LOCUS       NP_001153700             920 aa            linear   ROD 30-MAR-2024
DEFINITION  disintegrin and metalloproteinase domain-containing protein 19
            precursor [Rattus norvegicus].
ACCESSION   NP_001153700 XP_001069002 XP_220328
VERSION     NP_001153700.1
DBSOURCE    REFSEQ: accession NM_001160228.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 920)
  AUTHORS   Ramdas,V., McBride,M., Denby,L. and Baker,A.H.
  TITLE     Canonical transforming growth factor-beta signaling regulates
            disintegrin metalloprotease expression in experimental renal
            fibrosis via miR-29
  JOURNAL   Am J Pathol 183 (6), 1885-1896 (2013)
   PUBMED   24103556
  REMARK    GeneRIF: TGF-beta stimulation of renal cells results in a
            significant up-regulation of Adams 10, 17, 12, and 19
REFERENCE   2  (residues 1 to 920)
  AUTHORS   Zhao,M., Qiu,W., Li,Y., Sang,Q.A. and Wang,Y.
  TITLE     Dynamic change of Adamalysin 19 (ADAM19) in human placentas and its
            effects on cell invasion and adhesion in human trophoblastic cells
  JOURNAL   Sci China C Life Sci 52 (8), 710-718 (2009)
   PUBMED   19727588
REFERENCE   3  (residues 1 to 920)
  AUTHORS   Blobel,C.P.
  TITLE     ADAMs: key components in EGFR signalling and development
  JOURNAL   Nat Rev Mol Cell Biol 6 (1), 32-43 (2005)
   PUBMED   15688065
  REMARK    Review article
REFERENCE   4  (residues 1 to 920)
  AUTHORS   Kurohara,K., Komatsu,K., Kurisaki,T., Masuda,A., Irie,N., Asano,M.,
            Sudo,K., Nabeshima,Y., Iwakura,Y. and Sehara-Fujisawa,A.
  TITLE     Essential roles of Meltrin beta (ADAM19) in heart development
  JOURNAL   Dev Biol 267 (1), 14-28 (2004)
   PUBMED   14975714
REFERENCE   5  (residues 1 to 920)
  AUTHORS   Zhou,H.M., Weskamp,G., Chesneau,V., Sahin,U., Vortkamp,A.,
            Horiuchi,K., Chiusaroli,R., Hahn,R., Wilkes,D., Fisher,P.,
            Baron,R., Manova,K., Basson,C.T., Hempstead,B. and Blobel,C.P.
  TITLE     Essential role for ADAM19 in cardiovascular morphogenesis
  JOURNAL   Mol Cell Biol 24 (1), 96-104 (2004)
   PUBMED   14673146
REFERENCE   6  (residues 1 to 920)
  AUTHORS   Abram,C.L., Seals,D.F., Pass,I., Salinsky,D., Maurer,L., Roth,T.M.
            and Courtneidge,S.A.
  TITLE     The adaptor protein fish associates with members of the ADAMs
            family and localizes to podosomes of Src-transformed cells
  JOURNAL   J Biol Chem 278 (19), 16844-16851 (2003)
   PUBMED   12615925
REFERENCE   7  (residues 1 to 920)
  AUTHORS   Shirakabe,K., Wakatsuki,S., Kurisaki,T. and Fujisawa-Sehara,A.
  TITLE     Roles of Meltrin beta /ADAM19 in the processing of neuregulin
  JOURNAL   J Biol Chem 276 (12), 9352-9358 (2001)
   PUBMED   11116142
REFERENCE   8  (residues 1 to 920)
  AUTHORS   Wei,P., Zhao,Y.G., Zhuang,L., Ruben,S. and Sang,Q.X.
  TITLE     Expression and enzymatic activity of human disintegrin and
            metalloproteinase ADAM19/meltrin beta
  JOURNAL   Biochem Biophys Res Commun 280 (3), 744-755 (2001)
   PUBMED   11162584
REFERENCE   9  (residues 1 to 920)
  AUTHORS   Kurohara,K., Matsuda,Y., Nagabukuro,A., Tsuji,A., Amagasa,T. and
            Fujisawa-Sehara,A.
  TITLE     Meltrin beta (ADAM19) gene: cloning, mapping, and analysis of the
            regulatory region
  JOURNAL   Biochem Biophys Res Commun 270 (2), 522-527 (2000)
   PUBMED   10753657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before May 17, 2009 this sequence version replaced
            XP_220328.4, XP_001069002.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1372667.1,
                                           SRR26643292.39904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..920
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     Protein         1..920
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 19 precursor"
                     /note="a disintegrin and metalloproteinase domain 19
                     (meltrin beta); SRY-box containing gene 30; a disintegrin
                     and metallopeptidase domain 19 (meltrin beta); disintegrin
                     and metalloproteinase domain-containing protein 19"
                     /calculated_mol_wt=98373
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2770
     Region          45..163
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          211..409
                     /region_name="Reprolysin"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     pfam01421"
                     /db_xref="CDD:426256"
     Region          440..500
                     /region_name="DISIN"
                     /note="Homologues of snake disintegrins; smart00050"
                     /db_xref="CDD:214490"
     Region          502..650
                     /region_name="ACR"
                     /note="ADAM Cysteine-Rich Domain; smart00608"
                     /db_xref="CDD:214743"
     CDS             1..920
                     /gene="Adam19"
                     /gene_synonym="Sox30"
                     /coded_by="NM_001160228.1:92..2854"
                     /db_xref="GeneID:303068"
                     /db_xref="RGD:1585017"
ORIGIN      
        1 mpgragvarf cllalalqlq wplaacepew ttrgskedsp plqheliipq wrtsesprgg
       61 khpltaelrv maegrelild leknehlfap aytetcytas gnpqtttlks edhcfyhgtv
      121 rkvdessvtl stcrgirgli ivrsnlsyii epvpnsdnqh riyrsehlkl ppgncgfehs
      181 rptskdwtlq fthqtkkqpr rmkredlhsm kyvelylvad yaefqknrhd qdatkhklme
      241 ianyvdkfyr slsirialvg levwthgdkc evsenpystl wsflswrrkl ltqkshdnaq
      301 litgrsfqgt tiglaplmam csvyqsggvs mdhsenaigv astvaheigh nfgmshdsah
      361 ccstsaadgg cimaaatghp fpkvfsscnr keldrylqsg ggmclsnmpd trtlyggrrc
      421 gngyledgee cdcgeedeck npccnasnct lkegaecahg scchqcklva pgtqcreqvr
      481 qcdlpefctg ksphcptnyy qmdgtpcegg qaycyngmcl tyqeqcqqlw gpgarpaldl
      541 cfervnaagd tygncgkgln gkyrkcsprd akcgkiqcqs tqarplesna vsidttitln
      601 grrihcrgth vyrgpeeeeg egdmldpglv mtgtkcghnh icfegqcrnt sffetegcgk
      661 kcnghgvcnn nknchcfpgw appfcntpgd ggsidsgplp pksagpviag vfsalfvlav
      721 lvllchcyrq shklgkpsal pfklrqqfsc pfrvsqnggt ghanptfklq tpqgkrkvtn
      781 tpetlrkpsh ppprpppdyl rveshpaplp ahlnraagss peagaqierk esarrpppsr
      841 pmppapncll sqdfsrprpp qkalpanpvp gqrtvprpgg tslfhppttg pqpprppavs
      901 vpklpeyrsq riggitsski
//
