LOCUS       NM_020306               4102 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 17 (Adam17), mRNA.
ACCESSION   NM_020306
VERSION     NM_020306.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4102)
  AUTHORS   Abo-El Fetoh,M.E., Abdel-Fattah,M.M., Mohamed,W.R., Ramadan,L.A.A.
            and Afify,H.
  TITLE     Cyclooxygenase-2 activates EGFR-ERK1/2 pathway via PGE2-mediated
            ADAM-17 signaling in testosterone-induced benign prostatic
            hyperplasia
  JOURNAL   Inflammopharmacology 31 (1), 499-516 (2023)
   PUBMED   36586043
  REMARK    GeneRIF: Cyclooxygenase-2 activates EGFR-ERK1/2 pathway via
            PGE2-mediated ADAM-17 signaling in testosterone-induced benign
            prostatic hyperplasia.
REFERENCE   2  (bases 1 to 4102)
  AUTHORS   Xue,F., Cheng,J., Liu,Y., Cheng,C., Zhang,M., Sui,W., Chen,W.,
            Hao,P., Zhang,Y. and Zhang,C.
  TITLE     Cardiomyocyte-specific knockout of ADAM17 ameliorates left
            ventricular remodeling and function in diabetic cardiomyopathy of
            mice
  JOURNAL   Signal Transduct Target Ther 7 (1), 259 (2022)
   PUBMED   35909160
  REMARK    GeneRIF: Cardiomyocyte-specific knockout of ADAM17 ameliorates left
            ventricular remodeling and function in diabetic cardiomyopathy of
            mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4102)
  AUTHORS   Qu,Y., Zhang,J., Zhang,J. and Xiao,W.
  TITLE     MiR-708-3p Alleviates Inflammation and Myocardial Injury After
            Myocardial Infarction by Suppressing ADAM17 Expression
  JOURNAL   Inflammation 44 (3), 1083-1095 (2021)
   PUBMED   33492555
  REMARK    GeneRIF: MiR-708-3p Alleviates Inflammation and Myocardial Injury
            After Myocardial Infarction by Suppressing ADAM17 Expression.
REFERENCE   4  (bases 1 to 4102)
  AUTHORS   Khoury,E.E., Knaney,Y., Fokra,A., Kinaneh,S., Azzam,Z., Heyman,S.N.
            and Abassi,Z.
  TITLE     Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2
            and ADAM17 in rats with heart failure: Potential implication for
            COVID-19 disease
  JOURNAL   J Cell Mol Med 25 (8), 3840-3855 (2021)
   PUBMED   33660945
  REMARK    GeneRIF: Pulmonary, cardiac and renal distribution of ACE2, furin,
            TMPRSS2 and ADAM17 in rats with heart failure: Potential
            implication for COVID-19 disease.
REFERENCE   5  (bases 1 to 4102)
  AUTHORS   Gao,J., Sun,C.H., Zhu,Y.F., Tian,H.T., Liang,H.Y. and Zhang,D.P.
  TITLE     Influences of miR-708 on cerebral ischemia-reperfusion injury
            through targeted regulation of ADAM17
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (22), 11793-11800 (2020)
   PUBMED   33275250
  REMARK    GeneRIF: Influences of miR-708 on cerebral ischemia-reperfusion
            injury through targeted regulation of ADAM17.
REFERENCE   6  (bases 1 to 4102)
  AUTHORS   Roghani,M., Becherer,J.D., Moss,M.L., Atherton,R.E.,
            Erdjument-Bromage,H., Arribas,J., Blackburn,R.K., Weskamp,G.,
            Tempst,P. and Blobel,C.P.
  TITLE     Metalloprotease-disintegrin MDC9: intracellular maturation and
            catalytic activity
  JOURNAL   J Biol Chem 274 (6), 3531-3540 (1999)
   PUBMED   9920899
REFERENCE   7  (bases 1 to 4102)
  AUTHORS   Peschon,J.J., Slack,J.L., Reddy,P., Stocking,K.L., Sunnarborg,S.W.,
            Lee,D.C., Russell,W.E., Castner,B.J., Johnson,R.S., Fitzner,J.N.,
            Boyce,R.W., Nelson,N., Kozlosky,C.J., Wolfson,M.F., Rauch,C.T.,
            Cerretti,D.P., Paxton,R.J., March,C.J. and Black,R.A.
  TITLE     An essential role for ectodomain shedding in mammalian development
  JOURNAL   Science 282 (5392), 1281-1284 (1998)
   PUBMED   9812885
REFERENCE   8  (bases 1 to 4102)
  AUTHORS   Patel,I.R., Attur,M.G., Patel,R.N., Stuchin,S.A., Abagyan,R.A.,
            Abramson,S.B. and Amin,A.R.
  TITLE     TNF-alpha convertase enzyme from human arthritis-affected
            cartilage: isolation of cDNA by differential display, expression of
            the active enzyme, and regulation of TNF-alpha
  JOURNAL   J Immunol 160 (9), 4570-4579 (1998)
   PUBMED   9574564
REFERENCE   9  (bases 1 to 4102)
  AUTHORS   Moss,M.L., Jin,S.L., Milla,M.E., Bickett,D.M., Burkhart,W.,
            Carter,H.L., Chen,W.J., Clay,W.C., Didsbury,J.R., Hassler,D.,
            Hoffman,C.R., Kost,T.A., Lambert,M.H., Leesnitzer,M.A.,
            McCauley,P., McGeehan,G., Mitchell,J., Moyer,M., Pahel,G.,
            Rocque,W., Overton,L.K., Schoenen,F., Seaton,T., Su,J.L.,
            Becherer,J.D. et al.
  TITLE     Cloning of a disintegrin metalloproteinase that processes precursor
            tumour-necrosis factor-alpha
  JOURNAL   Nature 385 (6618), 733-736 (1997)
   PUBMED   9034191
  REMARK    Erratum:[Nature 1997 Apr 17;386(6626):738]
REFERENCE   10 (bases 1 to 4102)
  AUTHORS   Black,R.A., Rauch,C.T., Kozlosky,C.J., Peschon,J.J., Slack,J.L.,
            Wolfson,M.F., Castner,B.J., Stocking,K.L., Reddy,P., Srinivasan,S.,
            Nelson,N., Boiani,N., Schooley,K.A., Gerhart,M., Davis,R.,
            Fitzner,J.N., Johnson,R.S., Paxton,R.J., March,C.J. and
            Cerretti,D.P.
  TITLE     A metalloproteinase disintegrin that releases tumour-necrosis
            factor-alpha from cells
  JOURNAL   Nature 385 (6618), 729-733 (1997)
   PUBMED   9034190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Mar 29, 2021 this sequence version replaced NM_020306.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ012603.1, SRR26360190.2174819.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-336               JAXUCZ010000006.1  46649009-46649344   c
            337-469             JAXUCZ010000006.1  46637427-46637559   c
            470-600             JAXUCZ010000006.1  46629950-46630080   c
            601-689             JAXUCZ010000006.1  46628280-46628368   c
            690-858             JAXUCZ010000006.1  46626328-46626496   c
            859-992             JAXUCZ010000006.1  46623900-46624033   c
            993-1082            JAXUCZ010000006.1  46621904-46621993   c
            1083-1196           JAXUCZ010000006.1  46619385-46619498   c
            1197-1341           JAXUCZ010000006.1  46617048-46617192   c
            1342-1430           JAXUCZ010000006.1  46616837-46616925   c
            1431-1583           JAXUCZ010000006.1  46613810-46613962   c
            1584-1783           JAXUCZ010000006.1  46610939-46611138   c
            1784-1887           JAXUCZ010000006.1  46609740-46609843   c
            1888-2022           JAXUCZ010000006.1  46609112-46609246   c
            2023-2153           JAXUCZ010000006.1  46607128-46607258   c
            2154-2232           JAXUCZ010000006.1  46606244-46606322   c
            2233-2321           JAXUCZ010000006.1  46605377-46605465   c
            2322-2372           JAXUCZ010000006.1  46603713-46603763   c
            2373-4102           JAXUCZ010000006.1  46601583-46603312   c
FEATURES             Location/Qualifiers
     source          1..4102
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..4102
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /note="ADAM metallopeptidase domain 17"
                     /db_xref="GeneID:57027"
                     /db_xref="RGD:620404"
     exon            1..336
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..2723
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /EC_number="3.4.24.86"
                     /note="a disintegrin and metalloprotease domain 17;
                     disintegrin and metalloproteinase domain-containing
                     protein 17; ADAM 17; TNF-alpha convertase;
                     TNF-alpha-converting enzyme; a disintegrin and
                     metalloproteinase domain 17 (tumor necrosis factor, alpha,
                     converting enzyme); a disintegrin and metallopeptidase
                     domain 17"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 17 precursor"
                     /protein_id="NP_064702.2"
                     /db_xref="GeneID:57027"
                     /db_xref="RGD:620404"
                     /translation="MRQRLLFLTTLVPFVLAPRPPEEPGSGSHPRLEKLDSLLSDYDI
                     LSLSNIQQHSIRKRDLQSATHLETLLTFSALKRHFKLYLTSSTERFSQNLRVVVVDGK
                     EESEYSVKWQDFFSGHVVGEPDSRVLAHIGDDDVTVRINTDGAEYNIEPLWRFVNDTK
                     DKRMLVYKSEDIKDFSRLQSPKVCGYLNADSEELLPKGLIDREPSEEFVRRVKRRAEP
                     NPLKNTCKLLVVADHRFYKYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYG
                     VQIEQIRILKSPQEVKPGERHFNMAKSFPNEEKDAWDVKMLLEQFSLDIAEEASKVCL
                     AHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYNPGVKKNIYLNSGLTSTKNYGK
                     TILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
                     SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTL
                     KPGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGDAEDDTV
                     CLDLGKCKAGKCIPFCKREQELESCACADTDNSCKVCCRNLSGPCVPYVDAEQKNLFL
                     RKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLI
                     FWIPFSILVHCVDKKLDKQYESLSLFHHSNIEMLSSMDSASVRIIKPFPAPQTPGRLQ
                     ALQPAAMMPPVSAAPKLDHQRMDTIQEDPSTDSHVDDDGFEKDPFPNSSAAAKSFEDL
                     TDHPVTRSEKAASFKLQRQSRVDSKETEC"
     exon            337..469
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            470..600
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            601..689
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            690..858
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            859..992
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1082
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1196
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1341
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1430
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1583
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1783
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1887
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2022
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2153
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2232
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2321
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2372
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..4102
                     /gene="Adam17"
                     /gene_synonym="TACE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccggctgt gggcagcagg gtggtcagcg actgcggccg gaagcaggct gagcggctct
       61 gggcgagcgc cgcctgtact tccggggact tcagcctagc tcttgagttt tccctgtagg
      121 cggcgcggga gggaaaagtt tgcagggccg tgctgggaag atcacctccg cttcccaatg
      181 tgagcagttt ctcgaacgct ctctctagaa ggttgcccag agaggtggtg gacgggaaca
      241 tgaggcagcg tctcctcttc ctgaccactt tggtgccttt cgtcctggca ccccgacctc
      301 cggaggaacc aggctctggc tcccacccgc gacttgagaa gcttgattct ttgctctcag
      361 actacgatat cctctcttta tctaatatcc agcagcactc cataaggaaa agggatctac
      421 agtctgcgac acacttagaa acactactaa ctttttcagc tttgaaaagg cattttaaat
      481 tatacttgac atcaagtaca gaacgctttt cacagaactt gcgagtcgtg gtggtggatg
      541 ggaaagagga aagcgagtac agtgtgaagt ggcaggactt cttcagcgga catgtggttg
      601 gtgagcctga ctctagggtt ctagcgcaca taggagatga tgatgtcaca gtaagaatca
      661 acacagatgg ggcagaatat aacatagagc cactttggag gtttgttaat gatactaaag
      721 ataaaaggat gctggtgtat aagtctgaag atatcaagga tttttcacgt ttgcagtctc
      781 caaaagtatg tggttattta aatgcagata gtgaagagtt gcttccaaaa gggctcatag
      841 acagagagcc atctgaagag tttgtccgtc gagtgaagag gcgagctgaa cctaacccat
      901 tgaagaatac ttgtaaatta ctggtggtgg cagatcatcg attttataag tacatgggcc
      961 gaggagaaga gagcactact acaaattact taatagagtt aattgaccga gttgatgaca
     1021 tataccggaa cacctcgtgg gacaatgcag gatttaaagg ttatggagta cagatagaac
     1081 agattcgaat tctcaagtct ccacaagagg taaaacctgg tgaaagacac ttcaatatgg
     1141 caaaaagttt tccaaatgaa gaaaaggatg cttgggatgt gaagatgctg ctggagcaat
     1201 ttagccttga tatagctgaa gaggcctcta aagtctgcct ggctcatctt ttcacctacc
     1261 aagattttga tatgggaact cttggattag cttacgttgg ttctcccaga gcaaacagtc
     1321 atggaggggt ttgtccaaaa gcttattaca acccaggtgt gaagaagaac atctatttga
     1381 atagtggtct gacaagtaca aaaaattatg gtaaaaccat ccttacaaag gaggctgacc
     1441 tggttacaac tcatgaattg ggacacaatt ttggagcaga acatgatcct gatgggctgg
     1501 cagagtgtgc cccaaatgag gaccaaggag gaaagtatgt tatgtacccc atagctgtga
     1561 gtggtgacca tgagaataat aagatgtttt caaactgcag taaacagtcc atctacaaga
     1621 ccatagaaag caaggctcaa gagtgcttcc aggagcgcag caacaaggtg tgcggcaact
     1681 ccagggtgga cgaaggagaa gagtgtgacc cgggcatcat gtacctgaac aacgacacct
     1741 gctgcaatag tgactgcaca ctgaagccag gtgtgcagtg cagtgatagg aatagtcctt
     1801 gctgtaaaaa ttgtcagttt gagacggccc agaagaagtg ccaggaggct atcaatgcta
     1861 cttgcaaagg agtgtcttac tgcacaggga atagcagtga gtgcccccca ccaggagatg
     1921 ctgaagatga cactgtgtgc ttggacctgg gcaagtgcaa ggctgggaaa tgcatccctt
     1981 tctgcaagag ggagcaggag ctggagtcct gcgcatgtgc tgacaccgac aactcgtgca
     2041 aggtatgctg caggaacctt tctggcccat gtgtgcctta cgtcgatgca gagcaaaaga
     2101 acttattttt gaggaaaggg aagccctgta cagtagggtt ttgtgacatg aatggcaaat
     2161 gtgagaaacg ggtacaggac gtaattgagc ggttttggga tttcattgac cagctgagca
     2221 tcaacacttt tgggaagttt ctggcagaca acatcgttgg gtctgttctg gttttctcct
     2281 tgatattttg gattcctttc agcattcttg tccactgtgt ggataagaaa ctggacaagc
     2341 agtatgagtc cctgtctctg tttcatcaca gtaacattga gatgttgagc agcatggact
     2401 cagcatctgt tcgcattatc aagccgttcc ctgcacccca gactccaggt cgtctgcagg
     2461 ccctgcagcc ggctgcaatg atgccgccag tgtctgcggc tccaaaactg gatcaccaga
     2521 ggatggacac catccaggaa gaccccagca cagattcaca tgtggatgat gatggctttg
     2581 agaaggaccc cttccccaac agcagtgcag ccgccaagtc ctttgaggac ctcacagacc
     2641 acccagtcac caggagtgag aaggccgcct ccttcaagct gcagcgtcag agccgagttg
     2701 acagcaaaga gacagagtgt tagtgggagc ctgggcctgc tctgggggac acagacctac
     2761 agatgttcca cagagctgac ctgaatcaaa atagactgta atgatctgag aaacgggagc
     2821 agcttagcag atgctggtca tgtgacagga ccttcacatg acatcctgtg tatgtaggcc
     2881 ctttgaagag gtgaggtaaa tctggcttat ttaaggcttt caggttttgg ggttttcttt
     2941 tgtaatctaa aaatctcctt tgacctgtgg tgcagaagca gaaaataagg ctggatcaag
     3001 ttcctggtga cagcactgat taagccttca gtctgttttt ctgtatgctg taaggtcctc
     3061 tcactacggt gaagcactta gcagtgagga tgactggaac acagactttt tgggggtttt
     3121 ggccttcaca tgtgcgttgt ctccaaatgc cgtctgtctt ggcactgaac tttgtggata
     3181 cagtcctttc caagatgaag actagctctg gaacagtcta tacaaacagc cacatgaact
     3241 tcaagatggc ctattaactg cttagcccca ggttccctgg gcagtttttc cgttttgcaa
     3301 aaagtgtctt cacgggtctc taaacattgt ttgccttaaa aaatactggg ctggagagtt
     3361 ggccccacag ttaagagcac ttggtttcat tcccagtacc cacacggtgg ctcttaactc
     3421 caatcccagg ggagatgaca tcttctgaac tctagaacac aaggcatgca ttggtgcagt
     3481 caaacatgca ggcaacacac acaaatttag aaagccaagt gctgtaagaa gttgcacatc
     3541 ccccaaccta cagtgcttcg cggtctgagc tggagtggag ctctctcctg aacactctgg
     3601 aaggctggca ggtgctgagc tggctaggga gacgggtggg gcccagccct ggaagaaccg
     3661 tcttcagcct cagcaagcag acactcgcgt tacctcaggc tttggggctt caggacccag
     3721 gatgttttgt acttattgtg tgaggataaa taccattagc ctgaattctc atttctgtaa
     3781 gttttagtta taaaagcttt ttttcttcta agaattgcaa tgtgctcacc agcaaacacg
     3841 tcttaaccag aataacttgt aactctgagg acagttaacc aaacctgtgc cttgtctctc
     3901 ctgagggtgt ctgttacact aatacttgaa catgtacctt gtggtattgg ctccttttac
     3961 tagtcatgac agccttatat gttagttaca ctttgaggat ttgctctaag gtgagtgggg
     4021 tgtgtgggtg tatgtatgaa tgaaacagtt ggcagaatat aagaaaacca tttttataaa
     4081 attgtgactt tttaaaccaa aa
//
