LOCUS       NM_020078               2917 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 1a (Adam1a), mRNA.
ACCESSION   NM_020078 XM_346440
VERSION     NM_020078.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2917)
  AUTHORS   Nishimura,H., Kim,E., Nakanishi,T. and Baba,T.
  TITLE     Possible function of the ADAM1a/ADAM2 Fertilin complex in the
            appearance of ADAM3 on the sperm surface
  JOURNAL   J Biol Chem 279 (33), 34957-34962 (2004)
   PUBMED   15194697
REFERENCE   2  (bases 1 to 2917)
  AUTHORS   Rosselot,C., Kierszenbaum,A.L., Rivkin,E. and Tres,L.L.
  TITLE     Chronological gene expression of ADAMs during testicular
            development: prespermatogonia (gonocytes) express fertilin beta
            (ADAM2)
  JOURNAL   Dev Dyn 227 (3), 458-467 (2003)
   PUBMED   12815633
REFERENCE   3  (bases 1 to 2917)
  AUTHORS   McLaughlin,E.A., Frayne,J., Barker,H.L., Jury,J.A., Jones,R.,
            Ford,W.C. and Hall,L.
  TITLE     Cloning and sequence analysis of rat fertilin alpha and
            beta--developmental expression, processing and immunolocalization
  JOURNAL   Mol Hum Reprod 3 (9), 801-809 (1997)
   PUBMED   9358007
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Y08616.1.
            
            [WARNING] On Mar 12, 2025 this sequence was replaced by
            NM_020078.2.
            
            On Jan 12, 2005 this sequence version replaced XM_346440.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y08616.1, BC081807.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2917
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2917
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="ADAM metallopeptidase domain 1a"
                     /db_xref="GeneID:56777"
                     /db_xref="RGD:621467"
     exon            1..2868
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..2609
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
                     /note="disintegrin and metalloproteinase domain-containing
                     protein 1; a disintegrin and metalloprotease domain 1
                     (fertilin alpha); ADAM 1; fertilin subunit alpha; a
                     disintegrin and metalloproteinase domain 1 (fertilin
                     alpha); PH-30 alpha; a disintegrin and metallopeptidase
                     domain 1a"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 1 precursor"
                     /protein_id="NP_064463.1"
                     /db_xref="GeneID:56777"
                     /db_xref="RGD:621467"
                     /translation="MSVAASASRSASTLCSPQIQQGALKEAKVPPHIWAARHWNLGLR
                     LVPGHASVRAGILVLLIFLPSTLCDLGSVYDSSYETVIPERLPGQGSDDPGGKVSYVL
                     LMQGQKQLLHLEVKGHYSERNFPVYSYHHGILGQEVPLLSQACHYEGHIEGVPGSFVS
                     VSICSGLRGVLIKEETAYGIEPLLFSTDFEHILYTMAHQPVVLCNVTPTDSLGDSSQR
                     QGSSKTDELLALSDLWSHAKYVEMFVVVNHQRFQMWGSDVNTTVQAVVDIIALANSFT
                     RGINTEVVLVGLEIWTEGDPIEVPVDLQATLRNFNLWRQEKLMGRVRHDVAHLIVGHR
                     PGANEGQAFLDGACSGGFAAAVEAFHHEDVLLFAALMAHELGHNLGIRHDRPGCTCGP
                     KHLCLMHETISKTSGFSNCSSDHFLRFLHDHRGACLLDRPWHQSHKRRDAHCGNGVVE
                     ESEECDCGNACDSHPCCEPTCTLKVGAQCSEGLCCYKCTFKKKGTLCRPAEDVCDLPE
                     YCNGITGECPANSYMQDGTQCDRIYYCSGGLCKNPDKQCARIYGYPARSAPEECYISV
                     NTKANRFGNCGHPTSANLKYEACSNEDIFCGKLVCTDVRYLPQVKPLHSLLQIPYGDD
                     WCWSMDAYNVTDIPDYGDVQGGTYCAPKKVCMESICTGHATLQYDCHPQEMCHGNGVC
                     NNFKHCHCDAGFSPPDCSSGGNGGSVDSGPVGKPADRNLSLFGVGESPDSRMEDEEIN
                     LKVVVLVVPIFLIVLLCCLMLIAYLWSEVQEAVSPGSSSTTSSSESESD"
     polyA_site      2868
                     /gene="Adam1a"
                     /gene_synonym="Adam1; PH-30a"
ORIGIN      
        1 gggctcgtct ccatgagcgt caaaggaact taagccacac tggagctctt ccacttgaca
       61 aaagtccctg tgctgcacat aaccaacgag gccaggagaa aaataagacc agagataccg
      121 cctgaggcca gaggattcac gcaggggagc accccttaag ggacaggctt gggtctggga
      181 aagcagtgag ttgccactga tggacataga tcctacgcta tccacagttt gtttgaacca
      241 tgtcagtggc agcatcagcg agcaggagtg cgtccacgct gtgttctcca cagatccagc
      301 aaggagcctt aaaagaagct aaggtgcccc ctcacatctg ggctgcacgg cattggaacc
      361 tgggtctacg actagtgcca ggacacgcat ctgttagagc agggatcttg gtgctactga
      421 tttttctccc gagcacgctc tgtgacctag gatctgtata tgactcttcc tatgagacgg
      481 tcatccccga gagactgcca ggccagggga gtgacgatcc tggagggaag gtgtcctacg
      541 tgctgttgat gcaaggccaa aagcagctgc ttcacctcga ggtaaaggga cactactctg
      601 agaggaactt cccggtctac agctaccacc atggtatcct ggggcaagaa gtgcccctcc
      661 tctcccaggc ctgccactat gaaggccaca tagaaggggt gccaggctcc tttgtttctg
      721 tcagcatctg ttcaggcctc aggggggtct tgatcaaaga ggaaacagcc tatggcatcg
      781 agcccctgct cttttccaca gactttgagc acatcctcta taccatggcg caccagcctg
      841 tggtcctctg caatgtcact cctacagaca gcctggggga ctccagccag cgacaaggga
      901 gcagcaagac cgatgagctg ctggctctgt ctgacttgtg gtcacacgcc aagtatgtgg
      961 agatgtttgt cgtggtcaac caccagcgct tccagatgtg gggcagtgat gtcaacacga
     1021 cggtccaggc ggtagtggac atcattgctc tggccaacag cttcactagg ggaataaaca
     1081 cagaggtggt gctggtgggc ctggagatct ggacagaggg ggacccgata gaggtcccag
     1141 tggacctgca ggctacactg aggaatttca acttgtggag acaggagaaa ctcatgggcc
     1201 gggtcaggca cgatgtggca cacttgatcg tcgggcatcg cccaggagcg aacgagggcc
     1261 aggcgtttct cgatggtgcc tgttcaggcg ggtttgcggc ggccgtggag gccttccatc
     1321 atgaggatgt cctcctgttt gcggcgctca tggcccacga gcttgggcac aacctgggta
     1381 tccggcacga ccgtccaggc tgcacctgtg gtcctaagca cctctgcctc atgcatgaga
     1441 cgatcagtaa gaccagtggc ttcagcaact gcagctctga ccacttcctc cgtttcctcc
     1501 atgaccacag aggggcctgc ctgcttgacc ggccttggca ccagagccac aagcgcagag
     1561 atgcccattg tggaaacggt gtggtagagg agtcggagga gtgtgactgt ggtaatgcct
     1621 gtgacagtca cccatgctgt gagccaacat gtacactgaa ggtgggtgcg cagtgcagtg
     1681 agggactctg ctgctacaaa tgtacattca agaagaaagg gaccttatgt cgtcctgctg
     1741 aggatgtatg tgaccttccc gagtactgca atggcattac tggagaatgc cctgcaaaca
     1801 gctacatgca ggacggcacg cagtgcgata ggatttatta ctgctctggg ggtttgtgta
     1861 agaaccctga taagcaatgt gcaaggatct atgggtatcc tgcaagatcg gcccccgagg
     1921 agtgttacat ttcagttaat actaaagcca accggtttgg aaattgtggc catcccacct
     1981 cggctaacct aaaatatgaa gcatgttcca atgaggatat attttgtggg aagttggtat
     2041 gcacggatgt tagatacttg ccccaagtca agcccctaca ctcactcctc cagattcctt
     2101 acggagatga ctggtgttgg agcatggatg cctataacgt cactgacatc cctgattacg
     2161 gtgacgtgca gggcggtacc tactgtgccc caaaaaaagt ctgcatggag tccatctgca
     2221 ccggtcatgc cacgctccag tatgactgtc atccacagga aatgtgtcat gggaatggag
     2281 tgtgcaacaa cttcaaacac tgtcactgtg atgctggctt ctcccctcct gactgcagca
     2341 gtggaggaaa tggggggagt gtggacagtg gtcctgtcgg gaagccagct gaccgaaact
     2401 tgagtctttt tggagttggg gagagtccgg attcgaggat ggaggatgag gagatcaacc
     2461 tcaaagtggt ggtgcttgtg gtccccatct tccttattgt cctgctgtgc tgtctaatgc
     2521 tcatcgccta cctctggtct gaagtacaag aggcagtgtc tccagggtct tcaagcacaa
     2581 cctcgtcctc agagtccgag tccgactgac gtccgcagac ctcctcgtgg gctgttgcta
     2641 ccgaggccgt gtgtttgcgg ggcagttttt cctccgtggt ttttagggct tgttgcatgc
     2701 acactgttta ctgtaatgtg ttgtatatac acttgtgttg ctcttctcta ccgtaacaac
     2761 tggtattatc gtgtgaaagt ttttatggga tctaaatgtt ctaacttgcc ctgtcagcta
     2821 ctgttcataa aatacaagtc attttaaata aacatgaata acaaggccaa aaaaaaaaaa
     2881 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
