LOCUS       NM_019254               3785 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ADAM metallopeptidase domain 10 (Adam10), mRNA.
ACCESSION   NM_019254 XM_001054737 XM_217197
VERSION     NM_019254.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3785)
  AUTHORS   Thonda,S., Puttapaka,S.N., Kona,S.V. and Kalivendi,S.V.
  TITLE     Extracellular-Signal-Regulated Kinase Inhibition Switches APP
            Processing from beta- to alpha-Secretase under Oxidative Stress:
            Modulation of ADAM10 by SIRT1/NF-kappaB Signaling
  JOURNAL   ACS Chem Neurosci 12 (21), 4175-4186 (2021)
   PUBMED   34647720
  REMARK    GeneRIF: Extracellular-Signal-Regulated Kinase Inhibition Switches
            APP Processing from beta- to alpha-Secretase under Oxidative
            Stress: Modulation of ADAM10 by SIRT1/NF-kappaB Signaling.
REFERENCE   2  (bases 1 to 3785)
  AUTHORS   Marcello,E., Musardo,S., Vandermeulen,L., Pelucchi,S., Gardoni,F.,
            Santo,N., Antonucci,F. and Di Luca,M.
  TITLE     Amyloid-beta Oligomers Regulate ADAM10 Synaptic Localization
            Through Aberrant Plasticity Phenomena
  JOURNAL   Mol Neurobiol 56 (10), 7136-7143 (2019)
   PUBMED   30989630
  REMARK    GeneRIF: Abeta1-42 oligomers trigger an aberrant plasticity
            mechanism according to which Abeta1-42 oligomers can downregulate
            Abeta generation through the modulation of ADAM10 synaptic
            availability.
REFERENCE   3  (bases 1 to 3785)
  AUTHORS   Walkiewicz,K., Strzelczyk,J., Waniczek,D., Biernacki,K.,
            Muc-Wierzgon,M., Copija,A. and Nowakowska-Zajdel,E.
  TITLE     Adamalysines as Biomarkers and a Potential Target of Therapy in
            Colorectal Cancer Patients: Preliminary Results
  JOURNAL   Dis Markers 2019, 5035234 (2019)
   PUBMED   31565100
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3785)
  AUTHORS   Defourny,J., Peuckert,C., Kullander,K. and Malgrange,B.
  TITLE     EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium
            through Local Disruption of Adherens Junctions
  JOURNAL   iScience 11, 246-257 (2019)
   PUBMED   30639848
REFERENCE   5  (bases 1 to 3785)
  AUTHORS   Shah,J., Rouaud,F., Guerrera,D., Vasileva,E., Popov,L.M.,
            Kelley,W.L., Rubinstein,E., Carette,J.E., Amieva,M.R. and Citi,S.
  TITLE     A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to
            Promote alpha-Toxin Cytotoxicity
  JOURNAL   Cell Rep 25 (8), 2132-2147 (2018)
   PUBMED   30463011
REFERENCE   6  (bases 1 to 3785)
  AUTHORS   Lim,R., Winteringham,L.N., Williams,J.H., McCulloch,R.K.,
            Ingley,E., Tiao,J.Y., Lalonde,J.P., Tsai,S., Tilbrook,P.A., Sun,Y.,
            Wu,X., Morris,S.W. and Klinken,S.P.
  TITLE     MADM, a novel adaptor protein that mediates phosphorylation of the
            14-3-3 binding site of myeloid leukemia factor 1
  JOURNAL   J Biol Chem 277 (43), 40997-41008 (2002)
   PUBMED   12176995
REFERENCE   7  (bases 1 to 3785)
  AUTHORS   Hartmann,D., de Strooper,B., Serneels,L., Craessaerts,K.,
            Herreman,A., Annaert,W., Umans,L., Lubke,T., Lena Illert,A., von
            Figura,K. and Saftig,P.
  TITLE     The disintegrin/metalloprotease ADAM 10 is essential for Notch
            signalling but not for alpha-secretase activity in fibroblasts
  JOURNAL   Hum Mol Genet 11 (21), 2615-2624 (2002)
   PUBMED   12354787
REFERENCE   8  (bases 1 to 3785)
  AUTHORS   Namba,K., Nishio,M., Mori,K., Miyamoto,N., Tsurudome,M., Ito,M.,
            Kawano,M., Uchida,A. and Ito,Y.
  TITLE     Involvement of ADAM9 in multinucleated giant cell formation of
            blood monocytes
  JOURNAL   Cell Immunol 213 (2), 104-113 (2001)
   PUBMED   11831872
REFERENCE   9  (bases 1 to 3785)
  AUTHORS   Dallas,D.J., Genever,P.G., Patton,A.J., Millichip,M.I., McKie,N.
            and Skerry,T.M.
  TITLE     Localization of ADAM10 and Notch receptors in bone
  JOURNAL   Bone 25 (1), 9-15 (1999)
   PUBMED   10423016
REFERENCE   10 (bases 1 to 3785)
  AUTHORS   Howard,L., Lu,X., Mitchell,S., Griffiths,S. and Glynn,P.
  TITLE     Molecular cloning of MADM: a catalytically active mammalian
            disintegrin-metalloprotease expressed in various cell types
  JOURNAL   Biochem J 317 (Pt 1) (Pt 1), 45-50 (1996)
   PUBMED   8694785
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Sep 2, 2012 this sequence version replaced
            XM_217197.6, XM_001054737.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.46184.1,
                                           SRR26643299.36021.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               JAXUCZ010000008.1  80226862-80227123
            263-413             JAXUCZ010000008.1  80256439-80256589
            414-532             JAXUCZ010000008.1  80285874-80285992
            533-691             JAXUCZ010000008.1  80290672-80290830
            692-792             JAXUCZ010000008.1  80310184-80310284
            793-945             JAXUCZ010000008.1  80313420-80313572
            946-1038            JAXUCZ010000008.1  80315575-80315667
            1039-1222           JAXUCZ010000008.1  80317429-80317612
            1223-1386           JAXUCZ010000008.1  80325089-80325252
            1387-1570           JAXUCZ010000008.1  80333713-80333896
            1571-1721           JAXUCZ010000008.1  80340972-80341122
            1722-1905           JAXUCZ010000008.1  80341890-80342073
            1906-2014           JAXUCZ010000008.1  80342826-80342934
            2015-2235           JAXUCZ010000008.1  80343596-80343816
            2236-2362           JAXUCZ010000008.1  80355667-80355793
            2363-3785           JAXUCZ010000008.1  80357306-80358728
FEATURES             Location/Qualifiers
     source          1..3785
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3785
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /note="ADAM metallopeptidase domain 10"
                     /db_xref="GeneID:29650"
                     /db_xref="RGD:2032"
     exon            1..262
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..2457
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /EC_number="3.4.24.81"
                     /note="disintegrin and metalloproteinase domain-containing
                     protein 10; RGD1566370; ADAM 10; kuzbanian protein
                     homolog; mammalian disintegrin-metalloprotease; a
                     disintegrin and metalloprotease domain 10; a disintegrin
                     and metallopeptidase domain 10"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 10 precursor"
                     /protein_id="NP_062127.1"
                     /db_xref="GeneID:29650"
                     /db_xref="RGD:2032"
                     /translation="MVLPTVLILLLSWAAGLGGQYGNPLNKYIRHYEGLSYNVDSLHQ
                     KHQRAKRAVSHEDQFLLLDFHAHGRQFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHI
                     YTGHIYGEEGSFSHGSVVDGRFEGFIQTRGGTFYIEPAERYIKDRILPFHSVIYHEDD
                     INYPHKYGPQGGCADHSVFERMRKYQMTGVEEGTRAHSEEHAASMGPELLRKKRTTLA
                     ERNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRI
                     RINTTSDEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWV
                     GAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGS
                     PHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRN
                     NCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGKKCKLKPGKQCSPSQ
                     GPCCTAQCAFKSKSEKCRDDSDCAKEGICNGFTALCPASDPKPNFTDCNRHTQVCING
                     QCAGSICEKYDLEECTCASSDGKDDKELCHVCCMKKMAPSTCASTGSLQWNKQFNGRT
                     ITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPQLYENIAEWIVAHWWAV
                     LLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPPRQRPRE
                     SYQMGHMRR"
     exon            263..413
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            414..532
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            533..691
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            692..792
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            793..945
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1038
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1222
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1386
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1570
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1721
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1905
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2014
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2235
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2362
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..3785
                     /gene="Adam10"
                     /gene_synonym="MADM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaagggag gaaggaagag gccgaggggg agggagggcc ctgttttggc ggagtagggc
       61 gcgcggctgg gcccctgaag tggagcgaga gggaggcgct tcgccggtgc cactgccggg
      121 gaggctcgtc gggacccagc gccggtcgcg gctccctcag gatcgatgca ccgcggttaa
      181 cccgtgagga ggcggcggcc gcggaagatg gtgttgccga cagtgttaat tctgctcctc
      241 tcctgggcgg cggggctggg aggtcagtat ggaaatcctt taaataaata tattagacat
      301 tatgaaggat tatcttacaa tgtggattca ttacaccaaa aacaccagcg tgccaaacga
      361 gcagtctcac acgaggacca gtttttactt ctagatttcc atgctcatgg aagacaattc
      421 aacctacgaa tgaagaggga cacttccctt tttagtgatg aatttaaagt agaaacgtca
      481 aataaagtac ttgattatga tacctctcat atttacactg gacatattta tggtgaagaa
      541 ggaagcttta gtcatgggtc tgtcgttgat ggaagatttg aaggtttcat ccagactcgg
      601 ggtggcacat tttatattga gccagcagag agatatatta aagaccgaat cctgccgttt
      661 cactctgtca tttatcatga agatgatatt aactatcccc ataaatacgg cccacagggg
      721 ggctgtgcag atcactccgt ctttgaaagg atgaggaaat accaaatgac tggagtagag
      781 gaaggaactc gggcacattc agaggagcat gctgctagta tgggtcctga gctcctgagg
      841 aaaaagcgca caactctggc tgagagaaat acttgtcagc tctatatcca gacagatcac
      901 ctgttcttta aatactatgg aacacgagaa gctgtgattg ctcagatatc cagtcatgtt
      961 aaagcaattg atacaattta ccagactaca gacttctccg gaatccgtaa catcagcttt
     1021 atggtgaaac gcataagaat caatacaaca tctgatgaaa aagatcctac aaatcctttc
     1081 cgtttcccaa atattggtgt ggagaagttc ctggagttga attctgagca gaatcatgat
     1141 gactactgct tggcctatgt cttcacggac cgggattttg atgatggtgt tcttggtctg
     1201 gcatgggttg gagcaccttc aggaagctct ggaggaatat gtgagaaaag caagttgtat
     1261 tcagatggca agaagaagtc attgaacacg ggcatcatta ctgttcagaa ctatggctct
     1321 cacgtgcctc ccaaagtctc tcatattact tttgctcatg aagttggaca taactttgga
     1381 tctccacatg attctggaac agagtgcact ccaggagagt ctaagaactt aggacaaaaa
     1441 gaaaatggca attacatcat gtatgcgaga gcaacgtctg gggacaaact taacaacaac
     1501 aaattttcac tctgcagcat taggaacata agccaagtgc ttgagaagaa gaggaacaac
     1561 tgttttgttg aatctggcca gcctatctgt ggaaatggga tggtggagca aggggaagag
     1621 tgtgactgtg gctacagtga ccaatgcaaa gatgagtgct gcttcgatgc aaaccagcca
     1681 gaggggaaga aatgcaagct gaagcctggg aagcagtgca gtccaagtca aggaccctgc
     1741 tgtacagcac agtgtgcatt caagtcaaag tctgagaaat gtcgggatga ttctgactgt
     1801 gcaaaggaag ggatatgcaa tggcttcaca gccctttgcc cagcatctga tcccaagccc
     1861 aactttacag actgtaacag gcatacacaa gtgtgcatta atgggcaatg tgcaggttct
     1921 atctgtgaga agtatgactt ggaggagtgc acctgtgcca gctctgatgg caaagatgat
     1981 aaggaattat gtcatgtttg ctgcatgaag aaaatggccc catcaacttg tgccagtaca
     2041 ggctctttgc agtggaacaa gcagttcaat ggtcggacta tcactctgca gccaggctct
     2101 ccatgtaatg acttcagagg ctactgtgat gttttcatgc ggtgcagatt agtagatgct
     2161 gatggccctc tagctaggct gaaaaaagca atttttagtc cacaactcta tgaaaacatt
     2221 gctgagtgga ttgtggctca ctggtgggca gtactgctta tgggaattgc cctgatcatg
     2281 ctaatggctg gatttatcaa gatttgcagt gttcacactc caagtagtaa tccaaagttg
     2341 cctcctccta aaccacttcc aggcacttta aagaggagga gaccgccaca gcccattcag
     2401 cagcccccgc gtcagaggcc ccgggagagt tatcaaatgg gacacatgcg acgctgatgc
     2461 agcttttgcc ttggttcttc ctagtgccta cagtgggaaa acttcactcc aaagagaaac
     2521 ctgttaagtc atcatctgca aatgaaaccc tcacagttaa tagttgaaga aaaaatggca
     2581 agagatcatg tcctcagacc aggtggaatt acctaaaatt taaagcctga aaattccaat
     2641 tttttggggg gggtgggatg gaaaaggaac ccaattttct tatggacaga tatttttaac
     2701 ctaatggcac aaagtcttag aatattatta tgtgccctgt gttccctgtt cttcgttgct
     2761 gcattttctt cacttgcaga cagacttggc tctcgataaa cttttatcac aaattgaaat
     2821 atattttttt caactgccaa tcaaggctgg gaggctcgac cacctcaaca ttggatacat
     2881 cacttgccaa tgtacatacc ttgttatatg cagacatgta tttcttacgt acactgtact
     2941 tctctgtgca attgtaaaca gaaattgcaa tatggatgtt tctttgtatt ataaattttt
     3001 ccgctcttaa tgaaaaatta ctgtttaatt gacatactca ggataacaga gaatggtggt
     3061 gtgcagtggt ccaggattct gtaatgcttc atgcaggcca ttttgaaatg agaattgttt
     3121 tccctttttc ttatggtgga gttggttctt acatgcatcc ttttccctgt tccatggctg
     3181 ctgtgagtag gagaggctgt gttgaagagc tcagctggtg gcttacaaac cgggcagcaa
     3241 cagcgtttgg cttcagtcag ttcttcatgt cattgtctga tttctgcgtt agtactttat
     3301 actttctaaa tcaactccgt tttaaattgc taggtgaatt ttttttcacg ccttggtagg
     3361 aattatgttg gaaatgatcg ttttcatctg tagcctgctt attactctgt gtattccatg
     3421 tacttcaagc ctgctaattc tgtttttatc tgatatggaa aagaaaatca gtgtcttcat
     3481 tgaaatattt ggacagttct tcagcacact gtcactgatc attggtaacc actagagatg
     3541 agtaatttgc tcagcaggta gttgaaattg tagataggtt ttctgatgtt gttttccccc
     3601 caagacattt tagcaacaat gaaggtagac agcacagtgt cccattacaa acttccgttt
     3661 ttaagcagat ataaatattg gcatttttaa agaaagagaa agcaaaagca tttaatgtat
     3721 taacaggctt atcgctatgc agaaaatgga gggggcatta aaaatatgta agcttgtgac
     3781 atact
//
