LOCUS       XM_017590240            8110 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus ADAM metallopeptidase domain 12
            (Adam12), mRNA.
ACCESSION   XM_017590240
VERSION     XM_017590240.2
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051336.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Jan 18, 2024 this sequence was replaced by
            NM_001427293.1.
            
            On Jan 21, 2021 this sequence version replaced XM_017590240.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8110
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..8110
                     /gene="Adam12"
                     /note="ADAM metallopeptidase domain 12; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 22 ESTs, 30 long SRA reads, 10 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 34 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:679837"
                     /db_xref="RGD:1583652"
     CDS             699..3410
                     /gene="Adam12"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 12"
                     /protein_id="XP_017445729.1"
                     /db_xref="GeneID:679837"
                     /db_xref="RGD:1583652"
                     /translation="MAERPARRAPPARALLLALAGALLAPRAARGVSLWDQRGAYEVA
                     KASLLTKDPGSPGQSIPAKDHPDVLTVQLQLESRELILSLERNEGLIANGFTETHYLQ
                     DGSDVSFTRNYTDHCYYHGHVQGDAASVVSLSTCSGLRGLIVFENKTYILEPMKNTTD
                     RYKLVPAENMKNIQGLCGSHHNKSSLTMEDVFPEPSQMWGRRHKRETLKMTKYVELVI
                     VADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDIDKCSISQD
                     PFTSLHEFLDWRKLKLLPRKSHDNAQLISGVYFQGTTIGMAPIMSMCTAEQSGGVVMD
                     HSDSPLGAAVTLAHELGHNFGMNHDTLERGCSCRMAAEKGGCIMNPSTGFPFPMVFSS
                     CSRKDLEASLEKGMGMCLFNLPEVKQAFGGRKCGNGYVEDGEECDCGEPEECTNRCCN
                     ATTCTLKPDAVCAHGQCCEDCQLKPPGTACRGSSNSCDLPEFCTGTAPHCPANVYLHD
                     GHPCQGVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKDSKS
                     SFVKCELRDAKCGKIQCQGGASRPVIGTNAVSIETNIPQQEGGRILCRGTHVYLGDDM
                     PDPGLVLAGTKCAEGKICLNRQCQNISVFGVHKCAMQCHGRGVCNNRKNCHCEAHWAP
                     PFCDKFGFGGSTDSGPIRQADNQGLTVGILVSVLCLLAAGFVVYLKRKTLMRLLFTHK
                     KNTMEKLRCVHTSRTPSGPRPGQAHHILGKGPLMSRPPHFNTTKDRHSLKCQNIDISR
                     PLNARVVPQPQSPQRVLLPLHQAPRAPSGPARPLPANPAVRQAQGTHKPSPPQKPLPA
                     DPLSRTSRLTGALVRTPGQQESGHRPAPIRPAPKHQVPRLSHNAYIK"
ORIGIN      
        1 tcccagacct gttcctcagg tcccgccgat acccagctag ccagcagcta gcagcccagt
       61 catcctttcc agcctcagtc tggaaagctg gaccccggcg ccgcgtgtgc tcttggctgc
      121 cggcgcccag ggccccgtgg ccacatcatc ctgaggctgg gaagtgtgcg ttctcgcgcc
      181 tttgcgccac gaagccgggt ctacgcggcg tcccacacaa ggggtctggg ggcatcctgc
      241 atctagccac cccggagagt ggataggacc cgggcggtgg gggaccccag agcggtctct
      301 aggacccgcg ggacgccgca ggcgggcggg gtgcggggga gacgctaatt tgttccgtgg
      361 taatgagaac ggcgactgct ggccgcggat ccattgcaca gacccgccct cagatcgctg
      421 gtccccggcg ccaactcgga caggctgctc atttattgca acggtcaagg gcggctcgtg
      481 ccagagtagc gcgcgcgcgc acgcacacac tcggggaggg gagaaagttt ttttttgaaa
      541 aatgaaaggc tagacttgct gctccgcgac ccgggcgctg cgcgaggggg tcgtggcaga
      601 ctcggggcag taggacgtcc accggctcgg cgcccgcgtg ggatgctgca gcgctggtcg
      661 cggggcccct gaagcagctg cacgccaggc cggcgacaat ggcagagcgc ccggcgcggc
      721 gcgcgccccc cgcccgcgcc ctcctgctgg ccctggctgg ggccctgctg gcgccccgtg
      781 cagcccgagg agtgagtttg tgggaccaga gaggagctta tgaagtggcc aaagcctccc
      841 ttctgacaaa ggaccctggg agcccaggac agagcatccc agccaaggat cacccagatg
      901 tgctgactgt gcagctgcag ctggagagcc gagaactgat cctcagcttg gagaggaatg
      961 agggactcat tgccaatggc ttcacagaga cccattatct gcaagatggt agtgatgtct
     1021 ccttcactcg aaattacacg gaccattgtt actaccatgg acatgtgcaa ggtgatgctg
     1081 catcagtggt cagcctcagt acttgctctg gtctcagggg actaatcgtg tttgaaaata
     1141 aaacctacat cttagaaccg atgaaaaaca ccactgacag atacaaactc gtcccggctg
     1201 agaacatgaa gaacatccaa gggctgtgtg ggtcacatca taacaagtcc agcctcacca
     1261 tggaggatgt cttccctgaa ccctctcaga tgtggggaag aaggcataaa agagagaccc
     1321 ttaagatgac caagtatgta gaactggtta ttgtggcaga caacagagag tttcagaggc
     1381 aaggaaaaga tctggagaaa gtgaagcagc ggttaataga gatcgccaat cacgtggaca
     1441 agttttacag accactgaac atccgtattg tcctggtggg agtagaagtg tggaatgaca
     1501 ttgacaaatg ctctataagc caggacccat tcaccagcct ccatgagttt ctagactgga
     1561 gaaagttaaa gcttctacct cgcaaatccc acgacaacgc tcagcttatc agtggggttt
     1621 atttccaagg aaccacgatt ggcatggcac ccatcatgag catgtgcact gcagaacagt
     1681 ccggaggagt ggtcatggac cattcagaca gcccccttgg tgccgcagtg accttggcac
     1741 atgagctggg ccacaacttc gggatgaatc acgacacact ggaaaggggc tgcagctgca
     1801 ggatggctgc ggagaaagga ggctgcatca tgaacccttc cacagggttc ccgttcccca
     1861 tggtgttcag cagctgcagc aggaaggacc tggaggctag cctggagaag gggatgggga
     1921 tgtgcctctt caacctacca gaggtcaagc aggcctttgg gggccggaag tgtggaaatg
     1981 gctatgtgga agacggagaa gagtgtgact gcggggagcc agaggagtgt accaatcgct
     2041 gctgcaacgc cacgacctgt actctgaagc cagatgctgt gtgtgcgcat gggcagtgct
     2101 gcgaagactg tcagctgaag cctccaggaa ctgcatgcag gggctccagc aactcctgcg
     2161 acctcccaga attctgcaca gggaccgccc ctcactgccc agccaatgtg tacctacatg
     2221 atgggcaccc gtgtcaggga gtggatggtt actgctacaa tggcatctgc cagacccatg
     2281 agcagcagtg cgtcacactc tggggaccag gtgctaaacc ggctcctggc atctgctttg
     2341 agagagtcaa ctctgcagga gatccttacg gcaactgtgg caaagactcc aagagctcct
     2401 tcgtcaagtg tgaactgaga gatgccaagt gtggaaaaat ccagtgtcaa ggtggtgcca
     2461 gccgacccgt cattggtacc aatgctgttt ccatagaaac aaatatcccg cagcaggaag
     2521 gaggccggat tctgtgccgg gggacccatg tgtacttggg tgacgacatg ccggacccag
     2581 ggcttgtgct tgcaggaacc aagtgtgcag agggaaaaat ctgcctcaat cgtcaatgtc
     2641 agaatatcag tgtcttcggc gttcataagt gtgcaatgca gtgccacggc cgaggggtat
     2701 gtaataacag gaagaactgc cattgtgaag cccactgggc tcctcccttc tgtgacaagt
     2761 ttggctttgg aggaagcaca gacagtggtc ccatccggca agcagataac cagggcttga
     2821 ctgtagggat cctggttagt gtcctgtgtc tgctcgctgc tggatttgtg gtatatctca
     2881 aaaggaagac gttgatgcgg ctgctgttca cacataagaa aaacactatg gaaaaactaa
     2941 ggtgtgtaca cacttcccgg acacccagtg gccctcgccc tggccaggct caccacatcc
     3001 tcgggaaagg cccactgatg agccggcccc cacatttcaa caccaccaag gacaggcact
     3061 cactgaaatg ccagaatatc gacatcagca ggcccctcaa tgctcgagtg gtccctcagc
     3121 ctcagtcccc tcagcgagtg ctcctgcctc tccaccaggc cccacgtgca cccagtggcc
     3181 ctgccaggcc cctgcccgcc aatcctgcag tcaggcaggc ccagggcacc cacaagccca
     3241 gccctcctca gaagcctctg cctgctgatc cattgagcag gacttctcgg ctcactggtg
     3301 ccttggtgag gaccccaggg cagcaggaat ctgggcatcg cccagccccc atcagacctg
     3361 cccctaagca tcaagtacct agactctccc acaatgccta catcaagtga gaagccagcc
     3421 cagaccggtc ctcagcagtg aagacagaag tttgcactat cttcgactcc atcggagttg
     3481 ttttgtacca actttcagaa tttctaaagt gtttaaaaca ccattatttc cagaacttgg
     3541 agctcctgcc atccgtcggt gctgtgccgt ggtgctttgt gtacttgctc aggtccttgt
     3601 aagttattaa tttatgcaga gtgtctatta ccgcgcaggg cgccgtagca ggcatttgtg
     3661 ccatcacggg gcttttctac agaaggaagg cacctcgtgc ttttgttttt ctggaggact
     3721 tgaaatatcc tgcttgatgg gacccaagat gagatgttta ctttctgttt gagaccttat
     3781 tggaaaacag ctcccccacg tcccaaggct gtgttatggt accagacaca cagctcagga
     3841 caccccaggt ggaacctgga atggctttta ttttattttt tattctttgg aatccctgtc
     3901 ttgggttgta gccaggggct tcaggaaggt ctcagcgtgc cttcaggcct gtaccctgaa
     3961 gttctagaca acaggtaggc tctggtttct aaccagcagc tttgaagaga acctggggta
     4021 ctgaaaagaa ggtttgaggc cacaccagga tagagactgg aaccctaatc tggacaaaca
     4081 tttgaccttg acctgagcag ccacgagcac ctctggagag caaggacggc tgtggtgctg
     4141 cgggggcttt gctttgggag ctgccgggag cgtctctctg gctgccctgt gcacagtgct
     4201 cgctggcgtg ggcacgttgt ttacattggg aacagtggta tttctacaag gaagccactg
     4261 cctgggcact gcagacctct gtctcctgcc catttagagt taagcaaatt accacattgt
     4321 cttcttgact gtaatacaat gaccctgtgt tctgacagat agaggaggct ttctaaggga
     4381 ccataaccat tttcagatgt gaactggtaa ccagatctag tcgatcaact ctggagatag
     4441 aaatctcctt ttttactgca aggctcaact tattaaaaat taggcagaat ccatatgctt
     4501 gcaaaagcta taaccacatg gaatgctatt ctcatggtac agtctaagtc tggtatccgt
     4561 attagtagcc actggacaaa gaacccaaag ttacccatgt gttctcttca gggcatccta
     4621 atttcttcag cataggcact cagtctttct ctcactctga acaaacctgt taacccattc
     4681 taagatggcg aggcaatcca ctccctaata ctgactttgc tcctgaaagg caaacttggt
     4741 caagcaactc tttaccttta ttctgtcaat gtctgactgg gaagctacct ttagaagcag
     4801 atcttcaaga tgcctcaacc cattggcatg aaagatataa tttttaaaag ttatgtaagg
     4861 caaaatgcca gaggccttcc ctgcctccag atgggtggat gcctagctct cacattaaaa
     4921 ggtaactgac agcagttctg tacctcatct gactgctcta agaccaaggc ttctttggaa
     4981 gggtcacatt agtggctggt ctgtgccttg aagcagaagg aaaatgcaga catagaatct
     5041 ggttcacttt ctagaatctg agtctgtatt cagtgttggg aagcatggtc ttcatgacag
     5101 agtaaataaa tccacatcac tgatgcataa aagaacagct cttagaacat gcttcttttc
     5161 ctggcacaga aacaatgttg ctgccactga aatgcataca gaatttttta actgatatgg
     5221 cattgggtag ttgtattaag gccaaacata cgcaactgta aagccttaca gagttgtgtg
     5281 agcattgtct ttggagacac gcaaagcctt agctggagta tgtgagcccc tcctcagggt
     5341 gggagtgaag gggaagctaa gaacatatat ttcttctgtc atacagatga cagaagaact
     5401 ttggttttag cggaccagag agagtttagt ttaaaggaag ttggagccat gatcttctgc
     5461 catttcccga gtggccacta aggatgctga tggtaccttg ccagctgtgc attgcctact
     5521 tgcttgcttt tacagagcca tgcatacatt tctgaataag gacagattta atcctgatat
     5581 tcccttaccg gacagacagt gttactaaag gaatacctct aaggtatagt agttatcaat
     5641 taaagcatat ttagcagtaa cttcaatttt aacaaaattg ggaaccagta actagtgttg
     5701 ggctcttttg atacagggca ggttctctct ccctttctcc atccttcaaa tgacagaaac
     5761 caaagtgaat acagtccaat tgcagtctat cttatgctta tacacactag aggtatgatt
     5821 agcagtggtt gagtcttggg agaccagccc tgaaaaaatc cagtaggtca agagcctaga
     5881 catggggtgt ggctggatgt tctcctttcc ttcctacatt gaggaatagt tataggttat
     5941 gtgaccccac ttcacaggca agtgggaggc aaaccttgca ggcattccac ttaaaagctg
     6001 gtctcctacc atagtcccaa gtctgttttc ccagcagcac atggaaagca acagtacagt
     6061 tttccatttc aaaatatgca tgccgagttt gcactctgtg tgagtgtttc caggttacac
     6121 atgtgggatg acatcacaga aaccacacaa gcaacaaatt aaattctacg ggaagaaata
     6181 ctcctgactg gtctctgagg agacattttt atgccttctt aactttatta ggaattctca
     6241 ggctgaagct atgggtcatt gttctccaac aaatcaatac aagccatcaa tgcactaaga
     6301 actgccaaac cctgatctgt gtgaatgttc ttaggagcct gtgatcccca tggtgctaca
     6361 aagaggctgg agctgggcca atgagaaggc ctaagaatcc tcctgccttc agcagatgtt
     6421 tactgagcac tctgagccag caacaccaca ccagtaactg ggaggacagc agctgggcag
     6481 tagggtgccc agccacttga atctcttttc ctctgaggca tgttttaatc ctcttatatc
     6541 agaccccagc caggggacac tttgtctaca gatcctcccc cacagttttc agatggccta
     6601 agccatacac aaatgactca gactaagaaa catcaatact cccagaagcc ccaagagctg
     6661 atttttgagc agtatgacaa gtggaagagg atattacaga ggccattttt ttctcctcct
     6721 cccgctcata ctagaagcta gccctccact cctagctcct ccacacaagt tggcagtggt
     6781 tccattacac caatggcaca ggaaaacaca ggtaccggtt tgccttcctc ccttgccaat
     6841 cacaagtgcc ttactctgac cagaccctat gccgaaacct ctctcgtcca agagaaccaa
     6901 atctctacat ttgttactac ttcaagtcaa tgtggtaact gctactcttc aagattcacc
     6961 taaacagtac agtccaacct tctccagggc cacagcacag agcaacctct agcacacacc
     7021 agccttgaat ctgttccaca gcatatcaac cacagtaacc tccctccctc ccactgcctc
     7081 gctctaatta caaggtgaag ttggccataa aaaaaaatca agttagcact gattacaaaa
     7141 tgcttttgat gcaacctgaa ttccccagtg cttttaaact ctgacgatgc tctgggatct
     7201 gtgagcccca tgctcagagc cactgggcag ttggagaacc cttgcaggag acatctgcac
     7261 acacatgaat gtaccgtttc catgcctttt gtggagaaca tacacacata catgcatact
     7321 ttcattcaca cacatacaca catatacaca cttacattag taatagttta ttatcaaacc
     7381 acggcaagct cttctcatat aagacacact gggataagag agtgttgagt gtggagttgt
     7441 taggaccctc agtagtggac agagattgcc aggaggccta acactcagga gtcatcttca
     7501 actgggaaat gacttgcccc ctgcaagttg aaagccccac cacttgccta cctttctaca
     7561 ccttcaaaga gcatgttctg tgatacctgt aattctccaa gaaagtaaca ttttagccct
     7621 taatttagca catttaaata aagacagagt cgatgtcagg taacttcttc acaaacaaat
     7681 cagatgctgg tttgcgttcg ctggcctgtg tgttggtact tcctaaagca gtgatcagaa
     7741 agcacacaaa tctcctgaga gactagaaac agaatgagca gccctcccat cagggcaacg
     7801 tggtagtggt tgggatagcc agtcatctga atgtttgtgg taacaaacaa cacaacctga
     7861 actggccaca ggctgcttag ctccgttctc attaatgtta acatctcagt taaccggcac
     7921 agccattctg cagggctttg tccattgata gcgctttggt tagctcatgt tttcacattt
     7981 gtatgttaca tgctgttatt tttgtatgca tttctcatat ggagggatct acaggtaaac
     8041 acagcctcct agttcagtag aaaatgacat tgttaagagt attatatcca ataaagagta
     8101 aacagaaaaa
//
