
     1441 tgtgaagaag acttctttgt tcaagacggt cacccatgtg cagaacagaa gtggatctgt
     1501 attaatggca cctgtcagag tggagcacag cagtgccggg atctgtttgg cactgatgca
     1561 gactatggta caaaagaatg ttactcggag ctgaattcca aaagtgacat atctgggagc
     1621 tgcggtatca ctcctacggg gtacaaggac tgcgcaccta atgaccggat gtgtggaaaa
     1681 ctaatatgta tataccaaag tgaagacata cttaaaatga ggtctgccat tgttatctat
     1741 gccaatataa gcgggcaaat ctgcatctcc ctggaatacc ccccaggtca caaagagagc
     1801 aagaagatgt gggtgagaga tggaactgtc tgcgggtcag ggaaggtttg cttgaatcaa
     1861 gagtgtgtag aagatacttt cttgaactat gattgcaccc cagaaaaatg caaccaccat
     1921 ggggtatgta ataacaagaa gcattgccac tgtgagccca catacttacc tccggattgt
     1981 aaaaatacgg aggatacatg gcctggtggg agcgttgaca gtggcaacca gcaacgggct
     2041 gaatccatcc ctgcacggtc ctatgttgca agtgcctacc gctccaagtc tgcaaggtgg
     2101 ccatttttcc tgatcatccc tttctacgtg gtgatccttg tcctgatcgg catgctggta
     2161 aaagtctatt cccaaagaaa aaaatggaga atggatgact tctcaagtga agaacaattt
     2221 gaaagtgaaa gtgaatccaa agactagtct ggacagcaaa gattccagtg tcatgtaatt
     2281 ctcttcagtg gacagaaaaa aaagtggaaa agaaaaacct atgcatcatc tgtttgcctg
     2341 aaagtcaagc ctgcatattg tggtttccat ctggccagaa atcatatctc tccatacaca
     2401 tgtgtgatac atatatgtgt atataattcc ataaatgatt tacttgtaag aaatgaatga
     2461 ttatgaattt tatattatgc tttgatattt taccctactt ctggtagtcg gtaggcacaa
     2521 attgtattat ctagtaggca cattacagga gaggctgtaa gaaaataaat gtggtaccat
     2581 ga
//
