LOCUS       NM_001375316            2354 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 18 (Adam18), mRNA.
ACCESSION   NM_001375316 XM_017587608 XM_017600383
VERSION     NM_001375316.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2354)
  AUTHORS   Frayne,J., Hurd,E.A. and Hall,L.
  TITLE     Human tMDC III: a sperm protein with a potential role in oocyte
            recognition
  JOURNAL   Mol Hum Reprod 8 (9), 817-822 (2002)
   PUBMED   12200459
REFERENCE   2  (bases 1 to 2354)
  AUTHORS   Frayne,J., Jury,J.A., Barker,H.L., Perry,A.C., Jones,R. and Hall,L.
  TITLE     Macaque MDC family of proteins: sequence analysis, tissue
            distribution and processing in the male reproductive tract
  JOURNAL   Mol Hum Reprod 4 (5), 429-437 (1998)
   PUBMED   9665629
REFERENCE   3  (bases 1 to 2354)
  AUTHORS   Frayne,J., Jury,J.A., Barker,H.L. and Hall,L.
  TITLE     Rat MDC family of proteins: sequence analysis, tissue distribution,
            and expression in prepubertal and adult rat testis
  JOURNAL   Mol Reprod Dev 48 (2), 159-167 (1997)
   PUBMED   9291465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On or before Oct 22, 2019 this sequence version replaced
            XM_017600383.1, XM_017587608.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.75649.1,
                                           SRR26360181.106461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               JAXUCZ010000016.1  74055025-74055139
            116-192             JAXUCZ010000016.1  74055670-74055746
            193-248             JAXUCZ010000016.1  74074027-74074082
            249-327             JAXUCZ010000016.1  74076708-74076786
            328-404             JAXUCZ010000016.1  74077268-74077344
            405-576             JAXUCZ010000016.1  74079223-74079394
            577-642             JAXUCZ010000016.1  74081450-74081515
            643-714             JAXUCZ010000016.1  74082987-74083058
            715-881             JAXUCZ010000016.1  74083254-74083420
            882-963             JAXUCZ010000016.1  74084165-74084246
            964-1100            JAXUCZ010000016.1  74090499-74090635
            1101-1278           JAXUCZ010000016.1  74091921-74092098
            1279-1374           JAXUCZ010000016.1  74099095-74099190
            1375-1573           JAXUCZ010000016.1  74101836-74102034
            1574-1679           JAXUCZ010000016.1  74104394-74104499
            1680-1866           JAXUCZ010000016.1  74105593-74105779
            1867-1947           JAXUCZ010000016.1  74109161-74109241
            1948-2062           JAXUCZ010000016.1  74112738-74112852
            2063-2220           JAXUCZ010000016.1  74117371-74117528
            2221-2354           JAXUCZ010000016.1  74127725-74127858
FEATURES             Location/Qualifiers
     source          1..2354
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4-q12.5"
     gene            1..2354
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /note="ADAM metallopeptidase domain 18"
                     /db_xref="GeneID:57029"
                     /db_xref="RGD:620405"
     exon            1..115
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..2217
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /note="disintegrin and metalloproteinase domain-containing
                     protein 18; ADAM 18; transmembrane metalloproteinase-like,
                     disintegrin-like, and cysteine-rich protein III; tMDC III;
                     a disintegrin and metalloproteinase domain 18; a
                     disintegrin and metallopeptidase domain 18"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 18 precursor"
                     /protein_id="NP_001362245.1"
                     /db_xref="GeneID:57029"
                     /db_xref="RGD:620405"
                     /translation="MPLFFILAELAMLLAALDSEGIWLHITVPQKIEPFKGGDSEGKV
                     SYVITIDGKPYFLHLRNYSFLSRNFSVYAYNETGSLYSDSPHFLAHCHYRGYVGEVPD
                     SIVTLSLCSGLRGFLQLENTSYGIEPLESSARFEHIVYQMKSNSSTLAANYSCIWQTS
                     RQLDKGHFREQDKNDSQLLPKSLKLHIIVGKFLFDYMGSDIMAVTQKIFQIIGLVNTM
                     FTQLNLNVVLASLELWSDKNQISTDGNASDILQRLLGWKRDYLTPQSNEITHLLIYRK
                     HLKYIGATSPGELCNESYVAGVGTYPEDIGLEGLSMVITQLIGLHIGLTYDDVDNCSC
                     PRAPCIMQPEALSSSGMKTFSNCSVHDYTHYASKLDMQCLGDLSNVLQPKQSVCGNGI
                     VEGSEECDCGNETECQFKECCNHETCKLKGSAQCGSGTCCTPKCELSAAGTPCRKAVD
                     PECDFTEYCDGSSSHCVPDTFALDGHLCRLGSAYCYNGRCQALNDQCVSLFGKGSQGA
                     SYACFEKVNSQRENLANCDSKNSYSLPCGQKDVLCGKLACFRPNKNYKSSTQSVLYSY
                     VHGSVCLSIPPGLSMRSDGKDNAYVADGTVCGPQMYCINGSCKEVNFTGNDCNAAKKC
                     KGNGICNNFGHCQCFPDYRPPDCNLQIGSPGGSIDDGNLLRTDSALATKRLSQHADSW
                     VILGFFIFLPFIMTLFLGIIKRNERKIVPQKEQER"
     exon            116..192
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            193..248
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            249..327
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            328..404
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            405..576
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            577..642
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            643..714
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            715..881
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            882..963
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1100
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1278
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1374
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1573
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1679
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1866
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1947
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2062
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2220
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2354
                     /gene="Adam18"
                     /gene_synonym="tMDCIII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacgtgcccc acggctgcca acggtcttga gctcagctga gcttcctgca tttggaccca
       61 accatgcctc tgttcttcat tctcgctgag cttgccatgc tgttagccgc cctcgattcg
      121 gaaggaatat ggctgcatat cacagtgcca cagaagatag agccattcaa gggcggagat
      181 tcagaaggga aggtgtctta cgtcattacc attgacggga aaccctactt tctgcacctc
      241 aggaactact catttttatc ccggaatttt tcggtttatg catataatga aactggatcc
      301 ctgtattccg actctccgca ctttttggct cattgccatt accgaggata tgttggtgaa
      361 gtaccagatt ccattgtgac actcagcctc tgctccggcc tcaggggatt cctgcagttg
      421 gaaaatacca gctatggaat cgaaccactg gagtcttcag caagattcga gcacatagtt
      481 tatcaaatga agagcaacag ctcaacgtta gcagcaaatt acagctgtat ttggcagaca
      541 agccgccagc ttgataaagg ccacttccgt gagcaggaca aaaacgattc acagctgcta
      601 cctaaaagtc taaaattgca cattattgtg ggaaaatttt tgtttgatta tatgggatct
      661 gacattatgg ctgtaacaca gaagatcttc cagattattg ggcttgttaa cactatgttc
      721 actcagctga acttaaatgt tgtgttggcc tccttggaac tgtggtcaga taaaaatcaa
      781 atttctactg acgggaatgc tagcgatatt ttacaaagac ttttgggctg gaaacgagac
      841 tatcttaccc cacagtccaa cgaaataaca cacttactca tttacaggaa acatctgaaa
      901 tacatcggag ctacgtcacc gggtgaatta tgcaatgaaa gctatgtcgc gggggttggt
      961 acgtatccag aagacatagg tttggaggga ctctccatgg ttatcactca actgattggc
     1021 cttcacatag gattaacata cgacgatgtt gataattgtt cctgccccag agctccatgc
     1081 ataatgcaac cggaagcatt gagttccagt gggatgaaga cttttagcaa ctgcagcgtg
     1141 cacgactaca cgcattatgc ttcgaagctt gacatgcaat gtcttggtga cctgtcaaat
     1201 gtattacaac caaagcaatc cgtgtgcggc aatggaatcg tggaaggcag tgaggaatgt
     1261 gactgtggta acgagacgga atgtcaattt aaagagtgct gcaaccacga aacatgcaaa
     1321 ctgaaaggct cagcacagtg tggatctgga acgtgctgca cacccaagtg tgagctgtca
     1381 gcagcaggca ctccctgtag gaaggctgtt gacccagagt gtgatttcac agaatattgc
     1441 gatggatcct ctagccactg tgtccctgac acctttgcgt tggatggtca tttgtgcagg
     1501 ttgggatcgg catattgcta caatggacga tgccaagctc ttaacgacca gtgcgtcagt
     1561 ttgtttggaa aaggttctca aggcgcttcc tacgcctgtt ttgaaaaagt taattcgcaa
     1621 cgtgaaaatc tggcaaactg tgactctaaa aattcatact cgttaccttg tggacagaag
     1681 gatgttctgt gtggaaaatt agcttgtttt cggccaaaca agaattataa aagctctact
     1741 caatctgtcc tgtattcgta tgtccatggc agcgtgtgtc tctccatacc tcctgggtta
     1801 tctatgagat cagacggcaa agataacgca tacgtggctg atggcactgt gtgtggacca
     1861 caaatgtact gtataaatgg aagctgcaaa gaagttaatt tcacgggaaa cgactgcaac
     1921 gccgctaaga agtgcaaagg gaatgggata tgtaataact ttggtcattg ccaatgcttc
     1981 cctgactaca ggcctccaga ttgtaactta cagattggat caccaggggg cagcattgac
     2041 gatggaaacc ttctccgaac tgattcggct ttggctacaa agcgtctgag tcaacacgcg
     2101 gacagctggg tgatcctggg cttcttcatc ttcctgcctt tcatcatgac tctcttcctt
     2161 gggatcataa agagaaacga aaggaaaatt gtgccccaga aagaacaaga aagatgaggg
     2221 caactcactg ccccgtaaat ctgctgaaga ggttagcagt ggatggacca aaggaggaag
     2281 tgcgtgctct aatctctctg ttaccctgga aacgctttag gtctcagact tttggaaaat
     2341 aaaactgaca aacg
//
