LOCUS       NM_001399128            2968 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 15 (Adam15),
            transcript variant 1, mRNA.
ACCESSION   NM_001399128 XM_006232742
VERSION     NM_001399128.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2968)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2968)
  AUTHORS   Lee,H.D., Koo,B.H., Kim,Y.H., Jeon,O.H. and Kim,D.S.
  TITLE     Exosome release of ADAM15 and the functional implications of human
            macrophage-derived ADAM15 exosomes
  JOURNAL   FASEB J 26 (7), 3084-3095 (2012)
   PUBMED   22505472
REFERENCE   3  (bases 1 to 2968)
  AUTHORS   Rybnikova,E., Gluschenko,T., Galeeva,A., Tulkova,E.,
            Nalivaeva,N.N., Makova,N.Z., Turner,A.J. and Samoilov,M.
  TITLE     Differential expression of ADAM15 and ADAM17 metalloproteases in
            the rat brain after severe hypobaric hypoxia and hypoxic
            preconditioning
  JOURNAL   Neurosci Res 72 (4), 364-373 (2012)
   PUBMED   22230263
  REMARK    GeneRIF: The present findings implicate ADAM15 in the processes of
            neuronal hypoxic injury
REFERENCE   4  (bases 1 to 2968)
  AUTHORS   Nath,A.K., Krauthammer,M., Li,P., Davidov,E., Butler,L.C.,
            Copel,J., Katajamaa,M., Oresic,M., Buhimschi,I., Buhimschi,C.,
            Snyder,M. and Madri,J.A.
  TITLE     Proteomic-based detection of a protein cluster dysregulated during
            cardiovascular development identifies biomarkers of congenital
            heart defects
  JOURNAL   PLoS One 4 (1), e4221 (2009)
   PUBMED   19156209
REFERENCE   5  (bases 1 to 2968)
  AUTHORS   Yamada,D., Ohuchida,K., Mizumoto,K., Ohhashi,S., Yu,J., Egami,T.,
            Fujita,H., Nagai,E. and Tanaka,M.
  TITLE     Increased expression of ADAM 9 and ADAM 15 mRNA in pancreatic
            cancer
  JOURNAL   Anticancer Res 27 (2), 793-799 (2007)
   PUBMED   17465204
REFERENCE   6  (bases 1 to 2968)
  AUTHORS   Fourie,A.M., Coles,F., Moreno,V. and Karlsson,L.
  TITLE     Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on
            synthetic peptide substrates and in ectodomain cleavage of CD23
  JOURNAL   J Biol Chem 278 (33), 30469-30477 (2003)
   PUBMED   12777399
REFERENCE   7  (bases 1 to 2968)
  AUTHORS   Rosselot,C., Kierszenbaum,A.L., Rivkin,E. and Tres,L.L.
  TITLE     Chronological gene expression of ADAMs during testicular
            development: prespermatogonia (gonocytes) express fertilin beta
            (ADAM2)
  JOURNAL   Dev Dyn 227 (3), 458-467 (2003)
   PUBMED   12815633
REFERENCE   8  (bases 1 to 2968)
  AUTHORS   Bosse,F., Petzold,G., Greiner-Petter,R., Pippirs,U., Gillen,C. and
            Muller,H.W.
  TITLE     Cellular localization of the disintegrin CRII-7/rMDC15 mRNA in rat
            PNS and CNS and regulated expression in postnatal development and
            after nerve injury
  JOURNAL   Glia 32 (3), 313-327 (2000)
   PUBMED   11102971
REFERENCE   9  (bases 1 to 2968)
  AUTHORS   Howard,L., Nelson,K.K., Maciewicz,R.A. and Blobel,C.P.
  TITLE     Interaction of the metalloprotease disintegrins MDC9 and MDC15 with
            two SH3 domain-containing proteins, endophilin I and SH3PX1
  JOURNAL   J Biol Chem 274 (44), 31693-31699 (1999)
   PUBMED   10531379
REFERENCE   10 (bases 1 to 2968)
  AUTHORS   Frayne,J., Jury,J.A., Barker,H.L. and Hall,L.
  TITLE     Rat MDC family of proteins: sequence analysis, tissue distribution,
            and expression in prepubertal and adult rat testis
  JOURNAL   Mol Reprod Dev 48 (2), 159-167 (1997)
   PUBMED   9291465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 4, 2022 this sequence version replaced XM_006232742.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061796.1, SRR26643285.8835.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               JAXUCZ010000002.1  177062669-177062849 c
            182-291             JAXUCZ010000002.1  177061324-177061433 c
            292-368             JAXUCZ010000002.1  177060655-177060731 c
            369-447             JAXUCZ010000002.1  177060180-177060258 c
            448-524             JAXUCZ010000002.1  177059717-177059793 c
            525-717             JAXUCZ010000002.1  177059436-177059628 c
            718-783             JAXUCZ010000002.1  177058485-177058550 c
            784-852             JAXUCZ010000002.1  177058326-177058394 c
            853-1022            JAXUCZ010000002.1  177058078-177058247 c
            1023-1107           JAXUCZ010000002.1  177057875-177057959 c
            1108-1256           JAXUCZ010000002.1  177057280-177057428 c
            1257-1431           JAXUCZ010000002.1  177057000-177057174 c
            1432-1524           JAXUCZ010000002.1  177056725-177056817 c
            1525-1829           JAXUCZ010000002.1  177056262-177056566 c
            1830-2025           JAXUCZ010000002.1  177055978-177056173 c
            2026-2103           JAXUCZ010000002.1  177055700-177055777 c
            2104-2176           JAXUCZ010000002.1  177055034-177055106 c
            2177-2315           JAXUCZ010000002.1  177054674-177054812 c
            2316-2385           JAXUCZ010000002.1  177054238-177054307 c
            2386-2457           JAXUCZ010000002.1  177053608-177053679 c
            2458-2529           JAXUCZ010000002.1  177053132-177053203 c
            2530-2654           JAXUCZ010000002.1  177052780-177052904 c
            2655-2968           JAXUCZ010000002.1  177052363-177052676 c
FEATURES             Location/Qualifiers
     source          1..2968
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2968
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /note="ADAM metallopeptidase domain 15"
                     /db_xref="GeneID:57025"
                     /db_xref="RGD:620402"
     exon            1..181
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2697
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; disintegrin and metalloproteinase
                     domain-containing protein 15; CRII-7; MDC-15; ADAM 15;
                     metalloprotease RGD disintegrin protein;
                     metalloproteinase-like, disintegrin-like, and
                     cysteine-rich protein 15; a disintegrin and
                     metalloproteinase domain 15 (metargidin); tMDC VI; a
                     disintegrin and metallopeptidase domain 15 (metargidin)"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 15 isoform 1 precursor"
                     /protein_id="NP_001386057.1"
                     /db_xref="GeneID:57025"
                     /db_xref="RGD:620402"
                     /translation="MRLALLWALGLLGAGSPRPSPPLPNIGGTEEEQQASPERTQSRS
                     LENQVVQDSPPINLTEVLQTGLPETLRIGLELDGENHILELQQNRDLVPGRPTLVWYQ
                     PDGTRMVSEGHSLENCCYRGRVQGRPSSWVSLCACSGIRGLVVLSPERSYTLELGPGD
                     LQRPLIVSRIQDLLLPGHTCAPSWHAFVPTEAAPDLLLEQHHLRRLKRDVVTETKIVE
                     LVIVADNSEVRKYPDFQQLLNRTLEVALLLDTFFQPLNVRVALVGLEAWTQRDLIEMS
                     SNPAVLLDNFLRWRRTDLLPRLPHDSAQLVTVTSFSGPMVGMAIQNSICSPDFSGGVN
                     MDHSTSILGVASSIAHELGHSLGLDHDSPGNSCPCPGPAPAKSCIMEASTDFLPGLNF
                     SNCSRWALEKALLDGMGSCLFEWPPSRAPMSSLCGNMFVDPGEQCDCGFPDECTDPCC
                     DYFTCQLRPGAQCASDGPCCQNCKLQPAGWQCRLPTDDCDLPEFCLGDSSQCPPDIRL
                     GDGEPCASGEAVCMHGRCASYTRQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRSP
                     SGSYMPCNLRDAICGQLQCQWGRNQPLLGSVQDQLSEVLEANGTQLNCSWVDLDLGND
                     VAQPLLALPGTACGPGLVCIGHRCQPVDLLGAQECRSKCHGHGVCDSSRHCHCDEGWA
                     PPDCMTQLRATSSLTTGLLLSLLLLLVLVLLGASYWYRARLHQRLCQLKGSSCQYRAA
                     QSGPPERPGPPQRAQQMPGTKQANVSFPVPPSRPLPPNPVPKKLQAELADRSNPPTRP
                     LPADPVVWRPKPQGPTKPPPPRKPLPANPQGRPPLGDLPGPGDGSLQLVVPSRPAPPP
                     PAASSLYL"
     exon            182..291
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            292..368
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            369..447
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            448..524
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            525..717
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            718..783
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            784..852
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1022
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1107
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1256
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1431
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1524
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1829
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..2025
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2103
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2176
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2315
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2385
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2457
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2529
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2654
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2968
                     /gene="Adam15"
                     /gene_synonym="MDC15; tMDCVI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggctgtg ctgcgcggag ctggtgtccg acgcggcccc ggctgctcct ccacgcttag
       61 ccccgcacct gctgccctcg tccggcccgg agctccgcgg ccatgcggct ggcgctgctc
      121 tgggccctgg gactcctggg cgcgggcagc cctcggccct ccccgccgct gccaaatata
      181 ggaggtactg aggaagagca gcaagccagc ccagagagga cccagagtag atccttggag
      241 aaccaggttg ttcaggacag ccccccaatt aacctaacag aagtgcttca gactggttta
      301 cctgagaccc tgaggattgg attggagctg gacggtgaga atcatatcct ggagcttcaa
      361 cagaatagag atctggtccc tggccgcccg actctggtgt ggtatcagcc tgacggcacc
      421 cgaatggtca gcgaggggca cagtctggaa aactgctgct atcgaggacg agttcagggc
      481 cgccccagct cttgggtctc cctctgtgcc tgctctggga tcagggggct ggtagtcctg
      541 tcccctgaga gaagctatac actggagctg ggacctggag accttcagcg tcctctcatt
      601 gtttctcgga tccaagacct cctcttgcca ggccacacct gtgccccaag ctggcatgca
      661 tttgtgccca ccgaggcagc accagacctc cttttggaac agcaccacct tcgcaggctt
      721 aagcgggatg tagtaacaga gacgaaaatt gtcgaactgg tgattgtggc tgataattca
      781 gaggtcagga agtaccctga cttccaacaa ctgctgaacc gaacactaga agtggccctt
      841 ctgctagaca cattcttcca gcccctgaat gtccgggtag cacttgtggg cctagaggca
      901 tggacccagc gcgacctgat agagatgagc tccaacccag ctgtcctgct agacaacttc
      961 ctccgctggc gccggacaga cttgctgcct cgactgcccc atgatagtgc ccagcttgtg
     1021 actgttactt ccttctctgg gcccatggtg ggcatggcca ttcagaattc catctgttct
     1081 cctgacttct cgggaggtgt gaatatggac cactcgacaa gcatcttagg agttgcctcc
     1141 tccattgccc acgagttggg tcacagcctg ggcctagacc acgattcacc tgggaacagt
     1201 tgtccctgtc caggtccagc cccagccaag agctgcatca tggaggcctc cacagatttc
     1261 ctaccaggtc tgaacttcag caactgcagc cgatgggccc tggaaaaagc cctcctagat
     1321 gggatgggca gctgcctctt tgaatggcca cccagccggg cccctatgtc ctctttgtgt
     1381 ggaaatatgt ttgtggaccc tggagagcag tgtgactgtg gcttcccaga tgagtgcact
     1441 gatccttgct gtgactattt tacctgccag ctgaggccgg gagcacagtg tgcatctgac
     1501 ggaccctgtt gtcaaaactg caagttacag ccagctggct ggcagtgccg ccttcccaca
     1561 gacgattgcg atttgcctga gttctgccta ggagatagct ctcagtgccc ccctgacatc
     1621 aggcttgggg acggtgagcc ttgtgctagt ggagaggctg tgtgtatgca tgggcgctgt
     1681 gcctcctaca cccggcagtg ccagtcgctt tggggacctg gggcccagcc tgctgcacca
     1741 ctttgcctcc aaacagccaa cactcggggt aatgcctttg ggagctgtgg gcgcagcccc
     1801 agtggtagct acatgccttg caaccttaga gatgccattt gtgggcaact acagtgccag
     1861 tggggtagga accagcctct gctgggctca gtccaagatc agctctcgga ggtcctggaa
     1921 gccaatggga cacaattaaa ctgcagctgg gtagatctgg acttgggcaa tgatgtggcc
     1981 cagcctctcc tggctctacc tggcactgcc tgtggccctg gcctggtgtg catcggccat
     2041 cgatgccagc ctgtggatct cctgggagca caggaatgcc gcagcaaatg ccatggccat
     2101 ggggtctgcg acagcagcag gcactgccac tgtgacgagg gctgggcacc tcctgattgc
     2161 atgacccagc tcagagcaac cagctccctg accacaggcc tgctcctcag cctcctgttg
     2221 ttattggtcc tcgtactact tggtgccagc tactggtacc gtgcccgcct gcatcagcgg
     2281 ctctgccagc tcaagggatc cagctgccaa tatagggcag cccaatccgg tcctcctgag
     2341 cgaccaggac ctccacagag ggcacagcag atgccaggca ctaagcaagc taatgtcagc
     2401 tttccagtac ccccctccag gccgctgcca cctaaccccg tgcccaagaa actccaggct
     2461 gagctggctg accgatccaa tccccccact cgccctctgc ccgctgaccc tgtggtgtgg
     2521 cgcccaaagc ctcaggggcc taccaaaccc ccacccccaa gaaagccact gcccgccaac
     2581 ccacagggcc ggcccccgct gggtgacctg cctggcccag gagatggaag cttgcagctg
     2641 gtagtgcctt ccaggcctgc cccaccaccc ccagcagcat cttcgctcta cctctgaccc
     2701 ctcgagattc ggctgtctcc tgctcagttc taggacttaa agtggaacct ctgtctgaat
     2761 ctcccacaaa acactagaga agcagaagct tagacaatat ggcatccagc cctaaagaac
     2821 caccaggcgc tgttcagtag tacctgggac ccactgaatt acctgcagct gagtgttggg
     2881 aaggggctgg ggctggagta ggtggtggaa ggacgggaat gtggtctgtc tctgctctgt
     2941 tgtaataaat gtgaggtctt ggaatatg
//
